Cfh (complement factor H) - Rat Genome Database

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Gene: Cfh (complement factor H) Rattus norvegicus
Analyze
Symbol: Cfh
Name: complement factor H
RGD ID: 620428
Description: Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenomedullin binding protein-1; AMBP-1; AMBP1; complement component factor H; complement inhibitory factor H; Fh; platelet complement factor H
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)Ensembl
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (ISO)
amphetamine abuse  (IEP,ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (IMP,ISO)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
C3 Glomerulopathy 3  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (ISO)
gastrointestinal stromal tumor  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (ISO)
hemolytic-uremic syndrome  (ISO,ISS)
Hemorrhagic Shock  (IEP,ISO)
Intestinal Ischemia  (IEP)
Kidney Reperfusion Injury  (IEP,ISO)
Liver Reperfusion Injury  (IEP,ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (IEP)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (IEP)
obstructive jaundice  (IEP)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Pneumococcal Infections  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (IEP)
psoriasis  (ISO)
Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
retinal detachment  (ISO)
retinal drusen  (ISO)
sarcoidosis  (ISO)
Sepsis  (IEP,ISO)
squamous cell carcinoma  (ISO)
Stroke  (IEP)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
isoprenaline  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of membrane attack complex  (ISO)
angiogenesis  (ISO)
ATP metabolic process  (ISO)
bone development  (ISO)
cartilage development  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to lipopolysaccharide  (IEP,ISO)
complement activation  (IBA,IEP,ISO)
complement activation, alternative pathway  (ISO)
creatinine homeostasis  (ISO)
determination of adult lifespan  (ISO)
gene expression  (ISO)
glomerulus development  (ISO)
immune complex clearance  (ISO)
immune response  (ISO)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
kidney development  (ISO)
mitochondrial DNA metabolic process  (ISO)
mitochondrial gene expression  (ISO)
mitochondrion organization  (ISO)
monocyte aggregation  (ISO)
neuromuscular process  (ISO)
neutrophil homeostasis  (ISO)
organ or tissue specific immune response  (ISO)
organelle localization  (ISO)
photoreceptor cell differentiation  (ISO)
platelet aggregation  (ISO)
proteolysis  (ISO)
regulation of complement activation  (IDA,ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of complement-dependent cytotoxicity  (ISO)
response to cytokine  (ISO)
response to dietary excess  (ISO)
retina development in camera-type eye  (ISO)
retinal pigment epithelium development  (ISO)
retinal rod cell development  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
visual perception  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:12477932   PMID:12947022   PMID:15574507   PMID:16023208   PMID:16769899   PMID:17028856   PMID:17921253   PMID:18947875   PMID:19299737   PMID:19411110   PMID:19541934   PMID:19850925  
PMID:20675597   PMID:20702729   PMID:20813971   PMID:21148255   PMID:22471560   PMID:22516433   PMID:23487775   PMID:23533145   PMID:23844226   PMID:24006456   PMID:24835392   PMID:24929970  
PMID:25284781   PMID:25991857   PMID:26149919   PMID:26468283   PMID:27564415   PMID:27852797   PMID:28057640   PMID:28228282   PMID:29070671   PMID:29590637   PMID:30705315  


