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G |
A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
Isoproterenol results in increased expression of A2M mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCB1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression |
EXP ISO |
Isoproterenol results in decreased expression of ABCB4 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of ABCC3 mRNA Isoproterenol results in increased expression of ABCC3 mRNA |
CTD |
PMID:21335049 PMID:24286936 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCC4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABCG2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Abhd2 |
abhydrolase domain containing 2, acylglycerol lipase |
increases expression |
EXP |
Isoproterenol results in increased expression of ABHD2 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
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G |
Abhd4 |
abhydrolase domain containing 4, N-acyl phospholipase B |
increases expression |
ISO |
Isoproterenol results in increased expression of ABHD4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
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G |
Abi3 |
ABI family, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABI3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
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G |
Ablim3 |
actin binding LIM protein family, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ABLIM3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions increases phosphorylation decreases phosphorylation |
ISO EXP |
triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] Isoproterenol results in decreased phosphorylation of ACACA protein |
CTD |
PMID:18390901 PMID:27491814 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acadl |
acyl-CoA dehydrogenase, long chain |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADL mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]] |
CTD |
PMID:25045214 PMID:30303030 |
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NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
decreases activity decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased activity of ACADM protein Isoproterenol results in decreased expression of ACADM mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADM mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]] |
CTD |
PMID:19826179 PMID:25045214 PMID:30303030 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADS mRNA Isoproterenol results in decreased expression of ACADS mRNA |
CTD |
PMID:30303030 |
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NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of ACADVL mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADVL mRNA |
CTD |
PMID:30303030 |
|
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions increases activity |
EXP |
oleuropein inhibits the reaction [Isoproterenol results in increased activity of ACE protein] |
CTD |
PMID:26056852 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression multiple interactions decreases activity |
ISO EXP |
Isoproterenol results in increased expression of ACE2 mRNA Isoproterenol results in increased expression of ACE2 protein [Isoproterenol results in decreased activity of ACE2 protein] which results in decreased abundance of angiotensin I (1-7); xanthone inhibits the reaction [[Isoproterenol results in decreased activity of ACE2 protein] which results in decreased abundance of angiotensin I (1-7)]; xanthone inhibits the reaction [Isoproterenol results in decreased activity of ACE2 protein] |
CTD |
PMID:20003209 PMID:20409916 PMID:36414029 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acer2 |
alkaline ceramidase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ACER2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ACSL1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA] |
CTD |
PMID:10710348 |
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NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression increases expression |
ISO EXP |
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] Isoproterenol results in increased expression of ACTA2 mRNA; Isoproterenol results in increased expression of ACTA2 protein Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of ACTA2 protein]; xanthone inhibits the reaction [Isoproterenol results in increased expression of ACTA2 protein] |
CTD |
PMID:18089841 PMID:20003209 PMID:24945829 PMID:28526319 PMID:35305975 PMID:36414029 More...
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Actb |
actin, beta |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ACTB mRNA |
CTD |
PMID:20003209 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Actg2 |
actin gamma 2, smooth muscle |
increases expression |
ISO |
Isoproterenol results in increased expression of ACTG2 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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G |
Ada |
adenosine deaminase |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions increases expression |
EXP ISO |
bellidifolin inhibits the reaction [Isoproterenol results in increased expression of ADAM17 mRNA] |
CTD |
PMID:37528096 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Adam22 |
ADAM metallopeptidase domain 22 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAM22 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962
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G |
Adam8 |
ADAM metallopeptidase domain 8 |
increases expression |
EXP |
Isoproterenol results in increased expression of ADAM8 mRNA |
CTD |
PMID:20211217 |
|
NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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G |
Adamtsl2 |
ADAMTS-like 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAMTSL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554
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G |
Adamtsl4 |
ADAMTS-like 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADAMTSL4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:183,235,634...183,247,091
Ensembl chr 2:183,235,646...183,246,848
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance multiple interactions |
ISO |
ADCY5 protein results in increased susceptibility to Isoproterenol [ADCY5 protein results in increased susceptibility to Isoproterenol] which results in decreased expression of SOD2 protein; SOD2 protein inhibits the reaction [ADCY5 protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:12869393 PMID:23536361 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Adcy6 |
adenylate cyclase 6 |
affects response to substance |
ISO |
ADCY6 protein affects the susceptibility to Isoproterenol |
CTD |
PMID:12393090 |
|
NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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G |
Adcy9 |
adenylate cyclase 9 |
multiple interactions |
ISO |
[Isoproterenol co-treated with Miconazole] results in increased activity of ADCY9 protein alternative form |
CTD |
PMID:30607468 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Add3 |
adducin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ADD3 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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G |
Adgrd1 |
adhesion G protein-coupled receptor D1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:27,488,908...27,603,714
Ensembl chr12:27,488,908...27,603,696
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G |
Adgrf5 |
adhesion G protein-coupled receptor F5 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRF5 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968
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G |
Adgrl4 |
adhesion G protein-coupled receptor L4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ADGRL4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:240,354,909...240,457,231
Ensembl chr 2:240,354,941...240,457,225
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G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
increases expression |
ISO |
Isoproterenol results in increased expression of ADH1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adm |
adrenomedullin |
multiple interactions increases expression |
EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP] Isoproterenol results in increased expression of ADM mRNA; Isoproterenol results in increased expression of ADM protein |
CTD |
PMID:12732346 PMID:17250927 PMID:17306419 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Adra1b |
adrenoceptor alpha 1B |
multiple interactions decreases expression |
ISO |
ADRA1B protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP] Isoproterenol results in decreased expression of ADRA1B mRNA |
CTD |
PMID:12649302 PMID:20003209 |
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NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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G |
Adrb1 |
adrenoceptor beta 1 |
multiple interactions decreases expression increases uptake affects response to substance increases activity increases phosphorylation |
ISO EXP |
[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]; Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein] Isoproterenol results in decreased expression of ADRB1; Isoproterenol results in decreased expression of ADRB1 mRNA ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]; ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA] Isoproterenol results in increased uptake of ADRB1 protein ADRB1 protein polymorphism affects the susceptibility to Isoproterenol [ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol Isoproterenol results in increased phosphorylation of ADRB1 protein |
CTD |
PMID:1312942 PMID:8096834 PMID:8723169 PMID:11159692 PMID:12761341 PMID:12963636 PMID:14502278 PMID:14730417 PMID:15627480 PMID:16731636 PMID:17200720 PMID:17350036 PMID:18194989 PMID:18378355 PMID:18787115 PMID:20003209 More...
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NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
multiple interactions increases expression increases phosphorylation decreases expression increases activity increases uptake affects expression |
ISO EXP |
4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]; imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Isoproterenol binds to and results in increased activity of ADRB2 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein] Isoproterenol results in increased expression of ADRB2 mRNA Isoproterenol results in increased phosphorylation of ADRB2 protein [GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein; ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein] Isoproterenol results in decreased expression of ADRB2; Isoproterenol results in decreased expression of ADRB2 mRNA [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP] Isoproterenol results in increased uptake of ADRB2 protein Isoproterenol affects the expression of ADRB2 mRNA |
CTD |
PMID:9875846 PMID:10226872 PMID:10516654 PMID:11164953 PMID:11752207 PMID:12920204 PMID:12963636 PMID:14730417 PMID:15178407 PMID:16036225 PMID:16980553 PMID:17196553 PMID:17350036 PMID:17925438 PMID:18378355 PMID:18820136 PMID:19483313 PMID:21177286 PMID:21629661 PMID:24705868 PMID:27825928 PMID:34601065 More...
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions increases activity increases expression |
ISO EXP |
[Isoproterenol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Isoproterenol binds to and results in increased activity of ADRB3 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB3 protein]; L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein] 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]; 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased expression of ADRB3 protein]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 mRNA]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 protein]; Isoproterenol binds to and results in increased activity of ADRB3 protein [ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol Isoproterenol results in increased expression of ADRB3 mRNA; Isoproterenol results in increased expression of ADRB3 protein |
CTD |
PMID:1682311 PMID:7815362 PMID:11159692 PMID:14730417 PMID:15009959 PMID:17622774 PMID:18553954 PMID:18820136 PMID:20654104 More...
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NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Aen |
apoptosis enhancing nuclease |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AEN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Agbl5 |
AGBL carboxypeptidase 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AGBL5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:25,472,333...25,492,173
Ensembl chr 6:25,472,333...25,490,738
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G |
Agt |
angiotensinogen |
multiple interactions increases expression |
ISO EXP |
adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; ICI 118551 inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]] Propranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein] Isoproterenol results in increased expression of AGT mRNA; Isoproterenol results in increased expression of AGT protein AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA]; AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; xanthone inhibits the reaction [Isoproterenol results in increased expression of AGT protein] |
CTD |
PMID:1534315 PMID:1653766 PMID:7843740 PMID:11709406 PMID:16731636 PMID:19023134 PMID:19483313 PMID:20003209 PMID:20409916 PMID:24117263 PMID:27890915 PMID:36414029 More...
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AGTR1A mRNA |
CTD |
PMID:17350036 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Ahcy |
adenosylhomocysteinase |
increases expression |
ISO |
Isoproterenol results in increased expression of AHCY mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
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G |
Ahnak2 |
AHNAK nucleoprotein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of AHNAK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:131,830,668...131,876,311
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of AHR mRNA Isoproterenol results in decreased expression of AHR mRNA |
CTD |
PMID:24286936 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ahsg |
alpha-2-HS-glycoprotein |
increases expression |
ISO |
Isoproterenol results in increased expression of AHSG mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
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G |
Aif1 |
allograft inflammatory factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AIF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Ak4 |
adenylate kinase 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AK4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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G |
Akap1 |
A-kinase anchoring protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AKAP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
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G |
Akap13 |
A-kinase anchoring protein 13 |
increases expression |
ISO |
Isoproterenol results in increased expression of AKAP13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions decreases expression decreases phosphorylation |
ISO EXP |
Isoproterenol results in increased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein] Isoproterenol results in decreased expression of AKT1 mRNA 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of AKT1 protein]; [Isoproterenol co-treated with POSTN protein] results in decreased expression of AKT1 mRNA; [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15178407 PMID:15618457 PMID:15951400 PMID:16716347 PMID:17623046 PMID:18806606 PMID:19167487 PMID:20003209 PMID:30303030 PMID:31009642 PMID:32686902 PMID:35815753 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ALDH2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ALDH3A2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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G |
Alpk2 |
alpha-kinase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ALPK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
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G |
Alpk3 |
alpha-kinase 3 |
decreases expression multiple interactions |
ISO |
Isoproterenol results in decreased expression of ALPK3 mRNA; Isoproterenol results in decreased expression of ALPK3 protein MIR384 mRNA inhibits the reaction [Isoproterenol results in decreased expression of ALPK3 mRNA] |
CTD |
PMID:35510648 |
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NCBI chr 1:135,014,455...135,062,294
Ensembl chr 1:135,014,499...135,062,302
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G |
Alpp |
alkaline phosphatase, placental |
multiple interactions increases expression |
ISO |
Amphetamine promotes the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]; norfluoxetine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] |
CTD |
PMID:16036225 |
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NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Amy2a3 |
amylase 2a3 |
multiple interactions |
EXP |
Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein; Propranolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein] |
CTD |
PMID:21173550 |
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NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532
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G |
Ang |
angiogenin |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of ANG mRNA Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr15:24,312,711...24,323,361
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G |
Angpt2 |
angiopoietin 2 |
increases expression |
EXP |
Isoproterenol results in increased expression of ANGPT2 mRNA |
CTD |
PMID:22908232 |
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NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANGPTL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl6 |
angiopoietin-like 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANGPTL6 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925
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G |
Anp32a |
acidic nuclear phosphoprotein 32 family member A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ANP32A mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443
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G |
Anxa1 |
annexin A1 |
multiple interactions increases expression |
ISO |
ANXA1 affects the reaction [Isoproterenol results in decreased secretion of IL6 protein] Isoproterenol results in increased expression of ANXA1 mRNA |
CTD |
PMID:16835395 PMID:20003209 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions increases activity |
EXP |
Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; H 35-25 inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein] |
CTD |
PMID:2860926 PMID:6218830 |
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NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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G |
Aoc3 |
amine oxidase, copper containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of AOC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:86,272,757...86,280,702
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G |
Aox1 |
aldehyde oxidase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of AOX1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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G |
Ap1b1 |
adaptor related protein complex 1 subunit beta 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of AP1B1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of APAF1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of APEX1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Apln |
apelin |
multiple interactions decreases expression |
EXP |
Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN mRNA]; Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN protein] Isoproterenol results in decreased expression of APLN mRNA; Isoproterenol results in decreased expression of APLN protein |
CTD |
PMID:19960946 |
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NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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G |
Apoa2 |
apolipoprotein A2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APOA2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Isoproterenol results in increased expression of APOD mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G |
Appbp2 |
amyloid beta precursor protein binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APPBP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835
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G |
Appl2 |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of APPL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754
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G |
Arf2 |
ADP-ribosylation factor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ARF2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:88,867,836...88,889,654
Ensembl chr10:88,867,836...88,889,659
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G |
Arf4 |
ADP-ribosylation factor 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARF4 mRNA |
CTD |
PMID:21335049 |
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NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arhgap12 |
Rho GTPase activating protein 12 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP12 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:51,588,810...51,702,417
Ensembl chr17:51,588,842...51,702,080
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G |
Arhgap18 |
Rho GTPase activating protein 18 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ARHGAP18 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256
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G |
Arhgap20 |
Rho GTPase activating protein 20 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP20 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739
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G |
Arhgap24 |
Rho GTPase activating protein 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARHGAP24 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
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G |
Arhgdib |
Rho GDP dissociation inhibitor beta |
increases expression |
EXP |
Isoproterenol results in increased expression of ARHGDIB mRNA |
CTD |
PMID:30303030 |
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NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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G |
Arid4b |
AT-rich interaction domain 4B |
increases expression |
ISO |
Isoproterenol results in increased expression of ARID4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:51,138,419...51,262,894
Ensembl chr17:51,138,535...51,262,906
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G |
Arid5b |
AT-rich interaction domain 5B |
increases expression |
ISO |
Isoproterenol results in increased expression of ARID5B mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
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G |
Arl4a |
ADP-ribosylation factor like GTPase 4A |
increases expression |
ISO |
Isoproterenol results in increased expression of ARL4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:57,079,496...57,084,156
Ensembl chr 6:57,078,812...57,085,066
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G |
Arnt2 |
aryl hydrocarbon receptor nuclear translocator 2 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of ARNT2 mRNA Isoproterenol results in increased expression of ARNT2 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein] |
CTD |
PMID:18787115 |
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NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Arrb2 |
arrestin, beta 2 |
affects localization multiple interactions |
ISO EXP |
Isoproterenol affects the localization of ARRB2 protein ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; S-nitrosocysteine inhibits the reaction [Isoproterenol affects the localization of ARRB2 protein] |
CTD |
PMID:17482545 PMID:17925438 PMID:18787115 PMID:21078978 |
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NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Arrdc2 |
arrestin domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARRDC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
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G |
Arrdc3 |
arrestin domain containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ARRDC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
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G |
Asap1 |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ASAP1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
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G |
Asb11 |
ankyrin repeat and SOCS box containing 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of ASB11 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr X:30,014,485...30,037,808
Ensembl chr X:29,992,416...30,037,807
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G |
Ascc3 |
activating signal cointegrator 1 complex subunit 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ASCC3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Isoproterenol results in increased expression of ASNS mRNA |
CTD |
PMID:21335049 PMID:21823215 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ASPH mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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G |
Aspn |
asporin |
increases expression |
ISO |
Isoproterenol results in increased expression of ASPN mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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G |
Atad2 |
ATPase family, AAA domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATAD2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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G |
Atf2 |
activating transcription factor 2 |
multiple interactions increases phosphorylation |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] |
CTD |
PMID:18089841 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of ATF3 mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of ATF3 protein] |
CTD |
PMID:21823215 PMID:25136830 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atp10d |
ATPase phospholipid transporting 10D (putative) |
increases expression |
ISO |
Isoproterenol results in increased expression of ATP10D mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions decreases expression |
EXP |
astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA]; candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein]; Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein Isoproterenol results in decreased expression of ATP2A2 mRNA; Isoproterenol results in decreased expression of ATP2A2 protein |
CTD |
PMID:16723803 PMID:17509559 |
|
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions decreases expression |
EXP ISO |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1A mRNA Isoproterenol results in decreased expression of ATP5F1A mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1d |
ATP synthase F1 subunit delta |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1D mRNA |
CTD |
PMID:30303030 |
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NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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G |
Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5MC1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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G |
Atp5me |
ATP synthase membrane subunit e |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5ME mRNA |
CTD |
PMID:30303030 |
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NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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G |
Atp5pd |
ATP synthase peripheral stalk subunit d |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5PD mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5PO mRNA |
CTD |
PMID:30303030 |
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NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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G |
Atp6ap2 |
ATPase H+ transporting accessory protein 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP6AP2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
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G |
Atp6v1e1 |
ATPase H+ transporting V1 subunit E1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ATP6V1E1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:154,022,358...154,044,486
Ensembl chr 4:154,022,358...154,044,584
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G |
Atp8b1 |
ATPase phospholipid transporting 8B1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATP8B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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G |
Atxn10 |
ataxin 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of ATXN10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
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G |
Auts2 |
activator of transcription and developmental regulator AUTS2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of AUTS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416
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G |
Azi2 |
5-azacytidine induced 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of AZI2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
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G |
Bag1 |
BAG cochaperone 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BAG1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
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G |
Bag4 |
BAG cochaperone 4 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of BAG4 mRNA |
CTD |
PMID:30303030 |
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NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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G |
Bak1 |
BCL2-antagonist/killer 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BAK1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of BAX protein Isoproterenol results in increased expression of BAX mRNA; Isoproterenol results in increased expression of BAX protein Isoproterenol results in decreased expression of BAX mRNA 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein; [Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]; Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; erdosteine inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of BAX protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX mRNA]]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of BAX protein]]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA]; Tretinoin inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] |
CTD |
PMID:15052282 PMID:16116328 PMID:17961425 PMID:24286936 PMID:24954035 PMID:27491814 PMID:29414845 PMID:30152906 PMID:32007421 PMID:33210414 PMID:35430261 PMID:36593721 PMID:37806379 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of BCAT1 mRNA |
CTD |
PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of BCL2 protein Isoproterenol results in decreased expression of BCL2 mRNA; Isoproterenol results in decreased expression of BCL2 protein Isoproterenol results in increased expression of BCL2 mRNA 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein; [erdosteine co-treated with Isoproterenol] affects the expression of BCL2 protein; [Isoproterenol co-treated with POSTN protein] results in increased expression of BCL2 mRNA; [Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein; Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; echinocystic acid affects the reaction [Isoproterenol affects the expression of BCL2 mRNA]; Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in decreased expression of BCL2 mRNA]]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; punicalagin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein] |
CTD |
PMID:11218852 PMID:12791704 PMID:15052282 PMID:19573579 PMID:24954035 PMID:27491814 PMID:29414845 PMID:30152906 PMID:30303030 PMID:30623541 PMID:32007421 PMID:33210414 PMID:35430261 PMID:35608392 PMID:36593721 PMID:37806379 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of BCL2L1 mRNA Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein]; CGP 20712A inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA]; Metoprolol inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein]; Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form]; Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] Isoproterenol results in increased expression of BCL2L1 mRNA alternative form; Isoproterenol results in increased expression of BCL2L1 protein; Isoproterenol results in increased expression of BCL2L1 protein alternative form Isoproterenol results in decreased expression of BCL2L1 mRNA; Isoproterenol results in decreased expression of BCL2L1 protein |
CTD |
PMID:12738230 PMID:16116328 PMID:20003209 PMID:24286936 PMID:26996544 PMID:30152906 PMID:35608392 More...
