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Gene: Gamt (guanidinoacetate methyltransferase) Mus musculus
Symbol: Gamt
Name: guanidinoacetate methyltransferase
RGD ID: 10618
Description: Predicted to have guanidinoacetate N-methyltransferase activity and identical protein binding activity. Involved in several processes, including creatine biosynthetic process; regulation of growth; and spermatogenesis. Predicted to localize to cytoplasm and nucleus. Is expressed in pancreas. Used to study guanidinoacetate methyltransferase deficiency. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Orthologous to human GAMT (guanidinoacetate N-methyltransferase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; creatine metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA571402; guanidinoacetate N-methyltransferase; Spi; Spintz1
Homo sapiens (human) : GAMT (guanidinoacetate N-methyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gamt (guanidinoacetate N-methyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gamt (guanidinoacetate N-methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : GAMT (guanidinoacetate N-methyltransferase)
Canis lupus familiaris (dog) : GAMT (guanidinoacetate N-methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gamt (guanidinoacetate N-methyltransferase)
Sus scrofa (pig) : GAMT (guanidinoacetate N-methyltransferase)
Chlorocebus sabaeus (African green monkey) : GAMT (guanidinoacetate N-methyltransferase)
Heterocephalus glaber (naked mole-rat) : Gamt (guanidinoacetate N-methyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1080,258,151 - 80,261,012 (-)EnsemblGRCm38mm10GRCm38
GRCm381080,258,151 - 80,261,025 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,720,896 - 79,723,713 (-)NCBIGRCm37mm9NCBIm37
MGSCv361079,661,328 - 79,664,141 (-)NCBImm8
Celera1081,273,024 - 81,275,841 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gamt
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10618
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.