Coa6 (cytochrome c oxidase assembly factor 6) - Rat Genome Database

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Gene: Coa6 (cytochrome c oxidase assembly factor 6) Rattus norvegicus
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Symbol: Coa6
Name: cytochrome c oxidase assembly factor 6
RGD ID: 7559315
Description: Predicted to enable copper ion binding activity. Predicted to be involved in mitochondrial ATP synthesis coupled electron transport; plasma membrane ATP synthesis coupled electron transport; and respiratory chain complex IV assembly. Predicted to be located in mitochondrial intermembrane space and nucleoplasm. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 13. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6); INTERACTS WITH (-)-epigallocatechin 3-gallate (ortholog); (1->4)-beta-D-glucan (ortholog); 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: cytochrome c oxidase assembly factor 6 homolog; LOC102556031; uncharacterized LOC102556031; uncharacterized protein Coa6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81971,293,066 - 71,295,668 (+)NCBIGRCr8
mRatBN7.21954,395,746 - 54,398,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1954,395,742 - 54,399,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1961,183,156 - 61,185,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01962,043,083 - 62,045,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01964,127,656 - 64,130,257 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01959,327,328 - 59,333,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1959,328,960 - 59,331,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01970,007,574 - 70,012,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1953,749,521 - 53,753,539 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:22658674   PMID:24549041   PMID:25339201   PMID:25959673   PMID:26160915  


Genomics

Comparative Map Data
Coa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81971,293,066 - 71,295,668 (+)NCBIGRCr8
mRatBN7.21954,395,746 - 54,398,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1954,395,742 - 54,399,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1961,183,156 - 61,185,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01962,043,083 - 62,045,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01964,127,656 - 64,130,257 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01959,327,328 - 59,333,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1959,328,960 - 59,331,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01970,007,574 - 70,012,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1953,749,521 - 53,753,539 (+)NCBICelera
Cytogenetic Map19q12NCBI
COA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381234,373,456 - 234,385,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1234,373,456 - 234,385,080 (+)EnsemblGRCh38hg38GRCh38
GRCh371234,509,202 - 234,520,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,576,052 - 232,586,414 (+)NCBINCBI36Build 36hg18NCBI36
Celera1207,780,333 - 207,790,700 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1205,002,255 - 205,012,839 (+)NCBIHuRef
CHM1_11235,781,494 - 235,792,155 (+)NCBICHM1_1
T2T-CHM13v2.01233,763,601 - 233,775,236 (+)NCBIT2T-CHM13v2.0
Coa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398127,149,267 - 127,152,174 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8127,149,254 - 127,152,172 (+)EnsemblGRCm39 Ensembl
GRCm388126,422,501 - 126,425,435 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8126,422,515 - 126,425,433 (+)EnsemblGRCm38mm10GRCm38
MGSCv378128,946,401 - 128,949,335 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368129,308,618 - 129,311,524 (+)NCBIMGSCv36mm8
Celera8130,729,516 - 130,733,949 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map874.08NCBI
LOC102028200
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554925,316,594 - 5,324,913 (-)NCBIChiLan1.0ChiLan1.0
LOC100973340
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2114,817,518 - 14,871,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,028,339 - 15,084,473 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01209,913,610 - 209,914,929 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11214,935,609 - 214,944,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1214,934,998 - 214,944,496 (+)Ensemblpanpan1.1panPan2
COA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.145,447,252 - 5,454,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl45,447,249 - 5,454,456 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha45,426,137 - 5,434,318 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.045,464,242 - 5,472,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl45,465,164 - 5,472,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.145,476,834 - 5,485,012 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.045,595,299 - 5,602,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.045,817,161 - 5,825,343 (-)NCBIUU_Cfam_GSD_1.0
LOC101966578
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934441,646,576 - 41,650,580 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648417,812,157 - 17,815,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11456,751,142 - 56,758,956 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21460,803,286 - 60,811,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12571,550,057 - 71,561,012 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2571,550,617 - 71,560,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605573,574,625 - 73,586,002 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101702099
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477515,942,940 - 15,945,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coa6
10 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 38 22 18 22 8 11 29 17 29 10 8
Low 8 19 19 1 19 45 18 12 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000086865   ⟹   ENSRNOP00000069157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1959,328,960 - 59,331,192 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094498   ⟹   ENSRNOP00000078421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1954,395,742 - 54,399,407 (+)Ensembl
RefSeq Acc Id: NM_001401093   ⟹   NP_001388022
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81971,293,066 - 71,295,668 (+)NCBI
mRatBN7.21954,395,746 - 54,398,348 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388022 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078421
  ENSRNOP00000078421.1
RefSeq Acc Id: ENSRNOP00000069157   ⟸   ENSRNOT00000086865
RefSeq Acc Id: ENSRNOP00000078421   ⟸   ENSRNOT00000094498
RefSeq Acc Id: NP_001388022   ⟸   NM_001401093
- UniProtKB: A0A8I5ZL79 (UniProtKB/TrEMBL),   A6KJ47 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUM8-F1-model_v2 AlphaFold A0A0G2JUM8 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701256
Promoter ID:EPDNEW_R11775
Type:multiple initiation site
Name:Coa6_1
Description:Cytochrome c oxidase assembly factor 6 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01959,328,956 - 59,329,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7559315 AgrOrtholog
BioCyc Gene G2FUF-5179 BioCyc
Ensembl Genes ENSRNOG00000052701 Ensembl
  ENSRNOG00000062808 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000094498 ENTREZGENE
  ENSRNOT00000094498.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.140 UniProtKB/TrEMBL
InterPro COA6 UniProtKB/TrEMBL
  COX6B-like UniProtKB/TrEMBL
  Cyt_c_oxidase_su6B UniProtKB/TrEMBL
  Cyt_c_oxidase_su6B_sf UniProtKB/TrEMBL
NCBI Gene LOC102556031 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG UniProtKB/TrEMBL
  PTHR46690 UniProtKB/TrEMBL
Pfam COX6B UniProtKB/TrEMBL
PhenoGen Coa6 PhenoGen
PROSITE CHCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052701 RatGTEx
  ENSRNOG00000062808 RatGTEx
Superfamily-SCOP SSF47694 UniProtKB/TrEMBL
UniProt A0A8I5ZL79 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ47 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Coa6  cytochrome c oxidase assembly factor 6  Coa6  cytochrome c oxidase assembly factor 6  Data merged from RGD:149736252 737654 PROVISIONAL
2021-08-09 Coa6  cytochrome c oxidase assembly factor 6      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-12-21 Coa6  cytochrome c oxidase assembly factor 6  LOC102556031  uncharacterized LOC102556031  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102556031  uncharacterized LOC102556031      Symbol and Name status set to provisional 70820 PROVISIONAL