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of BCL2L11 protein Isoproterenol results in increased expression of BCL2L11 mRNA |
CTD |
PMID:14996839 PMID:24286936 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bdh1 |
3-hydroxybutyrate dehydrogenase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BDH1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
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G |
Bicd1 |
BICD cargo adaptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BICD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of BIRC2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BMAL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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G |
Bmf |
Bcl2 modifying factor |
increases expression |
EXP |
Isoproterenol results in increased expression of BMF mRNA |
CTD |
PMID:24286936 |
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NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp10 |
bone morphogenetic protein 10 |
multiple interactions decreases response to substance |
ISO |
BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; STAT3 protein affects the reaction [BMP10 protein results in decreased susceptibility to Isoproterenol] BMP10 protein inhibits the reaction [Isoproterenol results in increased cleavage of PARP1 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; STAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]] |
CTD |
PMID:31712309 |
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NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627
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G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression |
EXP |
isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
EXP |
isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmp7 |
bone morphogenetic protein 7 |
increases expression |
EXP |
isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
RGD |
PMID:26873969 |
RGD:11526363 |
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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G |
Bnip1 |
BCL2 interacting protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BNIP1 protein |
CTD |
PMID:15052282 |
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NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of BNIP3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bok |
BCL2 family apoptosis regulator BOK |
decreases expression |
ISO |
Isoproterenol results in decreased expression of BOK mRNA |
CTD |
PMID:21335049 |
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NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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G |
Brd4 |
bromodomain containing 4 |
decreases expression multiple interactions increases expression |
ISO |
Isoproterenol results in decreased expression of BRD4 mRNA bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 protein] Isoproterenol results in increased expression of BRD4 mRNA; Isoproterenol results in increased expression of BRD4 protein |
CTD |
PMID:20003209 PMID:37528096 |
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NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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G |
Brwd1 |
bromodomain and WD repeat domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BRWD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:35,286,364...35,378,768
Ensembl chr11:35,288,313...35,378,768
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G |
Bsdc1 |
BSD domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of BSDC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:141,798,918...141,827,091
Ensembl chr 5:141,798,981...141,827,092
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G |
C3 |
complement C3 |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of C3 mRNA Isoproterenol results in increased expression of C3 mRNA; Isoproterenol results in increased expression of C3 protein Isoproterenol results in decreased expression of C3 mRNA Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C3 protein] |
CTD |
PMID:20003209 PMID:24286936 PMID:32924446 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4b |
complement C4B |
increases expression |
ISO |
Isoproterenol results in increased expression of C4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
C5 |
complement C5 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of C5 protein Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C5 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C5 protein] |
CTD |
PMID:32924446 |
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NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
C9 |
complement C9 |
increases expression |
EXP |
Isoproterenol results in increased expression of C9 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
increases expression |
EXP |
Isoproterenol results in increased expression of CACNA1C mRNA |
CTD |
PMID:17526999 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cadm4 |
cell adhesion molecule 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CADM4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:80,075,163...80,097,423
Ensembl chr 1:80,075,202...80,097,423
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]] |
CTD |
PMID:17306419 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calcrl |
calcitonin receptor like receptor |
multiple interactions increases expression |
EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA Isoproterenol results in increased expression of CALCRL mRNA; Isoproterenol results in increased expression of CALCRL protein |
CTD |
PMID:16987513 PMID:17250927 PMID:17306419 |
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NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
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G |
Calm3 |
calmodulin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CALM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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G |
Calr |
calreticulin |
increases expression |
ISO |
Isoproterenol results in increased expression of CALR mRNA |
CTD |
PMID:21823215 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Calr3 |
calreticulin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CALR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
increases expression |
ISO |
Isoproterenol results in increased expression of CAMK2B mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Camk2d |
calcium/calmodulin-dependent protein kinase II delta |
multiple interactions increases expression |
EXP |
[Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of CAMK2D protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of CAMK2D protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased expression of CAMK2D protein] |
CTD |
PMID:26982530 |
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NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases phosphorylation |
EXP |
Isoproterenol results in decreased phosphorylation of CAMKK2 protein |
CTD |
PMID:27491814 |
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NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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G |
Capn1 |
calpain 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CAPN1 mRNA Quercetin inhibits the reaction [Isoproterenol results in increased expression of CAPN1 mRNA] |
CTD |
PMID:27527349 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn10 |
calpain 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of CAPN10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494
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G |
Capn2 |
calpain 2 |
multiple interactions increases expression |
EXP |
Quercetin inhibits the reaction [Isoproterenol results in increased expression of CAPN2 mRNA] |
CTD |
PMID:27527349 |
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NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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G |
Car4 |
carbonic anhydrase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of CAR4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
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G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CARMIL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
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G |
Casp1 |
caspase 1 |
decreases expression increases expression |
ISO |
Isoproterenol results in decreased expression of CASP1 mRNA Isoproterenol results in increased expression of CASP1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp2 |
caspase 2 |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of CASP2 mRNA Isoproterenol results in increased expression of CASP2 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity increases cleavage |
ISO EXP |
Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein]; BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; RAPGEF3 mutant form inhibits the reaction [Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; STAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]] Isoproterenol results in increased expression of CASP3 mRNA; Isoproterenol results in increased expression of CASP3 protein [Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; [erdosteine co-treated with Isoproterenol] affects the expression of CASP3 protein; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; anethole inhibits the reaction [Isoproterenol results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; benidipine inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of CASP3 mRNA]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Progesterone inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of CASP3 protein]; sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP3 mRNA] |
CTD |
PMID:11218852 PMID:17136323 PMID:17961425 PMID:20726854 PMID:21745194 PMID:24286936 PMID:25269373 PMID:25794854 PMID:26982530 PMID:27491814 PMID:28266775 PMID:30152906 PMID:30623541 PMID:31712309 PMID:32865837 PMID:32924446 PMID:33210414 PMID:34816538 PMID:35014750 PMID:35305975 PMID:35430261 PMID:36593721 PMID:37806379 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CASP6 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions decreases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein]; Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein Isoproterenol results in decreased expression of CASP7 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of CASP7 mRNA |
CTD |
PMID:17136323 PMID:24286936 PMID:30303030 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CASP8 mRNA; Isoproterenol results in increased expression of CASP8 protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]; Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] |
CTD |
PMID:25794854 PMID:26996544 PMID:30152906 PMID:34816538 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases expression multiple interactions increases activity increases cleavage |
EXP |
Isoproterenol results in increased expression of CASP9 mRNA; Isoproterenol results in increased expression of CASP9 protein anethole inhibits the reaction [Isoproterenol results in increased cleavage of CASP9 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]; sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP9 protein]; Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA] |
CTD |
PMID:24286936 PMID:25794854 PMID:26996544 PMID:30152906 PMID:32865837 PMID:34816538 PMID:35430261 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression increases expression increases activity multiple interactions decreases activity |
ISO EXP |
Isoproterenol results in decreased expression of CAT protein Isoproterenol results in increased expression of CAT mRNA Isoproterenol results in increased activity of CAT protein Isoproterenol results in decreased expression of CAT mRNA; Isoproterenol results in decreased expression of CAT protein 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; [Streptozocin co-treated with Isoproterenol] affects the activity of CAT protein; anethole inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; benidipine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Carvedilol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of CAT protein]; caryophyllene inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; dicarbine inhibits the reaction [Isoproterenol results in increased activity of CAT protein]; Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; erdosteine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; geraniol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of CAT mRNA]; Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; imetit inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of CAT protein]; Isoproterenol results in decreased expression of and results in decreased activity of CAT protein; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; punicalagin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]]; pyrvinium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Tretinoin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Vincristine inhibits the reaction [Isoproterenol results in decreased expression of CAT protein] |
CTD |
PMID:1840475 PMID:12708743 PMID:15740881 PMID:16584858 PMID:16697266 PMID:19146839 PMID:20003209 PMID:21322096 PMID:22391854 PMID:24201307 PMID:24954035 PMID:25269373 PMID:25496245 PMID:25537132 PMID:26721194 PMID:27527349 PMID:30152906 PMID:30623541 PMID:32007421 PMID:32946155 PMID:33210414 PMID:34816538 PMID:35014750 PMID:35130744 PMID:35305975 PMID:35430261 PMID:35608392 PMID:35815753 PMID:36593721 PMID:37806379 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] |
CTD |
PMID:18820136 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cav3 |
caveolin 3 |
affects localization |
EXP |
Isoproterenol affects the localization of CAV3 protein |
CTD |
PMID:19299911 |
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NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
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G |
Cblb |
Cbl proto-oncogene B |
increases expression |
ISO |
Isoproterenol results in increased expression of CBLB mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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G |
Ccdc80 |
coiled-coil domain containing 80 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCDC80 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137
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G |
Ccdc85a |
coiled-coil domain containing 85A |
increases expression |
ISO |
Isoproterenol results in increased expression of CCDC85A mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:102,126,574...102,359,207
Ensembl chr14:102,129,029...102,359,058
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
decreases secretion |
ISO |
Isoproterenol results in decreased secretion of CCL17 protein |
CTD |
PMID:12871855 |
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NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCL2 mRNA |
CTD |
PMID:21823215 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions decreases expression increases expression |
ISO |
Isoproterenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein] Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] Isoproterenol results in decreased expression of CCL3 mRNA Isoproterenol results in increased expression of CCL3 protein |
CTD |
PMID:9863660 PMID:12538206 PMID:21335049 PMID:24286936 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression decreases expression |
EXP ISO |
Isoproterenol results in increased expression of CCL7 mRNA Isoproterenol results in decreased expression of CCL7 mRNA |
CTD |
PMID:20211217 PMID:24286936 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccl9 |
C-C motif chemokine ligand 9 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCL6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of CCN2 mRNA Isoproterenol results in decreased expression of CCN2 mRNA Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein] Isoproterenol results in increased expression of CCN2 mRNA; Isoproterenol results in increased expression of CCN2 protein |
CTD |
PMID:20003209 PMID:24117263 PMID:24286936 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnd1 |
cyclin D1 |
decreases expression increases expression |
ISO |
Isoproterenol results in decreased expression of CCND1 mRNA Isoproterenol results in increased expression of CCND1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CCND3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccng2 |
cyclin G2 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of CCR1 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 8:123,556,286...123,561,841
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G |
Cd14 |
CD14 molecule |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of CD14 mRNA |
CTD |
PMID:20003209 PMID:20211217 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd163 |
CD163 molecule |
increases expression |
ISO |
Isoproterenol results in increased expression of CD163 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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G |
Cd302 |
CD302 molecule |
increases expression |
ISO |
Isoproterenol results in increased expression of CD302 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:44,722,324...44,756,045
Ensembl chr 3:44,722,325...44,756,045
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G |
Cd36 |
CD36 molecule |
decreases expression |
EXP |
Isoproterenol results in decreased expression of CD36 protein |
CTD |
PMID:19826179 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd38 |
CD38 molecule |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein] |
CTD |
PMID:23343681 |
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NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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G |
Cd74 |
CD74 molecule |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CD74 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CDC37 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdc37l1 |
cell division cycle 37-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDC37L1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175
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G |
Cdc42ep3 |
CDC42 effector protein 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDC42EP3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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G |
Cdc42ep4 |
CDC42 effector protein 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDC42EP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695
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G |
Cdh11 |
cadherin 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDH11 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh13 |
cadherin 13 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDH13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CDH2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of CDK1 mRNA; Isoproterenol results in increased expression of CDK1 protein Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] |
CTD |
PMID:9593584 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdo1 |
cysteine dioxygenase type 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDO1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
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G |
Cds2 |
CDP-diacylglycerol synthase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541
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G |
Cdv3 |
carnitine deficiency-associated gene expressed in ventricle 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CDV3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:103,934,006...103,947,173
Ensembl chr 8:103,933,996...103,947,192
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G |
Cdyl |
chromodomain Y-like |
increases expression |
ISO |
Isoproterenol results in increased expression of CDYL mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
increases expression |
ISO |
Isoproterenol results in increased expression of CEBPD mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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G |
Cebpg |
CCAAT/enhancer binding protein gamma |
increases expression |
ISO |
Isoproterenol results in increased expression of CEBPG mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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G |
Cenpa |
centromere protein A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CENPA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cep192 |
centrosomal protein 192 |
increases expression |
ISO |
Isoproterenol results in increased expression of CEP192 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379
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G |
Cfh |
complement factor H |
increases expression |
ISO |
Isoproterenol results in increased expression of CFH mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity |
ISO EXP |
[Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein; Baclofen promotes the reaction [Isoproterenol results in increased activity of CFTR protein]; Enkephalin, Leucine-2-Alanine promotes the reaction [Isoproterenol results in increased activity of CFTR protein]; Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein] |
CTD |
PMID:15020588 PMID:15039139 PMID:15151902 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
EXP |
Isoproterenol results in increased expression of CH25H mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CHAC1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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G |
Chka |
choline kinase alpha |
increases expression |
ISO |
Isoproterenol results in increased expression of CHKA mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CHUK mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cidec |
cell death-inducing DFFA-like effector c |
multiple interactions |
ISO |
Isoproterenol results in increased expression of and results in decreased degradation of CIDEC protein; KT 5720 inhibits the reaction [Isoproterenol results in increased expression of CIDEC protein] |
CTD |
PMID:21097823 |
|
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Cilp |
cartilage intermediate layer protein |
increases expression |
ISO |
Isoproterenol results in increased expression of CILP mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251
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G |
Cirbp |
cold inducible RNA binding protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CIRBP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CITED2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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G |
Cited4 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CITED4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
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G |
Ckb |
creatine kinase B |
multiple interactions increases activity |
EXP |
benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Carvedilol inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]; imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Isoproterenol results in increased expression of [CKM protein binds to CKB protein]; Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]; Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]; Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein] |
CTD |
PMID:19146839 PMID:22391854 PMID:25269373 PMID:25496245 PMID:34435724 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions increases secretion |
EXP |
[Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CKM protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CKM protein]; benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Carvedilol inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Carvedilol inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CKM protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]; imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]; Isoproterenol results in increased expression of [CKM protein binds to CKB protein]; Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]; Isoproterenol results in increased expression of and results in increased secretion of CKM protein; Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]; Quercetin inhibits the reaction [Isoproterenol results in increased secretion of CKM protein] |
CTD |
PMID:19146839 PMID:22391854 PMID:25269373 PMID:25496245 PMID:26982530 PMID:27527349 More...
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca1 |
chloride channel accessory 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLCA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
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G |
Clcn3 |
chloride voltage-gated channel 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLCN3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Clec1a |
C-type lectin domain family 1, member A |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247
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G |
Clec4a |
C-type lectin domain family 4, member A |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC4N mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
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G |
Clec4d |
C-type lectin domain family 4, member D |
increases expression |
ISO |
Isoproterenol results in increased expression of CLEC4D mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:156,589,591...156,599,279
Ensembl chr 4:156,589,792...156,598,848
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G |
Clic5 |
chloride intracellular channel 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLIC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427
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G |
Clip1 |
CAP-GLY domain containing linker protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CLIP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
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G |
Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLIP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:23,616,280...23,697,625 NCBI chr 6:23,718,580...23,729,231 NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874
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G |
Clpb |
ClpB family mitochondrial disaggregase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CLPB mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
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G |
Clu |
clusterin |
increases expression |
ISO |
Isoproterenol results in increased expression of CLU mRNA; Isoproterenol results in increased expression of CLU protein |
CTD |
PMID:15052282 PMID:20003209 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cnksr1 |
connector enhancer of kinase suppressor of Ras 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CNKSR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212
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G |
Cnksr3 |
Cnksr family member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CNKSR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:43,499,273...43,591,630
Ensembl chr 1:43,499,487...43,591,635
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G |
Cobll1 |
cordon-bleu WH2 repeat protein-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of COBLL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:49,753,260...49,915,168
Ensembl chr 3:49,753,262...49,915,194
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G |
Col15a1 |
collagen type XV alpha 1 chain |
decreases expression |
ISO |
Isoproterenol results in decreased expression of COL15A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression increases expression |
EXP ISO |
manidipine inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL1A1 mRNA] Isoproterenol results in increased expression of COL1A1 mRNA; Isoproterenol results in increased expression of COL1A1 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein] isoprenaline increases expression of Col1a1 protein in blood serum |
CTD RGD |
PMID:9559417 PMID:24945829 PMID:26692091 PMID:28526319 PMID:31009642 PMID:31712309 PMID:35014750 PMID:37269933 PMID:27318893 More...
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RGD:156430318 |
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions decreases expression |
ISO |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; U 0126 inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein] Isoproterenol results in decreased expression of COL2A1 mRNA; Isoproterenol results in decreased expression of COL2A1 protein |
CTD |
PMID:21177286 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions increases expression increases expression |
EXP ISO |
AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; manidipine inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL3A1 mRNA] Isoproterenol results in increased expression of COL3A1 mRNA; Isoproterenol results in increased expression of COL3A1 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein] isoprenaline increases expression of Col3a1 protein in blood serum |
CTD RGD |
PMID:9559417 PMID:20409916 PMID:26692091 PMID:31009642 PMID:31712309 PMID:35014750 PMID:27318893 More...
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RGD:156430318 |
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col5a1 |
collagen type V alpha 1 chain |
decreases expression |
ISO |
Isoproterenol results in decreased expression of COL5A1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
increases expression |
ISO |
Isoproterenol results in increased expression of COL5A2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Comt |
catechol-O-methyltransferase |
increases methylation |
ISO |
COMT protein results in increased methylation of Isoproterenol |
CTD |
PMID:11160877 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Cops3 |
COP9 signalosome subunit 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of COPS3 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
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G |
Corin |
corin, serine peptidase |
increases expression |
ISO |
Isoproterenol results in increased expression of CORIN mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
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G |
Cp |
ceruloplasmin |
multiple interactions increases expression decreases activity |
EXP ISO |
allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of CP protein] Isoproterenol results in increased expression of CP mRNA Isoproterenol results in increased expression of CP protein |
CTD |
PMID:1521861 PMID:15261977 PMID:20003209 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpne8 |
copine 8 |
increases expression |
ISO |
Isoproterenol results in increased expression of CPNE8 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
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G |
Cps1 |
carbamoyl-phosphate synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CPS1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT1A mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
multiple interactions decreases expression |
EXP |
Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]] |
CTD |
PMID:25045214 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of CPT2 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT2 mRNA; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]] |
CTD |
PMID:25045214 PMID:30303030 |
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NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Crb1 |
crumbs cell polarity complex component 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CRB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:50,801,484...50,989,261
Ensembl chr13:50,800,959...50,989,261
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G |
Crbn |
cereblon |
increases expression |
ISO |
Isoproterenol results in increased expression of CRBN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions increases phosphorylation |
ISO EXP |
oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein] CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:12791704 PMID:17141199 PMID:21745194 PMID:32686902 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crem |
cAMP responsive element modulator |
multiple interactions affects localization increases expression |
EXP |
CREM protein inhibits the reaction [Isoproterenol results in increased activity of CREB1 protein]; CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] Isoproterenol affects the localization of CREM protein Isoproterenol results in increased expression of CREM mRNA; Isoproterenol results in increased expression of CREM protein |
CTD |
PMID:12791704 PMID:20211217 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Crlf1 |
cytokine receptor-like factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CRLF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
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G |
Crp |
C-reactive protein |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CRP protein benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CRP protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of CRP protein]; Isoproterenol results in increased expression of and results in increased secretion of CRP protein |
CTD |
PMID:25269373 PMID:35608392 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Isoproterenol inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:8769853 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cryba4 |
crystallin, beta A4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CRYBA4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:44,378,734...44,393,226
Ensembl chr12:44,378,737...44,393,221
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G |
Cs |
citrate synthase |
decreases activity |
EXP |
Isoproterenol results in decreased activity of CS protein |
CTD |
PMID:27491814 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csdc2 |
cold shock domain containing C2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CSDC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
increases expression |
ISO |
Isoproterenol results in increased expression of CSF2RB mRNA; Isoproterenol results in increased expression of CSF2RB2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Csk |
C-terminal Src kinase |
multiple interactions |
ISO |
CSK protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] |
CTD |
PMID:1699227 |
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NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
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G |
Ctf1 |
cardiotrophin 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CTF1 mRNA; Isoproterenol results in increased expression of CTF1 protein Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] |
CTD |
PMID:23288202 |
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NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cth |
cystathionine gamma-lyase |
multiple interactions |
EXP |
[Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA |
CTD |
PMID:29447158 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Cthrc1 |
collagen triple helix repeat containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTHRC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
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G |
Ctnnal1 |
catenin alpha-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTNNAL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CTNNB1 mRNA; Isoproterenol results in increased expression of CTNNB1 protein [Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA; Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]; pyrvinium inhibits the reaction [[Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of CTNNB1 protein] |
CTD |
PMID:35305975 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctnnbip1 |
catenin, beta-interacting protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CTNNBIP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939
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G |
Ctps2 |
CTP synthase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of CTPS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:31,645,873...31,786,733
Ensembl chr X:31,645,873...31,786,733
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G |
Ctsb |
cathepsin B |
multiple interactions decreases activity decreases expression increases activity |
EXP ISO |
caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]; Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] Isoproterenol results in decreased expression of CTSB mRNA |
CTD |
PMID:2015110 PMID:8534267 PMID:17188415 PMID:18294627 PMID:20391626 PMID:21335049 PMID:25560919 More...
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions increases expression decreases activity increases activity affects activity |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]; caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol affects the activity of CTSD protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; Plant Extracts inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] Isoproterenol results in increased expression of CTSD mRNA; Isoproterenol results in increased expression of CTSD protein |
CTD |
PMID:894732 PMID:2015110 PMID:8534267 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:17623887 PMID:18294627 PMID:18424012 PMID:19172585 PMID:19641666 PMID:20391626 PMID:21762681 PMID:25560919 More...
