1,2-dimethylhydrazine multiple interactions ISO Pde4a (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDE4A mRNA CTD PMID:22206623 1,2-dimethylhydrazine affects expression ISO Pde4a (Mus musculus) 6480464 1 and 2-Dimethylhydrazine affects the expression of PDE4A mRNA CTD PMID:22206623 17beta-estradiol multiple interactions ISO PDE4A (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of PDE4A mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO PDE4A (Homo sapiens) 6480464 Estradiol results in increased expression of PDE4A mRNA CTD PMID:31614463 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Pde4a (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of PDE4A mRNA CTD PMID:21570461 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PDE4A mRNA CTD PMID:30071829 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO PDE4A (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE4A mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 and 2-dithiol-3-thione results in increased expression of PDE4A mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO Pde4a (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of PDE4A mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol decreases methylation ISO Pde4a (Mus musculus) 6480464 bisphenol S results in decreased methylation of PDE4A exon and bisphenol S results in decreased methylation of PDE4A promoter CTD PMID:33297965 4-nitrophenyl beta-D-xyloside multiple interactions EXP 6480464 4-nitrophenyl beta-D-xyloside inhibits the reaction [FSHB protein results in increased activity of PDE4A protein] CTD PMID:17261351 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PDE4A mRNA CTD PMID:30047161 acetamide increases expression EXP 6480464 acetamide results in increased expression of PDE4A mRNA CTD PMID:31881176 aflatoxin B1 affects methylation ISO PDE4A (Homo sapiens) 6480464 Aflatoxin B1 affects the methylation of PDE4A intron CTD PMID:30157460 albuterol multiple interactions ISO PDE4A (Homo sapiens) 6480464 [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA CTD PMID:10763856 all-trans-retinoic acid decreases expression ISO PDE4A (Homo sapiens) 6480464 Tretinoin results in decreased expression of PDE4A mRNA CTD PMID:33167477 ammonia affects response to substance ISO Pde4a (Mus musculus) 6480464 PDE4A protein affects the susceptibility to Ammonia CTD PMID:17445227 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PDE4A mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO PDE4A (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of PDE4A mRNA CTD PMID:24449571 arsenite(3-) increases expression ISO Pde4a (Mus musculus) 6480464 arsenite results in increased expression of PDE4A mRNA CTD PMID:33053406 arsenous acid decreases expression ISO PDE4A (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PDE4A mRNA CTD PMID:15070760 atrazine decreases activity ISO PDE4A (Homo sapiens) 6480464 Atrazine results in decreased activity of PDE4A protein CTD PMID:21251949 benzene increases expression ISO PDE4A (Homo sapiens) 6480464 Benzene results in increased expression of PDE4A mRNA CTD PMID:19162166 benzo[a]pyrene multiple interactions ISO Pde4a (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PDE4A mRNA and AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PDE4A mRNA] CTD PMID:22228805 and PMID:27858113 benzo[a]pyrene increases methylation ISO PDE4A (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PDE4A 5' UTR more ... CTD PMID:27901495 benzo[a]pyrene decreases expression ISO PDE4A (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of PDE4A mRNA CTD PMID:26238291 benzo[a]pyrene decreases expression ISO Pde4a (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of PDE4A mRNA CTD PMID:22228805 benzo[b]fluoranthene multiple interactions ISO Pde4a (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PDE4A mRNA CTD PMID:27858113 benzo[e]pyrene increases methylation ISO PDE4A (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of PDE4A intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PDE4A mRNA CTD PMID:25181051 more ... bisphenol A increases methylation ISO PDE4A (Homo sapiens) 6480464 bisphenol A results in increased methylation of PDE4A gene CTD PMID:31601247 bisphenol A multiple interactions ISO PDE4A (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE4A mRNA CTD PMID:28628672 bromacil affects activity ISO PDE4A (Homo sapiens) 6480464 bromacil affects the activity of PDE4A protein CTD PMID:21251949 buta-1,3-diene decreases expression ISO Pde4a (Mus musculus) 6480464 1 and 3-butadiene results in decreased expression of PDE4A mRNA CTD PMID:29038090 butanal increases methylation ISO PDE4A (Homo sapiens) 6480464 butyraldehyde results in increased methylation of PDE4A gene CTD PMID:30002397 cadmium atom multiple interactions ISO PDE4A (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PDE4A mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO PDE4A (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PDE4A mRNA CTD PMID:35301059 cantharidin decreases expression ISO Pde4a (Mus musculus) 6480464 Cantharidin results in decreased