Thoc3 (THO complex subunit 3) - Rat Genome Database

Name: Thoc3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Thoc3 (THO complex subunit 3) Rattus norvegicus

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Symbol:

Thoc3

Name:

THO complex subunit 3

RGD ID:

1311669

Description:

Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC3 (THO complex subunit 3); PARTICIPATES IN RNA transport pathway; spliceosome pathway; INTERACTS WITH 2,4,6-trinitrotoluene; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC290519; THO complex 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	THOC3 (THO complex subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	THOC3 (THO complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	THOC3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Thoc3 (THO complex 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	THOC3 (THO complex subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Thoc3 (THO complex 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	thoc3 (THO complex 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TEX1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	tex	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	thoc-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	thoc3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	10,148,281 - 10,157,472 (+)	NCBI		GRCr8
mRatBN7.2	17	10,143,184 - 10,152,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,143,139 - 10,152,370 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,157,081 - 10,166,261 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,690,656 - 11,699,832 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	10,153,524 - 10,162,704 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,676,943 - 10,686,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,676,943 - 10,686,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	12,803,773 - 12,812,964 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,233,851 - 16,243,042 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,217,971 - 16,242,379 (+)	NCBI
Celera	17	10,215,590 - 10,224,767 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2-methylcholine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

chromium(6+) (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

flutamide (EXP)

gentamycin (EXP)

isoprenaline (ISO)

ivermectin (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA export from nucleus (IBA,ISO)

Cellular Component

chromosome, telomeric region (ISO)

THO complex part of transcription export complex (IBA,ISO)

transcription export complex (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA transport pathway (IEA)

spliceosome pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15833825	PMID:15998806	PMID:17190602	PMID:18974867	PMID:23222130	PMID:24270157

Genomics

Comparative Map Data

Thoc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	10,148,281 - 10,157,472 (+)	NCBI		GRCr8
mRatBN7.2	17	10,143,184 - 10,152,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	10,143,139 - 10,152,370 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	10,157,081 - 10,166,261 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,690,656 - 11,699,832 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	10,153,524 - 10,162,704 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,676,943 - 10,686,134 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,676,943 - 10,686,134 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	12,803,773 - 12,812,964 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	16,233,851 - 16,243,042 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	16,217,971 - 16,242,379 (+)	NCBI
Celera	17	10,215,590 - 10,224,767 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

THOC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	175,959,531 - 175,968,315 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	175,917,873 - 176,034,680 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	175,386,534 - 175,395,318 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	175,319,140 - 175,328,151 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	177,235,132 - 177,243,873	NCBI
Celera	5	122,313,128 - 122,314,601 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	172,063,942 - 172,065,852 (+)	NCBI		HuRef
CHM1_1	5	174,819,332 - 174,828,116 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	176,503,198 - 176,512,029 (-)	NCBI		T2T-CHM13v2.0

Thoc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	54,606,650 - 54,616,653 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	54,606,650 - 54,616,662 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	54,458,837 - 54,468,840 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	54,458,837 - 54,468,849 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	54,560,198 - 54,570,201 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	54,469,140 - 54,478,441 (-)	NCBI		MGSCv36	mm8
Celera	13	55,524,317 - 55,534,319 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	28.69	NCBI

Thoc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	28,467,540 - 28,480,613 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	28,467,540 - 28,480,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

THOC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	171,048,030 - 171,101,061 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	169,187,568 - 169,240,599 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	171,310,321 - 171,319,192 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	178,205,744 - 178,214,684 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	178,205,744 - 178,214,684 (-)	Ensembl	panpan1.1		panPan2

THOC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	37,130,944 - 37,151,479 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,057,940 - 37,199,448 (+)	NCBI	CanFam3.1		canFam3	CanFam3.1
CanFam3.1 Ensembl	4	37,057,940 - 37,199,448 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	4	37,497,845 - 37,518,160 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	37,425,038 - 37,666,348 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	37,323,077 - 37,343,388 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	37,511,047 - 37,531,365 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	38,020,440 - 38,040,769 (+)	NCBI		UU_Cfam_GSD_1.0

Thoc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	121,399,735 - 121,411,954 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936597	433,865 - 436,852 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

