Mmp15 (matrix metallopeptidase 15)

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Gene: Mmp15 (matrix metallopeptidase 15) Rattus norvegicus

Analyze

Symbol:

Mmp15

Name:

matrix metallopeptidase 15

RGD ID:

1308937

Description:

Predicted to have metalloendopeptidase activity. Involved in response to estradiol. Predicted to localize to extracellular matrix and integral component of plasma membrane. Orthologous to human MMP15 (matrix metallopeptidase 15); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

LOC291848; matrix metalloproteinase 15; matrix metalloproteinase-15

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MMP15 (matrix metallopeptidase 15)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mmp15 (matrix metallopeptidase 15)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mmp15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MMP15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MMP15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mmp15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MMP15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MMP15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mmp15 (matrix metallopeptidase 15)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MMP15 (matrix metallopeptidase 15)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Mmp15 (matrix metallopeptidase 15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	mmp15a (matrix metallopeptidase 15a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	mmp15b (matrix metallopeptidase 15b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Mmp1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Mmp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	zmp-3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	zmp-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	9,663,449 - 9,684,943 (-)	NCBI
Rnor_6.0 Ensembl	19	10,079,765 - 10,101,451 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	19	10,079,881 - 10,101,380 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	10,064,056 - 10,085,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	10,122,553 - 10,143,853 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	10,128,673 - 10,167,980 (-)	NCBI
Celera	19	9,556,223 - 9,577,713 (-)	NCBI		Celera
Cytogenetic Map	19	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Liver Reperfusion Injury (IEP)

Mammary Neoplasms, Experimental (ISO)

prostate cancer (ISO)

Spontaneous Abortions (ISO)

transitional cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (EXP,ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

candesartan (EXP)

carbon nanotube (ISO)

chloroprene (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diazinon (ISO)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethanol (ISO)

fulvestrant (ISO)

genistein (ISO)

hydroquinone (ISO)

isoprenaline (ISO)

methapyrilene (EXP)

methotrexate (ISO)

N-nitrosodimethylamine (EXP)

nickel sulfate (ISO)

orphenadrine (EXP)

paracetamol (ISO)

pentanal (ISO)

potassium bromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

propiconazole (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

collagen catabolic process (IBA)

endodermal cell differentiation (ISO)

extracellular matrix organization (IBA)

proteolysis (IEA)

response to estradiol (IEP)

Cellular Component

extracellular matrix (IEA)

integral component of plasma membrane (IEA)

Molecular Function

metalloendopeptidase activity (IBA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated


1.	Bu YH, etal., J Endocrinol Invest. 2009 May 26.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Kitagawa Y, etal., J Urol. 1998 Oct;160(4):1540-5.
5.	MGD data from the GO Consortium
6.	RGD automated data pipeline
7.	RGD automated import pipeline for gene-chemical interactions
8.	Riddick AC, etal., Br J Cancer. 2005 Jun 20;92(12):2171-80.
9.	Szabova L, etal., J Cell Physiol. 2005 Oct;205(1):123-32.
10.	Zhao D and Yang BX, Zhonghua Wai Ke Za Zhi. 2009 Mar 1;47(5):373-6.

Additional References at PubMed

PMID:23154389

Genomics

Comparative Map Data

Mmp15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	9,663,449 - 9,684,943 (-)	NCBI
Rnor_6.0 Ensembl	19	10,079,765 - 10,101,451 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	19	10,079,881 - 10,101,380 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	19	10,064,056 - 10,085,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	10,122,553 - 10,143,853 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	10,128,673 - 10,167,980 (-)	NCBI
Celera	19	9,556,223 - 9,577,713 (-)	NCBI		Celera
Cytogenetic Map	19	p13	NCBI

MMP15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	16	58,025,754 - 58,046,901 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	16	58,025,754 - 58,046,901 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	58,059,658 - 58,080,805 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	56,616,783 - 56,638,306 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	56,616,782 - 56,638,303	NCBI
Celera	16	42,556,594 - 42,578,117 (+)	NCBI
Cytogenetic Map	16	q21	NCBI
HuRef	16	43,926,416 - 43,947,940 (+)	NCBI		HuRef
CHM1_1	16	59,466,544 - 59,487,878 (+)	NCBI		CHM1_1

