Gene: Cfh (complement factor H) Rattus norvegicus
Analyze
Symbol:
Cfh
Name:
complement factor H
Description:
Predicted to have complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Localizes to several cellular components, including the extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
adrenomedullin binding protein-1; AMBP-1; AMBP1; complement component factor H; complement inhibitory factor H; Fh; platelet complement factor H
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CFH (complement factor H) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Cfh (complement component factor h) HGNC
Treefam, EggNOG, OrthoMCL, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Pan paniscus (bonobo/pygmy chimpanzee):
CFH (complement factor H) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CFH (complement factor H) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CFH (complement factor H) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CFHR3 (complement factor H related 3) HGNC
Panther, Treefam
Homo sapiens (human):
CFHR4 (complement factor H related 4) HGNC
Panther, Treefam
Homo sapiens (human):
CFHR5 (complement factor H related 5) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Cfh (complement component factor h)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
CFH (complement factor H)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Gm4788 (predicted gene 4788)
Alliance
DIOPT (Ensembl Compara, OMA, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cfhr2 (complement factor H-related 2)
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cfhl1 (complement factor H like 1)
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cfh (complement factor H)
Alliance
DIOPT (OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cfhl5 (complement factor H like 5)
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
cfhl2 (complement factor H like 2)
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Hasp
Alliance
DIOPT (Ensembl Compara, OMA, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 56,979,155 - 57,080,540 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 56,978,607 - 57,080,622 (-) Ensembl Rnor_5.0 13 61,997,444 - 62,094,826 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 53,252,249 - 53,355,987 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 53,266,346 - 53,370,041 (-) NCBI Celera 13 51,770,541 - 51,871,522 (-) NCBI Celera Cytogenetic Map 13 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
amphetamine abuse ISO RGD:1353869 7364944 protein:increased expression:serum: RGD amphetamine abuse IEP 7364944 protein:increased expression:serum, hippocampus: RGD anterior uveitis ISO RGD:1353869 7411695 DNA:SNP, haplotype: :rs800292 (human) RGD atypical hemolytic-uremic syndrome IMP 7364995 DNA:deletion:Cds: RGD atypical hemolytic-uremic syndrome ISO RGD:1353869 11040768 DNA:nonsense mutations, missense mutations, splice-site mutation: :multiple RGD atypical hemolytic-uremic syndrome ISO RGD:1353869 11041172 ; 11041162 RGD atypical hemolytic-uremic syndrome ISO RGD:1353869 1599886 DNA:missense mutation RGD atypical hemolytic-uremic syndrome ISO RGD:1353869 7364995 DNA:SNPs, Haplotype:: RGD atypical hemolytic-uremic syndrome ISO RGD:733427 7364995 DNA:deletion:Cds: RGD Bacteremia ISO RGD:1353869 7364945 associated with Meningococcal Infections RGD brain infarction treatment ISO RGD:1353869 5508764 RGD cardiovascular system disease ISO RGD:1353869 7365023 associated with Diabetes Mellitus, Type 1, DNA:SNP: :rs1410996(human) RGD Cerebral Hemorrhage severity ISO RGD:1353869 5684553 RGD Choroidal Neovascularization ISO RGD:1353869 7365031 DNA:SNPs:cds:p.Y402H, I62V(human) RGD Choroidal Neovascularization treatment ISO RGD:1353869 7364943 RGD Choroidal Neovascularization ISO RGD:1353869 7365030 associated with myopia, DNA:SNP: :rs1061170(human) RGD diabetic retinopathy ISO RGD:1353869 7365023 associated with Diabetes Mellitus, Type 1, DNA:SNP: :rs1410996(human) RGD diabetic retinopathy ISO RGD:1353869 7365019 associated with Diabetes Mellitus, Type 2, DNA:SNP: :rs800292(human) RGD Experimental Arthritis ISO RGD:733427 5684557 RGD glaucoma ISO RGD:1353869 7364950 protein:decreased expression:retina: RGD glomerulonephritis ISO RGD:733427 7365002 RGD Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency ISO RGD:733427 7364995 RGD Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency ISO RGD:1353869 7364995 DNA:SNPs, Haplotype:: RGD hemolytic-uremic syndrome ISO RGD:1353869 11041164 DNA:mutations, polymorphisms:promoter, exon:multiple RGD Hemorrhagic Shock IEP 7364990 RGD Hemorrhagic Shock treatment ISO RGD:1353869 11041173 ; 7364987 RGD Intestinal Ischemia IEP 7364988 protein:decreased expression:plasma RGD Kidney Reperfusion Injury treatment ISO RGD:1353869 7364948 RGD Kidney Reperfusion Injury IEP 7364948 protein:decreased expression:serum: RGD Liver Reperfusion Injury treatment ISO RGD:1353869 7364958 RGD Liver Reperfusion Injury IEP 7364958 mRNA more ... RGD lupus nephritis ISO RGD:1353869 5684551 RGD macular degeneration susceptibility ISO RGD:1353869 7365022 DNA:SNP: :rs1061170(human) RGD