THOC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	81,658,788 - 81,670,127 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	81,658,736 - 81,670,996 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	83,306,568 - 83,318,259 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

THOC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	78,106,835 - 78,115,342 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	78,106,635 - 78,115,269 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	473,479 - 482,230 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Thoc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	14,005,501 - 14,023,617 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	14,005,563 - 14,022,516 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Thoc3
36 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	162
Count of miRNA genes:	123
Interacting mature miRNAs:	142
Transcripts:	ENSRNOT00000000116
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7979968	16317111	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000116 ⟹ ENSRNOP00000000116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	10,143,139 - 10,152,370 (+)	Ensembl
Rnor_6.0 Ensembl	17	10,676,943 - 10,686,134 (+)	Ensembl

RefSeq Acc Id:

NM_001106059 ⟹ NP_001099529

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	10,148,281 - 10,157,472 (+)	NCBI
mRatBN7.2	17	10,143,184 - 10,152,375 (+)	NCBI
Rnor_6.0	17	10,676,943 - 10,686,134 (+)	NCBI
Rnor_5.0	17	12,803,773 - 12,812,964 (+)	NCBI
RGSC_v3.4	17	16,233,851 - 16,243,042 (+)	RGD
Celera	17	10,215,590 - 10,224,767 (+)	RGD

Sequence:

show sequence

CTCCAGCTTCCGGCGCGCGATCCTTGCGGAGAGGGCCATGGCGGTTCCCGCCGCTGTCCTGGGG
CCCTCTGCCCTCAGCCAGAGCGGCCCCGGGTCGATGGCGCCCTGGTGCTCGGTGAGCAGTGGCC
CGTCTCGTTATGTGCTCGGGATGCAGGAGTTGTTCCGAGGCCACAGCAAGACTCGTGAGTTCCC
GGCGCACAGTGCCAAGGTGCACTCGGTGGCCTGGAGCTGCGACGGTCGTCGCTTGGCCTCGGGA
TCTTTCGACAAGACTGCCAGCGTGTTCTTGCTGGAGAAGGACCGGCTGGTCAAGGAAAACAACT
ACCGTGGACATGGGGATAGCGTGGACCAGCTCTGCTGGCATCCAAGCAACCCTGACCTTTTTGT
CACCGCATCTGGAGATAAAACCATTCGCATCTGGGATGTGAGGACTACAAAATGCATCGCCACT
GTGAACACGAAAGGGGAGAACATTAACATCTGCTGGAGTCCCGACGGGCAGACCATTGCAGTGG
GCAACAAGGATGATGTCGTGACCTTTATTGACGCCAAGACGCACCGTTCCAAAGCGGAGGAGCA
GTTCAAGTTTGAGGTCAATGAGATCTCGTGGAACAACGACAACAACATGTTCTTCCTGACCAAT
GGCAACGGCTGTATCAACATCCTCAGCTACCCAGAACTGAAGCCTGTGCAGTCCATCAATGCCC
ACCCTTCTAACTGCATCTGTATCAAGTTTGACCCCATGGGGAAATACTTTGCCACAGGAAGTGC
GGATGCCTTGGTCAGCCTCTGGGACGTTGACGAGCTAGTGTGCGTGCGGTGCTTTTCCAGACTA
GATTGGCCTGTGAGGACCCTCAGTTTTAGCCACGATGGGAAAATGCTGGCGTCGGCTTCGGAGG
ACCATTTCATTGACATAGCTGAAGTAGAGACAGGAGACAAGCTGTGGGAGGTGCAGTGTGAGTC
CCCGACTTTCACCGTGGCTTGGCACCCCAAGAGGCCTCTGCTGGCTTTTGCCTGCGACGACAAA
GATGGCAAGTACGACAGCAGCCGGGAGGCTGGGACCGTGAAGCTCTTCGGGCTTCCCAATGACT
CCTGAGAGGACATAGCTGGAAGGAAGAGGACGACGGGCGGACTATTCAGGCTTCCTAATGACTG
GACCTGACGGGGAGAGGGGGCTGGGCGCAAGCCTTCCTTTTGTATAGTTCCGTGTGGTCTTTTG
GGCTTTGGGCACCCTAAATGTTTGTAAATGGCATACATTACAAAAACCCTTTGGTCAGGCTGTG
GTACCGGAGGATTGAACCAGCCTTGCACGTGGTGAGCAAGTGGCCCACTCAGCCAGCCCCGCCC
CACTGCCTGAGGTTTTTTGTTTTTTGTTTTTTGTTTTTTTTTGGTGTATTTTGTGTTAAGCAGT
TAGCTAATAAGGACTCTGCAAGTATGGGTCATAATCTGTTGTTGAGGGTTCTCTAAAGGAAGAG
AACTGGTAGAATGTCTGTCTGTCTCTCTCTTGTCTCTGTGTGTCCATACATGGGATTTTATCAG
AATGGCTGACAGGCTGTGGTCTGGGTTGTCATTCCAACGACGCTGCCGTCTCCTGACGGAAAGG
CCAAGGATCAGTAGCCGCTGAGACTCATCTGATGCGGAGTCCTGGGGAATCCTAGAGAGCTGCA
ATCGTCCGTCAGTGTTGGAATCCTGAAGAAGCAGGCTCTGTGGTTACCAGGGAGGGACTCCCTG
AGCAGCAGGGTGGATGGACCAGGCAGTGAGAGTGAGGGCAAACAGGCAGAAAGCGGAAGCCTTT
TGTGTGACTTTTTATACACTGCCACCAGCATGTGTCCCAGGTTTCCGGTGGCTCTTCCTACCTC
AGATGATCAAGATTTCTCTCAGGTGTGCCCTGCTGGTTGGGTTTCAGTGGTTTCCAGACGCTGC
AGTCAAGTTGACAGCCAAGATTGCCCACCACATGCCCAGCGTGGCATGCCCTTTGGGAGTGCCC
TGTGTTCTGGGTTTTAATATGGCAGTTTGTTGCTTAGGCAGTACCTACTTAGAGGGAGGGCAGC
ATAGGGATGGGATTTTTAAAAACAGCTTTGAGAACTGAGCATTCATTAAAGCCGGCTTTCGTTA
TGA