Mmp15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	96,078,924 - 96,100,921 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	96,078,896 - 96,101,708 (+)	Ensembl
GRCm38	8	95,352,296 - 95,374,293 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	95,352,268 - 95,375,080 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	97,876,237 - 97,898,193 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	98,241,466 - 98,263,422 (+)	NCBI			mm8
Celera	8	99,673,352 - 99,695,550 (+)	NCBI		Celera
Cytogenetic Map	8	C5	NCBI
cM Map	8	47.12	NCBI

Mmp15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	15,584,780 - 15,601,739 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	15,584,206 - 15,603,162 (+)	NCBI	ChiLan1.0	ChiLan1.0

MMP15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	57,436,611 - 57,457,122 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	57,433,813 - 57,457,122 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	16	38,304,856 - 38,326,193 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MMP15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	58,501,783 - 58,512,507 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	58,504,848 - 58,512,371 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	55,133,201 - 55,153,695 (-)	NCBI
ROS_Cfam_1.0	2	59,042,165 - 59,062,706 (-)	NCBI
UMICH_Zoey_3.1	2	55,873,315 - 55,893,796 (-)	NCBI
UNSW_CanFamBas_1.0	2	56,881,102 - 56,901,624 (-)	NCBI
UU_Cfam_GSD_1.0	2	57,774,141 - 57,794,621 (-)	NCBI

Mmp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	49,617,444 - 49,636,491 (-)	NCBI
SpeTri2.0	NW_004936475	9,951,876 - 9,971,631 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MMP15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	19,890,884 - 19,918,244 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	19,890,867 - 19,912,941 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	17,937,693 - 17,958,870 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MMP15
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	43,961,288 - 43,982,182 (+)	NCBI
ChlSab1.1 Ensembl	5	43,960,891 - 43,982,261 (+)	Ensembl

Mmp15
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	28,128,687 - 28,147,964 (-)	NCBI

Position Markers

RH139389

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	9,663,567 - 9,663,643 (+)	MAPPER
Rnor_6.0	19	10,080,000 - 10,080,075	NCBI	Rnor6.0
Rnor_5.0	19	10,064,175 - 10,064,250	UniSTS	Rnor5.0
RGSC_v3.4	19	10,122,672 - 10,122,747	UniSTS	RGSC3.4
Celera	19	9,556,342 - 9,556,417	UniSTS
RH 3.4 Map	19	96.7	UniSTS
Cytogenetic Map	19	p13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411590	Foco7	Food consumption QTL 7	6.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	19	1	24933090	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27635288	Rat
631678	Cm9	Cardiac mass QTL 9	4.27	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	19	1	29558305	Rat
631681	Cm12	Cardiac mass QTL 12	3.33	0.00053	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	19	1	29558305	Rat
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	32379055	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	1	38221845	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	38221845	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	1	38221845	Rat
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	1	38221845	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	1044648	46044648	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	1957707	46957707	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2432963	47217667	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2432963	62275575	Rat
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	3701835	48701835	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	3701835	48701835	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	5007571	43907843	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	6506761	60220581	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	8072545	47318201	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	523
Count of miRNA genes:	223
Interacting mature miRNAs:	275
Transcripts:	ENSRNOT00000017629
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	14	14		14	6	9	68	29	29	11	6
Low			43	27	19	27	2	2	6	6	11		2
Below cutoff											1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CB545319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB773519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK357842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017629 ⟹ ENSRNOP00000017629

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	19	10,079,765 - 10,101,451 (-)	Ensembl

RefSeq Acc Id:

NM_001106168 ⟹ NP_001099638

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	9,663,449 - 9,684,943 (-)	NCBI
Rnor_6.0	19	10,079,881 - 10,101,380 (-)	NCBI
Rnor_5.0	19	10,064,056 - 10,085,300 (-)	NCBI
RGSC_v3.4	19	10,122,553 - 10,143,853 (-)	RGD
Celera	19	9,556,223 - 9,577,713 (-)	RGD

