Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNKSR3 mRNA | CTD | PMID:22079256 | 1,2-dichloroethane | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of CNKSR3 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Cnksr3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CNKSR3 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CNKSR3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of CNKSR3 mRNA and EGF protein promotes the reaction [Estradiol results in increased expression of CNKSR3 mRNA] | CTD | PMID:24758408 and PMID:30165855 | 17beta-estradiol | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Estradiol affects the expression of CNKSR3 mRNA | CTD | PMID:22574217 | 17beta-estradiol | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Estradiol results in increased expression of CNKSR3 mRNA | CTD | PMID:24758408 and PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CNKSR3 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CNKSR3 mRNA | CTD | PMID:33387578 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:20959002 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CNKSR3 mRNA | CTD | PMID:24780913 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CNKSR3 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of CNKSR3 mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases methylation | ISO | CNKSR3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CNKSR3 gene | CTD | PMID:28458013 | aldrin | increases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Aldrin results in increased expression of CNKSR3 mRNA | CTD | PMID:18579281 | all-trans-retinoic acid | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CNKSR3 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of CNKSR3 mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of CNKSR3 mRNA | CTD | PMID:20488242 | aristolochic acid A | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of CNKSR3 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to CNKSR3 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CNKSR3 mRNA | CTD | PMID:20064835 and PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | CNKSR3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CNKSR3 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CNKSR3 promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CNKSR3 promoter | CTD | PMID:23359474 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CNKSR3 mRNA | CTD | PMID:34947998 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CNKSR3 gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CNKSR3 mRNA | CTD | PMID:25181051 | caffeine | decreases phosphorylation | ISO | CNKSR3 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of CNKSR3 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of CNKSR3 mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CNKSR3 gene] | CTD | PMID:28238834 | chlordecone | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of CNKSR3 mRNA | CTD | PMID:29980752 | cisplatin | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of CNKSR3 mRNA | CTD | PMID:27392435 | cobalt dichloride | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of CNKSR3 mRNA | CTD | PMID:19320972 | copper(II) sulfate | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CNKSR3 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of CNKSR3 mRNA | CTD | PMID:26577399 | DDT | decreases methylation | EXP | | 6480464 | DDT results in decreased methylation of CNKSR3 gene | CTD | PMID:31682807 | dexamethasone | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Dexamethasone results in increased expression of CNKSR3 mRNA | CTD | PMID:25047013 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of CNKSR3 mRNA | CTD | PMID:21266533 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CNKSR3 promoter | CTD | PMID:23359474 | dibutyl phthalate | increases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of CNKSR3 mRNA | CTD | PMID:17361019 and PMID:21266533 | dioxygen | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of CNKSR3 mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNKSR3 mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of CNKSR3 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CNKSR3 mRNA | CTD | PMID:29391264 | ethanol | affects expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Ethanol affects the expression of CNKSR3 mRNA | CTD | PMID:30319688 | folic acid | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CNKSR3 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Cnksr3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CNKSR3 mRNA | CTD | PMID:22206623 | folpet | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | folpet results in decreased expression of CNKSR3 mRNA | CTD | PMID:31558096 | formaldehyde | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of CNKSR3 mRNA | CTD | PMID:20655997 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CNKSR3 mRNA | CTD | PMID:33387578 | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of CNKSR3 gene | CTD | PMID:31011160 | hydrogen cyanide | increases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Hydrogen Cyanide results in increased expression of CNKSR3 mRNA | CTD | PMID:33914522 | hydrogen peroxide | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of CNKSR3 mRNA | CTD | PMID:20044591 | isoprenaline | increases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of CNKSR3 mRNA | CTD | PMID:20003209 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of CNKSR3 mRNA | CTD | PMID:20080153 | leflunomide | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | leflunomide results in increased expression of CNKSR3 mRNA | CTD | PMID:28988120 | lipopolysaccharide | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of CNKSR3 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CNKSR3 mRNA] | CTD | PMID:35811015 | melphalan | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of CNKSR3 mRNA | CTD | PMID:22363485 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CNKSR3 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Cnksr3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of CNKSR3 mRNA | CTD | PMID:27106289 | paracetamol | affects expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of CNKSR3 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CNKSR3 mRNA | CTD | PMID:33387578 | pentanal | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | pentanal results in decreased expression of CNKSR3 mRNA | CTD | PMID:26079696 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of CNKSR3 mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of CNKSR3 mRNA | CTD | PMID:19159669 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of CNKSR3 mRNA | CTD | PMID:19162173 | potassium chromate | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNKSR3 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of CNKSR3 mRNA | CTD | PMID:22079256 | potassium cyanide | increases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | Potassium Cyanide results in increased expression of CNKSR3 mRNA | CTD | PMID:33914522 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CNKSR3 mRNA] | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNKSR3 mRNA | CTD | PMID:27188386 | sodium arsenite | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of CNKSR3 mRNA | CTD | PMID:37682722 | sodium dichromate | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of CNKSR3 mRNA | CTD | PMID:31558096 | temozolomide | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of CNKSR3 mRNA | CTD | PMID:31758290 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CNKSR3 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Cnksr3 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CNKSR3 mRNA | CTD | PMID:29264374 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CNKSR3 mRNA | CTD | PMID:25729387 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CNKSR3 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of CNKSR3 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNKSR3 mRNA | CTD | PMID:27188386 | triclosan | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Triclosan results in increased expression of CNKSR3 mRNA | CTD | PMID:30510588 | valproic acid | affects expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CNKSR3 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | CNKSR3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CNKSR3 mRNA | CTD | PMID:24935251 | zinc atom | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of CNKSR3 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | CNKSR3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of CNKSR3 mRNA | CTD | PMID:18593933 | |