Kcnt2 (potassium sodium-activated channel subfamily T member 2) - Rat Genome Database

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Gene: Kcnt2 (potassium sodium-activated channel subfamily T member 2) Rattus norvegicus
Analyze
Symbol: Kcnt2
Name: potassium sodium-activated channel subfamily T member 2
RGD ID: 735074
Description: Enables chloride-activated potassium channel activity. Involved in potassium ion export across plasma membrane. Acts upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: potassium channel subfamily T member 2; potassium channel, sodium-activated subfamily T, member 2; potassium channel, subfamily T, member 2; sequence like an intermediate conductance potassium channel subunit; Slick; sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,214,831 - 54,609,889 (+)NCBIGRCr8
mRatBN7.21351,664,129 - 52,059,209 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,664,686 - 52,056,987 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1354,250,284 - 54,650,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,538,210 - 55,938,219 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,807,916 - 53,208,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01357,130,855 - 57,520,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1357,131,395 - 57,521,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01362,143,990 - 62,534,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,407,504 - 53,803,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11353,421,583 - 53,817,092 (+)NCBI
Celera1351,920,143 - 52,310,493 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IC,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. Bhattacharjee A, etal., J Neurosci 2003 Dec 17;23(37):11681-91.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy. Gururaj S, etal., Cell Rep. 2017 Oct 24;21(4):926-933. doi: 10.1016/j.celrep.2017.09.088.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15375169   PMID:15717307   PMID:18664322   PMID:19403831   PMID:25347289   PMID:26100633   PMID:26823461  


Genomics

Comparative Map Data
Kcnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,214,831 - 54,609,889 (+)NCBIGRCr8
mRatBN7.21351,664,129 - 52,059,209 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,664,686 - 52,056,987 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1354,250,284 - 54,650,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,538,210 - 55,938,219 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,807,916 - 53,208,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01357,130,855 - 57,520,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1357,131,395 - 57,521,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01362,143,990 - 62,534,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,407,504 - 53,803,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11353,421,583 - 53,817,092 (+)NCBI
Celera1351,920,143 - 52,310,493 (+)NCBICelera
Cytogenetic Map13q21NCBI
KCNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,225,779 - 196,608,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,225,779 - 196,609,225 (-)EnsemblGRCh38hg38GRCh38
GRCh371196,194,909 - 196,577,570 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,461,536 - 194,844,122 (-)NCBINCBI36Build 36hg18NCBI36
Celera1169,303,964 - 169,686,483 (-)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1167,436,578 - 167,819,452 (-)NCBIHuRef
CHM1_11197,616,644 - 197,999,107 (-)NCBICHM1_1
T2T-CHM13v2.01195,571,842 - 195,954,779 (-)NCBIT2T-CHM13v2.0
Kcnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,173,373 - 140,541,783 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,173,896 - 140,539,805 (+)EnsemblGRCm39 Ensembl
GRCm381140,245,657 - 140,614,045 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,246,158 - 140,612,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371142,142,834 - 142,506,838 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361142,062,668 - 142,426,672 (+)NCBIMGSCv36mm8
Celera1142,875,113 - 143,237,483 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
Kcnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,076,426 - 33,441,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,080,570 - 33,441,342 (-)NCBIChiLan1.0ChiLan1.0
KCNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2153,195,409 - 53,586,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,800,951 - 53,192,049 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01171,722,130 - 172,112,927 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,001,997 - 176,391,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,003,920 - 176,390,592 (-)Ensemblpanpan1.1panPan2
KCNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1383,006,639 - 3,382,234 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl383,006,140 - 3,380,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha383,097,770 - 3,473,355 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0383,003,542 - 3,376,325 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl383,003,375 - 3,377,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,999,648 - 3,374,824 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,391,702 - 3,766,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,591,639 - 3,964,394 (+)NCBIUU_Cfam_GSD_1.0
Kcnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,990,611 - 78,357,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366383,789,701 - 4,051,971 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366383,789,339 - 4,154,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21023,896,301 - 24,106,816 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,790,439 - 33,193,936 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2532,922,277 - 33,192,820 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605533,705,790 - 34,115,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247983,578,706 - 3,867,854 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247983,579,528 - 3,868,717 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnt2
3470 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000017884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
UniSTS:225072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,851,064 - 51,851,245 (+)MAPPERmRatBN7.2
Rnor_6.01357,316,406 - 57,316,586NCBIRnor6.0
Rnor_5.01362,329,932 - 62,330,112UniSTSRnor5.0
RGSC_v3.41353,594,840 - 53,595,020UniSTSRGSC3.4
Celera1352,105,283 - 52,105,463UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 77 76 45 23 45 6 201 95 93 44 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017884   ⟹   ENSRNOP00000017884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,664,686 - 52,056,987 (+)Ensembl
Rnor_6.0 Ensembl1357,131,395 - 57,519,674 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083693   ⟹   ENSRNOP00000071443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,664,686 - 52,056,987 (+)Ensembl
Rnor_6.0 Ensembl1357,243,877 - 57,521,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113684   ⟹   ENSRNOP00000093596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,664,686 - 52,056,987 (+)Ensembl
RefSeq Acc Id: NM_198762   ⟹   NP_942057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,215,307 - 54,607,924 (+)NCBI
mRatBN7.21351,664,612 - 52,057,244 (+)NCBI
Rnor_6.01357,131,395 - 57,519,674 (+)NCBI
Rnor_5.01362,143,990 - 62,534,723 (+)NCBI
RGSC_v3.41353,407,504 - 53,803,012 (+)RGD
Celera1351,920,143 - 52,310,493 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249943   ⟹   XP_006250005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,838 - 54,609,889 (+)NCBI
mRatBN7.21351,664,132 - 52,059,209 (+)NCBI
Rnor_6.01357,130,856 - 57,520,263 (+)NCBI
Rnor_5.01362,143,990 - 62,534,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598802   ⟹   XP_017454291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,833 - 54,609,889 (+)NCBI
mRatBN7.21351,664,130 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598803   ⟹   XP_017454292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,833 - 54,609,889 (+)NCBI
mRatBN7.21351,664,130 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598804   ⟹   XP_017454293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,835 - 54,609,889 (+)NCBI
mRatBN7.21351,664,131 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090723   ⟹   XP_038946651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,837 - 54,609,889 (+)NCBI
mRatBN7.21351,664,131 - 52,059,209 (+)NCBI
RefSeq Acc Id: XM_039090726   ⟹   XP_038946654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,832 - 54,514,465 (+)NCBI
mRatBN7.21351,664,130 - 51,963,784 (+)NCBI
RefSeq Acc Id: XM_039090727   ⟹   XP_038946655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,398,142 - 54,609,889 (+)NCBI
mRatBN7.21351,847,463 - 52,059,209 (+)NCBI
RefSeq Acc Id: XM_039090728   ⟹   XP_038946656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,833 - 54,514,464 (+)NCBI
mRatBN7.21351,664,130 - 51,963,779 (+)NCBI
RefSeq Acc Id: XM_063272313   ⟹   XP_063128383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,834 - 54,609,889 (+)NCBI
RefSeq Acc Id: XR_005492244
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,831 - 54,585,985 (+)NCBI
mRatBN7.21351,664,130 - 52,035,300 (+)NCBI
RefSeq Acc Id: XR_010056918
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,214,831 - 54,559,054 (+)NCBI
RefSeq Acc Id: NP_942057   ⟸   NM_198762
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250005   ⟸   XM_006249943
- Peptide Label: isoform X5
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot),   A0A8L2UJ52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454291   ⟸   XM_017598802
- Peptide Label: isoform X1
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454292   ⟸   XM_017598803
- Peptide Label: isoform X3
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454293   ⟸   XM_017598804
- Peptide Label: isoform X4
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071443   ⟸   ENSRNOT00000083693
Ensembl Acc Id: ENSRNOP00000017884   ⟸   ENSRNOT00000017884
RefSeq Acc Id: XP_038946654   ⟸   XM_039090726
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946656   ⟸   XM_039090728
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946651   ⟸   XM_039090723
- Peptide Label: isoform X2
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038946655   ⟸   XM_039090727
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000093596   ⟸   ENSRNOT00000113684
RefSeq Acc Id: XP_063128383   ⟸   XM_063272313
- Peptide Label: isoform X9
- UniProtKB: Q6UVM4 (UniProtKB/Swiss-Prot),   A0A8I6AJ80 (UniProtKB/TrEMBL)
Protein Domains
Calcium-activated potassium channel BK alpha   Calcium-activated potassium channel slowpoke-like   Potassium channel   RCK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UVM4-F1-model_v2 AlphaFold Q6UVM4 1-1142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735074 AgrOrtholog
BioCyc Gene G2FUF-18062 BioCyc
Ensembl Genes ENSRNOG00000013312 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017884.7 UniProtKB/TrEMBL
  ENSRNOT00000083693.2 UniProtKB/TrEMBL
  ENSRNOT00000113684.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Slo-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slo-like_RCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304827 UniProtKB/Swiss-Prot
NCBI Gene 304827 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM CHANNEL SUBFAMILY T MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slo-like_RCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnt2 PhenoGen
PROSITE RCK_N UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013312 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0H1_RAT UniProtKB/TrEMBL
  A0A8I6AJ80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UJ52 ENTREZGENE, UniProtKB/TrEMBL
  A6ICN3_RAT UniProtKB/TrEMBL
  KCNT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnt2  potassium sodium-activated channel subfamily T member 2  Kcnt2  potassium channel, sodium-activated subfamily T, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnt2  potassium channel, sodium-activated subfamily T, member 2  Kcnt2  potassium channel, subfamily T, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kcnt2  potassium channel, subfamily T, member 2  Slick  sodium- and chloride-activated ATP-sensitive potassium channel  Symbol and Name updated 1299863 APPROVED
2005-07-08 Slick  sodium- and chloride-activated ATP-sensitive potassium channel      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains C-terminal ATP binding site is required for ATP to reduce the channel's open probability 1299633
gene_expression expressed in the central nervous system and the heart 1299633