Sequence:

show sequence

GGCGGGCTCGTCGCTCTCTCAGACCAGTTCCCTGCGCCCCTCCCGGGACTGCCTGGGGATCCGG
GTCCGATTGGGCGCGGCAGCTAGTGGAGTCACCAGAGGGAAGCGCGCGCTCTGGGCAGCACGGG
GGAACCTGGGCATGGACAGAGAGAGCAGGGCGCGCAGGGGGCGCCGCGGGACCGGGCGGCCGGA
TCGCTGAGCCAGACAAAGGCTCTGGAGTTGGGCTTGCTCTCGGGGGGCCGGGGCCAGGGCGCAC
CGCGCCGACGCTGCAAGACTCTGCGGCGTGCAGCTCGGCCGGTCCCCTTCTCCAGCGGGCGAGT
CCCCGCGTGCCCCGACCTGCCCTGCCCGCTTCTCACCCGGTTTGGGAATTTGCAGAGGGGACCT
GAGCTGCTCCGGCAGGCACGGGGAGACCGAGGTCCGCCGCGCGCCCGCGGGGCTGGGAGCCAGG
GAGCGTCGCAAGTTTTCCAGCCGCGTGCGAGAACGCGGTGCTGGCCAGCGAGCTAGCCCGCGTG
CAGCGCTCCGGACCCGGCTGGCTGCCGAAGAGCATGGGCAGCGACCGGAGCGCACTCGGACGGC
CAGGCTGCGCTGGCAGCTGCCTCAGCAGTCGAGCTTCGCTGCTCCTGCTGCTACTGGTGCTTCT
GGACTGCCTGGGCGGCGGTACAGCGTCTGAAGACGCCGAAGTATACGCCGCTGAGAACTGGCTG
CGACTCTATGGCTACCTACCCCAGCCTAGCCGCCACATGTCCACCATGCGTTCTGCCCAGATCC
TGGCTTCTGCCCTTGCCGAGATGCAGAGTTTCTATGGGATCCCTGTCACGGGTGTGCTTGATGA
AGAGACAAAAACGTGGATGAAGCGACCCCGCTGTGGGGTTCCTGATCAGTTTGGGGTACGTGTG
AAAGCCAACCTGCGGCGGCGGCGGAGGCGTTACACCCTGACAGGAAAGACATGGAGCAACTACC
ATCTGACCTTCAGCATCCAGAACTACACAGAGAAGCTGGGCTGGTACAACTCAATGGAGGCGGT
GCGCAGGGCTTTCCAAGTGTGGGAGCAGGTCACGCCCTTGGTCTTCCAGGAAGTACCCTATGAC
GACATTCGGCTGCGAAGGCGAGCGGAGGCTGACATCATGGTACTCTTTGCCTCTGGCTTCCATG
GCGACAGCTCACCGTTTGATGGCGTGGGTGGCTTTCTGGCCCACGCCTATTTCCCCGGCCCTGG
TCTGGGTGGGGACACCCATTTCGACGCAGATGAACCCTGGACCTTCTCCAGCACTGACCTGCAT
GGAATCAGCCTCTTTCTGGTGGCTGTGCATGAGTTGGGCCACGCACTAGGACTGGAGCACTCAA
GCAACCCCAGCGCTATCATGGCACCCTTCTACCAGTGGATGGACACTGACAACTTCCAGCTGCC
CGAGGATGACCTTCGGGGCATCCAGCAGCTGTATGGCTCCCCAGATGGTAAGCCACAGCCCACC
CGGCCTCTCCCCACGGTGAGGCCCCGGCGGCCAGGACGGCCAGACCACCAGCCACCTCGGCCTC
CCCAGCCACCACATCCAGGTGGGAAGCCAGAGAGGCCCCCCAAACCAGGGCCCCCACCCCAGCC
CCGAGCCACAGAGAGGCCTGACCAGTATGGCCCCAACATCTGCGATGGCAACTTCGACACAGTG
GCTGTACTCCGTGGAGAGATGTTTGTGTTCAAGGGCCGCTGGTTCTGGCGAGTCCGGCACAACC
GTGTTCTGGACAACTACCCCATGCCAATTGGCCACTTCTGGCGTGGCCTGCCTGGGAACATTAG
TGCTGCCTATGAACGTCAGGATGGGCATTTCGTCTTCTTCAAAGGTAACCGCTACTGGCTTTTC
CGAGAAGCCAATCTGGAGCCTGGCTACCCGCAGCCACTGAGCAGCTATGGTACAGACATCCCCT
ATGACCGCATTGACACAGCCATCTGGTGGGAGCCCACAGGGCACACCTTCTTCTTTCAAGCTGA
CAGGTACTGGCGCTTCAATGAGGAGACACAGCATGGAGACCCTGGCTACCCCAAGCCCATCAGT
GTCTGGCAAGGGATCCCCAACTCTCCCAAAGGGGCCTTCCTCAGCAACGATGCAGCCTACACCT
ACTTCTACAAGGGCACCAAGTACTGGAAATTCAACAACGAGCGCCTGCGGATGGAACCCGGCCA
CCCCAAATCCATCCTGCGGGACTTCATGGGCTGCCAGGAGCACGTGGAGCCCCGATCGCGATGG
CCCGATGTGGCTCGTCCGCCCTTCAACCCCAACGGGGGTGCAGAGCCTGAGACAGAGGATGACA
GCAAGGAAGAGGATGTGGGAGACAAGGATGAGGGCAGCCGCGTGGTGGTGCAGATGGAGGAGGT
