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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnt2
Name: potassium sodium-activated channel subfamily T member 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnt2affects expressionISOKCNT2 (Homo sapiens)6480464CTDValproic Acid affects the expression of KCNT2 mRNAPMID:25979313
Kcnt2decreases expressionISOKCNT2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of KCNT2 mRNAPMID:23179753 PMID:24383497 PMID:25192806 PMID:27188386 PMID:28001369
Kcnt2decreases methylationISOKCNT2 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of KCNT2 genePMID:29154799
Kcnt2increases expressionISOKCNT2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of KCNT2 mRNAPMID:24935251 PMID:26705709
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