Tnik (TRAF2 and NCK interacting kinase) - Rat Genome Database

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Gene: Tnik (TRAF2 and NCK interacting kinase) Rattus norvegicus
Analyze
Symbol: Tnik
Name: TRAF2 and NCK interacting kinase
RGD ID: 1561817
Description: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294917; RGD1561817; similar to Traf2 and NCK interacting kinase, splice variant 4; TRAF2 and NCK-interacting protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82113,112,937 - 113,511,341 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2113,112,938 - 113,511,339 (+)EnsemblGRCr8
mRatBN7.22111,184,352 - 111,587,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2117,837,147 - 118,231,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,949,687 - 116,343,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02110,663,456 - 111,057,539 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,984,599 - 114,391,805 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,984,646 - 114,384,894 (+)Ensemblrn6Rnor6.0
Rnor_5.02133,688,695 - 134,091,198 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42115,599,466 - 116,003,005 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2106,374,076 - 106,767,167 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crotonaldehyde  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
haloperidol  (ISO)
hydroquinone  (ISO)
isoprenaline  (ISO)
lead diacetate  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration. Femia AP, etal., PLoS One. 2012;7(1):e29918. doi: 10.1371/journal.pone.0029918. Epub 2012 Jan 5.
2. Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study. Fennell DA, etal., PLoS One. 2014 Sep 24;9(9):e107455. doi: 10.1371/journal.pone.0107455. eCollection 2014.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. Hussain NK, etal., J Neurosci. 2010 Nov 3;30(44):14786-94. doi: 10.1523/JNEUROSCI.4124-10.2010.
5. Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis. Jin J, etal., Pathol Res Pract. 2014 Oct;210(10):621-7. doi: 10.1016/j.prp.2013.10.007. Epub 2014 Feb 24.
6. TNIK inhibition abrogates colorectal cancer stemness. Masuda M, etal., Nat Commun. 2016 Aug 26;7:12586. doi: 10.1038/ncomms12586.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer. Takahashi H, etal., BMC Cancer. 2015 Oct 24;15:794. doi: 10.1186/s12885-015-1783-y.
12. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Wang Q, etal., Mol Psychiatry. 2011 Oct;16(10):1006-23. doi: 10.1038/mp.2010.87. Epub 2010 Sep 14.
Additional References at PubMed
PMID:10521462   PMID:15342639   PMID:19061864   PMID:19816403   PMID:20159449   PMID:20458337   PMID:22206666   PMID:22797597   PMID:23035106   PMID:26674878  


Genomics

Comparative Map Data
Tnik
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82113,112,937 - 113,511,341 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2113,112,938 - 113,511,339 (+)EnsemblGRCr8
mRatBN7.22111,184,352 - 111,587,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2117,837,147 - 118,231,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,949,687 - 116,343,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02110,663,456 - 111,057,539 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,984,599 - 114,391,805 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,984,646 - 114,384,894 (+)Ensemblrn6Rnor6.0
Rnor_5.02133,688,695 - 134,091,198 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42115,599,466 - 116,003,005 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2106,374,076 - 106,767,167 (+)NCBICelera
Cytogenetic Map2q24NCBI
TNIK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383171,058,414 - 171,460,408 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3171,058,414 - 171,460,408 (-)Ensemblhg38GRCh38
GRCh373170,776,203 - 171,178,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363172,264,364 - 172,660,546 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3169,180,163 - 169,578,027 (-)NCBICelera
Cytogenetic Map3q26.2-q26.31NCBI
HuRef3168,150,160 - 168,548,398 (-)NCBIHuRef
CHM1_13170,743,498 - 171,141,357 (-)NCBICHM1_1
T2T-CHM13v2.03173,842,724 - 174,244,711 (-)NCBIT2T-CHM13v2.0
Tnik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39328,317,362 - 28,724,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl328,317,363 - 28,730,007 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38328,261,901 - 28,670,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl328,263,214 - 28,675,858 (+)Ensemblmm10GRCm38
MGSCv37328,162,136 - 28,569,507 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36328,454,287 - 28,866,927 (+)NCBIMGSCv36mm8
Celera328,220,689 - 28,624,613 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map311.92NCBI
Tnik
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554201,166,340 - 1,542,326 (-)Ensembl
ChiLan1.0NW_0049554201,166,340 - 1,542,712 (-)NCBIChiLan1.0ChiLan1.0
TNIK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,942,615 - 169,341,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,947,339 - 169,345,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03168,067,839 - 168,466,290 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13176,250,090 - 176,651,195 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3176,255,547 - 176,650,795 (-)EnsemblpanPan2panpan1.1
TNIK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13435,426,716 - 35,727,308 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3435,427,217 - 35,807,059 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3444,437,640 - 44,820,028 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03435,509,666 - 35,891,390 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3435,509,416 - 35,891,334 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13435,448,700 - 35,832,182 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03435,418,689 - 35,795,208 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,680,818 - 36,057,283 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnik
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602102,075,693 - 102,459,787 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365931,167,395 - 1,540,399 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365931,166,995 - 1,546,253 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNIK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,643,895 - 110,052,236 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113109,642,848 - 110,052,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213118,585,748 - 118,697,232 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNIK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11518,011,137 - 18,403,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1518,011,170 - 18,399,981 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606326,771,815 - 27,173,807 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnik
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473049,090,222 - 49,497,646 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473049,087,876 - 49,497,981 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnik
2395 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000016799
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat

Markers in Region
D2Rat77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,263,994 - 111,264,166 (+)MAPPERmRatBN7.2
Rnor_6.02114,063,655 - 114,063,826NCBIRnor6.0
Rnor_5.02133,766,652 - 133,766,823UniSTSRnor5.0
RGSC_v3.42115,680,559 - 115,680,731RGDRGSC3.4
RGSC_v3.42115,680,560 - 115,680,731UniSTSRGSC3.4
Celera2106,453,358 - 106,453,529UniSTS
RGSC_v3.12115,625,522 - 115,625,693RGD
RH 3.4 Map2700.9UniSTS
RH 3.4 Map2700.9RGD
FHH x ACI Map252.2399UniSTS
FHH x ACI Map252.2399RGD
Cytogenetic Map2q24UniSTS
D2Rat280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,362,447 - 111,362,592 (+)MAPPERmRatBN7.2
Rnor_6.02114,164,800 - 114,164,944NCBIRnor6.0
Rnor_5.02133,866,023 - 133,866,167UniSTSRnor5.0
Celera2106,551,521 - 106,551,665UniSTS
SHRSP x BN Map239.8998RGD
SHRSP x BN Map239.8998UniSTS
Cytogenetic Map2q24UniSTS
D2Got187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,190,665 - 111,190,781 (+)MAPPERmRatBN7.2
Rnor_6.02113,990,925 - 113,991,039NCBIRnor6.0
Rnor_5.02133,695,259 - 133,695,373UniSTSRnor5.0
RGSC_v3.42115,605,744 - 115,605,860RGDRGSC3.4
RGSC_v3.42115,605,745 - 115,605,860UniSTSRGSC3.4
Celera2106,380,355 - 106,380,470UniSTS
RGSC_v3.12115,550,707 - 115,550,822RGD
RH 3.4 Map2700.8RGD
RH 3.4 Map2700.8UniSTS
Cytogenetic Map2q24UniSTS
D2Got398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,545,367 - 111,545,506 (+)MAPPERmRatBN7.2
Rnor_6.02114,349,857 - 114,349,997NCBIRnor6.0
Rnor_5.02134,049,250 - 134,049,390UniSTSRnor5.0
RGSC_v3.42115,970,026 - 115,970,166UniSTSRGSC3.4
Celera2106,734,165 - 106,734,303UniSTS
Cytogenetic Map2q24UniSTS
D2Ulb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,388,724 - 111,389,025 (+)MAPPERmRatBN7.2
Rnor_6.02114,193,152 - 114,193,455NCBIRnor6.0
Rnor_5.02133,892,419 - 133,892,722UniSTSRnor5.0
Celera2106,577,811 - 106,578,098UniSTS
Cytogenetic Map2q24UniSTS
AI451411  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,580,792 - 111,580,914 (+)MAPPERmRatBN7.2
Rnor_6.02114,385,280 - 114,385,401NCBIRnor6.0
Rnor_5.02134,084,673 - 134,084,794UniSTSRnor5.0
RGSC_v3.42116,005,449 - 116,005,570UniSTSRGSC3.4
Celera2106,769,611 - 106,769,732UniSTS
Cytogenetic Map2q24UniSTS
RH142274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,581,778 - 111,581,932 (+)MAPPERmRatBN7.2
Rnor_6.02114,386,266 - 114,386,419NCBIRnor6.0
Rnor_5.02134,085,659 - 134,085,812UniSTSRnor5.0
RGSC_v3.42116,006,435 - 116,006,588UniSTSRGSC3.4
Celera2106,770,597 - 106,770,750UniSTS
RH 3.4 Map2706.6UniSTS
Cytogenetic Map2q24UniSTS
BF386414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,541,311 - 111,541,462 (+)MAPPERmRatBN7.2
Rnor_6.02114,346,020 - 114,346,170NCBIRnor6.0
Rnor_5.02134,045,413 - 134,045,563UniSTSRnor5.0
RGSC_v3.42115,965,971 - 115,966,121UniSTSRGSC3.4
Celera2106,730,200 - 106,730,350UniSTS
RH 3.4 Map2704.7UniSTS
Cytogenetic Map2q24UniSTS
BF405470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,540,873 - 111,541,071 (+)MAPPERmRatBN7.2
Rnor_6.02114,345,582 - 114,345,779NCBIRnor6.0
Rnor_5.02134,044,975 - 134,045,172UniSTSRnor5.0
RGSC_v3.42115,965,533 - 115,965,730UniSTSRGSC3.4
Celera2106,729,762 - 106,729,959UniSTS
RH 3.4 Map2705.4UniSTS
Cytogenetic Map2q24UniSTS
AW532604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,577,628 - 111,577,839 (+)MAPPERmRatBN7.2
Rnor_6.02114,382,117 - 114,382,327NCBIRnor6.0
Rnor_5.02134,081,510 - 134,081,720UniSTSRnor5.0
RGSC_v3.42116,002,286 - 116,002,496UniSTSRGSC3.4
Celera2106,766,448 - 106,766,658UniSTS
RH 3.4 Map2705.0UniSTS
Cytogenetic Map2q24UniSTS
BQ207408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22111,485,270 - 111,485,422 (+)MAPPERmRatBN7.2
Rnor_6.02114,290,062 - 114,290,213NCBIRnor6.0
Rnor_5.02133,989,442 - 133,989,593UniSTSRnor5.0
RGSC_v3.42115,909,791 - 115,909,942UniSTSRGSC3.4
Celera2106,674,343 - 106,674,494UniSTS
RH 3.4 Map2705.4UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 12 76 180 91 90 59 131 59 6 427 242 13 164 97 111 31 28 28

Sequence


Ensembl Acc Id: ENSRNOT00000016799   ⟹   ENSRNOP00000016799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)Ensembl
Rnor_6.0 Ensembl2113,984,646 - 114,382,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086399   ⟹   ENSRNOP00000072950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2113,113,036 - 113,509,928 (+)Ensembl
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)Ensembl
Rnor_6.0 Ensembl2113,984,824 - 114,384,894 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096096   ⟹   ENSRNOP00000082629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2113,112,938 - 113,511,339 (+)Ensembl
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098071   ⟹   ENSRNOP00000088180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2111,185,185 - 111,580,750 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106609   ⟹   ENSRNOP00000080133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2113,112,938 - 113,511,339 (+)Ensembl
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115354   ⟹   ENSRNOP00000095929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2113,113,041 - 113,511,339 (+)Ensembl
mRatBN7.2 Ensembl2111,184,387 - 111,580,750 (+)Ensembl
RefSeq Acc Id: NM_001106422   ⟹   NP_001099892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,112,937 - 113,506,874 (+)NCBI
mRatBN7.22111,184,387 - 111,578,349 (+)NCBI
Rnor_6.02113,984,646 - 114,382,836 (+)NCBI
Rnor_5.02133,688,695 - 134,091,198 (+)NCBI
RGSC_v3.42115,599,466 - 116,003,005 (+)RGD
Celera2106,374,076 - 106,767,167 (+)RGD
Sequence:
RefSeq Acc Id: XM_008760897   ⟹   XP_008759119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
mRatBN7.22111,184,355 - 111,587,993 (+)NCBI
Rnor_6.02113,984,600 - 114,391,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590730   ⟹   XP_017446219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
mRatBN7.22111,184,355 - 111,587,993 (+)NCBI
Rnor_6.02113,984,599 - 114,391,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590731   ⟹   XP_017446220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
mRatBN7.22111,184,355 - 111,587,993 (+)NCBI
Rnor_6.02113,984,600 - 114,391,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590732   ⟹   XP_017446221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
mRatBN7.22111,184,354 - 111,587,993 (+)NCBI
Rnor_6.02113,984,599 - 114,391,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281546   ⟹   XP_063137616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
RefSeq Acc Id: XM_063281547   ⟹   XP_063137617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
RefSeq Acc Id: XM_063281548   ⟹   XP_063137618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,113,221 - 113,511,341 (+)NCBI
RefSeq Acc Id: XM_063281549   ⟹   XP_063137619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82113,243,780 - 113,511,341 (+)NCBI
RefSeq Acc Id: NP_001099892   ⟸   NM_001106422
- UniProtKB: A6IHI7 (UniProtKB/TrEMBL),   A0A8I5ZV95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759119   ⟸   XM_008760897
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017446219   ⟸   XM_017590730
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017446221   ⟸   XM_017590732
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GFX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446220   ⟸   XM_017590731
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000016799   ⟸   ENSRNOT00000016799
Ensembl Acc Id: ENSRNOP00000072950   ⟸   ENSRNOT00000086399
Ensembl Acc Id: ENSRNOP00000082629   ⟸   ENSRNOT00000096096
Ensembl Acc Id: ENSRNOP00000095929   ⟸   ENSRNOT00000115354
Ensembl Acc Id: ENSRNOP00000088180   ⟸   ENSRNOT00000098071
Ensembl Acc Id: ENSRNOP00000080133   ⟸   ENSRNOT00000106609
RefSeq Acc Id: XP_063137616   ⟸   XM_063281546
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137617   ⟸   XM_063281547
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GFX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137618   ⟸   XM_063281548
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GFX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137619   ⟸   XM_063281549
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GFX7 (UniProtKB/TrEMBL)
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K490-F1-model_v2 AlphaFold A0A0G2K490 1-1360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691274
Promoter ID:EPDNEW_R1792
Type:single initiation site
Name:Tnik_1
Description:TRAF2 and NCK interacting kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02113,984,750 - 113,984,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561817 AgrOrtholog
BioCyc Gene G2FUF-53485 BioCyc
Ensembl Genes ENSRNOG00000012422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016799.5 UniProtKB/TrEMBL
  ENSRNOT00000086399 ENTREZGENE
  ENSRNOT00000086399.2 UniProtKB/TrEMBL
  ENSRNOT00000096096.1 UniProtKB/TrEMBL
  ENSRNOT00000098071.1 UniProtKB/TrEMBL
  ENSRNOT00000106609 ENTREZGENE
  ENSRNOT00000106609.1 UniProtKB/TrEMBL
  ENSRNOT00000115354 ENTREZGENE
  ENSRNOT00000115354.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Citron UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
  STE20_Ser-Thr_kinase UniProtKB/TrEMBL
KEGG Report rno:294917 UniProtKB/TrEMBL
NCBI Gene 294917 ENTREZGENE
PANTHER CNH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MISSHAPEN LIKE KINASE 1 UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Tnik PhenoGen
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012422 RatGTEx
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K490 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQ07_RAT UniProtKB/TrEMBL
  A0A8I5ZV95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFX7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLD8 ENTREZGENE, UniProtKB/TrEMBL
  A6IHI6 ENTREZGENE, UniProtKB/TrEMBL
  A6IHI7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZQ0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Tnik  TRAF2 and NCK interacting kinase  RGD1561817  similar to Traf2 and NCK interacting kinase, splice variant 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561817  similar to Traf2 and NCK interacting kinase, splice variant 4   RGD1561817_predicted  similar to Traf2 and NCK interacting kinase, splice variant 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561817_predicted  similar to Traf2 and NCK interacting kinase, splice variant 4 (predicted)  LOC294917  similar to Traf2 and NCK interacting kinase, splice variant 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294917  similar to Traf2 and NCK interacting kinase, splice variant 4      Symbol and Name status set to provisional 70820 PROVISIONAL