Adamtsl2 (ADAMTS-like 2) - Rat Genome Database

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Gene: Adamtsl2 (ADAMTS-like 2) Rattus norvegicus
Analyze
Symbol: Adamtsl2
Name: ADAMTS-like 2
RGD ID: 1305459
Description: Predicted to enable microfibril binding activity. Predicted to act upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADAMTS-like protein 2; LOC311827; RGD1305459; similar to KIAA0605 gene product
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,795,882 - 30,832,635 (+)NCBIGRCr8
mRatBN7.2310,397,774 - 10,434,557 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,404,626 - 10,434,554 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,624,473 - 5,654,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,624,506 - 5,654,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,986,871 - 11,017,273 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,976,490 - 6,004,532 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,974,890 - 6,004,472 (+)NCBI
Celera35,202,855 - 5,232,817 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17509843   PMID:18677313   PMID:25762570   PMID:34611183  


Genomics

Comparative Map Data
Adamtsl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,795,882 - 30,832,635 (+)NCBIGRCr8
mRatBN7.2310,397,774 - 10,434,557 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,404,626 - 10,434,554 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,624,473 - 5,654,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,624,506 - 5,654,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,986,871 - 11,017,273 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,976,490 - 6,004,532 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,974,890 - 6,004,472 (+)NCBI
Celera35,202,855 - 5,232,817 (+)NCBICelera
Cytogenetic Map3p12NCBI
ADAMTSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,532,164 - 133,575,519 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,532,164 - 133,575,519 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,397,286 - 136,440,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,389,796 - 135,430,462 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,429,528 - 133,470,194NCBI
Celera9106,945,251 - 106,987,558 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,898,534 - 105,940,653 (+)NCBIHuRef
CHM1_19136,547,413 - 136,590,097 (+)NCBICHM1_1
T2T-CHM13v2.09145,746,173 - 145,789,503 (+)NCBIT2T-CHM13v2.0
Adamtsl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,969,348 - 26,998,993 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,969,391 - 26,998,993 (+)EnsemblGRCm39 Ensembl
GRCm38227,079,336 - 27,108,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,079,379 - 27,108,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,934,901 - 26,964,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,901,390 - 26,930,622 (+)NCBIMGSCv36mm8
Celera226,782,439 - 26,811,671 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.22NCBI
Adamtsl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,849,271 - 2,879,848 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,849,310 - 2,879,130 (+)NCBIChiLan1.0ChiLan1.0
ADAMTSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,777,730 - 5,818,004 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,780,066 - 5,820,346 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,658,540 - 104,698,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,269,369 - 133,309,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,269,369 - 133,309,602 (+)Ensemblpanpan1.1panPan2
ADAMTSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,925,738 - 49,958,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,925,755 - 49,958,300 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,206,839 - 49,239,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,799,767 - 50,833,236 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,799,856 - 50,833,228 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,561,488 - 49,594,623 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,903,420 - 49,936,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,981,616 - 50,014,897 (+)NCBIUU_Cfam_GSD_1.0
Adamtsl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,977,965 - 200,011,067 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,363,867 - 3,397,402 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,363,991 - 3,397,099 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,119,904 - 273,155,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,119,826 - 273,155,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,093,734 - 307,129,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,562,213 - 4,602,494 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,562,864 - 4,602,282 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058386,871 - 426,942 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamtsl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,949,907 - 1,976,894 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,948,302 - 1,977,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamtsl2
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:107
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000036995
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
RH131264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,434,260 - 10,434,474 (+)MAPPERmRatBN7.2
Rnor_6.035,654,594 - 5,654,807NCBIRnor6.0
Rnor_5.0311,016,977 - 11,017,190UniSTSRnor5.0
RGSC_v3.436,004,239 - 6,004,452UniSTSRGSC3.4
Celera35,232,521 - 5,232,734UniSTS
Cytogenetic Map3p12UniSTS
BE107590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,426,285 - 10,426,488 (+)MAPPERmRatBN7.2
Rnor_6.035,646,620 - 5,646,822NCBIRnor6.0
Rnor_5.0311,009,003 - 11,009,205UniSTSRnor5.0
RGSC_v3.435,996,265 - 5,996,467UniSTSRGSC3.4
Celera35,224,547 - 5,224,749UniSTS
RH 3.4 Map314.3UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 1 11 20 11 12 9
Low 3 21 49 37 5 37 8 11 54 24 23 2 8
Below cutoff 7 4 3 4 6

Sequence


RefSeq Acc Id: ENSRNOT00000036995   ⟹   ENSRNOP00000030753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,404,626 - 10,434,554 (+)Ensembl
Rnor_6.0 Ensembl35,624,506 - 5,654,910 (+)Ensembl
RefSeq Acc Id: NM_001427090   ⟹   NP_001414019
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,802,700 - 30,832,635 (+)NCBI
RefSeq Acc Id: XM_039106142   ⟹   XP_038962070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,795,882 - 30,832,635 (+)NCBI
mRatBN7.2310,397,774 - 10,434,557 (+)NCBI
RefSeq Acc Id: XM_039106143   ⟹   XP_038962071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,802,691 - 30,832,635 (+)NCBI
mRatBN7.2310,404,603 - 10,434,557 (+)NCBI
RefSeq Acc Id: XM_039106144   ⟹   XP_038962072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,802,673 - 30,826,768 (+)NCBI
mRatBN7.2310,404,584 - 10,428,690 (+)NCBI
RefSeq Acc Id: XM_063283923   ⟹   XP_063139993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,802,680 - 30,827,838 (+)NCBI
RefSeq Acc Id: XM_063283924   ⟹   XP_063139994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,813,216 - 30,832,635 (+)NCBI
RefSeq Acc Id: ENSRNOP00000030753   ⟸   ENSRNOT00000036995
RefSeq Acc Id: XP_038962070   ⟸   XM_039106142
- Peptide Label: isoform X1
- UniProtKB: D4A4X6 (UniProtKB/TrEMBL),   A6JTK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962072   ⟸   XM_039106144
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038962071   ⟸   XM_039106143
- Peptide Label: isoform X2
- UniProtKB: A6JTK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139993   ⟸   XM_063283923
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414019   ⟸   NM_001427090
- Peptide Label: precursor
- UniProtKB: A6JTK4 (UniProtKB/TrEMBL),   D4A4X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139994   ⟸   XM_063283924
- Peptide Label: isoform X4
Protein Domains
PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4X6-F1-model_v2 AlphaFold D4A4X6 1-957 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691927
Promoter ID:EPDNEW_R2447
Type:single initiation site
Name:Adamtsl2_1
Description:ADAMTS-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,624,502 - 5,624,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305459 AgrOrtholog
BioCyc Gene G2FUF-50307 BioCyc
Ensembl Genes ENSRNOG00000027742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036995.7 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
InterPro ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report rno:311827 UniProtKB/TrEMBL
NCBI Gene 311827 ENTREZGENE
PANTHER ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
  NO LONG NERVE CORD, ISOFORM C UniProtKB/TrEMBL
Pfam ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamtsl2 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027742 RatGTEx
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP TSP1 UniProtKB/TrEMBL
UniProt A6JTK4 ENTREZGENE, UniProtKB/TrEMBL
  D4A4X6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Adamtsl2  ADAMTS-like 2  RGD1305459_predicted  similar to KIAA0605 gene product (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305459_predicted  similar to KIAA0605 gene product (predicted)  LOC311827_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311827_predicted  similar to KIAA0605 gene product (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL