Mir208a (microRNA 208a) - Rat Genome Database

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Gene: Mir208a (microRNA 208a) Rattus norvegicus
Analyze
Symbol: Mir208a
Name: microRNA 208a
RGD ID: 7489029
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in cardiac muscle cell apoptotic process and cellular response to mechanical stimulus. Located in cytoplasm. Biomarker of myocardial infarction. Orthologous to human MIR208A (microRNA 208a); INTERACTS WITH 2,5-hexanedione; Allylamine; cadmium atom.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: Mir208; rno-mir-208; rno-mir-208a
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,395,552 - 32,395,634 (-)NCBIGRCr8
mRatBN7.21528,425,570 - 28,425,652 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1530,271,287 - 30,271,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,418,489 - 31,418,571 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,661,159 - 29,661,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,613,451 - 33,613,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1528,003,251 - 28,003,333 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,5-hexanedione  (EXP)
Allylamine  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
Diosbulbin B  (ISO)
isoprenaline  (EXP)
paraquat  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (EXP,ISO)
triclosan  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. Cyclic stretching boosts microRNA-499 to regulate Bcl-2 via microRNA-208a in atrial fibroblasts. Chua SK, etal., J Cell Mol Med. 2021 Mar;25(6):3113-3123. doi: 10.1111/jcmm.16373. Epub 2021 Feb 18.
3. Trbp regulates heart function through microRNA-mediated Sox6 repression. Ding J, etal., Nat Genet. 2015 Jul;47(7):776-83. doi: 10.1038/ng.3324. Epub 2015 Jun 1.
4. MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK). Huang Y, etal., Curr Pharm Des. 2016;22(31):4868-4875. doi: 10.2174/1381612822666160210143047.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI Patients Undergoing Primary Percutaneuos Coronary Intervention. Salama AM, etal., J Cardiovasc Transl Res. 2020 Dec;13(6):988-995. doi: 10.1007/s12265-020-10020-9. Epub 2020 May 26.
8. MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Tony H, etal., Mediators Inflamm. 2015;2015:479123. doi: 10.1155/2015/479123. Epub 2015 Nov 25.
9. Mechanical stretch via transforming growth factor-beta1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes. Wang BW, etal., J Formos Med Assoc. 2013 Oct;112(10):635-43. doi: 10.1016/j.jfma.2013.01.002. Epub 2013 Feb 4.
Additional References at PubMed
PMID:12554859   PMID:16381832   PMID:17379774   PMID:19188439   PMID:19726871   PMID:19922871   PMID:20403161   PMID:23623871   PMID:24246300   PMID:24392114   PMID:25092230   PMID:25156787  
PMID:25287062   PMID:26381051   PMID:26627004   PMID:27314868   PMID:27577116   PMID:28202391   PMID:28283792   PMID:28303410   PMID:29681568   PMID:29746886   PMID:30249926   PMID:30923228  
PMID:33343806   PMID:38163563   PMID:39133103  


Genomics

Comparative Map Data
Mir208a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,395,552 - 32,395,634 (-)NCBIGRCr8
mRatBN7.21528,425,570 - 28,425,652 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1530,271,287 - 30,271,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,418,489 - 31,418,571 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,661,159 - 29,661,241 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,613,451 - 33,613,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1528,003,251 - 28,003,333 (-)NCBICelera
Cytogenetic Map15p13NCBI
MIR208A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,388,596 - 23,388,666 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,388,596 - 23,388,666 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,857,805 - 23,857,875 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,927,644 - 22,927,714 (-)NCBINCBI36Build 36hg18NCBI36
Celera143,720,516 - 3,720,586 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,974,223 - 3,974,293 (-)NCBIHuRef
CHM1_11423,856,477 - 23,856,547 (-)NCBICHM1_1
T2T-CHM13v2.01417,589,612 - 17,589,682 (-)NCBIT2T-CHM13v2.0
Mir208a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,186,517 - 55,186,599 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,186,517 - 55,186,599 (-)EnsemblGRCm39 Ensembl
GRCm381454,949,060 - 54,949,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,949,060 - 54,949,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,567,897 - 55,567,979 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1452,755,093 - 52,755,175 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.0NCBI
MIR208A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,636,919 - 3,636,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,636,919 - 3,636,987 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,585,129 - 3,585,197 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,744,651 - 3,744,719 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.183,436,201 - 3,436,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,497,685 - 3,497,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,759,684 - 3,759,752 (-)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:11545
Count of gene targets:6636
Count of transcripts:7105
Interacting mature miRNAs:rno-miR-208a-3p, rno-miR-208a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NR_031922
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,395,552 - 32,395,634 (-)NCBI
mRatBN7.21528,425,570 - 28,425,652 (-)NCBI
Rnor_6.01533,613,451 - 33,613,533 (-)NCBI
Celera1528,003,251 - 28,003,333 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7489029 AgrOrtholog
BioCyc Gene G2FUF-13754 BioCyc
miRBase MI0000949 ENTREZGENE
NCBI Gene Mir208a ENTREZGENE
PhenoGen Mir208a PhenoGen
RNAcentral URS000005FEE9 RNACentral
  URS000075ACCC RNACentral
  URS000075CBD8 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir208a  microRNA 208a  Mir208a  microRNA mir-208a  Name updated 61478 APPROVED
2013-12-10 Mir208a  microRNA mir-208a      Symbol and Name status set to provisional 70820 PROVISIONAL