![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SIX4 mRNA | CTD | PMID:22079256 | 1,1-dichloroethene | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of SIX4 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of SIX4 mRNA | CTD | PMID:27840820 | 2,2',4,4',5,5'-hexachlorobiphenyl | affects expression | ISO | SIX4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:20638727 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Six4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIX4 mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SIX4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIX4 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SIX4 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SIX4 mRNA | CTD | PMID:30047161 and PMID:33150595 | 6-propyl-2-thiouracil | increases methylation | EXP | | 6480464 | Propylthiouracil results in increased methylation of SIX4 promoter | CTD | PMID:33150595 | acrylamide | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of SIX4 mRNA | CTD | PMID:32763439 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of SIX4 mRNA | CTD | PMID:30047161 | antirheumatic drug | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SIX4 mRNA | CTD | PMID:24449571 | arsenite(3-) | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SIX4 mRNA] | CTD | PMID:32406909 | bis(2-chloroethyl) sulfide | increases expression | ISO | Six4 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of SIX4 mRNA | CTD | PMID:15674843 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SIX4 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SIX4 gene | CTD | PMID:28505145 | bisphenol A | affects methylation | ISO | Six4 (Mus musculus) | 6480464 | bisphenol A affects the methylation of SIX4 promoter | CTD | PMID:27334623 | caffeine | increases phosphorylation | ISO | SIX4 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of SIX4 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | SIX4 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SIX4 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SIX4 gene] | CTD | PMID:28238834 | chloroprene | increases expression | ISO | Six4 (Mus musculus) | 6480464 | Chloroprene results in increased expression of SIX4 mRNA | CTD | PMID:23125180 | choline | multiple interactions | ISO | Six4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIX4 gene | CTD | PMID:20938992 | chromium(6+) | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | chromium hexavalent ion results in increased expression of SIX4 mRNA | CTD | PMID:30690063 | cisplatin | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of SIX4 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SIX4 mRNA | CTD | PMID:17585979 | coumarin | affects phosphorylation | ISO | SIX4 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SIX4 protein | CTD | PMID:35688186 | diethyl maleate | increases expression | ISO | Six4 (Mus musculus) | 6480464 | diethyl maleate results in increased expression of SIX4 mRNA | CTD | PMID:25270620 | diuron | decreases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Diuron results in decreased expression of SIX4 mRNA | CTD | PMID:35967413 | doxorubicin | decreases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SIX4 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SIX4 protein | CTD | PMID:23301498 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of SIX4 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Six4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIX4 gene | CTD | PMID:20938992 | genistein | increases expression | ISO | Six4 (Mus musculus) | 6480464 | Genistein results in increased expression of SIX4 mRNA | CTD | PMID:32186404 | glycidol | increases methylation | EXP | | 6480464 | glycidol results in increased methylation of SIX4 promoter | CTD | PMID:33150595 | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of SIX4 mRNA | CTD | PMID:33150645 | isoprenaline | increases expression | ISO | Six4 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of SIX4 mRNA | CTD | PMID:20003209 | L-methionine | multiple interactions | ISO | Six4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIX4 gene | CTD | PMID:20938992 | leflunomide | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | leflunomide results in increased expression of SIX4 mRNA | CTD | PMID:28988120 | lipopolysaccharide | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of SIX4 mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | methamphetamine | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of SIX4 mRNA | CTD | PMID:19564919 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of SIX4 mRNA | CTD | PMID:19564919 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of SIX4 mRNA | CTD | PMID:30047161 | methylisothiazolinone | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of SIX4 mRNA | CTD | PMID:31629900 | phenobarbital | increases expression | ISO | Six4 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SIX4 mRNA | CTD | PMID:25270620 | potassium chromate | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SIX4 mRNA | CTD | PMID:22079256 | potassium chromate | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of SIX4 mRNA | CTD | PMID:22079256 and PMID:22714537 | resveratrol | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SIX4 mRNA | CTD | PMID:23557933 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SIX4 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SCH 23390 | decreases expression | EXP | | 6480464 | SCH 23390 results in decreased expression of SIX4 mRNA | CTD | PMID:19564919 | SCH 23390 | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of SIX4 mRNA | CTD | PMID:19564919 | sodium arsenate | increases expression | ISO | Six4 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SIX4 mRNA | CTD | PMID:21795629 | sodium arsenite | affects methylation | ISO | SIX4 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of SIX4 gene | CTD | PMID:28589171 | sodium arsenite | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SIX4 mRNA | CTD | PMID:36209798 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of SIX4 mRNA | CTD | PMID:30047161 | titanium dioxide | decreases expression | ISO | Six4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SIX4 mRNA | CTD | PMID:29264374 | tunicamycin | decreases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of SIX4 mRNA | CTD | PMID:29453283 | urethane | increases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Urethane results in increased expression of SIX4 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | SIX4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SIX4 mRNA | CTD | PMID:23179753 and PMID:28001369 | valproic acid | affects expression | ISO | SIX4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SIX4 mRNA | CTD | PMID:25979313 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of SIX4 promoter | CTD | PMID:33150595 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of SIX4 mRNA | CTD | PMID:33150595 | |