Gene: KCNT1 (potassium sodium-activated channel subfamily T member 1) Homo sapiens
Symbol: KCNT1
Name: potassium sodium-activated channel subfamily T member 1
Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA100C15.2; EIEE14; ENFL5; FLJ41282; KCa4.1; OTTHUMP00000022558; OTTHUMP00000215618; OTTHUMP00000215619; OTTHUMP00000215620; OTTHUMP00000215622; OTTHUMP00000215624; potassium channel subfamily T member 1; potassium channel subunit (slack); potassium channel, sodium activated subfamily T, member 1; potassium channel, subfamily T, member 1; Sequence like a calcium-activated K+ channel; SLACK; Slo2.2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389135,702,185 - 135,793,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379138,594,031 - 138,684,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,733,859 - 137,824,813 (+)NCBINCBI36hg18NCBI36
Build 349135,819,982 - 135,904,199NCBI
Celera9109,111,863 - 109,202,929 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,055,583 - 108,146,760 (+)NCBIHuRef
CHM1_19138,742,378 - 138,833,497 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734382
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-02-05
Status: ACTIVE