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Ctsl |
cathepsin L |
increases expression |
ISO |
Isoproterenol results in increased expression of CTSL mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cul1 |
cullin 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of CUL1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980
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Cul4b |
cullin 4B |
increases expression |
ISO |
Isoproterenol results in increased expression of CUL4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688
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Cux2 |
cut-like homeobox 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CUX2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
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Cuzd1 |
CUB and zona pellucida-like domains 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CUZD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546
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Cxcl13 |
C-X-C motif chemokine ligand 13 |
increases expression |
ISO |
Isoproterenol results in increased expression of CXCL13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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Cxcl9 |
C-X-C motif chemokine ligand 9 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CXCL9 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases activity |
ISO |
Isoproterenol results in increased activity of CXCR2 protein |
CTD |
PMID:15477226 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cxxc5 |
CXXC finger protein 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CXXC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673
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Cyba |
cytochrome b-245 alpha chain |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CYBA mRNA CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] |
CTD |
PMID:18594475 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cycs |
cytochrome c, somatic |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of CYCS protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein] |
CTD |
PMID:30152906 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases expression multiple interactions increases expression |
ISO EXP |
Isoproterenol results in decreased expression of CYP1A1 mRNA Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] Isoproterenol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:15627480 PMID:15710352 PMID:18725507 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO EXP |
Isoproterenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] |
CTD |
PMID:15710352 PMID:18493746 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of CYP1B1 mRNA |
CTD |
PMID:18725507 PMID:20003209 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of CYP2B10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of CYP2C11 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects expression |
EXP |
Isoproterenol affects the expression of CYP2E1 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of CYP4A3 mRNA |
CTD |
PMID:18725507 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Cysltr1 |
cysteinyl leukotriene receptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of CYSLTR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
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Cyss |
cystatin S |
multiple interactions increases expression |
EXP |
Reserpine inhibits the reaction [Isoproterenol results in increased expression of CYSS mRNA] |
CTD |
PMID:9447264 |
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NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610
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G |
Dag1 |
dystroglycan 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of DAG1 |
CTD |
PMID:18808529 |
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NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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Dap |
death-associated protein |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in increased expression of DAP mRNA Isoproterenol results in increased expression of DAP mRNA |
CTD |
PMID:30303030 |
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NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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Dbp |
D-box binding PAR bZIP transcription factor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DBP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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G |
Dcakd |
dephospho-CoA kinase domain containing |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DCAKD mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054
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Dcn |
decorin |
increases expression |
ISO |
Isoproterenol results in increased expression of DCN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dct |
dopachrome tautomerase |
increases expression |
ISO |
Isoproterenol results in increased expression of DCT mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
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Dctn5 |
dynactin subunit 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of DCTN5 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
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Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of DDIT3 mRNA [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]] |
CTD |
PMID:21823215 PMID:29414845 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
increases expression |
ISO |
Isoproterenol results in increased expression of DDOST mRNA |
CTD |
PMID:21823215 |
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NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Defb1 |
defensin beta 1 |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of DEFB1 mRNA Isoproterenol results in increased expression of DEFB1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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G |
Dennd4a |
DENN domain containing 4A |
increases expression |
ISO |
Isoproterenol results in increased expression of DENND4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:65,322,920...65,436,331
Ensembl chr 8:65,322,941...65,436,330
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G |
Derl2 |
derlin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DERL2 mRNA |
CTD |
PMID:21823215 |
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NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518
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G |
Derl3 |
derlin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DERL3 mRNA |
CTD |
PMID:21823215 |
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NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
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Des |
desmin |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of DES protein Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein] |
CTD |
PMID:34435724 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Dffb |
DNA fragmentation factor subunit beta |
increases expression |
ISO |
Isoproterenol results in increased expression of DFFB mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHCR24 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS3 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dhrs7 |
dehydrogenase/reductase 7 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS7 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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Dhrs7c |
dehydrogenase/reductase 7C |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DHRS7C mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:52,495,262...52,513,338
Ensembl chr10:52,495,262...52,513,338
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G |
Diaph2 |
diaphanous-related formin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DIAPH2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869
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G |
Dio2 |
iodothyronine deiodinase 2 |
increases expression increases activity |
ISO EXP |
Isoproterenol results in increased expression of DIO2 mRNA Isoproterenol results in increased activity of DIO2 protein |
CTD |
PMID:15345674 PMID:20003209 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dixdc1 |
DIX domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of DIXDC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DLAT mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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G |
Dmac2l |
distal membrane arm assembly component 2 like |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of DMAC2L mRNA |
CTD |
PMID:30303030 |
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NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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Dmd |
dystrophin |
multiple interactions decreases expression |
ISO EXP |
DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol] Isoproterenol results in decreased expression of DMD |
CTD |
PMID:18340010 PMID:18808529 |
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NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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G |
Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNAJB11 mRNA |
CTD |
PMID:21823215 |
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NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNAJB9 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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Dnm1l |
dynamin 1-like |
increases phosphorylation |
EXP |
Isoproterenol results in increased phosphorylation of DNM1L protein |
CTD |
PMID:27491814 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of DNMT3A mRNA Isoproterenol results in increased expression of DNMT3A protein |
CTD |
PMID:20003209 PMID:24945829 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
increases expression |
ISO |
Isoproterenol results in increased expression of DNMT3B mRNA |
CTD |
PMID:21335049 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dnttip2 |
deoxynucleotidyltransferase, terminal, interacting protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of DNTTIP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:210,374,321...210,386,366
Ensembl chr 2:210,374,289...210,385,581
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G |
Dock10 |
dedicator of cytokinesis 10 |
increases expression |
ISO |
Isoproterenol results in increased expression of DOCK10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
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G |
Dock9 |
dedicator of cytokinesis 9 |
increases expression |
ISO |
Isoproterenol results in increased expression of DOCK9 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:98,611,518...98,883,306
Ensembl chr15:98,618,084...98,883,153
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G |
Dpep1 |
dipeptidase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of DPEP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
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G |
Dpp7 |
dipeptidylpeptidase 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of DPP7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355
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G |
Dsg2 |
desmoglein 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DSG2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156
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G |
Dtx4 |
deltex E3 ubiquitin ligase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of DTX4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; DUSP1 protein inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21177286 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of DUSP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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G |
Dusp5 |
dual specificity phosphatase 5 |
decreases expression |
EXP |
isoprenaline decreases expression of Dusp5 mRNA and protein in cardiac muscle cells |
RGD |
PMID:27318893 |
RGD:156430318 |
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp8 |
dual specificity phosphatase 8 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of DUSP8 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
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G |
Dxo |
decapping exoribonuclease |
increases expression |
ISO |
Isoproterenol results in increased expression of DXO mRNA |
CTD |
PMID:21335049 |
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NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494
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G |
Ecm1 |
extracellular matrix protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ECM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of EDEM1 mRNA |
CTD |
PMID:21335049 PMID:21823215 |
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NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Edn1 |
endothelin 1 |
multiple interactions increases expression increases activity |
EXP |
Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]; Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] Isoproterenol results in increased expression of EDN1 mRNA; Isoproterenol results in increased expression of EDN1 protein |
CTD |
PMID:9861301 PMID:11435416 PMID:27174236 PMID:27890915 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ednra |
endothelin receptor type A |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of EDNRA mRNA CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] Isoproterenol results in increased expression of EDNRA mRNA; Isoproterenol results in increased expression of EDNRA protein |
CTD |
PMID:18594475 PMID:20003209 PMID:20307649 PMID:27174236 |
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NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Ednrb |
endothelin receptor type B |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRB mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDNRB protein] Isoproterenol results in increased expression of EDNRB mRNA; Isoproterenol results in increased expression of EDNRB protein |
CTD |
PMID:18594475 PMID:27174236 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eef1akmt1 |
EEF1A lysine methyltransferase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EEF1AKMT1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:31,694,284...31,711,367
Ensembl chr15:31,694,292...31,711,336
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G |
Efhd2 |
EF-hand domain family, member D2 |
increases expression |
ISO |
Isoproterenol results in increased expression of EFHD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980
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G |
Egfr |
epidermal growth factor receptor |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of EGFR mRNA Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein] |
CTD |
PMID:18787115 PMID:20003209 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] Isoproterenol results in decreased expression of EGR1 mRNA 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein] |
CTD |
PMID:10710348 PMID:15621046 PMID:20003209 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1a |
eukaryotic translation initiation factor 1A |
increases expression |
ISO |
Isoproterenol results in increased expression of EIF1A mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of EIF2AK3 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif4a2 |
eukaryotic translation initiation factor 4A2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EIF4A2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
decreases expression |
ISO |
Isoproterenol results in decreased expression of EIF4E mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Ell2 |
elongation factor for RNA polymerase II 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of ELL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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G |
Eln |
elastin |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with Hydralazine] results in increased expression of ELN protein Isoproterenol results in increased expression of ELN protein |
CTD |
PMID:3446201 |
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NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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G |
Elovl1 |
ELOVL fatty acid elongase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ELOVL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
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G |
Elp1 |
elongator acetyltransferase complex subunit 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ELP1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
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G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ENC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ENO1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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G |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of ENPP1 protein |
CTD |
PMID:21414308 |
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NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
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G |
Entpd1 |
ectonucleoside triphosphate diphosphohydrolase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ENTPD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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G |
Eps8 |
EGFR pathway substrate 8, signaling adaptor |
increases expression |
ISO |
Isoproterenol results in increased expression of EPS8 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
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G |
Ereg |
epiregulin |
increases expression |
ISO |
Isoproterenol results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Erp29 |
endoplasmic reticulum protein 29 |
increases expression |
ISO |
Isoproterenol results in increased expression of ERP29 mRNA |
CTD |
PMID:21335049 |
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NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ERRFI1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
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G |
Etf1 |
eukaryotic translation termination factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ETF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
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G |
Ezh1 |
enhancer of zeste 1 polycomb repressive complex 2 subunit |
increases expression |
ISO |
Isoproterenol results in increased expression of EZH1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
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G |
F13a1 |
coagulation factor XIII A1 chain |
increases expression |
ISO |
Isoproterenol results in increased expression of F13A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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G |
Fabp3 |
fatty acid binding protein 3 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of FABP3 protein Isoproterenol results in decreased expression of FABP3 protein |
CTD |
PMID:19549929 PMID:19826179 PMID:19854236 PMID:22878004 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp5 |
fatty acid binding protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of FABP5 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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G |
Fam110d |
family with sequence similarity 110, member D |
increases expression |
ISO |
Isoproterenol results in increased expression of FAM110D mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:146,471,048...146,474,019
Ensembl chr 5:146,471,049...146,474,056
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G |
Fam117b |
family with sequence similarity 117, member B |
increases expression |
ISO |
Isoproterenol results in increased expression of FAM117B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483
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G |
Farp1 |
FERM, ARH/RhoGEF and pleckstrin domain protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FARP1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of FAS mRNA Isoproterenol results in increased expression of FAS mRNA; Isoproterenol results in increased expression of FAS protein Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA]; Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA]; Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] |
CTD |
PMID:11218852 PMID:20003209 PMID:24286936 PMID:25794854 PMID:26996544 PMID:30152906 PMID:34816538 More...
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
Isoproterenol results in increased expression of FASLG protein |
CTD |
PMID:19001025 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fblim1 |
filamin binding LIM protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBLIM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
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G |
Fbln2 |
fibulin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBLN2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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G |
Fbxl20 |
F-box and leucine-rich repeat protein 20 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXL20 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162
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G |
Fbxo31 |
F-box protein 31 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXO31 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010
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G |
Fbxo32 |
F-box protein 32 |
increases expression |
ISO |
Isoproterenol results in increased expression of FBXO32 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fbxo9 |
f-box protein 9 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBXO9 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
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G |
Fbxw7 |
F-box and WD repeat domain containing 7 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FBXW7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
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G |
Fcgr2a |
Fc gamma receptor 2A |
increases expression |
ISO |
Isoproterenol results in increased expression of FCGR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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G |
Fcgr2b |
Fc gamma receptor 2B |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of FCGR2B mRNA |
CTD |
PMID:20003209 PMID:20211217 |
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NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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G |
Fcgr3a |
Fc gamma receptor 3A |
increases expression |
ISO |
Isoproterenol results in increased expression of FCGR4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Fen1 |
flap structure-specific endonuclease 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FEN1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Fetub |
fetuin B |
increases expression |
ISO |
Isoproterenol results in increased expression of FETUB mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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G |
Fgf16 |
fibroblast growth factor 16 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FGF16 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:70,816,658...70,828,028
Ensembl chr X:70,817,433...70,878,717
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G |
Fgfr3 |
fibroblast growth factor receptor 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of FGFR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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G |
Fhl1 |
four and a half LIM domains 1 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of FHL1 mRNA Isoproterenol results in increased expression of FHL1 mRNA |
CTD |
PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of FIS1 protein |
CTD |
PMID:27491814 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Fkbp1b |
FKBP prolyl isomerase 1B |
multiple interactions decreases expression |
EXP |
1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] Isoproterenol results in decreased expression of FKBP1B mRNA; Isoproterenol results in decreased expression of FKBP1B protein |
CTD |
PMID:20723002 |
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NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
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G |
Fkbp4 |
FKBP prolyl isomerase 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FKBP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
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G |
Fkbp5 |
FKBP prolyl isomerase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of FKBP5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FLT1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FMO1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of FMO2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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G |
Fn1 |
fibronectin 1 |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of FN1 protein Isoproterenol results in increased expression of FN1 mRNA Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein] |
CTD |
PMID:11821714 PMID:20003209 PMID:24117263 PMID:35305975 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO EXP |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] CREM protein inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]; Isoproterenol promotes the reaction [JUN protein binds to FOS protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of FOS] Isoproterenol results in increased expression of FOS; Isoproterenol results in increased expression of FOS mRNA Isoproterenol results in increased expression of FOS mRNA; Isoproterenol results in increased expression of FOS protein |
CTD |
PMID:7544033 PMID:7905536 PMID:10710348 PMID:12791704 PMID:14764439 PMID:18089841 PMID:21177286 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Isoproterenol results in increased expression of FOSB |
CTD |
PMID:7905536 |
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NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of FOSL1 mRNA Isoproterenol results in increased expression of FOSL1 mRNA; Isoproterenol results in increased expression of FOSL1 protein [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA] |
CTD |
PMID:20211217 PMID:21177286 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of FOSL2 mRNA; Isoproterenol results in increased expression of FOSL2 protein [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA] |
CTD |
PMID:21177286 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxo1 |
forkhead box O1 |
increases phosphorylation |
ISO |
Isoproterenol results in increased phosphorylation of FOXO1 protein |
CTD |
PMID:15618457 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxo3 |
forkhead box O3 |
increases expression |
ISO |
Isoproterenol results in increased expression of FOXO3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fry |
FRY microtubule binding protein |
increases expression |
ISO |
Isoproterenol results in increased expression of FRY mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of FSHB protein] |
CTD |
PMID:20307649 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of FTL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Fus |
Fus RNA binding protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of FUS mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
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G |
G3bp2 |
G3BP stress granule assembly factor 2 |
multiple interactions increases expression |
EXP |
G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB protein]; Isoproterenol promotes the reaction [G3BP2 protein binds to NFKBIA protein] Isoproterenol results in increased expression of G3BP2 mRNA; Isoproterenol results in increased expression of G3BP2 protein |
CTD |
PMID:28816235 |
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NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions increases activity |
EXP |
Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Cycloheximide inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein]; Gallopamil inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] |
CTD |
PMID:1978808 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabarapl1 |
GABA type A receptor associated protein like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GABARAPL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
Isoproterenol results in increased expression of GADD45G mRNA |
CTD |
PMID:21823215 |
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NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Gal |
galanin and GMAP prepropeptide |
multiple interactions decreases activity increases expression increases activity |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA] |
CTD |
PMID:2015110 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:19294532 More...
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Galnt15 |
polypeptide N-acetylgalactosaminyltransferase 15 |
increases expression |
ISO |
Isoproterenol results in increased expression of GALNT15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:7,227,232...7,267,002
Ensembl chr16:7,227,271...7,267,014
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G |
Gas5 |
growth arrest specific 5 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of GAS5 mRNA Isoproterenol results in decreased expression of GAS5 mRNA |
CTD |
PMID:20003209 PMID:28526319 |
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NCBI chr13:73,303,611...73,306,932
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G |
Gas6 |
growth arrest specific 6 |
multiple interactions decreases expression |
EXP |
natakalim inhibits the reaction [Isoproterenol results in decreased expression of GAS6 protein] |
CTD |
PMID:27890915 |
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NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
ISO EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA Isoproterenol promotes the reaction [NFATC1 protein binds to GATA4 protein] |
CTD |
PMID:10710348 PMID:11435416 |
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NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gbp6 |
guanylate binding protein family member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of GBP6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062 Ensembl chr14:4,730,453...4,839,062
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GCLC mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of GCLM mRNA Isoproterenol results in decreased expression of GCLM mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of GCLM mRNA |
CTD |
PMID:20003209 PMID:21335049 PMID:30303030 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GCNT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
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G |
Gda |
guanine deaminase |
increases expression |
ISO |
Isoproterenol results in increased expression of GDA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
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G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] |
CTD |
PMID:18089841 |
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NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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G |
Gfpt2 |
glutamine-fructose-6-phosphate transaminase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GFPT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329
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G |
Ggt5 |
gamma-glutamyltransferase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of GGT5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
increases expression |
EXP |
Isoproterenol results in increased expression of GHRL protein |
CTD |
PMID:20572026 |
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NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Ghsr |
growth hormone secretagogue receptor |
increases expression |
EXP |
Isoproterenol results in increased expression of GHSR mRNA; Isoproterenol results in increased expression of GHSR protein |
CTD |
PMID:20572026 |
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NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
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G |
Gigyf2 |
GRB10 interacting GYF protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GIGYF2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions increases expression decreases expression |
EXP ISO |
[Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] Isoproterenol results in increased expression of GJA1 mRNA; Isoproterenol results in increased expression of GJA1 protein |
CTD |
PMID:16352648 PMID:18089841 PMID:20003209 PMID:20215810 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gk |
glycerol kinase |
increases activity |
EXP |
Isoproterenol results in increased activity of GK protein |
CTD |
PMID:12736183 |
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NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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G |
Glb1 |
galactosidase, beta 1 |
multiple interactions affects activity increases activity |
EXP |
caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]; Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GLB1 protein] |
CTD |
PMID:20391626 PMID:25560919 |
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NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G |
Glg1 |
golgi glycoprotein 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of GLG1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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G |
Glul |
glutamate-ammonia ligase |
increases expression |
ISO |
Isoproterenol results in increased expression of GLUL mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gna15 |
G protein subunit alpha 15 |
multiple interactions increases response to substance |
ISO |
[GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein |
CTD |
PMID:9875846 |
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NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
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G |
Gnal |
G protein subunit alpha L |
increases response to substance multiple interactions |
ISO |
GNAL protein results in increased susceptibility to Isoproterenol Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:15598656 |
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NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
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G |
Gnas |
GNAS complex locus |
multiple interactions increases response to substance |
EXP ISO |
GNAS protein affects the susceptibility to [Potassium Chloride co-treated with Isoproterenol]; Isoproterenol affects the expression of and affects the localization of GNAS protein GNAS protein results in increased susceptibility to Isoproterenol Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to Isoproterenol] |
CTD |
PMID:10696522 PMID:12376418 PMID:15598656 |
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NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gng2 |
G protein subunit gamma 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of GNG2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
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G |
Gng3 |
G protein subunit gamma 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with Atorvastatin] affects the localization of GNG3 protein |
CTD |
PMID:19136528 |
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NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603
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G |
Gns |
glucosamine (N-acetyl)-6-sulfatase |
increases expression |
ISO |
Isoproterenol results in increased expression of GNS mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Carvedilol inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of GOT1 protein]; imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of GOT1 protein]; Isoproterenol results in increased expression of and results in increased secretion of GOT1 protein |
CTD |
PMID:25496245 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of GOT2 protein |
CTD |
PMID:19826179 |
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NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GPAM mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gpcpd1 |
glycerophosphocholine phosphodiesterase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GPCPD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517
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G |
Gpihbp1 |
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPIHBP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
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G |
Gpnmb |
glycoprotein nmb |
increases expression |
ISO |
Isoproterenol results in increased expression of GPNMB mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpr160 |
G protein-coupled receptor 160 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPR160 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:112,483,364...112,563,072
Ensembl chr 2:112,484,935...112,563,148
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G |
Gpr182 |
G protein-coupled receptor 182 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPR182 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210
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G |
Gpt |
glutamic--pyruvic transaminase |
increases activity multiple interactions |
EXP |
Isoproterenol results in increased activity of GPT protein Carvedilol inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of GPT protein]; imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of GPT protein]; Isoproterenol results in increased expression of and results in increased secretion of GPT protein; oleuropein inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of GPT protein] |
CTD |
PMID:25496245 PMID:26056852 PMID:35130744 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions decreases activity |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of GPX1 mRNA; benidipine inhibits the reaction [Isoproterenol results in decreased activity of GPX1 protein] |
CTD |
PMID:25269373 PMID:30303030 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of GPX3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Grina |
glutamate ionotropic receptor NMDA type subunit associated protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GRINA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of GRK2 mRNA AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA] Isoproterenol results in increased expression of GRK2 protein Isoproterenol results in increased expression of GRK2 mRNA; Isoproterenol results in increased expression of GRK2 protein |
CTD |
PMID:9788834 PMID:16731636 |
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NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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G |
Grk5 |
G protein-coupled receptor kinase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of GRK5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:15951400 PMID:16716347 PMID:18806606 PMID:31009642 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases expression increases activity decreases activity |
EXP |
abana inhibits the reaction [Isoproterenol results in decreased expression of GSR]; allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; benidipine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Catechin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; dicarbine inhibits the reaction [Isoproterenol results in increased activity of GSR protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of GSR protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Tretinoin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] Isoproterenol results in decreased expression of GSR; Isoproterenol results in decreased expression of GSR protein |
CTD |
PMID:1840475 PMID:12557918 PMID:15261977 PMID:15740881 PMID:16697266 PMID:16757080 PMID:19146839 PMID:23261676 PMID:25269373 PMID:32007421 PMID:35130744 PMID:36593721 More...
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity multiple interactions |
EXP |
Isoproterenol results in decreased activity of GSTA1 protein benidipine inhibits the reaction [Isoproterenol results in decreased activity of GSTA1 protein] |
CTD |
PMID:25269373 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of GSTO1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gtf2a1 |
general transcription factor 2A subunit 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of GTF2A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511
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G |
Gusb |
glucuronidase, beta |
multiple interactions increases expression decreases activity increases activity |
EXP |
[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GUSB mRNA] |
CTD |
PMID:2015110 PMID:8534267 PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:18294627 PMID:19172585 PMID:19294532 PMID:20391626 PMID:21762681 PMID:25560919 More...