GGTTCGGACAGTGAACGTGGTGATGGTGTTGGTCCCCTTGCTGTTGTTGCTCTGCATACTGGGC
CTGGCTTTCGCTCTGGTGCAGATGCAGCGCAAGGGCGCACCCCGCATGCTGCTCTACTGCAAGC
GCTCGCTGCAGGAGTGGGTGTGATCACGTGGCACCCGCAGCACCCGGTGCTCAGGTCTGCAGGG
TCTGTGTGGACCCGGATGCTCCGCGCGGCGCGGCGGGACGCCCTCCTAGCCACACACTCCCCCT
CAGTCCAGCCCCTGCCCTCCTTTATTTATGCCCAGGGGTCTTTTCTCTTGGGCACCCACCCTTT
GTTTCTGCTTTCCTGACTCCGGCCAGGAGATGCTTAGAGATCTCTGAGTGTACCGCTCCAGGCA
GGAACTAAGGGACAGAGGCTCACACCTCTGGAAGACGGACAGATGGCAGAGGGCTGGGAAGCTT
CTCCAGCTCTGGCCCTTGAGCCTGAACCTCTCTCCTCCCGCGTCTGAGCTGTGTTTGCCTTGAA
GGAGCCCAGCTGGGGCTCTACCCTCCTGAATTTGCCTTAGGGAGCGTACGGCCCAGGGGCCGCC
CTGATAACCTTGAGACTTGGTTCCGTCTTCTTAGGTTTACTAAGAAGCCCAGAATCCTGAAAGC
CCTCCCCAATCCTGGCATCGGGCAACTCCCACTCACCCCTGGGCTTGCAGCTTCCTTTCCTCTA
GGAAGAGGCCCTGACCCGTCTCACCAAGGACCAAAGGGAGCCCGCGAAGCTCCCCTCCCAGTGC
TAGTAACTAAGCTCCTCCTTCCCTAGACTGCCCATGTTCTCTTTCATTACCCCAAAGGTCTCAG
GAGGCTGGGCACTCCCTCTACCCTCTGGCTTCTGCTGTCCTTGTCCCAACCTTTGGGGACATGG
GGCAGACACACATACTAGGGTACCAGAGGTCCCCAGTCGATTCCTGGCAGTGTGGATGTTCAGC
AGGTCCCAGACCAGACTATGGACTTCCTCCCTTCCAGATTCCTGTTCCCACACAACACTACTAG
GCTCAGGCCAGCAGCTCACCCTACACAGAGCCTGTGGAACCCCCAAAGGAATCCACTAAGGCCT
GGGAAGTGTCCTAGGGGTGAAAGGGGGGCCCCCCTTCCTCTCTTCATCCTGGAGTCAGCAGGAG
GCTTCTGTGGGAAATGGTACTGTAACAGCTGGCTCTGGCTCTTCTGCCTCCTAAACCTTGAGGG
CGGCCACCCAGGGTCCTCTGGGTCACCGCCTCTCTGCAAGTGGTGGATTCTTAGAGCCTGGCAC
TAGAGGTGACAGATGGGAGGGGTGTGCCAGCAGCACCCTTTAGGTATCACCTCTACAGAACCTG
AGAGCCAGCGAGGGGTGGGGCCATCCACCCCCTCCCCGCATCGTTTAGTTCTGTAAATAATGTG
CACTGATTAAATGTACAGCCGGCGAGTGTGGCCGAGTTTGTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099638	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL87288	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001099638 ⟸ NM_001106168
- Peptide Label:	precursor
- UniProtKB:	D3ZCG5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSDRSALGRPGCAGSCLSSRASLLLLLLVLLDCLGGGTASEDAEVYAAENWLRLYGYLPQPSR HMSTMRSAQILASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVRVKANLRRRRRRY TLTGKTWSNYHLTFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVPYDDIRLRRRAEAD IMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHE LGHALGLEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRP GRPDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFK GRWFWRVRHNRVLDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQ PLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPNSPKG AFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPN GGAEPETEDDSKEEDVGDKDEGSRVVVQMEEVVRTVNVVMVLVPLLLLLCILGLAFALVQMQRK GAPRMLLYCKRSLQEWV hide sequence