macular degeneration susceptibility ISO RGD:1353869 7365034 ; 7365036 DNA:SNP:cds:p.Y402H(human) RGD macular degeneration ISO RGD:1353869 5684552 RGD macular degeneration ISO RGD:1353869 7364995 DNA:SNPs, Haplotype:: RGD macular degeneration susceptibility ISO RGD:1353869 7365021 DNA:SNP: :rs1410996(human) RGD macular degeneration disease_progression ISO RGD:1353869 7364999 DNA:SNP:cds:p.Y402H(human) RGD macular degeneration no_association ISO RGD:1353869 7365035 DNA:SNP: :rs1061170 (Y402H)(human) RGD macular degeneration ISO RGD:1353869 7365033 DNA:SNP: :rs800292(human) RGD membranous glomerulonephritis IEP 1599888 mRNA, protein:increased expression:glomerulus RGD Meningococcal Infections treatment ISO RGD:1353869 11041174 RGD Multifocal Choroiditis ISO RGD:1353869 7411728 DNA:SNPs, missense mutation:introns, cds:multiple RGD multiple sclerosis no_association ISO RGD:1353869 5684555 RGD nephrosis IEP 7364901 protein:altered expression:kidney: RGD obstructive jaundice IEP 7364952 protein:decreased expression:plasma: RGD panuveitis susceptibility ISO RGD:1353869 7365014 DNA:SNP:cds:p.Y402H(human) RGD Polypoidal Choroidal Vasculopathy susceptibility ISO RGD:1353869 7411726 DNA:SNP, missense mutation:promoter, cds:g.-257C>T, p.I62V (rs3753394, rs800292) (human) RGD Polypoidal Choroidal Vasculopathy no_association ISO RGD:1353869 7411726 DNA:missense mutation:cds:p.Y402H (rs1061170) (human) RGD posterior uveitis susceptibility ISO RGD:1353869 7365014 DNA:SNP:cds:p.Y402H(human) RGD proteinuria IEP 7364901 protein:altered expression:kidney: RGD psoriasis severity ISO RGD:1353869 8662318 protein:increased expression:plasma RGD Reperfusion Injury IEP 7364988 protein:increased expression:plasma: RGD retinal degeneration IEP 7364947 protein:increased expression:retina RGD retinal drusen ISO RGD:1353869 7365010 DNA:mutations:multiple: RGD retinal drusen susceptibility ISO RGD:1353869 7365005 DNA:SNPs: :p.Y402H, rs1410996(human) RGD sarcoidosis susceptibility ISO RGD:1353869 7365014 DNA:SNP:cds:p.Y402H(human) RGD Sepsis treatment ISO RGD:1353869 7364986 RGD Sepsis IEP 7364952 protein:decreased expression:plasma: RGD Sepsis treatment ISO RGD:1353869 7364952 associated with Jaundice, Obstructive RGD squamous cell carcinoma ISO RGD:1353869 8662319 mRNA:increased expression:skin RGD Stroke IEP 5508764 protein:decreased expression:plasma: RGD Systemic Inflammatory Response Syndrome ISO RGD:1353869 5684556 RGD systemic lupus erythematosus susceptibility ISO RGD:1353869 5684554 RGD Thrombotic Microangiopathies ISO RGD:1353869 11041165 associated with Kidney Failure, Chronic, DNA:missense mutations:exon:p.N516K (c.1548T>A), p.Q950H (c.2850G>T), p.K1186H (c.3557A>C) (human) RGD
Imported Annotations - ClinVar
age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:12697737 more ... age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:15870199 more ... age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:16936733 age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:16936732 more ... age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:15761120 more ... age related macular degeneration 4 ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 4 ClinVar PMID:24906858 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 ClinVar PMID:12697737 more ... atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:15870199 more ... atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:14583443 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:21881555 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:16299065 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:15800115 , PMID:21881555 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:15870199 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:11978762 more ... atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:15661753 , PMID:22171659 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:11170895 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:14978182 , PMID:9848786 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:11170896 more ... atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:12697737 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:9551389 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:18268093 atypical hemolytic-uremic syndrome ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:235400 ClinVar PMID:10577907 more ... basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:15870199 more ... basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:15761120 more ... basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:25741868 basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:14583443 basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:16299065 basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:15870199 basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:11978762 more ... basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar PMID:15661753 , PMID:22171659 basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Basal laminar drusen ClinVar basal laminar drusen ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:126700 ClinVar PMID:18252232 Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:609814 ClinVar PMID:10803850 , PMID:2966809 Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by term: CFH DEFICIENCY ClinVar PMID:12697737 more ... Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Factor H deficiency ClinVar PMID:10206995 more ... Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Factor H deficiency ClinVar PMID:10975323 Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:609814 ClinVar PMID:14978182 , PMID:2950269 Complement Factor H Deficiency ISO RGD:1353869 8554872 ClinVar Annotator: match by OMIM:609814 ClinVar PMID:14978182 macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:15870199 more ... macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:14583443 macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:16299065 macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:15870199 macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:11978762 more ... macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:15661753 , PMID:22171659 macular degeneration ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:14583443 membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:16299065 membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:15870199 membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:15661753 , PMID:22171659 membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:11978762 more ... membranoproliferative glomerulonephritis ISO RGD:1353869 8554872 ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II ClinVar PMID:15870199 more ...
Imported Annotations - CTD
atypical hemolytic-uremic syndrome ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14978182 , PMID:22019782 Chemical and Drug Induced Liver Injury ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25231249 macular degeneration ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16518403 more ... membranoproliferative glomerulonephritis ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14978182 Meningococcal Infections ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20694013 primary immunodeficiency disease ISO RGD:1353869 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14978182 Imported Annotations - MGI
hemolytic-uremic syndrome ISS RGD:733427 13592920 OMIM:235400 more ... MouseDO Imported Annotations - OMIM
age related macular degeneration 4 ISO RGD:1353869 7240710 OMIM atypical hemolytic-uremic syndrome susceptibility ISO RGD:1353869 7240710 OMIM basal laminar drusen ISO RGD:1353869 7240710 OMIM Complement Factor H Deficiency ISO RGD:1353869 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CFH mRNA] CTD PMID:31150632 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CFH mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of CFH mRNA CTD PMID:25729387 1-naphthyl isothiocyanate multiple interactions ISO RGD:1353869 6480464 [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 17alpha-ethynylestradiol affects expression ISO RGD:733427 6480464 Ethinyl Estradiol affects the expression of CFH mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1353869 6480464 [Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CFH mRNA CTD PMID:15834898 , PMID:17557909 17alpha-ethynylestradiol multiple interactions ISO RGD:733427 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of CFH mRNA CTD PMID:17351261 17alpha-ethynylestradiol increases expression ISO RGD:733427 6480464 Ethinyl Estradiol results in increased expression of CFH mRNA CTD PMID:17942748 17beta-estradiol affects expression ISO RGD:733427 6480464 Estradiol affects the expression of CFH mRNA CTD PMID:15598610 17beta-estradiol multiple interactions ISO RGD:1353869 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of CFH mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO RGD:733427 6480464 Estradiol results in increased expression of CFH mRNA CTD PMID:19484750 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733427 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733427 6480464 Tetrachlorodibenzodioxin results in decreased expression of CFH mRNA CTD PMID:23864506 , PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733427 6480464 Tetrachlorodibenzodioxin affects the expression of CFH mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CFH mRNA CTD PMID:18465118 , PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CFH mRNA CTD PMID:22298810 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:733427 6480464 Trinitrobenzenesulfonic Acid results in increased expression of CFH mRNA CTD PMID:17982090 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of CFH mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CFH mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine increases expression ISO RGD:733427 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CFH mRNA CTD PMID:26251327 4,4'-diaminodiphenylmethane increases expression ISO RGD:733427 6480464 4, 4'-diaminodiphenylmethane results in increased expression of CFH mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:733427 6480464 Fenretinide results in