Genomics

Comparative Map Data
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)Ensembl
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,652,043 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1196,651,754 - 196,752,476 (+)EnsemblGRCh38hg38GRCh38
GRCh371196,621,173 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBINCBI36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBI
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
T2T-CHM13v2.01195,998,386 - 196,093,925 (+)NCBI
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBImm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,434,107 - 176,507,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0panPan3
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,970,756 - 3,047,389 (-)NCBI
ROS_Cfam_1.0382,876,209 - 2,953,077 (-)NCBI
ROS_Cfam_1.0 Ensembl382,875,485 - 2,953,035 (-)Ensembl
UMICH_Zoey_3.1382,869,120 - 2,945,692 (-)NCBI
UNSW_CanFamBas_1.0383,262,568 - 3,340,656 (-)NCBI
UU_Cfam_GSD_1.0383,463,162 - 3,540,549 (-)NCBI
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0
Cfh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Cfh  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,595,293 - 51,595,835 (+)MAPPERmRatBN7.2
Rnor_6.01357,062,011 - 57,062,552NCBIRnor6.0
Rnor_5.01362,076,228 - 62,076,769UniSTSRnor5.0
RGSC_v3.41353,337,425 - 53,337,966UniSTSRGSC3.4
Celera1351,853,213 - 51,853,754UniSTS
Cytogenetic Map13q13UniSTS
RH130216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,512,407 - 51,512,612 (+)MAPPERmRatBN7.2
Rnor_6.01356,979,187 - 56,979,391NCBIRnor6.0
Rnor_5.01361,997,476 - 61,997,680UniSTSRnor5.0
RGSC_v3.41353,252,281 - 53,252,485UniSTSRGSC3.4
Celera1351,770,573 - 51,770,777UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:165
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000017749, ENSRNOT00000060111
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 1 15 48 36 7 36 8 8 27 35 24 11 8
Low 2 22 8 4 12 4 3 47 15
Below cutoff 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017749   ⟹   ENSRNOP00000017749
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1356,979,648 - 57,080,491 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000060111   ⟹   ENSRNOP00000056859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,512,376 - 51,613,829 (-)Ensembl
Rnor_6.0 Ensembl1356,979,169 - 57,080,622 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086572   ⟹   ENSRNOP00000072850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)Ensembl
Rnor_6.0 Ensembl1356,978,607 - 57,080,549 (-)Ensembl
RefSeq Acc Id: NM_130409   ⟹   NP_569093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,512,376 - 51,613,829 (-)NCBI
Rnor_6.01356,979,155 - 57,080,540 (-)NCBI
Rnor_5.01361,997,444 - 62,094,826 (-)NCBI
RGSC_v3.41353,252,249 - 53,355,987 (-)RGD
Celera1351,770,541 - 51,871,522 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569093 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83174 (Get FASTA)   NCBI Sequence Viewer  
  AAL77269 (Get FASTA)   NCBI Sequence Viewer  
  CAC67513 (Get FASTA)   NCBI Sequence Viewer  
  EDM09615 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_569093   ⟸   NM_130409
- Peptide Label: precursor
- UniProtKB: G3V9R2 (UniProtKB/TrEMBL),   Q5XJW6 (UniProtKB/TrEMBL),   Q91YB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072850   ⟸   ENSRNOT00000086572
RefSeq Acc Id: ENSRNOP00000056859   ⟸   ENSRNOT00000060111
RefSeq Acc Id: ENSRNOP00000017749   ⟸   ENSRNOT00000017749
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9R2-F1-model_v2 AlphaFold G3V9R2 1-1235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698882
Promoter ID:EPDNEW_R9394
Type:initiation region
Name:Cfh_1
Description:complement factor H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01357,080,570 - 57,080,630EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620428 AgrOrtholog
BioCyc Gene G2FUF-18064 BioCyc
Ensembl Genes ENSRNOG00000030715 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017749 UniProtKB/TrEMBL
  ENSRNOP00000056859 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072850 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017749 UniProtKB/TrEMBL
  ENSRNOT00000060111 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000086572 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096787 IMAGE-MGC_LOAD
InterPro Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:155012 UniProtKB/TrEMBL
MGC_CLONE MGC:91522 IMAGE-MGC_LOAD
NCBI Gene 155012 ENTREZGENE
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cfh PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniProt F1M983_RAT UniProtKB/TrEMBL
  G3V9R2 ENTREZGENE, UniProtKB/TrEMBL
  Q5XJW6 ENTREZGENE, UniProtKB/TrEMBL
  Q91YB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Cfh  complement factor H  Cfh  complement component factor H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cfh  complement component factor H    complement component factor h  Name updated 1299863 APPROVED
2002-08-07 Cfh  complement component factor h      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoplasm and nucleus 632369
gene_domains 11 short consensus repeats (SCRs); each SCR contains four characteristic cysteine residues 628500
gene_expression expressed in neurons of telencephalon, diencephalon, mesencephalon, pons, medulla, and cerebellum 632369
gene_expression expressed in glomerular epithelial cells, liver 628500
gene_function beta globulin 628500
gene_homology shows 24-79% homology to SCRs from human FHR-5 protein 628500
gene_physical_interaction binds to C3b 628500
gene_process may be involved in the decay of C3 convertase 628500
gene_process acts as a regulator of the activation of complement cascade 628500
gene_protein two N-linked glycosylation sites at positions 136 and 388 628500
gene_protein 76 kDa(predicted) 628500
gene_regulation may be induced as a response to glomerular injury 628500
gene_transcript 2729 bp long;568 bp long 3-UTR 628500