Cfh (complement factor H) - Rat Genome Database
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Gene: Cfh (complement factor H) Rattus norvegicus
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Symbol: Cfh
Name: complement factor H
RGD ID: 620428
Description: Predicted to have anion binding activity; complement component C3b binding activity; and identical protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Localizes to several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; and lupus nephritis. Orthologous to several human genes including CFH (complement factor H); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adrenomedullin binding protein-1; AMBP-1; AMBP1; complement component factor H; complement inhibitory factor H; Fh; platelet complement factor H
Orthologs:
Homo sapiens (human) : CFH (complement factor H)  HGNC  Alliance
Mus musculus (house mouse) : Cfh (complement component factor h)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CFH (complement factor H)
Canis lupus familiaris (dog) : CFH (complement factor H)
Sus scrofa (pig) : CFH (complement factor H)
Chlorocebus sabaeus (African green monkey) : CFH (complement factor H)
Heterocephalus glaber (naked mole-rat) : Cfh (complement factor H)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (ISO)
amphetamine abuse  (IEP,ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (IMP,ISO)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
CFHR5 Deficiency  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (ISO)
hemolytic-uremic syndrome  (ISO,ISS)
Hemorrhagic Shock  (IEP,ISO)
Intestinal Ischemia  (IEP)
Kidney Reperfusion Injury  (IEP,ISO)
Liver Reperfusion Injury  (IEP,ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (IEP)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (IEP)
obstructive jaundice  (IEP)
panuveitis  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (IEP)
psoriasis  (ISO)
Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
retinal detachment  (ISO)
retinal drusen  (ISO)
sarcoidosis  (ISO)
Sepsis  (IEP,ISO)
squamous cell carcinoma  (ISO)
Stroke  (IEP)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
isoprenaline  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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15. GOA data from the GO Consortium
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26. NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Ohali M, etal., Pediatr Nephrol. 1998 Oct;12(8):619-24.
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29. OMIM Disease Annotation Pipeline
30. Pickering MC, etal., J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.
31. Pipeline to import KEGG annotations from KEGG into RGD
32. Qiang X, etal., Mol Med. 2008 Jul-Aug;14(7-8):443-50. doi: 10.2119/2008-00015.Qiang.
33. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
34. Raychaudhuri S, etal., Nat Genet. 2011 Oct 23;43(12):1232-6. doi: 10.1038/ng.976.
35. Ren G, etal., J Biol Chem 2002 Dec 13;277(50):48351-8.
36. Ren G, etal., Kidney Int. 2003 Sep;64(3):914-22.
37. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. RGD automated import pipeline for gene-chemical interactions
39. RGD comprehensive gene curation
40. Riihila PM, etal., J Invest Dermatol. 2014 Feb;134(2):498-506. doi: 10.1038/jid.2013.346. Epub 2013 Aug 12.
41. Schlaf G, etal., Lab Invest 2002 Feb;82(2):183-92.
42. Seddon JM, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):586-91. doi: 10.1167/iovs.08-2514. Epub 2008 Oct 20.
43. Seddon JM, etal., JAMA. 2007 Apr 25;297(16):1793-800.
44. Serrano J, etal., Neuroscience 2003;116(4):947-62.
45. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
46. Shaughnessy J, etal., Clin Vaccine Immunol. 2014 Oct;21(10):1452-9. doi: 10.1128/CVI.00444-14. Epub 2014 Aug 20.
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Additional References at PubMed
PMID:12477932   PMID:12947022   PMID:15574507   PMID:16023208   PMID:16769899   PMID:17028856   PMID:17921253   PMID:18947875   PMID:19299737   PMID:19411110   PMID:19541934   PMID:19850925  
PMID:20675597   PMID:20702729   PMID:20813971   PMID:21148255   PMID:22471560   PMID:22516433   PMID:23487775   PMID:23533145   PMID:23844226   PMID:24006456   PMID:24835392   PMID:24929970  
PMID:25284781   PMID:25991857   PMID:26149919   PMID:26468283   PMID:27564415   PMID:27852797   PMID:28057640   PMID:28228282   PMID:29070671   PMID:29590637   PMID:30705315  


Genomics

Comparative Map Data
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1196,651,878 - 196,747,504 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1196,652,043 - 196,747,504 (+)EnsemblGRCh38hg38GRCh38
GRCh381196,652,033 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371196,621,008 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBINCBI36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBI
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBI
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBImm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,434,107 - 176,507,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0panPan3
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBI
Cfh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBI