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
H19 |
H19 imprinted maternally expressed transcript |
increases expression increases expression |
ISO EXP |
Isoproterenol results in increased expression of H19 mRNA isoprenaline increases expression of H19 RNA in cardiac muscle cells |
CTD RGD |
PMID:20003209 PMID:27318893 |
RGD:156430318 |
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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G |
H1f2 |
H1.2 linker histone, cluster member |
increases expression |
ISO |
Isoproterenol results in increased expression of H1F2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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H1f4 |
H1.4 linker histone, cluster member |
increases expression |
ISO |
Isoproterenol results in increased expression of H1F4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Isoproterenol results in increased expression of H2AX mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of HADHA mRNA |
CTD |
PMID:30303030 |
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NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Haghl |
hydroxyacylglutathione hydrolase-like |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HAGHL mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665
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Hamp |
hepcidin antimicrobial peptide |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of HAMP mRNA |
CTD |
PMID:20211217 PMID:21335049 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hap1 |
huntingtin-associated protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HAP1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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G |
Harbi1 |
harbinger transposase derived 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HARBI1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:77,681,431...77,689,749
Ensembl chr 3:77,681,431...77,689,724
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G |
Hdac2 |
histone deacetylase 2 |
increases phosphorylation multiple interactions |
ISO EXP |
Isoproterenol results in increased phosphorylation of HDAC2 protein plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] |
CTD |
PMID:31009642 |
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NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Heatr5b |
HEAT repeat containing 5B |
increases expression |
ISO |
Isoproterenol results in increased expression of HEATR5B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:16,243,424...16,323,444
Ensembl chr 6:16,243,461...16,323,435
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Heca |
hdc homolog, cell cycle regulator |
increases expression |
ISO |
Isoproterenol results in increased expression of HECA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:12,525,445...12,575,358
Ensembl chr 1:12,525,135...12,576,427
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Heph |
hephaestin |
increases expression |
ISO |
Isoproterenol results in increased expression of HEPH mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HERPUD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Herpud2 |
HERPUD family member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of HERPUD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:23,573,374...23,618,380
Ensembl chr 8:23,573,379...23,617,874
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G |
Hes1 |
hes family bHLH transcription factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HES1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hexa |
hexosaminidase subunit alpha |
increases expression |
ISO |
Isoproterenol results in increased expression of HEXA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013
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G |
Hfe |
homeostatic iron regulator |
increases expression |
ISO |
Isoproterenol results in increased expression of HFE mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIF1A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hif1an |
hypoxia inducible factor 1 subunit alpha inhibitor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIF1AN mRNA |
CTD |
PMID:24286936 |
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NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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G |
Hif3a |
hypoxia inducible factor 3 subunit alpha |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of HIF3A mRNA |
CTD |
PMID:24286936 |
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NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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G |
Hipk1 |
homeodomain interacting protein kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HIPK1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902
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G |
Hipk2 |
homeodomain interacting protein kinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HIPK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
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G |
Hipk3 |
homeodomain interacting protein kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of HIPK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759
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G |
Hk2 |
hexokinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hlf |
HLF transcription factor, PAR bZIP family member |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HLF mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases activity |
EXP |
7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] |
CTD |
PMID:16640830 PMID:16906524 PMID:19595682 PMID:26995004 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HMGCS1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein] Isoproterenol results in increased expression of HMOX1 mRNA [erdosteine co-treated with Isoproterenol] results in increased expression of HMOX1 protein; anethole promotes the reaction [Isoproterenol results in increased expression of HMOX1 mRNA]; anethole promotes the reaction [Isoproterenol results in increased expression of HMOX1 protein]; Doxorubicin inhibits the reaction [Isoproterenol results in increased expression of HMOX1 mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of HMOX1 mRNA]; punicalagin inhibits the reaction [Isoproterenol results in decreased expression of HMOX1 protein] Isoproterenol results in increased expression of HMOX1 mRNA; Isoproterenol results in increased expression of HMOX1 protein Isoproterenol results in decreased expression of HMOX1 mRNA; Isoproterenol results in decreased expression of HMOX1 protein |
CTD |
PMID:15179140 PMID:19483313 PMID:20003209 PMID:21823215 PMID:22908232 PMID:24929186 PMID:33210414 PMID:35430261 PMID:36593721 PMID:37806379 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnph3 |
heterogeneous nuclear ribonucleoprotein H3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HNRNPH3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
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G |
Hnrnpr |
heterogeneous nuclear ribonucleoprotein R |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HNRNPR mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867
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G |
Homer1 |
homer scaffold protein 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of HOMER1 mRNA alternative form |
CTD |
PMID:16786172 |
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NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hopx |
HOP homeobox |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HOPX mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
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G |
Hpca |
hippocalcin |
affects localization |
EXP |
Isoproterenol affects the localization of HPCA protein |
CTD |
PMID:21078978 |
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NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
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G |
Hpse |
heparanase |
increases expression |
EXP |
Isoproterenol results in increased expression of HPSE protein |
CTD |
PMID:16327176 |
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NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
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G |
Hras |
HRas proto-oncogene, GTPase |
increases activity |
EXP |
Isoproterenol results in increased activity of HRAS protein |
CTD |
PMID:8484791 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hs2st1 |
heparan sulfate 2-O-sulfotransferase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HS2ST1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:233,508,018...233,641,769
Ensembl chr 2:233,508,021...233,641,769
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSD3B1 mRNA; Isoproterenol results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of HSPA1L mRNA Isoproterenol results in decreased expression of HSPA1L mRNA |
CTD |
PMID:20003209 PMID:24286936 |
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NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of HSPA2 mRNA |
CTD |
PMID:20211217 PMID:24286936 |
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NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of HSPA5 mRNA Isoproterenol results in decreased expression of HSPA5 mRNA [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]] |
CTD |
PMID:21335049 PMID:24286936 PMID:29414845 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSPA8 mRNA |
CTD |
PMID:20003209 PMID:24286936 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions increases expression |
EXP |
Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein] Isoproterenol results in increased expression of HSP27 protein; Isoproterenol results in increased expression of HSPB1 protein |
CTD |
PMID:10559386 PMID:20125031 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb7 |
heat shock protein family B (small) member 7 |
increases expression |
EXP |
Isoproterenol results in increased expression of HSPB7 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
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G |
Hspg2 |
heparan sulfate proteoglycan 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HSPG2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of HSPH1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Htra2 |
HtrA serine peptidase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HTRA2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
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G |
Htra3 |
HtrA serine peptidase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of HTRA3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315
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G |
Hyou1 |
hypoxia up-regulated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of HYOU1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ICAM1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id1 |
inhibitor of DNA binding 1 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of ID1 mRNA isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
CTD RGD |
PMID:21335049 PMID:26873969 |
RGD:11526363 |
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Ier3 |
immediate early response 3 |
multiple interactions affects response to substance |
ISO |
IER3 protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; Pertussis Toxin affects the reaction [IER3 protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP]]; Pertussis Toxin affects the reaction [IER3 protein affects the susceptibility to Isoproterenol] |
CTD |
PMID:20713914 |
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NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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G |
Ifna1 |
interferon, alpha 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of IFNA1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifng |
interferon gamma |
decreases secretion |
ISO |
Isoproterenol results in decreased secretion of IFNG protein |
CTD |
PMID:15342205 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr2 |
interferon gamma receptor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IFNGR2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
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G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of IFRD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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G |
Ift74 |
intraflagellar transport 74 |
increases expression |
ISO |
Isoproterenol results in increased expression of IFT74 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression multiple interactions increases expression |
ISO EXP |
Isoproterenol results in decreased expression of IGF1 mRNA candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 mRNA]; candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 protein] Isoproterenol results in increased expression of IGF1 mRNA; Isoproterenol results in increased expression of IGF1 protein |
CTD |
PMID:10547078 PMID:20003209 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
Isoproterenol results in increased expression of IGF1R mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2bp2 |
insulin-like growth factor 2 mRNA binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of IGF2BP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of IGFBP3 SI 27 inhibits the reaction [Isoproterenol results in decreased expression of IGFBP3] |
CTD |
PMID:12883319 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
ISO EXP |
Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] Isoproterenol results in decreased expression of IL10 protein Quercetin inhibits the reaction [Isoproterenol results in decreased expression of IL10 protein] |
CTD |
PMID:9038718 PMID:27527349 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
decreases expression |
EXP |
Isoproterenol results in decreased expression of IL12A protein |
CTD |
PMID:24286936 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
Isoproterenol results in increased expression of IL12B protein |
CTD |
PMID:24286936 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of IL17A protein Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of IL17A protein] |
CTD |
PMID:19909738 PMID:35305975 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17rd |
interleukin 17 receptor D |
increases expression |
ISO |
Isoproterenol results in increased expression of IL17RD mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556
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G |
Il18 |
interleukin 18 |
multiple interactions decreases expression increases expression |
ISO EXP |
ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]; ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein]; Isoproterenol results in increased expression of and results in increased secretion of IL18 protein; Isoproterenol results in increased expression of and results in increased stability of IL18 mRNA; Pertussis Toxin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL18 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]; wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] Isoproterenol results in decreased expression of IL18 mRNA |
CTD |
PMID:15178407 PMID:21335049 PMID:24286936 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of IL1A mRNA Isoproterenol results in increased expression of IL1A mRNA |
CTD |
PMID:24286936 PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression decreases expression |
ISO EXP |
SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of IL1B protein] 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]] Isoproterenol results in increased expression of IL1B; Isoproterenol results in increased expression of IL1B mRNA; Isoproterenol results in increased expression of IL1B protein Isoproterenol results in decreased expression of IL1B mRNA; Isoproterenol results in decreased expression of IL1B protein |
CTD |
PMID:9387890 PMID:12215284 PMID:15302781 PMID:18487443 PMID:19023134 PMID:19904010 PMID:21335049 PMID:21762681 PMID:24286936 PMID:25045214 PMID:32816093 PMID:35014750 PMID:35305975 PMID:35430261 PMID:35815753 PMID:36593721 PMID:37806379 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
affects response to substance |
ISO |
IL1RN protein affects the susceptibility to Isoproterenol |
CTD |
PMID:10487780 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of IL2 mRNA; Isoproterenol results in increased expression of IL2 protein Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]] |
CTD |
PMID:25045214 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il4 |
interleukin 4 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of IL4 mRNA Isoproterenol results in increased expression of IL4 protein Isoproterenol results in increased expression of IL4 mRNA |
CTD |
PMID:24286936 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il4r |
interleukin 4 receptor |
increases expression |
ISO |
Isoproterenol results in increased expression of IL4RA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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G |
Il5ra |
interleukin 5 receptor subunit alpha |
affects response to substance |
ISO |
IL5RA protein affects the susceptibility to Isoproterenol |
CTD |
PMID:10487780 |
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NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
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G |
Il6 |
interleukin 6 |
multiple interactions decreases secretion increases expression increases secretion decreases expression |
ISO EXP |
ANXA1 affects the reaction [Isoproterenol results in decreased secretion of IL6 protein]; biochanin A inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Genistein promotes the reaction [Isoproterenol results in increased secretion of IL6 protein]; Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]; SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL6]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] Isoproterenol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] Isoproterenol results in increased expression of IL6; Isoproterenol results in increased expression of IL6 mRNA; Isoproterenol results in increased expression of IL6 protein 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; erdosteine inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Isoproterenol inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Isoproterenol results in increased expression of and results in increased secretion of IL6 protein; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; xanthone inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] Isoproterenol results in decreased expression of IL6 mRNA |
CTD |
PMID:9038718 PMID:9688336 PMID:10525314 PMID:11406463 PMID:15302781 PMID:16835395 PMID:17141199 PMID:18487443 PMID:19023134 PMID:19909738 PMID:21088047 PMID:21762681 PMID:21823215 PMID:24286936 PMID:24842192 PMID:26277537 PMID:27527349 PMID:30152906 PMID:30623541 PMID:32007421 PMID:32946155 PMID:33210414 PMID:35130744 PMID:35430261 PMID:35608392 PMID:35815753 PMID:36414029 PMID:37016276 PMID:37806379 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7 |
interleukin 7 |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of IL7 protein |
CTD |
PMID:24286936 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Immt |
inner membrane mitochondrial protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IMMT mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
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G |
Inhbb |
inhibin subunit beta B |
increases expression |
ISO |
Isoproterenol results in increased expression of INHBB mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
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G |
Ins2 |
insulin 2 |
multiple interactions affects expression increases expression |
EXP |
INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]] Isoproterenol affects the expression of INS protein Isoproterenol results in increased expression of INS protein |
CTD |
PMID:1129332 PMID:1170870 PMID:19167487 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Ints3 |
integrator complex subunit 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of INTS3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709
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G |
Ipo13 |
importin 13 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IPO13 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:131,433,770...131,454,044
Ensembl chr 5:131,433,776...131,454,043
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G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of IRAK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G |
Irs1 |
insulin receptor substrate 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of IRS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irx4 |
iroquois homeobox 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of IRX4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]] |
CTD |
PMID:9762784 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions decreases expression |
ISO EXP |
DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol] Isoproterenol results in decreased expression of ITGB1 |
CTD |
PMID:18340010 PMID:18808529 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgbl1 |
integrin subunit beta like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITGBL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733
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G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITIH3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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G |
Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of ITIH4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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G |
Itk |
IL2-inducible T-cell kinase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ITK mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685
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G |
Itpkb |
inositol-trisphosphate 3-kinase B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ITPKB mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004
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G |
Jade2 |
jade family PHD finger 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of JADE2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984
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G |
Jarid2 |
jumonji and AT-rich interaction domain containing 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of JARID2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression decreases expression |
ISO EXP |
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA]; [Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA] [Isoproterenol co-treated with POSTN protein] results in decreased expression of JUN mRNA; Isoproterenol promotes the reaction [JUN protein binds to FOS protein] Isoproterenol results in increased expression of JUN mRNA; Isoproterenol results in increased expression of JUN protein Isoproterenol results in decreased expression of JUN mRNA |
CTD |
PMID:10710348 PMID:14764439 PMID:21177286 PMID:30303030 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of JUNB Isoproterenol results in increased expression of JUNB mRNA; Isoproterenol results in increased expression of JUNB protein [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA]; U 0126 inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA] |
CTD |
PMID:7905536 PMID:21177286 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Kank3 |
KN motif and ankyrin repeat domains 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of KANK3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:14,594,358...14,607,675
Ensembl chr 7:14,594,422...14,607,675
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNA5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Kcnb1 |
potassium voltage-gated channel subfamily B member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KCNB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
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G |
Kcnd2 |
potassium voltage-gated channel subfamily D member 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KCND2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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G |
Kcne1 |
potassium voltage-gated channel subfamily E regulatory subunit 1 |
multiple interactions decreases expression |
ISO |
Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] Isoproterenol results in decreased expression of KCNE1 mRNA |
CTD |
PMID:16909339 PMID:20003209 |
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NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
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G |
Kcnh6 |
potassium voltage-gated channel subfamily H member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNH6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:90,949,240...90,970,746
Ensembl chr10:90,949,846...90,970,701
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G |
Kcnq1 |
potassium voltage-gated channel subfamily Q member 1 |
multiple interactions |
ISO EXP |
Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] [Isoproterenol co-treated with POSTN protein] results in decreased expression of KCNQ1 mRNA |
CTD |
PMID:16909339 PMID:30303030 |
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NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
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G |
Kcnt2 |
potassium sodium-activated channel subfamily T member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of KCNT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:51,664,129...52,059,209
Ensembl chr13:51,664,686...52,056,987
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G |
Kdm6b |
lysine demethylase 6B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KDM6B mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
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G |
Kdr |
kinase insert domain receptor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KDR mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression multiple interactions increases expression |
EXP |
Isoproterenol results in decreased expression of KEAP1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of KEAP1 mRNA; anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] Isoproterenol results in increased expression of KEAP1 mRNA; Isoproterenol results in increased expression of KEAP1 protein |
CTD |
PMID:30303030 PMID:35430261 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kif1b |
kinesin family member 1B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KIF1B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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G |
Klf15 |
KLF transcription factor 15 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLF15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
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G |
Klf3 |
KLF transcription factor 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:43,474,767...43,505,801
Ensembl chr14:43,474,767...43,497,209
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G |
Klhdc8a |
kelch domain containing 8A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KLHDC8A mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277
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G |
Klhl2 |
kelch-like family member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:24,860,744...24,973,348
Ensembl chr16:24,860,667...24,973,341
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G |
Klhl24 |
kelch-like family member 24 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL24 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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G |
Klhl40 |
kelch-like family member 40 |
increases expression |
EXP |
Isoproterenol results in increased expression of KLHL40 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 8:121,441,285...121,446,801
Ensembl chr 8:121,441,287...121,446,800
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G |
Klhl41 |
kelch-like family member 41 |
increases expression |
EXP |
Isoproterenol results in increased expression of KLHL41 mRNA |
CTD |
PMID:20211217 |
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NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222
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G |
Klhl7 |
kelch-like family member 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of KLHL7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
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G |
Kmt5a |
lysine methyltransferase 5A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KMT5A mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
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G |
Kpna3 |
karyopherin subunit alpha 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA3 mRNA |
CTD |
PMID:30303030 |
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NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
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G |
Kpna6 |
karyopherin subunit alpha 6 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA6 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 5:141,988,111...142,021,483
Ensembl chr 5:141,991,568...142,021,120
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G |
Kras |
KRAS proto-oncogene, GTPase |
increases expression |
ISO |
Isoproterenol results in increased expression of KRAS mRNA |
CTD |
PMID:21335049 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Krt18 |
keratin 18 |
increases expression |
ISO |
Isoproterenol results in increased expression of KRT18 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Krt222 |
keratin 222 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KRT222 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:84,184,137...84,196,122
Ensembl chr10:84,186,173...84,196,015
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G |
Ky |
kyphoscoliosis peptidase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of KY mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024
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G |
Lama2 |
laminin subunit alpha 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of LAMA2 |
CTD |
PMID:18808529 |
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NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
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G |
Lamb1 |
laminin subunit beta 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LAMB1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
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G |
Lbh |
LBH regulator of WNT signaling pathway |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LBH mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
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G |
Lbp |
lipopolysaccharide binding protein |
increases expression |
ISO |
Isoproterenol results in increased expression of LBP mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions decreases activity |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; epigallocatechin gallate inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]; naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:15740881 PMID:16640830 PMID:16906524 PMID:19595682 PMID:20024955 |
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NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Lcn2 |
lipocalin 2 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions increases secretion increases expression |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; benidipine inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of LDHA protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHA protein]; Isoproterenol results in increased expression of and results in increased secretion of LDHA protein; naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]; oleuropein inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of LDHA protein] |
CTD |
PMID:17188415 PMID:19146839 PMID:21322096 PMID:21472895 PMID:21671307 PMID:25269373 PMID:26056852 More...