expression of PDE4A mRNA CTD PMID:36907384 carbon nanotube decreases expression ISO Pde4a (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 CGP 52608 multiple interactions ISO PDE4A (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to PDE4A gene] CTD PMID:28238834 chrysene multiple interactions ISO Pde4a (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PDE4A mRNA CTD PMID:27858113 cisplatin increases expression ISO PDE4A (Homo sapiens) 6480464 Cisplatin results in increased expression of PDE4A mRNA CTD PMID:27392435 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 cobalt dichloride decreases expression ISO PDE4A (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of PDE4A mRNA CTD PMID:19376846 cyanazine decreases activity ISO PDE4A (Homo sapiens) 6480464 cyanazine results in decreased activity of PDE4A protein CTD PMID:21251949 deisopropylatrazine decreases activity ISO PDE4A (Homo sapiens) 6480464 6-deisopropylatrazine results in decreased activity of PDE4A protein CTD PMID:21251949 dexamethasone multiple interactions ISO PDE4A (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE4A mRNA CTD PMID:28628672 dextran sulfate multiple interactions ISO Pde4a (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PDE4A mRNA CTD PMID:29950665 diarsenic trioxide decreases expression ISO PDE4A (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PDE4A mRNA CTD PMID:15070760 dicrotophos increases expression ISO PDE4A (Homo sapiens) 6480464 dicrotophos results in increased expression of PDE4A mRNA CTD PMID:28302478 dimethomorph decreases activity ISO PDE4A (Homo sapiens) 6480464 dimethomorph results in decreased activity of PDE4A protein CTD PMID:21251949 dioxygen increases expression ISO Pde4a (Mus musculus) 6480464 Oxygen deficiency results in increased expression of PDE4A mRNA CTD PMID:24205000 dorsomorphin multiple interactions ISO PDE4A (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4A mRNA CTD PMID:27188386 doxorubicin increases expression ISO PDE4A (Homo sapiens) 6480464 Doxorubicin results in increased expression of PDE4A mRNA CTD PMID:29803840 and PMID:30031762 entinostat increases expression ISO PDE4A (Homo sapiens) 6480464 entinostat results in increased expression of PDE4A mRNA CTD PMID:26272509 and PMID:27188386 entinostat multiple interactions ISO PDE4A (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4A mRNA CTD PMID:27188386 ethanol increases expression EXP 6480464 Ethanol results in increased expression of PDE4A mRNA CTD PMID:20655511 ethyl methanesulfonate decreases expression ISO PDE4A (Homo sapiens) 6480464 Ethyl Methanesulfonate results in decreased expression of PDE4A mRNA CTD PMID:23649840 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of PDE4A mRNA CTD PMID:30307764 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of PDE4A mRNA CTD PMID:12504921 folic acid decreases expression ISO PDE4A (Homo sapiens) 6480464 Folic Acid results in decreased expression of PDE4A mRNA CTD PMID:21867686 folic acid multiple interactions ISO Pde4a (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDE4A mRNA CTD PMID:22206623 formaldehyde decreases expression ISO PDE4A (Homo sapiens) 6480464 Formaldehyde results in decreased expression of PDE4A mRNA CTD PMID:23649840 formaldehyde increases expression ISO PDE4A (Homo sapiens) 6480464 Formaldehyde results in increased expression of PDE4A mRNA CTD PMID:27905399 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of PDE4A protein CTD PMID:20222156 heptanal increases methylation ISO PDE4A (Homo sapiens) 6480464 heptanal results in increased methylation of PDE4A gene CTD PMID:30002397 hexanal increases methylation ISO PDE4A (Homo sapiens) 6480464 n-hexanal results in increased methylation of PDE4A gene CTD PMID:30002397 indometacin multiple interactions ISO PDE4A (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE4A mRNA CTD PMID:28628672 isoprenaline decreases expression ISO Pde4a (Mus musculus) 6480464 Isoproterenol results in decreased expression of PDE4A mRNA CTD PMID:20003209 lead(0) affects expression ISO PDE4A (Homo sapiens) 6480464 Lead affects the expression of PDE4A mRNA CTD PMID:28903495 lipopolysaccharide increases activity ISO PDE4A (Homo sapiens) 6480464 Lipopolysaccharides results in increased activity of PDE4A protein CTD PMID:21913898 lithium atom decreases expression EXP 6480464 Lithium results in decreased expression of PDE4A protein CTD PMID:20222156 lithium hydride decreases expression EXP 6480464 Lithium results in decreased expression of PDE4A protein CTD PMID:20222156 methapyrilene increases methylation ISO PDE4A (Homo sapiens) 6480464 Methapyrilene results in increased methylation of PDE4A intron CTD PMID:30157460 methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of PDE4A mRNA CTD PMID:30047161 methyl methanesulfonate decreases expression ISO PDE4A (Homo sapiens) 6480464 Methyl Methanesulfonate results in decreased expression of PDE4A mRNA CTD PMID:23649840 nonanal increases methylation ISO PDE4A (Homo sapiens) 6480464 nonanal results in increased methylation of PDE4A gene CTD PMID:30002397 octanal increases methylation ISO PDE4A (Homo sapiens) 6480464 caprylic aldehyde results in increased methylation of PDE4A gene CTD PMID:30002397 ozone decreases expression EXP 6480464 Ozone results in decreased expression of PDE4A mRNA CTD PMID:16330353 paracetamol affects expression ISO Pde4a (Mus musculus) 6480464 Acetaminophen affects the expression of PDE4A mRNA CTD PMID:17562736 pentanal increases methylation ISO PDE4A (Homo sapiens) 6480464 pentanal results in increased methylation of PDE4A gene CTD PMID:30002397 pirinixic acid increases expression ISO Pde4a (Mus musculus) 6480464 pirinixic acid results in increased expression of PDE4A mRNA CTD PMID:23811191 pravastatin decreases expression ISO Pde4a (Mus musculus) 6480464 Pravastatin results in decreased expression of PDE4A mRNA CTD PMID:27225895 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of PDE4A mRNA CTD PMID:27225895 prometon affects activity ISO PDE4A (Homo sapiens) 6480464 prometone affects the activity of PDE4A protein CTD PMID:21251949 propanal increases methylation ISO PDE4A (Homo sapiens) 6480464 propionaldehyde results in increased methylation of PDE4A gene CTD PMID:30002397 propazine decreases activity ISO PDE4A (Homo sapiens) 6480464 propazine results in decreased activity of PDE4A protein CTD PMID:21251949 roflumilast decreases activity ISO PDE4A (Homo sapiens) 6480464 Roflumilast results in decreased activity of PDE4A protein CTD PMID:15901792 roflumilast multiple interactions EXP 6480464 Roflumilast inhibits the reaction [Rotenone results in increased activity of PDE4A protein] CTD PMID:36706892 rolipram multiple interactions ISO PDE4A (Homo sapiens) 6480464 [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA CTD PMID:10763856 rolipram decreases activity ISO Pde4a (Mus musculus) 6480464 Rolipram results in decreased activity of PDE4A protein CTD PMID:15922051 rotenone multiple interactions EXP 6480464 Roflumilast inhibits the reaction [Rotenone results in increased activity of PDE4A protein] CTD PMID:36706892 rotenone increases activity EXP 6480464 Rotenone results in increased activity of PDE4A protein CTD PMID:36706892 SB 431542 multiple interactions ISO PDE4A (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4A mRNA CTD PMID:27188386 silver atom increases expression ISO Pde4a (Mus musculus) 6480464 Silver results in increased expression of PDE4A mRNA CTD PMID:27131904 silver(0) increases expression ISO Pde4a (Mus musculus) 6480464 Silver results in increased expression of PDE4A mRNA CTD PMID:27131904 simazine decreases activity ISO PDE4A (Homo sapiens) 6480464 Simazine results in decreased activity of PDE4A protein CTD PMID:21251949 sodium arsenite decreases expression ISO PDE4A (Homo sapiens) 6480464 sodium arsenite results in decreased expression of PDE4A protein CTD PMID:21925251 sodium chlorate multiple interactions EXP 6480464 sodium chlorate inhibits the reaction [FSHB protein results in increased activity of PDE4A protein] CTD PMID:17261351 Soman decreases expression EXP 6480464 Soman results in decreased expression of PDE4A mRNA CTD PMID:19281266 Terbacil affects activity ISO PDE4A (Homo sapiens) 6480464 terbacil affects the activity of PDE4A protein CTD PMID:21251949 testosterone enanthate increases expression EXP 6480464 testosterone enanthate results in increased expression of PDE4A mRNA CTD PMID:21427060 and PMID:25603467 tetraphene increases expression ISO Pde4a (Mus musculus) 6480464 benz(a)anthracene results in increased expression of PDE4A mRNA CTD PMID:26377693 tetraphene multiple interactions ISO Pde4a (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PDE4A mRNA CTD PMID:27858113 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of PDE4A mRNA CTD PMID:34492290 titanium dioxide multiple interactions ISO Pde4a (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PDE4A mRNA CTD PMID:29950665 triadimefon decreases expression EXP 6480464 triadimefon results in decreased expression of PDE4A mRNA CTD PMID:30047161 triptonide decreases expression ISO Pde4a (Mus musculus) 6480464 triptonide results in decreased expression of PDE4A mRNA CTD PMID:33045310 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of PDE4A protein CTD PMID:20222156 valproic acid increases expression ISO PDE4A (Homo sapiens) 6480464 Valproic Acid results in increased expression of PDE4A mRNA CTD PMID:19101580 more ... valproic acid increases methylation ISO PDE4A (Homo sapiens) 6480464 Valproic Acid results in increased methylation of PDE4A gene CTD PMID:29154799 Yessotoxin multiple interactions ISO PDE4A (Homo sapiens) 6480464 PDE4A protein affects the reaction [yessotoxin affects the expression of PRKCD protein] and PDE4A protein promotes the reaction [yessotoxin results in decreased expression of MTOR protein modified form] CTD PMID:25576684 and PMID:26025416 zinc atom increases expression ISO PDE4A (Homo sapiens) 6480464 Zinc deficiency results in increased expression of PDE4A mRNA CTD PMID:18356318 zinc(0) increases expression ISO PDE4A (Homo sapiens) 6480464 Zinc deficiency results in increased expression of PDE4A mRNA CTD PMID:18356318