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Gene: Rhoj (ras homolog family member J) Rattus norvegicus

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Symbol:

Rhoj

Name:

ras homolog family member J

RGD ID:

1310528

Description:

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of cell migration involved in sprouting angiogenesis; and regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including Rho protein signal transduction; regulation of cell shape; and retina vasculature morphogenesis in camera-type eye. Predicted to be active in plasma membrane. Orthologous to human RHOJ (ras homolog family member J); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC299145; MGC106003; ras homolog gene family, member J; rho-related GTP-binding protein RhoJ; TC10-like Rho GTPase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RHOJ (ras homolog family member J)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rhoj (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rhoj (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RHOJ (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RHOJ (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rhoj (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RHOJ (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RHOJ (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rhoj (ras homolog family member J)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CTSD (cathepsin D)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RHOJ (ras homolog family member J)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rhoj (ras homolog family member J)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rhoj (ras homolog family member J)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rhoj	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	99,771,104 - 99,853,366 (+)	NCBI		GRCr8
mRatBN7.2	6	94,035,307 - 94,117,642 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,035,483 - 94,118,275 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	94,433,053 - 94,514,759 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	94,731,575 - 94,813,279 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	94,160,435 - 94,242,141 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	98,284,361 - 98,367,122 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	98,284,170 - 98,367,756 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	107,702,937 - 107,785,252 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	97,911,744 - 97,995,878 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	97,915,199 - 97,999,311 (+)	NCBI
Celera	6	92,465,594 - 92,546,315 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cardiomyopathy (ISO)

Colonic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt dichloride (ISO)

corticosterone (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dimethylarsinic acid (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethylparaben (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

inulin (ISO)

isoprenaline (ISO)

L-methionine (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

nitrates (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

PhIP (EXP)

resveratrol (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

Soman (EXP)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vanadyl sulfate (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

actin filament organization (IBA)

endocytosis (IBA)

establishment of cell polarity (IBA)

positive regulation of cell migration involved in sprouting angiogenesis (IEA,ISO)

regulation of cell shape (IEA,ISO)

regulation of endothelial cell migration (IEA,ISO)

regulation of sprouting angiogenesis (IEA,ISO)

retina vasculature morphogenesis in camera-type eye (IEA,ISO)

Rho protein signal transduction (IEA,ISO)

signal transduction (IBA)

small GTPase-mediated signal transduction (IEA)

Cellular Component

plasma membrane (IBA,IEA,ISO)

Molecular Function

GTP binding (IBA,IEA,ISO)

GTPase activity (IBA,IEA,ISO)

protein binding (ISO)

protein kinase binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10967094	PMID:12477932	PMID:18388891	PMID:21628409	PMID:22535667	PMID:23533145	PMID:27660391	PMID:28727754	PMID:30158707

Genomics

Comparative Map Data

Rhoj
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	99,771,104 - 99,853,366 (+)	NCBI		GRCr8
mRatBN7.2	6	94,035,307 - 94,117,642 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,035,483 - 94,118,275 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	94,433,053 - 94,514,759 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	94,731,575 - 94,813,279 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	94,160,435 - 94,242,141 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	98,284,361 - 98,367,122 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	98,284,170 - 98,367,756 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	107,702,937 - 107,785,252 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	97,911,744 - 97,995,878 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	97,915,199 - 97,999,311 (+)	NCBI
Celera	6	92,465,594 - 92,546,315 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

RHOJ
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	63,204,443 - 63,293,508 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	63,204,114 - 63,293,508 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	63,671,161 - 63,760,226 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	62,740,898 - 62,828,312 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	62,740,897 - 62,828,312	NCBI
Celera	14	43,721,815 - 43,809,227 (+)	NCBI		Celera
Cytogenetic Map	14	q23.2	NCBI
HuRef	14	43,837,525 - 43,926,644 (+)	NCBI		HuRef
CHM1_1	14	63,610,149 - 63,699,277 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	57,411,795 - 57,500,853 (+)	NCBI		T2T-CHM13v2.0

Rhoj
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	75,355,087 - 75,448,229 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	75,355,096 - 75,448,230 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	75,308,313 - 75,401,455 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	75,308,322 - 75,401,456 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	76,409,300 - 76,502,442 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	76,227,153 - 76,320,295 (+)	NCBI		MGSCv36	mm8
Celera	12	76,399,403 - 76,485,627 (+)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	32.63	NCBI

Rhoj
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	6,476,822 - 6,564,988 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955466	6,476,822 - 6,564,890 (-)	NCBI	ChiLan1.0	ChiLan1.0

RHOJ
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	64,312,926 - 64,401,985 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	63,529,470 - 63,618,501 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	43,783,185 - 43,872,000 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	62,039,436 - 62,126,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	62,039,418 - 62,126,908 (+)	Ensembl	panpan1.1		panPan2