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Ldhb |
lactate dehydrogenase B |
multiple interactions increases secretion increases expression |
EXP |
[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHB protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] |
CTD |
PMID:17188415 PMID:19146839 PMID:21322096 PMID:21472895 PMID:21671307 |
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NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Lep |
leptin |
decreases secretion multiple interactions increases expression increases secretion |
ISO EXP |
Isoproterenol results in decreased secretion of LEP protein Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] Isoproterenol results in increased secretion of LEP protein |
CTD |
PMID:11022189 PMID:20307649 PMID:25111128 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lepr |
leptin receptor |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR protein] Isoproterenol results in increased expression of LEPR mRNA; Isoproterenol results in increased expression of LEPR protein |
CTD |
PMID:20307649 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of LGALS3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lgi1 |
leucine-rich, glioma inactivated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LGI1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:236,043,269...236,084,617
Ensembl chr 1:236,042,954...236,084,616
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G |
Lgr6 |
leucine-rich repeat-containing G protein-coupled receptor 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LGR6 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:46,424,382...46,544,074
Ensembl chr13:46,424,383...46,543,945
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G |
Limd1 |
LIM domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LIMD1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714
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G |
Lin7a |
lin-7 homolog A, crumbs cell polarity complex component |
increases expression |
ISO |
Isoproterenol results in increased expression of LIN7A mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
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G |
Lipe |
lipase E, hormone sensitive type |
increases phosphorylation multiple interactions increases activity affects localization |
ISO EXP |
Isoproterenol results in increased phosphorylation of LIPE protein Sirolimus promotes the reaction [Isoproterenol results in increased phosphorylation of LIPE protein] Isoproterenol results in increased activity of LIPE protein Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] |
CTD |
PMID:10894095 PMID:11160373 PMID:21042876 |
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NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
increases expression |
ISO |
Isoproterenol results in increased expression of LITAF mRNA |
CTD |
PMID:20003209 PMID:21335049 |
|
NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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G |
Lman1 |
lectin, mannose-binding, 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LMAN1 mRNA |
CTD |
PMID:21823215 |
|
NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
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G |
Lmcd1 |
LIM and cysteine-rich domains 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of LMCD1 mRNA |
CTD |
PMID:20211217 PMID:23558518 |
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NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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G |
Lmod3 |
leiomodin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LMOD3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244
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G |
Lonrf3 |
LON peptidase N-terminal domain and ring finger 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of LONRF3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr X:115,565,214...115,603,886
Ensembl chr X:115,565,267...115,598,809
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G |
Lox |
lysyl oxidase |
increases expression |
ISO |
Isoproterenol results in increased expression of LOX mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Lpl |
lipoprotein lipase |
multiple interactions decreases activity increases expression decreases expression |
EXP ISO |
cirazoline promotes the reaction [Isoproterenol results in increased expression of LPL mRNA]; naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein] Isoproterenol results in decreased expression of LPL mRNA |
CTD |
PMID:9032464 PMID:16906524 PMID:21335049 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrat |
lecithin retinol acyltransferase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LRAT mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619
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G |
Lrg1 |
leucine-rich alpha-2-glycoprotein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRG1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
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G |
Lrpprc |
leucine-rich pentatricopeptide repeat containing |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of LRPPRC mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
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G |
Lrrc52 |
leucine rich repeat containing 52 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC52 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:79,597,244...79,620,640
Ensembl chr13:79,597,245...79,620,640
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G |
Lrrc58 |
leucine rich repeat containing 58 |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC58 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829
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G |
Lrrc8c |
leucine rich repeat containing 8 VRAC subunit C |
increases expression |
ISO |
Isoproterenol results in increased expression of LRRC8C mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:4,223,901...4,315,590
Ensembl chr14:4,227,832...4,315,249
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G |
Lsm14a |
LSM14A mRNA processing body assembly factor |
increases expression |
ISO |
Isoproterenol results in increased expression of LSM14A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:86,964,800...87,009,325
Ensembl chr 1:86,964,828...87,009,276
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G |
Lsm3 |
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
decreases expression |
ISO |
Isoproterenol results in decreased expression of LSM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269
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G |
Ltbp2 |
latent transforming growth factor beta binding protein 2 |
increases expression increases expression |
ISO |
Isoproterenol results in increased expression of LTBP2 mRNA Isoproterenol increases expression of Ltbp2 mRNA in the heart |
CTD RGD |
PMID:20003209 PMID:29950403 |
RGD:156451654 |
NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
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G |
Ly6a |
lymphocyte antigen 6 family member A |
increases expression |
ISO |
Isoproterenol results in increased expression of LY6A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:107,177,191...107,189,436
Ensembl chr 7:107,183,469...107,189,981
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G |
Lyve1 |
lymphatic vessel endothelial hyaluronan receptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of LYVE1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
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G |
Maf |
MAF bZIP transcription factor |
increases expression |
EXP |
Isoproterenol results in increased expression of MAF mRNA |
CTD |
PMID:30303030 |
|
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Isoproterenol results in increased expression of MAFF mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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G |
Man1a1 |
mannosidase, alpha, class 1A, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAN1A mRNA |
CTD |
PMID:20003209 |
|
NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824
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G |
Man2a1 |
mannosidase, alpha, class 2A, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAN2A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
EXP ISO |
MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein] MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:10888249 PMID:21177286 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP2K4 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Map3k2 |
mitogen activated protein kinase kinase kinase 2 |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP3K2 mRNA Isoproterenol results in decreased expression of MAP3K2 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MAP3K5 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Map3k6 |
mitogen-activated protein kinase kinase kinase 6 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
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G |
Map3k8 |
mitogen-activated protein kinase kinase kinase 8 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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G |
Map7 |
microtubule-associated protein 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of MAP7 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity multiple interactions increases phosphorylation |
ISO EXP |
Isoproterenol results in increased activity of MAPK1 protein [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein] erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK1 protein; Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein] DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:10888249 PMID:11093795 PMID:15292328 PMID:16980553 PMID:17623046 PMID:17925438 PMID:19002953 PMID:19483313 PMID:21177286 PMID:26692091 PMID:33210414 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:18089841 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases activity increases phosphorylation increases expression |
ISO EXP |
[Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein] Isoproterenol results in increased activity of MAPK3 protein erdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of MAPK3 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein; Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] DUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:10888249 PMID:11093795 PMID:15292328 PMID:16980553 PMID:17623046 PMID:17925438 PMID:19002953 PMID:19483313 PMID:20215810 PMID:21177286 PMID:26692091 PMID:33210414 PMID:35608392 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation increases activity increases expression |
ISO EXP |
candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of MAPK8 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] Isoproterenol results in increased activity of MAPK8 protein |
CTD |
PMID:10591028 PMID:15951400 PMID:20562518 PMID:35608392 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Marchf7 |
membrane associated ring-CH-type finger 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of MARCHF7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MAS1 protein |
CTD |
PMID:20409916 |
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NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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G |
Mb |
myoglobin |
increases expression increases secretion multiple interactions |
EXP |
Isoproterenol results in increased expression of MB protein Isoproterenol results in increased secretion of MB protein sinapinic acid inhibits the reaction [Isoproterenol results in increased expression of MB protein] |
CTD |
PMID:533011 PMID:19628585 PMID:32627257 |
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NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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G |
Mbd1 |
methyl-CpG binding domain protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MBD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
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G |
Mbd5 |
methyl-CpG binding domain protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of MBD5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:33,588,854...33,738,730
Ensembl chr 3:33,333,554...33,730,156
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G |
Mccc2 |
methylcrotonyl-CoA carboxylase subunit 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MCCC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
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G |
Mcf2l |
MCF.2 cell line derived transforming sequence-like |
increases expression |
ISO |
Isoproterenol results in increased expression of MCF2L mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733
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G |
Mdga1 |
MAM domain containing glycosylphosphatidylinositol anchor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MDGA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:7,900,327...7,964,309
Ensembl chr20:7,904,358...7,963,471
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G |
Mef2c |
myocyte enhancer factor 2C |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of MEF2C mRNA Isoproterenol results in increased expression of MEF2C mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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G |
Meig1 |
meiosis/spermiogenesis associated 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MEIG1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:74,810,791...74,828,433
Ensembl chr17:74,814,632...74,828,433
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G |
Metrn |
meteorin, glial cell differentiation regulator |
decreases expression |
ISO |
Isoproterenol results in decreased expression of METRN mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701
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G |
Mfap5 |
microfibril associated protein 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of MFAP5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458
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G |
Mfn1 |
mitofusin 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MFN1 protein |
CTD |
PMID:27491814 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mfn2 |
mitofusin 2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of MFN2 protein |
CTD |
PMID:26692091 PMID:27491814 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mgll |
monoglyceride lipase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MGLL mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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G |
Mgp |
matrix Gla protein |
increases expression |
ISO |
Isoproterenol results in increased expression of MGP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MGST1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Miat |
myocardial infarction associated transcript |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of MIAT Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT] |
CTD |
PMID:34435724 |
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NCBI chr12:44,414,620...44,429,852
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G |
Mib1 |
MIB E3 ubiquitin protein ligase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MIB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689
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G |
Mir122 |
microRNA 122 |
multiple interactions increases expression |
EXP |
xanthone inhibits the reaction [Isoproterenol results in increased expression of MIR122 mRNA] |
CTD |
PMID:36414029 |
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NCBI chr18:58,758,703...58,758,787
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G |
Mir133a1 |
microRNA 133a-1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MIR133A1 |
CTD |
PMID:19893015 |
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NCBI chr18:1,885,082...1,885,168
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G |
Mir142 |
microRNA 142 |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR142 mRNA |
CTD |
PMID:29355689 |
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NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
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G |
Mir145 |
microRNA 145 |
increases expression |
ISO |
isoprenaline increases expression of miRNA145 RNA in left ventricular myocardial tissues |
RGD |
PMID:35139769 |
RGD:155260312 |
NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
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G |
Mir155 |
microRNA 155 |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR155 mRNA |
CTD |
PMID:29355689 |
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NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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G |
Mir19a |
microRNA 19a |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR19A mRNA |
CTD |
PMID:29355689 |
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NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
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G |
Mir200a |
microRNA 200a |
multiple interactions decreases expression |
EXP |
Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA] |
CTD |
PMID:34435724 |
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NCBI chr 5:166,648,494...166,648,582
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G |
Mir208a |
microRNA 208a |
increases expression decreases expression |
EXP |
Isoproterenol results in increased expression of MIR208A Isoproterenol results in decreased expression of MIR208A mRNA |
CTD |
PMID:26454886 PMID:29355689 |
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NCBI chr15:28,425,570...28,425,652
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G |
Mir208b |
microRNA 208b |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR208B mRNA |
CTD |
PMID:29355689 |
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NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749
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G |
Mir21 |
microRNA 21 |
increases expression |
EXP |
Isoproterenol results in increased expression of MIR21 mRNA |
CTD |
PMID:28526319 PMID:29355689 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir214 |
microRNA 214 |
multiple interactions increases expression |
EXP |
MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein] Isoproterenol results in increased expression of MIR214 mRNA |
CTD |
PMID:26692091 |
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NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
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G |
Mir30e |
microRNA 30e |
decreases expression |
EXP |
Isoproterenol decreases expression of Mir30e mRNA in the heart |
RGD |
PMID:28777253 |
RGD:401827856 |
NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323
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G |
Mix23 |
mitochondrial matrix import factor 23 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MIX23 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000
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G |
Mknk2 |
MAPK interacting serine/threonine kinase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of MKNK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
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G |
Mlf1 |
myeloid leukemia factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MLF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:151,648,492...151,681,654
Ensembl chr 2:151,648,511...151,681,652
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G |
Mlh1 |
mutL homolog 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MLH1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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G |
Mmd |
monocyte to macrophage differentiation-associated |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MMD mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
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G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of MMP1 SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP1] |
CTD |
PMID:12883319 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp11 |
matrix metallopeptidase 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of MMP11 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
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G |
Mmp14 |
matrix metallopeptidase 14 |
increases expression |
ISO |
Isoproterenol results in increased expression of MMP14 mRNA |
CTD |
PMID:21335049 |
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NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp15 |
matrix metallopeptidase 15 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MMP15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions increases expression increases activity |
ISO EXP |
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]; Isoproterenol results in increased expression of and results in increased activity of MMP2 protein Isoproterenol results in increased expression of MMP2 mRNA; Isoproterenol results in increased expression of MMP2 protein geraniol inhibits the reaction [Isoproterenol results in increased expression of MMP2 mRNA] |
CTD |
PMID:16327176 PMID:18089841 PMID:24929186 PMID:35608392 PMID:37016276 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions increases expression |
ISO EXP |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA] SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP3] |
CTD |
PMID:12883319 PMID:18089841 PMID:20003209 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases activity increases expression |
ISO EXP |
Propranolol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA] Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9] CPU0213 inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA] |
CTD |
PMID:16574429 PMID:18089841 PMID:18594475 PMID:24929186 PMID:35608392 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mmrn1 |
multimerin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MMRN1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474
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G |
Mospd2 |
motile sperm domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of MOSPD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:29,420,485...29,472,099
Ensembl chr X:29,420,586...29,462,398
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G |
Mpo |
myeloperoxidase |
multiple interactions increases activity increases expression |
EXP |
caffeic acid phenethyl ester inhibits the reaction [Isoproterenol results in increased activity of MPO protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of MPO protein]; pyrvinium inhibits the reaction [Isoproterenol results in increased activity of MPO protein]; sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of MPO protein] Isoproterenol results in increased expression of MPO protein |
CTD |
PMID:20693123 PMID:32865837 PMID:35014750 PMID:35305975 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mpp7 |
MAGUK p55 scaffold protein 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of MPP7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:55,439,939...55,706,810
Ensembl chr17:55,442,696...55,706,748
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G |
Mrc1 |
mannose receptor, C type 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MRC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Mrpl41 |
mitochondrial ribosomal protein L41 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MRPL41 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:7,780,658...7,781,576
Ensembl chr 3:7,779,143...7,782,818
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G |
Mrpl45 |
mitochondrial ribosomal protein L45 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MRPL45 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474
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G |
Msr1 |
macrophage scavenger receptor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MSR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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G |
Mt1 |
metallothionein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MT1 mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mt2A |
metallothionein 2A |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mtch2 |
mitochondrial carrier 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of MTCH2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation multiple interactions |
EXP |
Isoproterenol results in increased phosphorylation of MTOR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]] |
CTD |
PMID:17623046 PMID:25045214 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mtss1 |
MTSS I-BAR domain containing 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MTSS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
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G |
Mustn1 |
musculoskeletal, embryonic nuclear protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of MUSTN1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,072,908...6,075,161
Ensembl chr16:6,072,833...6,075,161
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G |
Mybpc3 |
myosin binding protein C3 |
multiple interactions affects response to substance |
ISO |
MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine] MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine] MYBPC3 protein affects the susceptibility to Isoproterenol |
CTD |
PMID:22076249 PMID:23896226 |
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NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP ISO |
Isoproterenol results in increased expression of MYC mRNA |
CTD |
PMID:20003209 PMID:20211217 PMID:21823215 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Mycn |
MYCN proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MYCN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of MYD88 mRNA; Isoproterenol results in increased expression of MYD88 protein anethole inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of MYD88 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA] |
CTD |
PMID:24842192 PMID:35430261 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Myh6 |
myosin heavy chain 6 |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of MYH6 protein plantamajoside inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in decreased expression of MYH6 mRNA]]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein] |
CTD |
PMID:31009642 PMID:37269933 |
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NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions increases expression |
ISO EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] Isoproterenol results in increased expression of MYH7 mRNA; Isoproterenol results in increased expression of MYH7 protein bellidifolin inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of MYH7 protein]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]] |
CTD |
PMID:10710348 PMID:18089841 PMID:18851973 PMID:25045214 PMID:28816235 PMID:31009642 PMID:37528096 More...
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Myh7b |
myosin heavy chain 7B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of MYH7B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:144,076,911...144,122,714
Ensembl chr 3:144,098,190...144,122,084
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G |
Myl1 |
myosin, light chain 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of MYL1 protein |
CTD |
PMID:19854236 |
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NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
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Myl3 |
myosin light chain 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of MYL3 protein |
CTD |
PMID:24286936 |
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NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816
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Mylip |
myosin regulatory light chain interacting protein |
increases expression |
ISO |
Isoproterenol results in increased expression of MYLIP mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
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Myo5a |
myosin VA |
increases expression |
ISO |
Isoproterenol results in increased expression of MYO5A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
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Myot |
myotilin |
increases expression |
ISO |
Isoproterenol results in increased expression of MYOT mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:36,705,244...36,724,849
Ensembl chr18:36,705,314...36,724,841
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Myrip |
myosin VIIA and Rab interacting protein |
increases expression |
ISO |
Isoproterenol results in increased expression of MYRIP mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:120,017,749...120,184,821
Ensembl chr 8:120,017,524...120,183,833
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G |
N4bp2l1 |
NEDD4 binding protein 2-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of N4BP2L1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257
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G |
Nab1 |
Ngfi-A binding protein 1 |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA |
CTD |
PMID:10710348 |
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NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098
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G |
Nab2 |
Ngfi-A binding protein 2 |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA] |
CTD |
PMID:10710348 |
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NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
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G |
Nabp1 |
nucleic acid binding protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NABP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107
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G |
Naglu |
N-acetyl-alpha-glucosaminidase |
multiple interactions increases activity |
EXP |
Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of NAGLU protein] |
CTD |
PMID:25560919 |
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NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
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G |
Nars1 |
asparaginyl-tRNA synthetase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of NARS1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
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G |
Nbn |
nibrin |
decreases expression increases expression |
ISO |
Isoproterenol results in decreased expression of NBN mRNA Isoproterenol results in increased expression of NBN mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions increases expression |
EXP |
CPU0213 inhibits the reaction [Isoproterenol results in increased expression of NCF1 mRNA] |
CTD |
PMID:18594475 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
multiple interactions increases expression |
EXP |
1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein] Isoproterenol results in increased expression of NCF2 mRNA; Isoproterenol results in increased expression of NCF2 protein |
CTD |
PMID:20723002 |
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NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
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G |
Ncstn |
nicastrin |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of NCSTN mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of NCSTN mRNA |
CTD |
PMID:30303030 |
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NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
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G |
Ndrg1 |
N-myc downstream regulated 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of NDRG1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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G |
Ndufa10l1 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFA10L1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 6:59,879,819...59,881,252
Ensembl chr 6:59,879,312...59,881,241
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G |
Ndufa11 |
NADH:ubiquinone oxidoreductase subunit A11 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFA11 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 9:1,550,487...1,554,546
Ensembl chr 9:1,550,468...1,555,601
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G |
Ndufa2 |
NADH:ubiquinone oxidoreductase subunit A2 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of NDUFA2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
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G |
Ndufb2 |
NADH:ubiquinone oxidoreductase subunit B2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851 Ensembl chr 4:46,536,062...46,536,851
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G |
Ndufb5 |
NADH:ubiquinone oxidoreductase subunit B5 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB5 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
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G |
Ndufb8 |
NADH:ubiquinone oxidoreductase subunit B8 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB8 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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G |
Ndufs1 |
NADH:ubiquinone oxidoreductase core subunit S1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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G |
Ndufs3 |
NADH:ubiquinone oxidoreductase core subunit S3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS3 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS4 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Ndufs8 |
NADH:ubiquinone oxidoreductase core subunit S8 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS8 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
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G |
Ndufv1 |
NADH:ubiquinone oxidoreductase core subunit V1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFV1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
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G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFV2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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G |
Neb |
nebulin |
increases expression |
ISO |
Isoproterenol results in increased expression of NEB mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574
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G |
Nes |
nestin |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NES mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
affects localization multiple interactions |
EXP |
Isoproterenol affects the localization of NFATC1 protein Cyclosporine inhibits the reaction [Isoproterenol affects the localization of NFATC1 protein]; Isoproterenol promotes the reaction [NFATC1 protein binds to GATA4 protein] |
CTD |
PMID:11435416 |
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NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression multiple interactions increases expression |
EXP |
Isoproterenol results in decreased expression of NFE2L2 mRNA; Isoproterenol results in decreased expression of NFE2L2 protein [erdosteine co-treated with Isoproterenol] results in increased expression of NFE2L2 protein; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFE2L2 mRNA; anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 mRNA]; anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 protein]; Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]; punicalagin inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] Isoproterenol results in increased expression of NFE2L2 mRNA; Isoproterenol results in increased expression of NFE2L2 protein |
CTD |
PMID:28266775 PMID:30303030 PMID:32007421 PMID:33210414 PMID:34435724 PMID:35130744 PMID:35430261 PMID:36593721 PMID:37806379 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfic |
nuclear factor I/C |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NFIC mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936
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G |
Nfil3 |
nuclear factor, interleukin 3 regulated |
increases expression |
ISO |
Isoproterenol results in increased expression of NFIL3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases activity increases expression |
ISO EXP |
Isoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]] Isoproterenol results in increased activity of NFKB1 protein [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFKB1 mRNA Isoproterenol results in increased expression of NFKB1 mRNA |
CTD |
PMID:15178407 PMID:18487443 PMID:30303030 PMID:35014750 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions decreases expression increases degradation |
ISO EXP |
Isoproterenol results in increased expression of NFKBIA mRNA Isoproterenol results in increased phosphorylation of and results in increased degradation of NFKBIA protein Isoproterenol results in decreased expression of NFKBIA protein Isoproterenol results in decreased expression of NFKBIA mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFKBIA mRNA; Isoproterenol promotes the reaction [G3BP2 protein binds to NFKBIA protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased degradation of NFKBIA protein] |
CTD |
PMID:15178407 PMID:18487443 PMID:20003209 PMID:21335049 PMID:25045214 PMID:28816235 PMID:30303030 More...
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
Isoproterenol results in increased expression of NFKBIZ mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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G |
Ngf |
nerve growth factor |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of NGF mRNA [Isoproterenol results in increased abundance of Cyclic AMP] which results in increased expression of NGF mRNA; Propranolol inhibits the reaction [Isoproterenol results in increased expression of NGF mRNA] |
CTD |
PMID:2174743 PMID:2853697 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nherf4 |
NHERF family PDZ scaffold protein 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NHERF4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:44,584,390...44,588,838
Ensembl chr 8:44,584,390...44,588,860
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G |
Ninj1 |
ninjurin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of NINJ1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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G |
Nkiras2 |
NFKB inhibitor interacting Ras-like 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NKIRAS2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:85,554,704...85,562,072
Ensembl chr10:85,557,944...85,562,072
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G |
Nkx2-5 |
NK2 homeobox 5 |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA |
CTD |
PMID:10710348 |
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NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
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G |
Nme6 |
NME/NM23 nucleoside diphosphate kinase 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of NME6 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301
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G |
Nmrk2 |
nicotinamide riboside kinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NMRK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:8,514,855...8,517,916
Ensembl chr 7:8,514,927...8,517,922
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G |
Noct |
nocturnin |
increases expression |
ISO |
Isoproterenol results in increased expression of NOCT mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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G |
Nol3 |
nucleolar protein 3 |
decreases phosphorylation |
EXP |
Isoproterenol results in decreased phosphorylation of NOL3 protein |
CTD |
PMID:19001025 |
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NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
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G |
Nos1 |
nitric oxide synthase 1 |
increases expression decreases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of NOS1 protein Isoproterenol results in decreased expression of NOS1 protein thymoquinone inhibits the reaction [Isoproterenol results in decreased expression of NOS1 protein] |
CTD |
PMID:16702995 PMID:35940283 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions increases expression |
ISO EXP |
Isoproterenol results in decreased expression of NOS2 mRNA [Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide; Apigenin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Ascorbic Acid inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; caryophyllene inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; natakalim inhibits the reaction [[Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NOS2]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; Tretinoin inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA] Isoproterenol results in increased expression of NOS2; Isoproterenol results in increased expression of NOS2 mRNA; Isoproterenol results in increased expression of NOS2 protein |
CTD |
PMID:18594475 PMID:18816294 PMID:19168511 PMID:19466570 PMID:24286936 PMID:27174236 PMID:27890915 PMID:30152906 PMID:32007421 PMID:34816538 PMID:35130744 PMID:35940283 PMID:37806379 More...
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions affects response to substance decreases expression increases expression decreases phosphorylation |
EXP ISO |
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol affects the expression of NOS3 mRNA]; 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol affects the expression of NOS3 protein]; 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of NOS3 protein]; [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA; caryophyllene inhibits the reaction [Isoproterenol results in decreased expression of NOS3 protein]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in decreased expression of NOS3 mRNA]; natakalim inhibits the reaction [Isoproterenol results in decreased expression of NOS3 mRNA]; thymoquinone inhibits the reaction [Isoproterenol results in increased expression of NOS3 protein] NOS3 inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] NOS3 protein affects the susceptibility to Isoproterenol Isoproterenol results in decreased expression of NOS3 mRNA; Isoproterenol results in decreased expression of NOS3 protein Isoproterenol results in increased expression of NOS3 mRNA; Isoproterenol results in increased expression of NOS3 protein |
CTD |
PMID:12224825 PMID:16702995 PMID:17403420 PMID:17996136 PMID:18816294 PMID:19168511 PMID:27890915 PMID:29447158 PMID:32007421 PMID:34816538 PMID:35130744 PMID:35815753 PMID:35940283 More...
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of NOTCH1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of NOTCH1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Notch4 |
notch receptor 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of NOTCH4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions increases expression |
ISO EXP |
bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 protein]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA] Isoproterenol results in increased expression of NOX4 mRNA; Isoproterenol results in increased expression of NOX4 protein |
CTD |
PMID:18089841 PMID:20003209 PMID:37528096 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Npm1 |
nucleophosmin 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NPM1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
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G |
Npm3 |
nucleophosmin/nucleoplasmin, 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NPM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591
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G |
Nppa |
natriuretic peptide A |
multiple interactions decreases expression increases expression decreases secretion increases expression |
ISO EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]; celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; NOS3 inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]; Atorvastatin inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]; CREM protein inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPA protein]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manidipine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPA protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA] Isoproterenol results in increased expression of NPPA mRNA; Isoproterenol results in increased expression of NPPA protein isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
CTD RGD |
PMID:8077211 PMID:9043801 PMID:9559417 PMID:10710348 PMID:10888249 PMID:10997724 PMID:11299230 PMID:11804996 PMID:12224825 PMID:12791704 PMID:18378355 PMID:18816294 PMID:18851973 PMID:19136528 PMID:19667237 PMID:23288202 PMID:25045214 PMID:28816235 PMID:31009642 PMID:32686902 PMID:34023961 PMID:35940283 PMID:37269933 PMID:37528096 PMID:37611474 PMID:26873969 More...
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RGD:11526363 |
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions increases expression decreases secretion increases expression |
EXP ISO |
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; G3BP2 protein promotes the reaction [Isoproterenol results in increased expression of NPPB protein]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; N-(1-methylethyl)-1,1,2-trimethylpropylamine inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; thymoquinone inhibits the reaction [Isoproterenol results in decreased secretion of NPPB protein modified form]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]] Isoproterenol results in increased expression of NPPB mRNA; Isoproterenol results in increased expression of NPPB protein bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; swietenine inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] isoprenaline increases expression of mRNA in neonatal rat cardiomyocytes |
CTD RGD |
PMID:9043801 PMID:11804996 PMID:18806606 PMID:25045214 PMID:27890915 PMID:28816235 PMID:31009642 PMID:32686902 PMID:34023961 PMID:35940283 PMID:37269933 PMID:37528096 PMID:37611474 PMID:26873969 More...
