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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDIsoproterenol results in increased expression of DDIT3 mRNAPMID:29414845
Ddit3multiple interactionsEXP 6480464CTD[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of DDIT3 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of DDIT3 mRNA]]PMID:29414845
Ddit3increases expressionISODdit3 (Mus musculus)6480464CTDIsoproterenol results in increased expression of DDIT3 mRNAPMID:21823215
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