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Protein Sequences


Protein RefSeqs	NP_001099529	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68852	(Get FASTA)	NCBI Sequence Viewer
	EDL94059	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000116.5

RefSeq Acc Id:

NP_001099529 ⟸ NM_001106059

- UniProtKB:

B5DEY5 (UniProtKB/TrEMBL), A6KB01 (UniProtKB/TrEMBL), F7EUM8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVPAAVLGPSALSQSGPGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFPAHSAKVHSVAWS
CDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWD
VRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNN
DNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDEL
VCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRP
LLAFACDDKDGKYDSSREAGTVKLFGLPNDS

hide sequence

Ensembl Acc Id:

ENSRNOP00000000116 ⟸ ENSRNOT00000000116

Protein Domains

Anaphase-promoting complex subunit 4-like WD40

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEY5-F1-model_v2	AlphaFold	B5DEY5	1-351	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700325

Promoter ID:

EPDNEW_R10849

Type:

initiation region

Name:

Thoc3_1

Description:

THO complex 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	10,676,947 - 10,677,007	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311669	AgrOrtholog
BioCyc Gene	G2FUF-10169	BioCyc
Ensembl Genes	ENSRNOG00000000104	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000116.6	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	Apc4_WD40_dom	UniProtKB/TrEMBL
	G-protein_beta_WD-40_rep_reg	UniProtKB/TrEMBL
	PD40	UniProtKB/TrEMBL
	Tex1/THOC3	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:290519	UniProtKB/TrEMBL
NCBI Gene	290519	ENTREZGENE
PANTHER	PTHR22839	UniProtKB/TrEMBL
	THO COMPLEX SUBUNIT 3	UniProtKB/TrEMBL
Pfam	ANAPC4_WD40	UniProtKB/TrEMBL
	PD40	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PhenoGen	Thoc3	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000104	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A6KB01	ENTREZGENE, UniProtKB/TrEMBL
	B5DEY5	ENTREZGENE
	F7EUM8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B5DEY5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-09-30	Thoc3	THO complex subunit 3	Thoc3	THO complex 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Thoc3	THO complex 3	Thoc3_predicted	THO complex 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Thoc3_predicted	THO complex 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)