increased expression of CFH mRNA CTD PMID:28973697 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of CFH mRNA CTD PMID:23630614 aflatoxin B1 decreases methylation ISO RGD:1353869 6480464 Aflatoxin B1 results in decreased methylation of CFH gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:1353869 6480464 Aflatoxin B1 results in decreased expression of CFH mRNA CTD PMID:27153756 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CFH mRNA CTD PMID:16483693 arsenite(3-) decreases expression ISO RGD:1353869 6480464 arsenite results in decreased expression of CFH mRNA CTD PMID:23974009 astemizole decreases expression EXP 6480464 Astemizole results in decreased expression of CFH mRNA CTD PMID:20221588 benzo[a]pyrene decreases expression ISO RGD:733427 6480464 Benzo(a)pyrene results in decreased expression of CFH mRNA CTD PMID:19770486 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CFH mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:733427 6480464 bisphenol A results in increased expression of CFH mRNA CTD PMID:25594700 , PMID:30245210 butanal decreases expression ISO RGD:1353869 6480464 butyraldehyde results in decreased expression of CFH mRNA CTD PMID:26079696 cadmium atom affects binding ISO RGD:1353869 6480464 CFH protein binds to Cadmium CTD PMID:23896426 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of CFH mRNA CTD PMID:22110744 carbon nanotube increases expression ISO RGD:733427 6480464 Nanotubes, Carbon analog results in increased expression of CFH mRNA, Nanotubes, Carbon results in increased expression of CFH mRNA CTD PMID:25620056 chlorpromazine multiple interactions ISO RGD:1353869 6480464 [Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 cisplatin multiple interactions ISO RGD:1353869 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of CFH mRNA CTD PMID:27392435 clofibrate multiple interactions ISO RGD:733427 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA] CTD PMID:17585979 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of CFH mRNA CTD PMID:12851107 clorgyline increases expression ISO RGD:1353869 6480464 Clorgyline results in increased expression of CFH mRNA CTD PMID:19691856 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of CFH mRNA CTD PMID:24386269 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of CFH mRNA CTD PMID:17898221 copper atom affects binding ISO RGD:1353869 6480464 CFH protein binds to Copper CTD PMID:23896426 copper atom decreases expression EXP 6480464 Copper results in decreased expression of CFH mRNA CTD PMID:30556269 copper(0) affects binding ISO RGD:1353869 6480464 CFH protein binds to Copper CTD PMID:23896426 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of CFH mRNA CTD PMID:30556269 copper(2+) affects binding ISO RGD:1353869 6480464 CFH protein binds to Copper CTD PMID:23896426 copper(2+) decreases expression EXP 6480464 Copper results in decreased expression of CFH mRNA CTD PMID:30556269 cyclosporin A decreases expression ISO RGD:1353869 6480464 Cyclosporine results in decreased expression of CFH mRNA CTD PMID:20106945 more ... cyclosporin A multiple interactions ISO RGD:1353869 6480464 [Cyclosporine co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 cyclosporin A decreases expression ISO RGD:733427 6480464 Cyclosporine results in decreased expression of CFH mRNA CTD PMID:19770486 , PMID:23830897 cylindrospermopsin increases expression ISO RGD:733427 6480464 cylindrospermopsin results in increased expression of CFH mRNA CTD PMID:20936652 dextran sulfate multiple interactions ISO RGD:733427 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CFH mRNA CTD PMID:29950665 dichloroacetic acid decreases expression ISO RGD:733427 6480464 Dichloroacetic Acid results in decreased expression of CFH mRNA CTD PMID:28962523 diclofenac increases expression ISO RGD:733427 6480464 Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 diuron decreases expression EXP 6480464 Diuron results in decreased expression of CFH mRNA CTD PMID:21551480 doxorubicin decreases expression ISO RGD:1353869 6480464 Doxorubicin results in decreased expression of CFH mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:1353869 6480464 Selenium results in decreased expression of CFH mRNA CTD PMID:19244175 endosulfan decreases expression ISO RGD:733427 6480464 Endosulfan results in decreased expression of CFH mRNA CTD PMID:23208437 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CFH mRNA CTD PMID:29391264 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CFH protein CTD PMID:19609968 ethanol decreases expression ISO RGD:1353869 6480464 Ethanol results in decreased expression of CFH mRNA CTD PMID:31059573 ethanol increases expression ISO RGD:733427 6480464 Ethanol results in increased expression of CFH mRNA CTD PMID:30319688 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CFH mRNA CTD PMID:24136188 , PMID:24793618 fumonisin B1 decreases expression ISO RGD:733427 6480464 fumonisin B1 results in decreased expression of CFH mRNA CTD PMID:16221962 furan decreases expression EXP 6480464 furan results in decreased expression of CFH mRNA CTD PMID:25539665 , PMID:26194646 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CFH mRNA CTD PMID:21081137 isoprenaline increases expression ISO RGD:733427 6480464 Isoproterenol results in increased expression of CFH mRNA CTD PMID:20003209 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of CFH mRNA CTD PMID:19638242 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of CFH mRNA CTD PMID:24136188 nickel atom affects binding ISO RGD:1353869 6480464 CFH protein binds to Nickel CTD PMID:23896426 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of CFH mRNA CTD PMID:24136188 olanzapine decreases phosphorylation ISO RGD:1353869 6480464 olanzapine results in decreased phosphorylation of CFH protein CTD PMID:25821032 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of CFH mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CFH mRNA CTD PMID:25729387 paracetamol multiple interactions ISO RGD:733427 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA] CTD PMID:17585979 paracetamol increases expression ISO RGD:1353869 6480464 Acetaminophen results in increased expression of CFH mRNA CTD PMID:26690555 paracetamol decreases expression ISO RGD:1353869 6480464 Acetaminophen results in decreased expression of CFH mRNA CTD PMID:27761495 perfluorooctane-1-sulfonic acid affects expression ISO RGD:733427 6480464 perfluorooctane sulfonic acid affects the expression of CFH mRNA CTD PMID:19429403 perfluorooctanoic acid affects expression ISO RGD:733427 6480464 perfluorooctanoic acid affects the expression of CFH mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression ISO RGD:733427 6480464 perfluorooctanoic acid results in decreased expression of CFH mRNA CTD PMID:18467677 , PMID:20936131 perfluorooctanoic acid multiple interactions ISO RGD:733427 6480464 PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CFH mRNA] CTD PMID:18467677 phenobarbital affects expression ISO RGD:1353869 6480464 Phenobarbital affects the expression of CFH mRNA CTD PMID:19159669 phenobarbital affects expression ISO RGD:733427 6480464 Phenobarbital affects the expression of CFH mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:733427 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of CFH mRNA, PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CFH mRNA] CTD PMID:18467677 , PMID:20813756 pirinixic acid decreases expression ISO RGD:733427 6480464 pirinixic acid results in decreased expression of CFH mRNA CTD PMID:16221962 more ... progesterone increases expression ISO RGD:1353869 6480464 Progesterone results in increased expression of CFH mRNA CTD PMID:20864642 , PMID:21795739 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of CFH mRNA CTD PMID:20726854 propiconazole decreases expression ISO RGD:733427 6480464 propiconazole results in decreased expression of CFH mRNA CTD PMID:21278054 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of CFH mRNA CTD PMID:25905778 selenium atom decreases expression ISO RGD:1353869 6480464 Selenium results in decreased expression of CFH mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:1353869 6480464 Silicon Dioxide analog results in decreased expression of CFH mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO RGD:733427 6480464 Silicon Dioxide results in decreased expression of CFH mRNA CTD PMID:19073995 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of CFH mRNA CTD PMID:22110744 tamoxifen affects expression ISO RGD:733427 6480464 Tamoxifen affects the expression of CFH mRNA CTD PMID:17555576 testosterone enanthate affects expression ISO RGD:1353869 6480464 testosterone enanthate affects the expression of CFH mRNA CTD PMID:17440010 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CFH mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CFH mRNA CTD PMID:31150632 titanium dioxide multiple interactions ISO RGD:733427 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CFH mRNA CTD PMID:29950665 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CFH mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of CFH mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:1353869 6480464 trichostatin A results in increased expression of CFH mRNA CTD PMID:24935251 trimellitic anhydride decreases expression ISO RGD:733427 6480464 trimellitic anhydride results in decreased expression of CFH mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:1353869 6480464 troglitazone results in decreased expression of CFH mRNA CTD PMID:19140230 valproic acid decreases expression ISO RGD:1353869 6480464 Valproic Acid results in decreased expression of CFH mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:733427 6480464 Valproic Acid affects the expression of CFH mRNA CTD PMID:17963808 vancomycin decreases expression ISO RGD:733427 6480464 Vancomycin results in decreased expression of CFH mRNA CTD PMID:18930951 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CFH mRNA CTD PMID:23034163 zinc atom affects binding ISO RGD:1353869 6480464 CFH protein binds to Zinc CTD PMID:23896426 zinc(0) affects binding ISO RGD:1353869 6480464 CFH protein binds to Zinc CTD PMID:23896426
Gene-Chemical Interaction Annotations