RHOJ
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	37,803,460 - 37,880,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	37,803,717 - 37,882,207 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	37,560,607 - 37,637,620 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	38,030,147 - 38,108,957 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	38,030,239 - 38,108,013 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	37,647,128 - 37,724,061 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	37,726,711 - 37,803,608 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	38,079,926 - 38,156,853 (+)	NCBI		UU_Cfam_GSD_1.0

Rhoj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	67,013,327 - 67,097,318 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	7,094,513 - 7,174,371 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	7,094,522 - 7,174,371 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHOJ
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	194,760,939 - 194,844,356 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	194,761,588 - 194,843,867 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	216,775,655 - 216,796,767 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RHOJ
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	40,352,967 - 40,458,993 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	40,353,075 - 40,459,484 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	28,578,164 - 28,680,770 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rhoj
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	37,736,256 - 37,832,008 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	37,720,834 - 37,831,907 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rhoj
522 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	439
Count of miRNA genes:	208
Interacting mature miRNAs:	243
Transcripts:	ENSRNOT00000031979
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	89762877	106752806	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	82523650	110548006	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	81132889	104393926	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	83190345	106747639	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1300076	Glom8	Glomerulus QTL 8	7	9e-09	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat

Markers in Region

BI284631

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	99,852,555 - 99,852,728 (+)	Marker Load Pipeline
mRatBN7.2	6	94,116,830 - 94,117,004 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	98,366,311 - 98,366,484	NCBI	Rnor6.0
Rnor_5.0	6	107,784,441 - 107,784,614	UniSTS	Rnor5.0
RGSC_v3.4	6	97,995,067 - 97,995,240	UniSTS	RGSC3.4
Celera	6	92,545,504 - 92,545,677	UniSTS
RH 3.4 Map	6	668.8	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031979 ⟹ ENSRNOP00000030536

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	94,035,752 - 94,118,275 (+)	Ensembl
Rnor_6.0 Ensembl	6	98,284,170 - 98,367,756 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099066 ⟹ ENSRNOP00000095177

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	94,035,483 - 94,109,912 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110727 ⟹ ENSRNOP00000081847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	94,035,563 - 94,118,275 (+)	Ensembl

RefSeq Acc Id:

NM_001008320 ⟹ NP_001008321

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	99,771,383 - 99,853,366 (+)	NCBI
mRatBN7.2	6	94,035,652 - 94,117,642 (+)	NCBI
Rnor_6.0	6	98,284,361 - 98,367,122 (+)	NCBI
Rnor_5.0	6	107,702,937 - 107,785,252 (+)	NCBI
RGSC_v3.4	6	97,911,744 - 97,995,878 (+)	RGD
Celera	6	92,465,594 - 92,546,315 (+)	RGD

Sequence:

show sequence

ACGAGAGTTCCTCAACTCCAGCTCTACTCCAACTCCTCTTCTCCGTTGGGATTGGGAGAAAGGA
ACGGACCCTTTTCATCCCTCCTCCCAAGAGTGCGTTGCCTTTCTTCTGCAGCATGGTGAGCGGC
GGGGCTCGCGTGTGTCTGGGCTGTGCCTGGGAGAGCCGGGCCAGCCACAGTCAGGCCGCCTGAG
CTCCAGCCCCGGGCCCGTGCCACCGCTCCATGCACTACAGAAGCCCCAGCAGCTGCTGCGGGAG
CCACCAACATGAGCTGCAGAGAGGGGACTGACAGCAGCTGCGGCTGCGGTGGGCGCGATGAAAA
CAGGATCCTGAAGTGCGTGGTGGTCGGGGACGGCGCGGTGGGGAAGACTTGCCTGCTGATGAGC
TACGCCAACGACGCCTTCCCGGAGGAATACGTGCCCACTGTGTTTGACCACTACGCAGTTACCG
TGACAGTGGGAGGCAAGCAGCACCTGCTTGGACTGTACGACACCGCGGGACAGGAGGACTACAA
CCAGCTGCGGCCCCTCTCTTACCCCAACACCGACGTGTTTCTCATCTGCTTCTCTGTCGTGAAC
CCTGCCTCTTACCACAACGTTCAGGAGGAGTGGGTCCCGGAGCTGAAGGACTGCATGCCTCACG
TGCCTTACGTGCTCATTGGGACCCAGATTGATCTCCGAGATGACCCCAAAACCTTGGCGCGTCT
GCTGTACATGAAGGAGAAGCCCCTCACCTATGAGCACGGCGTGAAACTGGCGAAAGCGATAGGA
GCTCAGTGCTACTTGGAATGCTCTGCCCTGACTCAGAAGGGTCTCAAAGCTGTTTTTGATGAAG
CCATCCTCACCATTTTCCACCCCAAGAAAAAAAAGAAAGGCTGCCACGGCTGCTGTGTAATCAT
CTGAAGTTGCCTGAGACCCGTCTCTCCGCCATGCAAAGAGGGAAGCCAGTCTCTGAGAACCAAC
GCTAGCCGAAAGGAGGGCGTGACCAGAAAGGAATTCCTGCATCCTCAAAGCCTGTCCCCACACC
CTGCCAATTCCCCAGCTCAGTATCCTGTAAGCCACTGCCACAGCCCCAAGCCAGCCAGACATCC
ACACTGCGCATGGAGAAAGCAGAGGCTCGTTCAAACCGCAGGCTGGCGAGGTGTTGGAAGCCGA
GTGAAGATCCGTCCAGTATTTCACATCTTCTCTCTCACGGTTATGAACCAACCGGAAGTCATGA
CGGGCAAACCAAGTACTCTCTGTCCTGAACCAATGGCCTTAGTTCATGTCTTCACCAACCTTGG
GAATACGACAACTTTTTTTTTTCTGAGTCTTTTACTCAAGCCCCTTGCCGTTCATTTATTTCTA
CTGCAGTTTCCTGTTGTCCAATCACTTGAGCCTTACAAATCCACATCAAAATAACCGAAAGACA
AGCTGGATTGTGTTTATGCCAACTGACAGTGGCTCTCTGCCAATGTTCTTAGAGCTGCCATGTA
CCTCTGAATGCCTAATTACAAAAAAAAAATTACAACTTTTATAAACTGACAGACCCATAATGTT
TTTAACCTTTTTAAAAGAAAGCATCCTGTGAATTATTACAGCTCCCCGAGTTTGGCCAAAGATC
AACCTACAAATGCTGCAGGTGATAGGGGGTCTGCTCTTGCAAAGCCTTACTGTCATTCAAAAAC
GGACTGTCGTGGAAGAAACCGTTTTCTACTCCTCCTCTAAACTGGTCAGGACAATAATAGAGCA
AAGCTATCTTCCCACTGCAGGAGAGTGAGCCTGACCCACCCTGTTCATGTAGTATCTTCACTTT
TTCTCCTGTGCCCACTGTGTTCCCAGTCAAAGCTTGCCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039112008 ⟹ XP_038967936