Position Markers
Cfh  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01357,062,011 - 57,062,552NCBIRnor6.0
Rnor_5.01362,076,228 - 62,076,769UniSTSRnor5.0
RGSC_v3.41353,337,425 - 53,337,966UniSTSRGSC3.4
Celera1351,853,213 - 51,853,754UniSTS
Cytogenetic Map13q13UniSTS
RH130216  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01356,979,187 - 56,979,391NCBIRnor6.0
Rnor_5.01361,997,476 - 61,997,680UniSTSRnor5.0
RGSC_v3.41353,252,281 - 53,252,485UniSTSRGSC3.4
Celera1351,770,573 - 51,770,777UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:165
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000017749, ENSRNOT00000060111
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 1 15 48 36 7 36 8 8 27 35 24 11 8
Low 2 22 8 4 12 4 3 47 15
Below cutoff 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017749   ⟹   ENSRNOP00000017749
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1356,979,648 - 57,080,491 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000060111   ⟹   ENSRNOP00000056859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1356,979,169 - 57,080,622 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086572   ⟹   ENSRNOP00000072850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1356,978,607 - 57,080,549 (-)Ensembl
RefSeq Acc Id: NM_130409   ⟹   NP_569093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01356,979,155 - 57,080,540 (-)NCBI
Rnor_5.01361,997,444 - 62,094,826 (-)NCBI
RGSC_v3.41353,252,249 - 53,355,987 (-)RGD
Celera1351,770,541 - 51,871,522 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569093 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83174 (Get FASTA)   NCBI Sequence Viewer  
  AAL77269 (Get FASTA)   NCBI Sequence Viewer  
  CAC67513 (Get FASTA)   NCBI Sequence Viewer  
  EDM09615 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_569093   ⟸   NM_130409
- Peptide Label: precursor
- UniProtKB: G3V9R2 (UniProtKB/TrEMBL),   Q5XJW6 (UniProtKB/TrEMBL),   Q91YB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072850   ⟸   ENSRNOT00000086572
RefSeq Acc Id: ENSRNOP00000056859   ⟸   ENSRNOT00000060111
RefSeq Acc Id: ENSRNOP00000017749   ⟸   ENSRNOT00000017749
Protein Domains
Sushi

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698882
Promoter ID:EPDNEW_R9394
Type:initiation region
Name:Cfh_1
Description:complement factor H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01357,080,570 - 57,080,630EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620428 AgrOrtholog
Ensembl Genes ENSRNOG00000030715 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017749 UniProtKB/TrEMBL
  ENSRNOP00000056859 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072850 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017749 UniProtKB/TrEMBL
  ENSRNOT00000060111 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000086572 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096787 IMAGE-MGC_LOAD
InterPro Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:155012 UniProtKB/TrEMBL
MGC_CLONE MGC:91522 IMAGE-MGC_LOAD
NCBI Gene 155012 ENTREZGENE
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cfh PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniGene Rn.101777 ENTREZGENE
UniProt F1M983_RAT UniProtKB/TrEMBL
  G3V9R2 ENTREZGENE, UniProtKB/TrEMBL
  Q5XJW6 ENTREZGENE, UniProtKB/TrEMBL
  Q91YB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Cfh  complement factor H  Cfh  complement component factor H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cfh  complement component factor H    complement component factor h  Name updated 1299863 APPROVED
2002-08-07 Cfh  complement component factor h      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoplasm and nucleus 632369
gene_domains 11 short consensus repeats (SCRs); each SCR contains four characteristic cysteine residues 628500
gene_expression expressed in neurons of telencephalon, diencephalon, mesencephalon, pons, medulla, and cerebellum 632369
gene_expression expressed in glomerular epithelial cells, liver 628500
gene_function beta globulin 628500
gene_homology shows 24-79% homology to SCRs from human FHR-5 protein 628500
gene_physical_interaction binds to C3b 628500
gene_process may be involved in the decay of C3 convertase 628500
gene_process acts as a regulator of the activation of complement cascade 628500
gene_protein two N-linked glycosylation sites at positions 136 and 388 628500
gene_protein 76 kDa(predicted) 628500
gene_regulation may be induced as a response to glomerular injury 628500
gene_transcript 2729 bp long;568 bp long 3-UTR 628500