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RGD:11526363 |
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of NQO1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of NQO1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NQO2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of NR1H4 mRNA Isoproterenol results in increased expression of NR1H4 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NR4A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of NR4A3 mRNA |
CTD |
PMID:34601065 |
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NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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G |
Nsmaf |
neutral sphingomyelinase activation associated factor |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of NSMAF mRNA |
CTD |
PMID:30303030 |
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NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627
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G |
Ntf3 |
neurotrophin 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of NTF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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G |
Nucb2 |
nucleobindin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of NUCB2 mRNA |
CTD |
PMID:21823215 |
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NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353
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G |
Nxt2 |
nuclear transport factor 2-like export factor 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of NXT2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899
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G |
Oaz2 |
ornithine decarboxylase antizyme 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of OAZ2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:66,199,694...66,213,513
Ensembl chr 8:66,199,706...66,231,453
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions increases activity |
ISO |
Propranolol inhibits the reaction [Isoproterenol results in increased activity of ODC1 protein] |
CTD |
PMID:6284819 PMID:10354516 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Oga |
O-GlcNAcase |
increases expression |
ISO |
Isoproterenol results in increased expression of OGA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
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G |
Ogdh |
oxoglutarate dehydrogenase |
decreases expression multiple interactions decreases activity |
EXP |
Isoproterenol results in decreased expression of OGDH mRNA naringin inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased expression of OGDH mRNA]; sinapinic acid inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]; Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] |
CTD |
PMID:9753871 PMID:17182065 PMID:17994577 PMID:26721194 PMID:32627257 |
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NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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G |
Omd |
osteomodulin |
increases expression |
ISO |
Isoproterenol results in increased expression of OMD mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
decreases expression |
EXP |
Isoproterenol results in decreased expression of OPA1 protein |
CTD |
PMID:27491814 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Osmr |
oncostatin M receptor |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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G |
Otub1 |
OTU deubiquitinase, ubiquitin aldehyde binding 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of OTUB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
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G |
P3h2 |
prolyl 3-hydroxylase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of P3H2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421
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G |
P4hb |
prolyl 4-hydroxylase subunit beta |
increases expression |
ISO |
Isoproterenol results in increased expression of P4HB mRNA |
CTD |
PMID:21823215 |
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NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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G |
Pacrg |
parkin coregulated |
increases expression |
ISO |
Isoproterenol results in increased expression of PACRG mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:49,882,671...50,305,564
Ensembl chr 1:49,882,630...50,305,430
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G |
Palld |
palladin, cytoskeletal associated protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PALLD mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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G |
Papss2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of PAPSS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
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G |
Paqr9 |
progestin and adipoQ receptor family member 9 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PAQR9 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:96,114,249...96,116,546
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
decreases expression increases cleavage multiple interactions increases expression |
ISO EXP |
Isoproterenol results in decreased expression of PARP1 protein Isoproterenol results in increased cleavage of PARP1 protein BMP10 protein inhibits the reaction [Isoproterenol results in increased cleavage of PARP1 protein] Isoproterenol results in increased expression of PARP1 protein erdosteine affects the reaction [Isoproterenol results in increased expression of PARP1 protein] |
CTD |
PMID:29438734 PMID:31712309 PMID:33210414 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions increases expression |
ISO EXP |
[Isoproterenol co-treated with rosiglitazone] results in increased expression of PCK1 mRNA; Dexamethasone inhibits the reaction [Isoproterenol results in increased expression of PCK1 mRNA] |
CTD |
PMID:9518257 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcmtd2 |
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of PCMTD2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:168,960,312...168,979,504
Ensembl chr 3:168,960,305...168,979,497
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G |
Pde3b |
phosphodiesterase 3B |
multiple interactions |
EXP |
[PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein] |
CTD |
PMID:19167487 |
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NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
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G |
Pde4a |
phosphodiesterase 4A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PDE4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
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G |
Pde7a |
phosphodiesterase 7A |
increases expression |
ISO |
Isoproterenol results in increased expression of PDE7A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
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G |
Pdgfd |
platelet derived growth factor D |
increases expression |
ISO |
Isoproterenol results in increased expression of PDGFD mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
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G |
Pdia4 |
protein disulfide isomerase family A, member 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of PDIA4 mRNA |
CTD |
PMID:21335049 PMID:21823215 |
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NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
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G |
Pdia6 |
protein disulfide isomerase family A, member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of PDIA6 mRNA |
CTD |
PMID:21823215 |
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NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PDK1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pdxdc1 |
pyridoxal-dependent decarboxylase domain containing 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PDXDC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:2,025,056...2,113,712
Ensembl chr10:2,025,360...2,113,520
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G |
Pebp1 |
phosphatidylethanolamine binding protein 1 |
multiple interactions decreases expression |
ISO EXP |
PEBP1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP] [Isoproterenol co-treated with POSTN protein] results in decreased expression of PEBP1 mRNA Isoproterenol results in decreased expression of PEBP1 mRNA |
CTD |
PMID:26670611 PMID:30303030 |
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NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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G |
Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PECR mRNA |
CTD |
PMID:30303030 |
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NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
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G |
Peg3 |
paternally expressed 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of PEG3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671
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G |
Penk |
proenkephalin |
multiple interactions increases expression |
EXP |
Metoprolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA]; Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] |
CTD |
PMID:1363325 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Per3 |
period circadian regulator 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PER3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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G |
Pex12 |
peroxisomal biogenesis factor 12 |
increases expression |
ISO |
Isoproterenol results in increased expression of PEX12 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:68,095,776...68,103,812
Ensembl chr10:68,095,776...68,099,428
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G |
Pex2 |
peroxisomal biogenesis factor 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of PEX2 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
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G |
Pgm2l1 |
phosphoglucomutase 2-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PGM2L1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902
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G |
Phf3 |
PHD finger protein 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of PHF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:33,063,855...33,136,013
Ensembl chr 9:33,063,857...33,135,994
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G |
Phka1 |
phosphorylase kinase regulatory subunit alpha 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PHKA1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr X:67,601,302...67,738,504
Ensembl chr X:67,601,302...67,738,455
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G |
Phlda1 |
pleckstrin homology-like domain, family A, member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PHLDA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PHLDA3 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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G |
Phyhd1 |
phytanoyl-CoA dioxygenase domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PHYHD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:13,535,670...13,553,797
Ensembl chr 3:13,540,056...13,553,797
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G |
Picalm |
phosphatidylinositol binding clathrin assembly protein |
increases expression |
ISO |
Isoproterenol results in increased expression of PICALM mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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G |
Piga |
phosphatidylinositol glycan anchor biosynthesis, class A |
increases expression |
ISO |
Isoproterenol results in increased expression of PIGA mRNA |
CTD |
PMID:21823215 |
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NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804
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G |
Pigb |
phosphatidylinositol glycan anchor biosynthesis, class B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PIGB mRNA |
CTD |
PMID:21823215 |
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NCBI chr 8:73,751,756...73,775,679
Ensembl chr 8:73,751,798...73,775,679
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G |
Pik3cg |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
multiple interactions increases activity |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]; wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein] |
CTD |
PMID:15178407 |
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NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PIK3R1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pim3 |
Pim-3 proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
Isoproterenol results in increased expression of PIM3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587
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G |
Pir |
pirin |
increases expression |
ISO |
Isoproterenol results in increased expression of PIR mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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G |
Pirb |
paired Ig-like receptor B |
increases expression |
ISO |
Isoproterenol results in increased expression of LILRB3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666
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G |
Pitpnc1 |
phosphatidylinositol transfer protein, cytoplasmic 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PITPNC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:92,163,558...92,428,971
Ensembl chr10:92,167,196...92,429,297
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G |
Pla2g4a |
phospholipase A2 group 4A |
increases expression |
EXP |
Isoproterenol results in increased expression of PLA2G4A mRNA |
CTD |
PMID:20211217 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Pla2g7 |
phospholipase A2 group VII |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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G |
Plagl1 |
PLAG1 like zinc finger 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PLAGL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions increases expression increases secretion |
EXP |
Cycloheximide promotes the reaction [Isoproterenol results in increased expression of PLAT mRNA] Isoproterenol results in increased secretion of PLAT protein |
CTD |
PMID:2477232 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plau |
plasminogen activator, urokinase |
increases expression |
EXP |
Isoproterenol results in increased expression of PLAU mRNA |
CTD |
PMID:20211217 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Plcb4 |
phospholipase C, beta 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of PLCB4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
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G |
Pld1 |
phospholipase D1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PLD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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G |
Pln |
phospholamban |
multiple interactions increases phosphorylation decreases phosphorylation |
EXP |
astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]; candesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]; Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein] Isoproterenol results in increased phosphorylation of PLN protein |
CTD |
PMID:10997724 PMID:16723803 PMID:17509559 PMID:21268078 |
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NCBI chr20:32,629,537...32,639,559
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G |
Plxnd1 |
plexin D1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PLXND1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PMAIP1 mRNA |
CTD |
PMID:24286936 |
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NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Pnlip |
pancreatic lipase |
multiple interactions increases activity |
EXP |
oleuropein inhibits the reaction [Isoproterenol results in increased activity of PNLIP protein] |
CTD |
PMID:26056852 |
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NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654
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G |
Pnp |
purine nucleoside phosphorylase |
increases expression |
ISO |
Isoproterenol results in increased expression of PNP mRNA |
CTD |
PMID:20003209 PMID:21335049 |
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NCBI chr15:24,170,607...24,178,269
Ensembl chr15:24,170,602...24,203,986
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G |
Pnpla7 |
patatin-like phospholipase domain containing 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of PNPLA7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497
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G |
Pomc |
proopiomelanocortin |
increases secretion |
EXP |
Isoproterenol results in increased secretion of POMC protein alternative form |
CTD |
PMID:10898105 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Popdc3 |
popeye domain containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of POPDC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:48,772,397...48,800,677
Ensembl chr20:48,772,462...48,800,593
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G |
Postn |
periostin |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of POSTN mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADL mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADM mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADS mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACADVL mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ACSL1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of AKT1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1A mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5F1D mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5MC1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP5PO mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ATP6AP2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of AZI2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of BAG4 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of BIRC2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CASP7 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CDC37 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CHUK mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of COPS3 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT1A mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CPT2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of CUL1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of DMAC2L mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ELP1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of GCLM mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of GLG1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of GPX1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of HADHA mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of JUN mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of KCNQ1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of KEAP1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA3 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of KPNA6 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of LRPPRC mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP2K4 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of MAP3K2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NCSTN mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFA10L1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFA11 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB5 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFB8 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS3 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS4 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFS8 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFV1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFV2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFE2L2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFKB1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFKBIA mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NKIRAS2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NOTCH1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NQO1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NSMAF mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PEBP1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PECR mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PRKACA mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMA7 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB5 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB8 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMC5 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMC6 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD11 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD13 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD5 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of SLC25A20 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of SOD2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of STAT1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of STAT3 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of TBK1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of TXNRD2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of UBA1 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of USP2 mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of XDH mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of YWHAG mRNA; [Isoproterenol co-treated with POSTN protein] results in decreased expression of ZFAND5 mRNA; [Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5ME mRNA; [Isoproterenol co-treated with POSTN protein] results in increased expression of ATP5PD mRNA; [Isoproterenol co-treated with POSTN protein] results in increased expression of BCL2 mRNA; [Isoproterenol co-treated with POSTN protein] results in increased expression of DAP mRNA; [Isoproterenol co-treated with POSTN protein] results in increased expression of TNF mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of PPARA mRNA osthol inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in decreased expression of MYH6 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]] Isoproterenol results in decreased expression of PPARA mRNA; Isoproterenol results in decreased expression of PPARA protein Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]] |
CTD |
PMID:21854795 PMID:24286936 PMID:25045214 PMID:37269933 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of PPARG mRNA osthol inhibits the reaction [Isoproterenol results in decreased expression of PPARG mRNA] Isoproterenol results in decreased expression of PPARG mRNA; Isoproterenol results in decreased expression of PPARG protein 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; [Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein; Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein] |
CTD |
PMID:21854795 PMID:24286936 PMID:24954035 PMID:30623541 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression decreases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of PPARGC1A mRNA Isoproterenol results in decreased expression of PPARGC1A mRNA; Isoproterenol results in decreased expression of PPARGC1A protein Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]] |
CTD |
PMID:19808358 PMID:25045214 PMID:34601065 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppargc1b |
PPARG coactivator 1 beta |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PPARGC1B mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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G |
Ppfibp1 |
PPFIA binding protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PPFIBP1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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G |
Ppfibp2 |
PPFIA binding protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of PPFIBP2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:161,504,774...161,687,339
Ensembl chr 1:161,504,890...161,655,212
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G |
Ppif |
peptidylprolyl isomerase F |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PPIF mRNA |
CTD |
PMID:20003209 |
|
NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
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G |
Ppil6 |
peptidylprolyl isomerase like 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of PPIL6 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr20:44,989,509...45,017,833
Ensembl chr20:44,988,943...45,018,340
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G |
Ppip5k2 |
diphosphoinositol pentakisphosphate kinase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of PPIP5K2 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:98,315,220...98,394,537
Ensembl chr 9:98,315,252...98,390,814
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G |
Ppm1e |
protein phosphatase, Mg2+/Mn2+ dependent, 1E |
increases expression |
ISO |
Isoproterenol results in increased expression of PPM1E mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282
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G |
Ppm1j |
protein phosphatase, Mg2+/Mn2+ dependent, 1J |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PPM1J mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
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G |
Ppp1r14c |
protein phosphatase 1, regulatory (inhibitor) subunit 14c |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PPP1R14C mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:39,773,403...39,886,970
Ensembl chr 1:39,773,403...39,886,956
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
Isoproterenol results in increased expression of PPP1R15A mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
affects response to substance |
ISO |
PPP2CA protein affects the susceptibility to Isoproterenol |
CTD |
PMID:15247211 |
|
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions decreases expression |
EXP |
geraniol inhibits the reaction [Isoproterenol results in decreased expression of PRDX1 mRNA]; geraniol inhibits the reaction [Isoproterenol results in decreased expression of PRDX1 protein] Isoproterenol results in decreased expression of PRDX1 mRNA; Isoproterenol results in decreased expression of PRDX1 protein |
CTD |
PMID:35608392 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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G |
Prg4 |
proteoglycan 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of PRG4 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions increases phosphorylation |
ISO EXP |
Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein] [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein] |
CTD |
PMID:18390901 PMID:19167487 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of PRKAA2 mRNA xanthone inhibits the reaction [Isoproterenol results in decreased expression of PRKAA2 mRNA] |
CTD |
PMID:36414029 |
|
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PRKACA mRNA |
CTD |
PMID:30303030 |
|
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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G |
Prkar2b |
protein kinase cAMP-dependent type II regulatory subunit beta |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of PRKAR2B protein natakalim inhibits the reaction [Isoproterenol results in decreased expression of PRKAR2B protein] |
CTD |
PMID:27890915 |
|
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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G |
Prkca |
protein kinase C, alpha |
increases expression |
EXP |
Isoproterenol results in increased expression of PRKCA mRNA; Isoproterenol results in increased expression of PRKCA protein |
CTD |
PMID:12775975 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcb |
protein kinase C, beta |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PRKCB mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkcd |
protein kinase C, delta |
multiple interactions increases expression increases phosphorylation |
EXP |
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKCD protein] Isoproterenol results in increased expression of PRKCD mRNA; Isoproterenol results in increased expression of PRKCD protein |
CTD |
PMID:12775975 PMID:16716347 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions increases phosphorylation increases expression |
EXP |
1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKCE protein]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein modified form]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein] Isoproterenol results in increased expression of PRKCE mRNA; Isoproterenol results in increased expression of PRKCE protein; Isoproterenol results in increased expression of PRKCE protein modified form |
CTD |
PMID:12775975 PMID:16716347 PMID:20307649 PMID:20723002 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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Prl |
prolactin |
increases expression |
EXP |
Isoproterenol results in increased expression of PRL |
CTD |
PMID:1208595 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prmt1 |
protein arginine methyltransferase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PRMT1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
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Prnd |
prion like protein doppel |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PRND mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745
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Prodh |
proline dehydrogenase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PRODH mRNA |
CTD |
PMID:21335049 |
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NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
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Prox1 |
prospero homeobox 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PROX1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
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Psen1 |
presenilin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PSEN1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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Psip1 |
PC4 and SRSF1 interacting protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PSIP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
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G |
Psma7 |
proteasome 20S subunit alpha 7 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMA7 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672
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G |
Psmb1 |
proteasome 20S subunit beta 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
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G |
Psmb5 |
proteasome 20S subunit beta 5 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB5 mRNA |
CTD |
PMID:30303030 |
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NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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G |
Psmb8 |
proteasome 20S subunit beta 8 |
multiple interactions decreases expression |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMB8 mRNA Isoproterenol results in decreased expression of PSMB8 mRNA |
CTD |
PMID:30303030 |
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NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
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G |
Psmc5 |
proteasome 26S subunit, ATPase 5 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMC5 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMC6 mRNA |
CTD |
PMID:30303030 |
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NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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G |
Psmd1 |
proteasome 26S subunit, non-ATPase 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211
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G |
Psmd11 |
proteasome 26S subunit, non-ATPase 11 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD11 mRNA |
CTD |
PMID:30303030 |
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NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766
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G |
Psmd13 |
proteasome 26S subunit, non-ATPase 13 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD13 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905
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G |
Psmd2 |
proteasome 26S subunit ubiquitin receptor, non-ATPase 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043
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G |
Psmd5 |
proteasome 26S subunit, non-ATPase 5 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of PSMD5 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029
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G |
Psmd9 |
proteasome 26S subunit, non-ATPase 9 |
increases expression |
EXP |
Isoproterenol results in increased expression of PSMD9 mRNA |
CTD |
PMID:30303030 |
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NCBI chr12:33,337,182...33,357,468
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G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO EXP |
Isoproterenol results in increased expression of PTEN mRNA Isoproterenol results in increased expression of PTEN mRNA; Isoproterenol results in increased expression of PTEN protein |
CTD |
PMID:16188065 PMID:20003209 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptgds |
prostaglandin D2 synthase |
increases expression |
ISO |
Isoproterenol results in increased expression of PTGDS mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PTGS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression decreases expression |
EXP ISO |
Apigenin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein]; BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of PTGS2 mRNA]; Doxorubicin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein]; mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] Isoproterenol results in increased expression of PTGS2 mRNA; Isoproterenol results in increased expression of PTGS2 protein Isoproterenol results in decreased expression of PTGS2 mRNA |
CTD |
PMID:18424012 PMID:19466570 PMID:19667237 PMID:22908232 PMID:30152906 PMID:32816093 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pth1r |
parathyroid hormone 1 receptor |
increases expression |
ISO |
Isoproterenol results in increased expression of PTH1R mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
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G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
increases expression |
ISO |
Isoproterenol results in increased expression of PTP4A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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G |
Ptpn11 |
protein tyrosine phosphatase, non-receptor type 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of PTPN11 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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G |
Ptpn12 |
protein tyrosine phosphatase, non-receptor type 12 |
increases expression |
ISO |
Isoproterenol results in increased expression of PTPN12 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927
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G |
Ptpn5 |
protein tyrosine phosphatase, non-receptor type 5 |
multiple interactions increases expression |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; Anisomycin inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; Cycloheximide inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] |
CTD |
PMID:17623046 |
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NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
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G |
Ptprd |
protein tyrosine phosphatase, receptor type, D |
decreases expression |
ISO |
Isoproterenol results in decreased expression of PTPRD mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:90,046,993...90,698,977 NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
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G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
increases expression |
ISO |
Isoproterenol results in increased expression of PTPRF mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
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G |
Ptx3 |
pentraxin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of PTX3 mRNA |
CTD |
PMID:20003209 PMID:21823215 |
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NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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G |
Pvr |
PVR cell adhesion molecule |
increases expression |
EXP |
Isoproterenol results in increased expression of PVR mRNA |
CTD |
PMID:20211217 |
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NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
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G |
Pygl |
glycogen phosphorylase L |
increases activity |
EXP |
Isoproterenol results in increased activity of PYGL protein |
CTD |
PMID:6430282 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Qdpr |
quinoid dihydropteridine reductase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of QDPR mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
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G |
R3hdm1 |
R3H domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of R3HDM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:39,595,848...39,733,876
Ensembl chr13:39,595,848...39,733,876
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G |
Rab1a |
RAB1A, member RAS oncogene family |
increases expression |
ISO |
Isoproterenol results in increased expression of RAB1A mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248
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G |
Rab27a |
RAB27A, member RAS oncogene family |
increases expression |
ISO |
Isoproterenol results in increased expression of RAB27A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
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G |
Rab33b |
RAB33B, member RAS oncogene family |
increases expression |
ISO |
Isoproterenol results in increased expression of RAB33B mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:135,528,116...135,538,719
Ensembl chr 2:135,528,116...135,538,719
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G |
Rab4a |
RAB4A, member RAS oncogene family |
increases expression |
ISO |
Isoproterenol results in increased expression of RAB4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
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G |
Rad52 |
RAD52 homolog, DNA repair protein |
increases expression |
ISO |
Isoproterenol results in increased expression of RAD52 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207
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G |
Ramp1 |
receptor activity modifying protein 1 |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of RAMP1 mRNA Isoproterenol results in increased expression of RAMP1 mRNA; Isoproterenol results in increased expression of RAMP1 protein |
CTD |
PMID:16987513 PMID:17250927 PMID:17306419 PMID:20003209 |
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NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
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G |
Ramp2 |
receptor activity modifying protein 2 |
multiple interactions increases expression |
EXP |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA Isoproterenol results in increased expression of RAMP2 mRNA; Isoproterenol results in increased expression of RAMP2 protein |
CTD |
PMID:12732346 PMID:16987513 PMID:17250927 PMID:17306419 |
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NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
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G |
Ramp3 |
receptor activity modifying protein 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of RAMP3 mRNA; Isoproterenol results in increased expression of RAMP3 protein |
CTD |
PMID:16987513 PMID:17306419 |
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NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
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G |
Ranbp9 |
RAN binding protein 9 |
increases expression |
ISO |
Isoproterenol results in increased expression of RANBP9 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:21,220,807...21,303,009
Ensembl chr17:21,220,618...21,303,004
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G |
Rangap1 |
RAN GTPase activating protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of RANGAP1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438
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G |
Rapgef3 |
Rap guanine nucleotide exchange factor 3 |
increases expression multiple interactions increases response to substance |
ISO |
Isoproterenol results in increased expression of RAPGEF3 mRNA RAPGEF3 mutant form inhibits the reaction [Isoproterenol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]] RAPGEF3 results in increased susceptibility to Isoproterenol |
CTD |
PMID:17557924 PMID:21745194 |
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NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521
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G |
Rapgef4 |
Rap guanine nucleotide exchange factor 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of RAPGEF4 mRNA |
CTD |
PMID:17557924 |
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NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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G |
Raph1 |
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of RAPH1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:61,907,476...61,990,170
Ensembl chr 9:61,907,758...61,961,209
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G |
Rasa1 |
RAS p21 protein activator 1 |
affects localization multiple interactions |
EXP |
Isoproterenol affects the localization of RASA1 protein Isoproterenol results in increased expression of and results in increased phosphorylation of RASA1 protein |
CTD |
PMID:1382416 |
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NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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G |
Rasd1 |
ras related dexamethasone induced 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of RASD1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
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G |
Rasgef1b |
RasGEF domain family, member 1B |
increases expression |
ISO |
Isoproterenol results in increased expression of RASGEF1B mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741
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G |
Rasl10a |
RAS-like, family 10, member A |
increases expression |
ISO |
Isoproterenol results in increased expression of RASL10A mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:79,955,093...79,956,471
Ensembl chr14:79,954,398...79,956,468
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G |
Rassf1 |
Ras association domain family member 1 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of RASSF1 mRNA; Isoproterenol results in decreased expression of RASSF1 protein |
CTD |
PMID:24945829 |
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NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
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G |
Rassf4 |
Ras association domain family member 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of RASSF4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:149,897,525...149,932,658
Ensembl chr 4:149,897,543...149,932,411
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G |
Rbbp4 |
RB binding protein 4, chromatin remodeling factor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RBBP4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of RBL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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G |
Rbm33 |
RNA binding motif protein 33 |
increases expression |
ISO |
Isoproterenol results in increased expression of RBM33 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:6,980,807...7,088,334
Ensembl chr 4:6,983,970...7,089,918
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G |
Rbmx |
RNA binding motif protein, X-linked |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RBMX mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:135,305,237...135,314,806
Ensembl chr X:135,305,325...135,314,743
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G |
Rbp7 |
retinol binding protein 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of RBP7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
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G |
Reep1 |
receptor accessory protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of REEP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:103,746,004...103,862,347
Ensembl chr 4:103,745,633...103,862,338
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G |
Reg3b |
regenerating family member 3 beta |
decreases expression increases expression |
EXP |
Isoproterenol results in decreased expression of REG3B mRNA Isoproterenol results in increased expression of REG3B mRNA |
CTD |
PMID:20211217 PMID:24286936 |
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NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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G |
Reg3g |
regenerating family member 3 gamma |
decreases expression |
ISO |
Isoproterenol results in decreased expression of REG3G mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases activity increases localization increases expression affects localization |
ISO EXP |
Isoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]; osthol inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]] anethole inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; Isoproterenol affects the reaction [Lipopolysaccharides affects the localization of RELA protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of RELA protein]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of NPPA mRNA]; RELA mRNA promotes the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Sirolimus inhibits the reaction [Isoproterenol affects the localization of RELA protein] Isoproterenol results in increased activity of RELA protein Isoproterenol results in increased localization of RELA protein Isoproterenol results in increased expression of RELA mRNA; Isoproterenol results in increased expression of RELA protein |
CTD |
PMID:15178407 PMID:15710352 PMID:18487443 PMID:21854795 PMID:25045214 PMID:28816235 PMID:30303030 PMID:30623541 PMID:35430261 PMID:36593721 PMID:37806379 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
increases activity increases expression increases secretion multiple interactions |
ISO EXP |
Isoproterenol results in increased activity of REN protein Isoproterenol results in increased expression of REN protein Isoproterenol results in increased expression of REN mRNA Isoproterenol results in increased secretion of REN protein Propranolol inhibits the reaction [Isoproterenol results in increased expression of REN protein] [aliskiren co-treated with Carvedilol] inhibits the reaction [Isoproterenol results in increased activity of REN protein]; aliskiren inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein] [Sodium, Dietary deficiency results in increased susceptibility to Isoproterenol] which results in increased secretion of REN protein; Isoproterenol promotes the reaction [CD38 gene mutant form results in increased activity of REN protein] |
CTD |
PMID:1653766 PMID:3515047 PMID:3910304 PMID:6314140 PMID:9539862 PMID:10432392 PMID:11709406 PMID:21424707 PMID:23343681 PMID:26982530 More...
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rfc5 |
replication factor C subunit 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RFC5 mRNA |
CTD |
PMID:21335049 |
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NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
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Rhoj |
ras homolog family member J |
increases expression |
ISO |
Isoproterenol results in increased expression of RHOJ mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:94,035,307...94,117,642
Ensembl chr 6:94,035,483...94,118,275
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Rhou |
ras homolog family member U |
increases expression |
ISO |
Isoproterenol results in increased expression of RHOU mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552
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Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions increases expression |
EXP |
thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK1 protein] |
CTD |
PMID:35940283 |
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NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions increases expression |
EXP |
thymoquinone inhibits the reaction [Isoproterenol results in increased expression of RIPK3 protein] |
CTD |
PMID:35940283 |
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NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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Rln3 |
relaxin 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of RLN3 mRNA; Isoproterenol results in increased expression of RLN3 protein |
CTD |
PMID:16112403 |
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NCBI chr19:24,107,401...24,109,432
Ensembl chr19:24,107,401...24,109,886
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Rnase4 |
ribonuclease A family member 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of RNASE4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
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Rnd1 |
Rho family GTPase 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of RND1 mRNA |
CTD |
PMID:20211217 PMID:23558518 |
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NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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Rnf103 |
ring finger protein 103 |
increases expression |
ISO |
Isoproterenol results in increased expression of RNF103 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919
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Rnf128 |
ring finger protein 128 |
increases expression |
ISO |
Isoproterenol results in increased expression of RNF128 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:103,183,643...103,298,431
Ensembl chr X:103,183,831...103,298,423
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Rnf144b |
ring finger protein 144B |
increases expression |
ISO |
Isoproterenol results in increased expression of RNF144B mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760
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Rnf207 |
ring finger protein 207 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RNF207 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375
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Ro60 |
Ro60, Y RNA binding protein |
increases expression |
ISO |
Isoproterenol results in increased expression of RO60 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
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Rpl27a |
ribosomal protein L27A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RPL27A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:163,539,732...163,542,771
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Rpl37a |
ribosomal protein L37A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RPL37A mRNA |
CTD |
PMID:21335049 |
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NCBI chr 9:74,298,843...74,300,926
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Rpn1 |
ribophorin I |
increases expression |
ISO |
Isoproterenol results in increased expression of RPN1 mRNA |
CTD |
PMID:21823215 |
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NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069
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Rps26 |
ribosomal protein S26 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RPS26 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 7:1,057,332...1,058,882
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Rps27a |
ribosomal protein S27a |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RPS27A mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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Rps3a |
ribosomal protein S3a |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RPS3A mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
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Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases phosphorylation affects expression |
ISO EXP |
Isoproterenol results in increased phosphorylation of RPS6KB1 protein Isoproterenol affects the expression of RPS6KB1 mRNA |
CTD |
PMID:18812163 PMID:28099878 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Rrad |
RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
decreases expression |
ISO |
Isoproterenol results in decreased expression of RRAD mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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Rsf1 |
remodeling and spacing factor 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of RSF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
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RT1-Ba |
RT1 class II, locus Ba |
decreases expression |
ISO |
Isoproterenol results in decreased expression of H2-AA mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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RT1-Bb |
RT1 class II, locus Bb |
decreases expression |
ISO |
Isoproterenol results in decreased expression of H2-AB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1 |
RT1 class II, locus Db1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of H2-EB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-DMa |
RT1 class II, locus DMa |
decreases expression |
ISO |
Isoproterenol results in decreased expression of H2-DMA mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
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Ryr2 |
ryanodine receptor 2 |
multiple interactions increases phosphorylation |
EXP ISO |
candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] |
CTD |
PMID:16723803 PMID:21743453 |
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NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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S100a11 |
S100 calcium binding protein A11 |
increases expression |
EXP |
Isoproterenol results in increased expression of S100A11 protein |
CTD |
PMID:10886724 |
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NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
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S100a4 |
S100 calcium-binding protein A4 |
increases expression |
EXP |
Isoproterenol results in increased expression of S100A4 protein |
CTD |
PMID:10886724 |
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NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S100a8 |
S100 calcium binding protein A8 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9 |
S100 calcium binding protein A9 |
multiple interactions increases expression |
ISO EXP |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA] Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C3 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of C5 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of CASP3 protein] |
CTD |
PMID:18089841 PMID:20003209 PMID:32924446 |
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NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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S1pr1 |
sphingosine-1-phosphate receptor 1 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein] Isoproterenol results in increased expression of S1PR1 mRNA; Isoproterenol results in increased expression of S1PR1 protein |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
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Saa4 |
serum amyloid A4 |
increases expression |
ISO |
Isoproterenol results in increased expression of SAA4 mRNA |
CTD |
PMID:21335049 |
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NCBI chr 1:97,247,580...97,251,882
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Sbno2 |
strawberry notch homolog 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SBNO2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
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Scara5 |
scavenger receptor class A, member 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCARA5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373
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Scarb2 |
scavenger receptor class B, member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCARB2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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Scgb3a1 |
secretoglobin, family 3A, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCGB3A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:33,968,059...33,969,366
Ensembl chr10:33,968,059...33,969,476
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Scn3a |
sodium voltage-gated channel alpha subunit 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCN3A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
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Scn4b |
sodium voltage-gated channel beta subunit 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SCN4B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292
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Scn5a |
sodium voltage-gated channel alpha subunit 5 |
increases expression |
EXP |
Isoproterenol results in increased expression of SCN5A mRNA |
CTD |
PMID:17526999 |
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NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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Scn7a |
sodium voltage-gated channel alpha subunit 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCN7A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256
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Scpep1 |
serine carboxypeptidase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SCPEP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850
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Scube2 |
signal peptide, CUB domain and EGF like domain containing 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SCUBE2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:163,831,876...163,899,925
Ensembl chr 1:163,832,015...163,899,393
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Sdf2l1 |
stromal cell-derived factor 2-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SDF2L1 mRNA |
CTD |
PMID:21823215 |
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NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
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Sele |
selectin E |
multiple interactions |
ISO |
Isoproterenol inhibits the reaction [TNF protein results in increased secretion of SELE mRNA] |
CTD |
PMID:8780174 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Selenop |
selenoprotein P |
increases expression |
ISO |
Isoproterenol results in increased expression of SELENOP mRNA |
CTD |
PMID:21335049 |
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NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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Sell |
selectin L |
multiple interactions |
ISO |
Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]] |
CTD |
PMID:9762784 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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Sema3g |
semaphorin 3G |
increases expression |
ISO |
Isoproterenol results in increased expression of SEMA3G mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:6,413,589...6,425,221
Ensembl chr16:6,413,589...6,425,221
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Sema5a |
semaphorin 5A |
increases expression |
ISO |
Isoproterenol results in increased expression of SEMA5A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
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Serinc3 |
serine incorporator 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of SERINC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808
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Serpina3n |
serine (or cysteine) peptidase inhibitor, clade A, member 3N |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpina7 |
serpin family A member 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of SERPINA7 mRNA |
CTD |
PMID:21335049 |
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NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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Serpine1 |
serpin family E member 1 |
increases expression decreases expression |
EXP |
Isoproterenol results in increased expression of SERPINE1 mRNA Isoproterenol results in decreased expression of SERPINE1 protein |
CTD |
PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serping1 |
serpin family G member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SERPING1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Sesn1 |
sestrin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SESN1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Set |
Set nuclear proto-oncogene |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SET mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
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Setdb2 |
SET domain bifurcated histone lysine methyltransferase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SETDB2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470
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Sfn |
stratifin |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SFN mRNA |
CTD |
PMID:24286936 |
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NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Sgcg |
sarcoglycan, gamma |
decreases expression |
EXP |
Isoproterenol results in decreased expression of SGCG |
CTD |
PMID:18808529 |
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NCBI chr15:35,388,836...35,435,072
Ensembl chr15:35,386,534...35,435,148
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Sgms1 |
sphingomyelin synthase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SGMS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603
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Sh3d19 |
SH3 domain containing 19 |
increases expression |
ISO |
Isoproterenol results in increased expression of SH3D19 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:171,356,244...171,516,042
Ensembl chr 2:171,356,251...171,515,561
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G |
Sh3kbp1 |
SH3 domain-containing kinase-binding protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SH3KBP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747
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Shroom2 |
shroom family member 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SHROOM2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:21,812,469...21,983,724
Ensembl chr X:21,812,469...21,984,153
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Sik1 |
salt-inducible kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SIK1 mRNA |
CTD |
PMID:34601065 |
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NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Sirt6 |
sirtuin 6 |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of SIRT6 mRNA xanthone inhibits the reaction [Isoproterenol results in decreased expression of SIRT6 mRNA] |
CTD |
PMID:36414029 |
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NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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G |
Siva1 |
SIVA1, apoptosis-inducing factor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SIVA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
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Six4 |
SIX homeobox 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of SIX4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:91,802,328...91,816,002
Ensembl chr 6:91,802,329...91,815,992
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G |
Slc10a6 |
solute carrier family 10 member 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC10A6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037
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Slc25a10 |
solute carrier family 25 member 10 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SLC25A10 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
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G |
Slc25a20 |
solute carrier family 25 member 20 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of SLC25A20 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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G |
Slc25a30 |
solute carrier family 25, member 30 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC25A30 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
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G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC2A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4 |
solute carrier family 2 member 4 |
decreases expression |
EXP |
Isoproterenol results in decreased expression of SLC2A4 protein |
CTD |
PMID:19826179 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc36a2 |
solute carrier family 36 member 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SLC36A2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:39,278,002...39,306,082
Ensembl chr10:39,278,046...39,306,082
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Slc40a1 |
solute carrier family 40 member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC40A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
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Slc43a3 |
solute carrier family 43, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC43A3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749
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Slc45a3 |
solute carrier family 45, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC45A3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:43,407,293...43,427,588
Ensembl chr13:43,407,293...43,427,588
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G |
Slc6a1 |
solute carrier family 6 member 1 |
increases expression multiple interactions |
ISO |
Isoproterenol results in increased expression of SLC6A1 protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Isoproterenol results in increased expression of SLC6A1 protein] |
CTD |
PMID:30170018 |
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NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
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Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slc8a1 |
solute carrier family 8 member A1 |
multiple interactions increases expression |
ISO EXP |
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein] Isoproterenol results in increased expression of SLC8A1 mRNA |
CTD |
PMID:11179087 PMID:15621046 |
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NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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G |
Slco3a1 |
solute carrier organic anion transporter family, member 3a1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SLCO3A1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Isoproterenol results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Smad1 |
SMAD family member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SMAD1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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G |
Smad2 |
SMAD family member 2 |
increases expression |
EXP |
Isoproterenol results in increased expression of SMAD2 mRNA |
CTD |
PMID:35014750 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
increases expression |
EXP |
Isoproterenol results in increased expression of SMAD3 mRNA |
CTD |
PMID:35014750 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smap1 |
small ArfGAP 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SMAP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:26,249,978...26,342,170
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G |
Smarca1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SMARCA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:126,980,201...127,066,385
Ensembl chr X:126,994,947...127,066,347
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G |
Smc5 |
structural maintenance of chromosomes 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of SMC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096
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G |
Smoc2 |
SPARC related modular calcium binding 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SMOC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
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G |
Smtn |
smoothelin |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SMTN mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886
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G |
Smurf2 |
SMAD specific E3 ubiquitin protein ligase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SMURF2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
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G |
Smyd1 |
SET and MYND domain containing 1 |
multiple interactions decreases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766
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G |
Snapin |
SNAP-associated protein |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SNAPIN mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231
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G |
Snrpb |
small nuclear ribonucleoprotein polypeptides B and B1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SNRPB mRNA |
CTD |
PMID:21335049 |
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NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339
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G |
Snrpf |
small nuclear ribonucleoprotein polypeptide F |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SNRPF mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA] |
CTD |
PMID:18089841 PMID:20003209 PMID:21335049 PMID:21823215 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Sod1 |
superoxide dismutase 1 |
increases expression affects binding multiple interactions decreases activity |
EXP ISO |
Isoproterenol results in increased expression of SOD1 protein Isoproterenol binds to SOD1 protein; Isoproterenol binds to SOD1 protein mutant form benidipine inhibits the reaction [Isoproterenol results in decreased activity of SOD1 protein]; Carvedilol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of SOD1 protein]; imetit inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of SOD1 protein]; Isoproterenol results in decreased expression of and results in decreased activity of SOD1 protein |
CTD |
PMID:16702995 PMID:23612299 PMID:25269373 PMID:25496245 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO EXP |
[ADCY5 protein results in increased susceptibility to Isoproterenol] which results in decreased expression of SOD2 protein; SOD2 protein inhibits the reaction [ADCY5 protein results in increased susceptibility to Isoproterenol] [Isoproterenol co-treated with POSTN protein] results in decreased expression of SOD2 mRNA |
CTD |
PMID:23536361 PMID:30303030 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sorbs1 |
sorbin and SH3 domain containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SORBS1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
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G |
Sorbs3 |
sorbin and SH3 domain containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of SORBS3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:45,252,921...45,284,758
Ensembl chr15:45,253,379...45,284,758
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G |
Sorcs2 |
sortilin-related VPS10 domain containing receptor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SORCS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:74,371,089...74,735,943
Ensembl chr14:74,371,415...74,735,943
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G |
Sord |
sorbitol dehydrogenase |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SORD mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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G |
Sox17 |
SRY-box transcription factor 17 |
increases expression |
ISO |
Isoproterenol results in increased expression of SOX17 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
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G |
Sox6 |
SRY-box transcription factor 6 |
decreases expression multiple interactions |
ISO |
Isoproterenol results in decreased expression of SOX6 mRNA; Isoproterenol results in decreased expression of SOX6 protein JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 mRNA]; JUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 protein] |
CTD |
PMID:21177286 |
|
NCBI chr 1:169,723,306...170,334,846
Ensembl chr 1:169,729,194...170,277,386
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G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions increases expression |
ISO |
bellidifolin inhibits the reaction [Isoproterenol results in increased expression of SOX9 protein] |
CTD |
PMID:35586685 |
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NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] |
CTD |
PMID:10710348 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Spag9 |
sperm associated antigen 9 |
increases expression |
ISO |
Isoproterenol results in increased expression of SPAG9 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:78,943,439...79,077,797
Ensembl chr10:78,943,479...79,077,797
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G |
Sphk1 |
sphingosine kinase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SPHK1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Sphk2 |
sphingosine kinase 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SPHK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
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G |
Spns2 |
SPNS lysolipid transporter 2, sphingosine-1-phosphate |
increases expression |
ISO |
Isoproterenol results in increased expression of SPNS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
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G |
Spock2 |
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SPOCK2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272
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G |
Spp1 |
secreted phosphoprotein 1 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of SPP1 mRNA Isoproterenol results in decreased expression of SPP1 mRNA |
CTD |
PMID:20003209 PMID:20211217 PMID:21335049 PMID:23558518 PMID:24286936 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Spsb1 |
splA/ryanodine receptor domain and SOCS box containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SPSB1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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G |
Spta1 |
spectrin, alpha, erythrocytic 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SPTA1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371
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G |
Sptlc2 |
serine palmitoyltransferase, long chain base subunit 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of SPTLC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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G |
Sqle |
squalene epoxidase |
increases expression |
ISO |
Isoproterenol results in increased expression of SQLE mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of SQSTM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Srm |
spermidine synthase |
increases expression |
ISO |
Isoproterenol results in increased expression of SRM mRNA |
CTD |
PMID:21335049 |
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NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SRSF2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
St7l |
suppression of tumorigenicity 7-like |
increases expression |
ISO |
Isoproterenol results in increased expression of ST7L mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
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G |
St8sia6 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 |
increases expression |
ISO |
Isoproterenol results in increased expression of ST8SIA6 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:76,740,755...76,884,178
Ensembl chr17:76,745,224...76,884,299
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G |
Stard5 |
StAR-related lipid transfer domain containing 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of STARD5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:137,606,151...137,616,017
Ensembl chr 1:137,606,177...137,616,469
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of STAT1 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
affects localization multiple interactions increases expression increases phosphorylation |
EXP ISO |
Isoproterenol affects the localization of STAT3 protein [Isoproterenol co-treated with POSTN protein] results in decreased expression of STAT3 mRNA; Betaine promotes the reaction [Isoproterenol results in increased phosphorylation of STAT3 protein]; Cyclosporine inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein]; Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein; Verapamil inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased expression of STAT3 protein] Isoproterenol results in increased expression of STAT3; Isoproterenol results in increased expression of STAT3 protein Isoproterenol results in increased expression of STAT3 mRNA STAT3 protein affects the reaction [BMP10 protein results in decreased susceptibility to Isoproterenol] STAT3 protein affects the reaction [BMP10 protein inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]] |
CTD |
PMID:19299911 PMID:21335049 PMID:25080425 PMID:29355689 PMID:30303030 PMID:31712309 More...
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat5a |
signal transducer and activator of transcription 5A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of STAT5A mRNA |
CTD |
PMID:20003209 |
|
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Stc1 |
stanniocalcin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of STC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
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G |
Ston1 |
stonin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of STON1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449
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G |
Stt3a |
STT3 oligosaccharyltransferase complex catalytic subunit A |
increases expression |
ISO |
Isoproterenol results in increased expression of STT3A mRNA |
CTD |
PMID:21823215 |
|
NCBI chr 8:36,443,623...36,483,111
Ensembl chr 8:36,446,788...36,483,293
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G |
Stx3 |
syntaxin 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of STX3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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G |
Sult1b1 |
sulfotransferase family 1B member 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of SULT1B1 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
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G |
Syk |
spleen associated tyrosine kinase |
increases expression |
ISO |
Isoproterenol results in increased expression of SYK mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
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G |
Syn2 |
synapsin II |
increases expression |
ISO |
Isoproterenol results in increased expression of SYN2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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G |
Syt12 |
synaptotagmin 12 |
increases expression |
ISO |
Isoproterenol results in increased expression of SYT12 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609
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G |
Tac1 |
tachykinin, precursor 1 |
affects response to substance |
EXP |
TAC1 protein affects the susceptibility to Isoproterenol |
CTD |
PMID:11270094 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tacc2 |
transforming, acidic coiled-coil containing protein 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of TACC2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881
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G |
Tax1bp1 |
Tax1 binding protein 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TAX1BP1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100
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G |
Tbc1d15 |
TBC1 domain family, member 15 |
increases expression |
ISO |
Isoproterenol results in increased expression of TBC1D15 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175
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G |
Tbk1 |
TANK-binding kinase 1 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of TBK1 mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of TBK1 mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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G |
Tbl1xr1 |
TBL1X/Y related 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TBL1XR1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055
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G |
Tcf23 |
transcription factor 23 |
increases expression |
ISO |
Isoproterenol results in increased expression of TCF23 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:25,397,889...25,406,639
Ensembl chr 6:25,397,937...25,405,880
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G |
Tcf3 |
transcription factor 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TCF3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
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G |
Tcn2 |
transcobalamin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of TCN2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:78,813,343...78,828,549
Ensembl chr14:78,813,343...78,828,489
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G |
Tdg |
thymine-DNA glycosylase |
increases expression |
ISO |
Isoproterenol results in increased expression of TDG mRNA |
CTD |
PMID:21335049 |
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NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567
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G |
Tecrl |
trans-2,3-enoyl-CoA reductase-like |
increases expression |
ISO |
Isoproterenol results in increased expression of TECRL mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:24,732,241...24,805,272
Ensembl chr14:24,732,241...24,805,272
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G |
Tfdp2 |
transcription factor Dp-2 |
increases expression |
ISO |
Isoproterenol results in increased expression of TFDP2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
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G |
Tfrc |
transferrin receptor |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TFRC protein Isoproterenol results in decreased expression of TFRC mRNA |
CTD |
PMID:2989362 PMID:20003209 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions increases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of TGFB1 mRNA BAY 58-2667 inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein] Isoproterenol results in increased expression of TGFB1 mRNA; Isoproterenol results in increased expression of TGFB1 protein celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; osthol inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; osthol inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein] isoprenaline increases expression of Tgfb1 protein in blood serum |
CTD RGD |
PMID:11821714 PMID:19667237 PMID:21854795 PMID:24117263 PMID:35014750 PMID:35305975 PMID:36593721 PMID:37269933 PMID:27318893 More...
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RGD:156430318 |
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression |
EXP |
Isoproterenol results in increased expression of TGFB2 mRNA |
CTD |
PMID:20211217 PMID:23558518 |
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NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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G |
Tgm2 |
transglutaminase 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of TGM2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Thbs2 |
thrombospondin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of THBS2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
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G |
Thoc3 |
THO complex subunit 3 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of THOC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:10,143,184...10,152,375
Ensembl chr17:10,143,139...10,152,370
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with Amiodarone] results in increased expression of THRA mRNA alternative form Isoproterenol results in increased expression of THRA mRNA alternative form |
CTD |
PMID:7598731 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions increases expression |
EXP |
[Isoproterenol co-treated with Amiodarone] results in increased expression of THRB mRNA alternative form; Amiodarone inhibits the reaction [Isoproterenol results in increased expression of THRB mRNA alternative form] |
CTD |
PMID:7598731 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Thy1 |
Thy-1 cell surface antigen |
decreases expression multiple interactions |
ISO |
Isoproterenol results in decreased expression of THY1 Propranolol inhibits the reaction [Isoproterenol results in decreased expression of THY1] |
CTD |
PMID:7558147 |
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NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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G |
Tiam1 |
TIAM Rac1 associated GEF 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of TIAM1 mRNA |
CTD |
PMID:20211217 |
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NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of TIMP1 mRNA Isoproterenol results in decreased expression of TIMP1 mRNA Isoproterenol results in increased expression of TIMP1 mRNA; Isoproterenol results in increased expression of TIMP1 protein |
CTD |
PMID:20003209 PMID:20211217 PMID:23558518 PMID:24286936 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp3 |
TIMP metallopeptidase inhibitor 3 |
increases expression multiple interactions decreases expression |
ISO EXP |
Isoproterenol results in increased expression of TIMP3 protein natakalim inhibits the reaction [Isoproterenol results in decreased expression of TIMP3 protein] |
CTD |
PMID:24286936 PMID:27890915 |
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NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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G |
Timp4 |
TIMP metallopeptidase inhibitor 4 |
increases expression decreases expression |
ISO |
Isoproterenol results in increased expression of TIMP4 mRNA Isoproterenol results in decreased expression of TIMP4 protein |
CTD |
PMID:20003209 PMID:24286936 |
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NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
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G |
Tinagl1 |
tubulointerstitial nephritis antigen-like 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TINAGL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:142,513,710...142,523,730
Ensembl chr 5:142,513,714...142,523,720
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G |
Tk1 |
thymidine kinase 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TK1 mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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G |
Tle1 |
TLE family member 1, transcriptional corepressor |
increases expression |
ISO |
Isoproterenol results in increased expression of TLE1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
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G |
Tlr4 |
toll-like receptor 4 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of TLR4 mRNA Isoproterenol results in increased expression of TLR4 mRNA; Isoproterenol results in increased expression of TLR4 protein anethole inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA] |
CTD |
PMID:20003209 PMID:24842192 PMID:35430261 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tmbim1 |
transmembrane BAX inhibitor motif containing 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMBIM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069
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G |
Tmcc3 |
transmembrane and coiled-coil domain family 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMCC3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
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G |
Tmem140 |
transmembrane protein 140 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMEM140 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455
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G |
Tmem141 |
transmembrane protein 141 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TMEM141 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:8,439,533...8,441,491
Ensembl chr 3:8,439,533...8,441,491
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G |
Tmem144 |
transmembrane protein 144 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMEM144 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:164,960,649...164,993,562
Ensembl chr 2:164,961,247...164,992,368
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G |
Tmem164 |
transmembrane protein 164 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMEM164 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:106,288,019...106,448,642
Ensembl chr X:106,289,371...106,448,640
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G |
Tmem176a |
transmembrane protein 176A |
increases expression |
ISO |
Isoproterenol results in increased expression of TMEM176A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
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G |
Tmem38b |
transmembrane protein 38B |
increases expression |
ISO |
Isoproterenol results in increased expression of TMEM38B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025
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G |
Tmod4 |
tropomodulin 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TMOD4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
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G |
Tmsb4x |
thymosin beta 4, X-linked |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TMSB4X mRNA |
CTD |
PMID:21335049 |
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NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667
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G |
Tmtc1 |
transmembrane O-mannosyltransferase targeting cadherins 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TMTC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:181,142,937...181,357,979
Ensembl chr 4:181,146,251...181,359,289
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G |
Tmx1 |
thioredoxin-related transmembrane protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TMX1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression decreases expression increases secretion |
ISO EXP |
Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Isoproterenol inhibits the reaction [TNF protein results in increased secretion of SELE mRNA] bellidifolin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; SB 206553 inhibits the reaction [Isoproterenol results in increased expression of TNF]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of TNF protein] 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; [Isoproterenol co-treated with POSTN protein] results in increased expression of TNF mRNA; anethole inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; erdosteine inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ICI 118551 inhibits the reaction [Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Isoproterenol inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Isoproterenol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Isoproterenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Isoproterenol results in increased expression of and results in increased secretion of TNF protein; mangiferin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]; Tretinoin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] Isoproterenol results in increased expression of TNF; Isoproterenol results in increased expression of TNF mRNA Isoproterenol results in decreased expression of TNF mRNA Isoproterenol results in increased expression of TNF mRNA; Isoproterenol results in increased expression of TNF protein |
CTD |
PMID:8096834 PMID:8780174 PMID:9038718 PMID:9688336 PMID:10525314 PMID:11752888 PMID:15081246 PMID:15302781 PMID:15710352 PMID:18424012 PMID:19023134 PMID:19172585 PMID:19904010 PMID:21762681 PMID:24286936 PMID:24842192 PMID:25045214 PMID:26277537 PMID:27527349 PMID:30152906 PMID:30303030 PMID:30623541 PMID:32007421 PMID:32946155 PMID:33210414 PMID:35014750 PMID:35130744 PMID:35305975 PMID:35430261 PMID:35608392 PMID:35815753 PMID:36593721 PMID:37528096 PMID:37806379 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip6 |
TNF alpha induced protein 6 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TNFAIP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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G |
Tnfrsf12a |
TNF receptor superfamily member 12A |
increases expression |
ISO |
Isoproterenol results in increased expression of TNFRSF12A mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
decreases expression increases expression |
ISO EXP |
Isoproterenol results in decreased expression of TNFRSF1A mRNA Isoproterenol results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:24286936 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfsf10 |
TNF superfamily member 10 |
increases expression |
EXP |
Isoproterenol results in increased expression of TNFSF10 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tnik |
TRAF2 and NCK interacting kinase |
increases expression |
ISO |
Isoproterenol results in increased expression of TNIK mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
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G |
Tnks |
tankyrase |
increases expression |
ISO |
Isoproterenol results in increased expression of TNKS mRNA |
CTD |
PMID:20003209 |
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NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
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G |
Tnni3 |
troponin I3, cardiac type |
increases expression increases secretion multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of TNNI3 protein Isoproterenol results in increased secretion of TNNI3 protein 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; thymoquinone inhibits the reaction [Isoproterenol results in increased secretion of TNNI3 protein]; Tretinoin inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]; xanthone inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] |
CTD |
PMID:17654401 PMID:19549929 PMID:19854236 PMID:22878004 PMID:24286936 PMID:27491814 PMID:27527349 PMID:32007421 PMID:32946155 PMID:35130744 PMID:35305975 PMID:35430261 PMID:35815753 PMID:35940283 PMID:36414029 PMID:37806379 More...
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Tnnt1 |
troponin T1, slow skeletal type |
multiple interactions |
EXP |
Isoproterenol results in increased expression of and results in increased secretion of TNNT1 protein; oleuropein inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of TNNT1 protein] |
CTD |
PMID:26056852 |
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NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
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G |
Tnnt2 |
troponin T2, cardiac type |
affects expression increases expression increases secretion multiple interactions decreases expression |
EXP |
Isoproterenol affects the expression of TNNT2 protein Isoproterenol results in increased expression of TNNT2 protein Isoproterenol results in increased secretion of TNNT2 protein 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]; Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]; Vincristine inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein] |
CTD |
PMID:17188415 PMID:17654401 PMID:17848144 PMID:19146839 PMID:19812120 PMID:19854236 PMID:21762681 PMID:22878004 PMID:24286936 PMID:25537132 PMID:32946155 PMID:34435724 PMID:35815753 More...
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NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G |
Tnpo1 |
transportin 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of TNPO1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
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G |
Tp53 |
tumor protein p53 |
increases expression decreases expression multiple interactions |
EXP ISO |
Isoproterenol results in increased expression of TP53 protein Isoproterenol results in increased expression of TP53 mRNA Isoproterenol results in decreased expression of TP53 mRNA Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; S100A9 protein affects the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein] |
CTD |
PMID:19466570 PMID:24286936 PMID:32924446 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53inp1 |
tumor protein p53 inducible nuclear protein 1 |
multiple interactions increases expression |
ISO |
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA] |
CTD |
PMID:18089841 PMID:20003209 |
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NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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G |
Tpm1 |
tropomyosin 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TPM1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
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G |
Tpo |
thyroid peroxidase |
decreases activity |
EXP |
Isoproterenol results in decreased activity of TPO protein |
CTD |
PMID:26884060 |
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NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Trak1 |
trafficking kinesin protein 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TRAK1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367
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G |
Trim7 |
tripartite motif-containing 7 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TRIM7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:33,205,491...33,221,482
Ensembl chr10:33,205,491...33,221,468
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G |
Trmt5 |
tRNA methyltransferase 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of TRMT5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 6:91,963,558...91,987,660
Ensembl chr 6:91,943,724...91,987,555
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G |
Tsc22d3 |
TSC22 domain family, member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of TSC22D3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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G |
Tsc22d4 |
TSC22 domain family, member 4 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TSC22D4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:18,939,150...18,952,008
Ensembl chr12:18,914,398...18,952,008
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G |
Tsfm |
Ts translation elongation factor, mitochondrial |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TSFM mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:62,828,997...62,864,784
Ensembl chr 7:62,845,488...62,864,769
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G |
Tspyl4 |
TSPY-like 4 |
increases expression |
ISO |
Isoproterenol results in increased expression of TSPYL4 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:38,098,756...38,100,752
Ensembl chr20:38,098,677...38,103,053
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G |
Ttll7 |
tubulin tyrosine ligase like 7 |
increases expression |
ISO |
Isoproterenol results in increased expression of TTLL7 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:235,765,786...235,889,047
Ensembl chr 2:235,765,835...235,885,047
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G |
Ttr |
transthyretin |
increases expression |
ISO |
Isoproterenol results in increased expression of TTR mRNA |
CTD |
PMID:20003209 |
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NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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G |
Tuba1b |
tubulin, alpha 1B |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TUBA1B mRNA |
CTD |
PMID:20003209 |
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NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
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G |
Tuba4a |
tubulin, alpha 4A |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TUBA4A mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
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G |
Tuba8 |
tubulin, alpha 8 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TUBA8 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917
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G |
Tubb2a |
tubulin, beta 2A class IIa |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TUBB2A mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
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G |
Tubb5 |
tubulin, beta 5 class I |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TUBB5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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G |
Tubb6 |
tubulin, beta 6 class V |
increases expression |
EXP |
Isoproterenol results in increased expression of TUBB6 mRNA |
CTD |
PMID:20211217 |
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NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
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G |
Txn1 |
thioredoxin 1 |
decreases expression multiple interactions |
ISO EXP |
Isoproterenol results in decreased expression of TXN1 mRNA Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein] |
CTD |
PMID:21335049 PMID:34435724 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Txndc5 |
thioredoxin domain containing 5 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of TXNDC5 mRNA |
CTD |
PMID:20003209 |
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NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025
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G |
Txnip |
thioredoxin interacting protein |
increases expression multiple interactions |
EXP |
Isoproterenol results in increased expression of TXNIP protein Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein] |
CTD |
PMID:34435724 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of TXNRD2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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G |
Tyw1 |
tRNA-yW synthesizing protein 1 homolog |
increases expression |
ISO |
Isoproterenol results in increased expression of TYW1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:26,332,020...26,418,286
Ensembl chr12:26,330,351...26,418,208
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G |
U2af1 |
U2 small nuclear RNA auxiliary factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of U2AF1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832
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G |
Uap1 |
UDP-N-acetylglucosamine pyrophosphorylase 1 |
increases expression |
ISO |
Isoproterenol results in increased expression of UAP1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469
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G |
Uba1 |
ubiquitin-like modifier activating enzyme 1 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of UBA1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636
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G |
Ubb |
ubiquitin B |
increases expression |
ISO |
Isoproterenol results in increased expression of UBB mRNA |
CTD |
PMID:21335049 |
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NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
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G |
Ubc |
ubiquitin C |
decreases expression |
ISO |
Isoproterenol results in decreased expression of UBC mRNA |
CTD |
PMID:20003209 |
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NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
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G |
Ube2d1 |
ubiquitin-conjugating enzyme E2D 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of UBE2D1 mRNA |
CTD |
PMID:30303030 |
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NCBI chr20:17,309,315...17,343,770
Ensembl chr20:17,309,315...17,342,295
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G |
Ubr2 |
ubiquitin protein ligase E3 component n-recognin 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of UBR2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
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G |
Uchl1 |
ubiquitin C-terminal hydrolase L1 |
increases expression |
ISO |
Isoproterenol results in increased expression of UCHL1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
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G |
Uck2 |
uridine-cytidine kinase 2 |
increases expression |
EXP |
Isoproterenol results in increased expression of UCK2 mRNA |
CTD |
PMID:20211217 |
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NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352
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G |
Ucp1 |
uncoupling protein 1 |
increases expression |
EXP |
Isoproterenol results in increased expression of UCP1 protein |
CTD |
PMID:17250927 |
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NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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G |
Ucp2 |
uncoupling protein 2 |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of UCP2 mRNA Isoproterenol results in increased expression of UCP2 mRNA; Isoproterenol results in increased expression of UCP2 protein Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]; Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein] |
CTD |
PMID:16580698 PMID:20003209 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ucp3 |
uncoupling protein 3 |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of UCP3 mRNA Isoproterenol results in decreased expression of UCP3 mRNA |
CTD |
PMID:24286936 |
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NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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G |
Ugdh |
UDP-glucose 6-dehydrogenase |
increases expression |
ISO |
Isoproterenol results in increased expression of UGDH mRNA |
CTD |
PMID:21335049 |
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NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
ISO |
Isoproterenol results in increased expression of UGT1A2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ung |
uracil-DNA glycosylase |
increases expression |
ISO |
Isoproterenol results in increased expression of UNG mRNA |
CTD |
PMID:21335049 |
|
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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G |
Uqcc1 |
ubiquinol-cytochrome c reductase complex assembly factor 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of UQCC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 3:144,353,276...144,445,810
Ensembl chr 3:144,353,287...144,445,711
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G |
Usp2 |
ubiquitin specific peptidase 2 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of USP2 mRNA |
CTD |
PMID:30303030 |
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NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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G |
Uvrag |
UV radiation resistance associated |
increases expression |
ISO |
Isoproterenol results in increased expression of UVRAG mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
decreases expression multiple interactions |
EXP |
Isoproterenol results in decreased expression of VASP protein natakalim inhibits the reaction [Isoproterenol results in decreased expression of VASP protein] |
CTD |
PMID:27890915 |
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NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of VCAM1 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vcan |
versican |
increases expression |
EXP |
Isoproterenol results in increased expression of VCAN mRNA |
CTD |
PMID:20211217 |
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NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression decreases expression |
ISO EXP |
Isoproterenol results in increased expression of VEGFA mRNA Isoproterenol results in decreased expression of VEGFA mRNA Isoproterenol results in decreased expression of VEGF protein Isoproterenol results in decreased expression of VEGF protein; Isoproterenol results in decreased expression of VEGFA mRNA |
CTD |
PMID:10788502 PMID:21335049 PMID:24286936 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vgll3 |
vestigial-like family member 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of VGLL3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr11:3,642,993...3,692,590
Ensembl chr11:3,643,069...3,689,140
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G |
Vim |
vimentin |
decreases expression |
ISO |
Isoproterenol results in decreased expression of VIM mRNA |
CTD |
PMID:21335049 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Vwf |
von Willebrand factor |
increases expression |
ISO |
Isoproterenol results in increased expression of VWF mRNA |
CTD |
PMID:20003209 |
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NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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G |
Wdr3 |
WD repeat domain 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of WDR3 mRNA |
CTD |
PMID:20003209 |
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NCBI chr 2:187,505,816...187,528,432
Ensembl chr 2:187,505,816...187,528,432
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G |
Wfdc1 |
WAP four-disulfide core domain 1 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of WFDC1 mRNA |
CTD |
PMID:20003209 |
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NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108
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G |
Xdh |
xanthine dehydrogenase |
increases expression multiple interactions |
ISO EXP |
Isoproterenol results in increased expression of XDH mRNA [Isoproterenol co-treated with POSTN protein] results in decreased expression of XDH mRNA |
CTD |
PMID:20003209 PMID:30303030 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Xpa |
XPA, DNA damage recognition and repair factor |
increases expression |
ISO |
Isoproterenol results in increased expression of XPA mRNA |
CTD |
PMID:20003209 |
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NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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G |
Ypel2 |
yippee-like 2 |
increases expression |
ISO |
Isoproterenol results in increased expression of YPEL2 mRNA |
CTD |
PMID:20003209 |
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NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
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G |
Ypel3 |
yippee-like 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of YPEL3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
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G |
Ywhag |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of YWHAG mRNA |
CTD |
PMID:30303030 |
|
NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
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G |
Yy1 |
YY1 transcription factor |
increases expression |
ISO |
Isoproterenol results in increased expression of YY1 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
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G |
Zbtb11 |
zinc finger and BTB domain containing 11 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZBTB11 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr11:44,598,694...44,652,559
Ensembl chr11:44,616,289...44,651,050
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G |
Zbtb16 |
zinc finger and BTB domain containing 16 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZBTB16 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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G |
Zbtb44 |
zinc finger and BTB domain containing 44 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZBTB44 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163
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G |
Zfand5 |
zinc finger AN1-type containing 5 |
multiple interactions |
EXP |
[Isoproterenol co-treated with POSTN protein] results in decreased expression of ZFAND5 mRNA |
CTD |
PMID:30303030 |
|
NCBI chr 1:218,765,735...218,780,391
Ensembl chr 1:218,766,614...218,775,843
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G |
Zfp207 |
zinc finger protein 207 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZFP207 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386
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G |
Zfp236 |
zinc finger protein 236 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZFP236 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr18:75,976,478...76,072,428
Ensembl chr18:75,978,231...76,073,737
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G |
Zfp346 |
zinc finger protein 346 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZFP346 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr17:9,493,787...9,523,681
Ensembl chr17:9,493,803...9,523,635
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G |
Zfp428 |
zinc finger protein 428 |
decreases expression |
ISO |
Isoproterenol results in decreased expression of ZFP428 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 1:80,099,520...80,108,875
Ensembl chr 1:80,099,441...80,108,870
|
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G |
Zfp451 |
zinc finger protein 451 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZFP451 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652
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|
G |
Zmym5 |
zinc finger MYM-type containing 5 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZMYM5 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr15:30,920,479...30,941,249
Ensembl chr15:30,923,241...30,941,240
|
|
G |
Zranb3 |
zinc finger RANBP2-type containing 3 |
increases expression |
ISO |
Isoproterenol results in increased expression of ZRANB3 mRNA |
CTD |
PMID:20003209 |
|
NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670
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|
G |
Zw10 |
zw10 kinetochore protein |
increases expression |
ISO |
Isoproterenol results in increased expression of ZW10 mRNA |
CTD |
PMID:21335049 |
|
NCBI chr 8:49,396,541...49,424,743
Ensembl chr 8:49,396,545...49,421,805
|
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