RefSeq Acc Id:

ENSRNOP00000017629 ⟸ ENSRNOT00000017629

Protein Domains

ZnMc

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700929

Promoter ID:

EPDNEW_R11453

Type:

initiation region

Name:

Mmp15_1

Description:

matrix metallopeptidase 15

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	10,101,435 - 10,101,495	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308937	AgrOrtholog
Ensembl Genes	ENSRNOG00000012622	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017629	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017629	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.110.10.10	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
InterPro	DUF3377	UniProtKB/TrEMBL
	Hemopexin-like_dom_sf	UniProtKB/TrEMBL
	Hemopexin/matrixin	UniProtKB/TrEMBL
	Hemopexin/matrixin_CS	UniProtKB/TrEMBL
	Hemopexin/matrixin_repeat	UniProtKB/TrEMBL
	M10A_MMP	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	MMP15	UniProtKB/TrEMBL
	Pept_M10_metallopeptidase	UniProtKB/TrEMBL
	Pept_M10A_matrixin	UniProtKB/TrEMBL
	Pept_M10A_Zn_BS	UniProtKB/TrEMBL
	Peptidase_Metallo	UniProtKB/TrEMBL
	Peptidoglycan-bd-like	UniProtKB/TrEMBL
	PGBD-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:291848	UniProtKB/TrEMBL
NCBI Gene	291848	ENTREZGENE
PANTHER	PTHR10201:SF25	UniProtKB/TrEMBL
Pfam	DUF3377	UniProtKB/TrEMBL
	Hemopexin	UniProtKB/TrEMBL
	Peptidase_M10	UniProtKB/TrEMBL
	PG_binding_1	UniProtKB/TrEMBL
PhenoGen	Mmp15	PhenoGen
PIRSF	Peptidase_M10A_matrix	UniProtKB/TrEMBL
PRINTS	MATRIXIN	UniProtKB/TrEMBL
PROSITE	CYSTEINE_SWITCH	UniProtKB/TrEMBL
	HEMOPEXIN	UniProtKB/TrEMBL
	HEMOPEXIN_2	UniProtKB/TrEMBL
SMART	SM00120	UniProtKB/TrEMBL
	ZnMc	UniProtKB/TrEMBL
Superfamily-SCOP	Hemopexin	UniProtKB/TrEMBL
	PGBD_like	UniProtKB/TrEMBL
UniProt	D3ZCG5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Mmp15	matrix metallopeptidase 15	Mmp15_predicted	matrix metallopeptidase 15 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Mmp15_predicted	matrix metallopeptidase 15 (predicted)		matrix metalloproteinase 15 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Mmp15_predicted	matrix metalloproteinase 15 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD