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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDIsoproterenol results in decreased phosphorylation of AKT1 proteinPMID:35815753
Akt1increases phosphorylationEXP 6480464CTDIsoproterenol results in increased phosphorylation of AKT1 proteinPMID:15951400 PMID:16716347 PMID:17623046 PMID:18806606 PMID:31009642 PMID:32686902
Akt1multiple interactionsEXP 6480464CTD2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of AKT1 protein]; [Isoproterenol co-treated with POSTN protein] results in decreased expression of AKT1 mRNA; [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]PMID:15951400 PMID:17623046 PMID:18806606 PMID:19167487 PMID:30303030 PMID:31009642 PMID:32686902 PMID:35815753
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDIsoproterenol results in decreased expression of AKT1 mRNAPMID:20003209
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDIsoproterenol results in increased phosphorylation of AKT1 proteinPMID:15618457 PMID:31009642 PMID:32686902
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]PMID:15178407 PMID:31009642 PMID:32686902
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