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	99,771,104 - 99,852,370 (+)	NCBI
mRatBN7.2	6	94,035,307 - 94,116,676 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008321	(Get FASTA)	NCBI Sequence Viewer
	XP_038967936	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86525	(Get FASTA)	NCBI Sequence Viewer
	EDM03632	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000030536
	ENSRNOP00000030536.3
	ENSRNOP00000081847.1
	ENSRNOP00000095177
	ENSRNOP00000095177.1

RefSeq Acc Id:

NP_001008321 ⟸ NM_001008320

- UniProtKB:

Q5RJS2 (UniProtKB/TrEMBL), A0A8I5ZTS1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSCREGTDSSCGCGGRDENRILKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTVTV
GGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELKDCMPHVPY
VLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQKGLKAVFDEAIL
TIFHPKKKKKGCHGCCVII

hide sequence

Ensembl Acc Id:

ENSRNOP00000030536 ⟸ ENSRNOT00000031979

RefSeq Acc Id:	XP_038967936 ⟸ XM_039112008
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AJ60 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000081847 ⟸ ENSRNOT00000110727

Ensembl Acc Id:

ENSRNOP00000095177 ⟸ ENSRNOT00000099066

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RJS2-F1-model_v2	AlphaFold	Q5RJS2	1-211	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694671

Promoter ID:

EPDNEW_R5193

Type:

multiple initiation site

Name:

Rhoj_1

Description:

ras homolog family member J

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5194

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	98,284,234 - 98,284,294	EPDNEW

RGD ID:

13694670

Promoter ID:

EPDNEW_R5194

Type:

multiple initiation site

Name:

Rhoj_2

Description:

ras homolog family member J

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5193

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	98,284,461 - 98,284,521	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310528	AgrOrtholog
BioCyc Gene	G2FUF-37083	BioCyc
Ensembl Genes	ENSRNOG00000021919	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031979	ENTREZGENE
	ENSRNOT00000031979.5	UniProtKB/TrEMBL
	ENSRNOT00000099066	ENTREZGENE
	ENSRNOT00000099066.1	UniProtKB/TrEMBL
	ENSRNOT00000110727.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7303905	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	Small_GTP_bd	UniProtKB/TrEMBL
	Small_GTPase_Rho	UniProtKB/TrEMBL
KEGG Report	rno:299145	UniProtKB/TrEMBL
MGC_CLONE	MGC:106003	IMAGE-MGC_LOAD
NCBI Gene	299145	ENTREZGENE
PANTHER	PTHR24072	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Rhoj	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021919	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5ZTS1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AJ60	ENTREZGENE, UniProtKB/TrEMBL
	A6HC77_RAT	UniProtKB/TrEMBL
	Q5RJS2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-15	Rhoj	ras homolog family member J	Rhoj	ras homolog gene family, member J	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Rhoj	ras homolog gene family, member J	Rhoj_predicted	ras homolog gene family, member J (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rhoj_predicted	ras homolog gene family, member J (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD