Maf (MAF bZIP transcription factor) - Rat Genome Database

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Gene: Maf (MAF bZIP transcription factor) Rattus norvegicus
Analyze
Symbol: Maf
Name: MAF bZIP transcription factor
RGD ID: 3034
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bZip transcription factor c-maf; C-Maf; cMaf; LOC108348985; Maf2; proto-oncogene c-maf; transcription factor Maf; transcription factor Maf-2; uncharacterized LOC108348985; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf); v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81960,259,200 - 60,622,145 (-)NCBIGRCr8
mRatBN7.21943,353,867 - 43,713,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1943,360,342 - 43,712,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1950,534,463 - 50,536,407 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01951,187,718 - 51,189,656 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01953,428,393 - 53,430,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01948,179,826 - 48,200,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1948,194,804 - 48,196,748 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01958,976,694 - 58,999,741 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41945,859,510 - 45,861,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11945,864,390 - 45,866,335 (-)NCBI
Celera1943,012,985 - 43,014,923 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (ISO)
dapsone  (ISO)
deoxycholic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isoprenaline  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
menadione  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
oxazepam  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
Sinomenine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
Trapidil  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trovafloxacin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comprehensive mutational screening in a cohort of Danish families with hereditary congenital cataract. Hansen L, etal., Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3291-303. doi: 10.1167/iovs.08-3149. Epub 2009 Jan 31.
4. Pulverulent cataract with variably associated microcornea and iris coloboma in a MAF mutation family. Jamieson RV, etal., Br J Ophthalmol 2003 Apr;87(4):411-2.
5. Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma. Jamieson RV, etal., Hum Mol Genet 2002 Jan 1;11(1):33-42.
6. Rat maf-related factors: the specificities of DNA binding and heterodimer formation. Matsushima-Hibiya Y, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):412-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Identification of a novel missense mutation of MAF in a Japanese family with congenital cataract by whole exome sequencing: a clinical report and review of literature. Narumi Y, etal., Am J Med Genet A. 2014 May;164A(5):1272-6. doi: 10.1002/ajmg.a.36433. Epub 2014 Mar 24.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Expression of c-maf and mafB genes in the skin during rat embryonic development. Ogata A, etal., Acta Histochem. 2004 Feb;106(1):65-7.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. A heterozygous c-Maf transactivation domain mutation causes congenital cataract and enhances target gene activation. Perveen R, etal., Hum Mol Genet. 2007 May 1;16(9):1030-8. Epub 2007 Mar 20.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rat maf related genes: specific expression in chondrocytes, lens and spinal cord. Sakai M, etal., Oncogene 1997 Feb 13;14(6):745-50.
Additional References at PubMed
PMID:10383433   PMID:10403649   PMID:10603348   PMID:12381733   PMID:12835653   PMID:14512017   PMID:14765989   PMID:15063720   PMID:15249232   PMID:15790681   PMID:16847327   PMID:17550853  
PMID:19414009   PMID:19623612   PMID:21460847   PMID:21795542   PMID:23305647   PMID:29748249  


Genomics

Comparative Map Data
Maf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81960,259,200 - 60,622,145 (-)NCBIGRCr8
mRatBN7.21943,353,867 - 43,713,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1943,360,342 - 43,712,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1950,534,463 - 50,536,407 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01951,187,718 - 51,189,656 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01953,428,393 - 53,430,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01948,179,826 - 48,200,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1948,194,804 - 48,196,748 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01958,976,694 - 58,999,741 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41945,859,510 - 45,861,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11945,864,390 - 45,866,335 (-)NCBI
Celera1943,012,985 - 43,014,923 (-)NCBICelera
Cytogenetic Map19q12NCBI
MAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381679,202,622 - 79,600,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1679,585,843 - 79,600,737 (-)EnsemblGRCh38hg38GRCh38
GRCh371679,627,735 - 79,634,634 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361678,185,732 - 78,192,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 341678,185,735 - 78,192,112NCBI
Celera1663,926,698 - 63,933,512 (-)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1665,384,643 - 65,391,409 (-)NCBIHuRef
CHM1_11681,039,513 - 81,046,247 (-)NCBICHM1_1
T2T-CHM13v2.01685,268,951 - 85,657,071 (-)NCBIT2T-CHM13v2.0
Maf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398116,429,992 - 116,433,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8116,409,681 - 116,434,533 (-)EnsemblGRCm39 Ensembl
GRCm388115,703,253 - 115,706,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8115,682,942 - 115,707,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv378118,227,153 - 118,230,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368118,589,230 - 118,592,871 (-)NCBIMGSCv36mm8
Celera8119,915,403 - 119,918,981 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map862.61NCBI
Maf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555222,514,313 - 2,519,694 (-)NCBIChiLan1.0ChiLan1.0
MAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21889,333,211 - 89,339,592 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11695,251,476 - 95,257,980 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01660,188,494 - 60,194,871 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11679,618,156 - 79,624,460 (-)NCBIpanpan1.1PanPan1.1panPan2
MAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1571,965,291 - 71,982,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl571,965,500 - 71,981,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha571,912,571 - 71,918,461 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0572,271,569 - 72,277,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl572,271,341 - 72,302,366 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1572,211,442 - 72,217,331 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0572,047,056 - 72,052,965 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0572,524,417 - 72,530,335 (+)NCBIUU_Cfam_GSD_1.0
MAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl68,468,413 - 8,485,030 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.168,468,736 - 8,910,012 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.268,568,594 - 8,571,175 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1565,064,715 - 65,078,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604710,795,871 - 10,802,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247467,653,690 - 7,672,404 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Maf
2002 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:94
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000016577
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat

Markers in Region
D19Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,710,798 - 43,711,077 (+)MAPPERmRatBN7.2
Rnor_6.01948,195,179 - 48,195,457NCBIRnor6.0
Rnor_5.01958,998,158 - 58,998,436UniSTSRnor5.0
RGSC_v3.41945,859,885 - 45,860,163UniSTSRGSC3.4
Celera1943,013,360 - 43,013,638UniSTS
Cytogenetic Map19q12UniSTS
Maf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,711,004 - 43,711,276 (+)MAPPERmRatBN7.2
Rnor_6.01948,195,385 - 48,195,656NCBIRnor6.0
Rnor_5.01958,998,364 - 58,998,635UniSTSRnor5.0
RGSC_v3.41945,860,091 - 45,860,362UniSTSRGSC3.4
Celera1943,013,566 - 43,013,837UniSTS
Cytogenetic Map19q12UniSTS
AA957811  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,709,102 - 43,709,215 (+)MAPPERmRatBN7.2
Rnor_6.01948,193,483 - 48,193,595NCBIRnor6.0
Rnor_5.01958,996,462 - 58,996,574UniSTSRnor5.0
RGSC_v3.41945,858,189 - 45,858,301UniSTSRGSC3.4
Celera1943,011,664 - 43,011,776UniSTS
RH 3.4 Map19614.6UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 80 44 51 44 36 45 159 111 86 49 24
Low 141 147 103 18 103 91 59 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000016577   ⟹   ENSRNOP00000016577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1943,360,342 - 43,712,365 (-)Ensembl
Rnor_6.0 Ensembl1948,194,804 - 48,196,748 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095407   ⟹   ENSRNOP00000097791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1943,709,996 - 43,712,365 (-)Ensembl
RefSeq Acc Id: NM_019318   ⟹   NP_062191
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,619,412 - 60,621,356 (-)NCBI
mRatBN7.21943,710,424 - 43,712,368 (-)NCBI
Rnor_6.01948,194,804 - 48,196,748 (-)NCBI
Rnor_5.01958,976,694 - 58,999,741 (-)NCBI
RGSC_v3.41945,859,510 - 45,861,454 (-)RGD
Celera1943,012,985 - 43,014,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255696   ⟹   XP_006255758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,617,633 - 60,622,145 (-)NCBI
mRatBN7.21943,708,642 - 43,713,162 (-)NCBI
Rnor_6.01948,193,022 - 48,200,993 (-)NCBI
Rnor_5.01958,976,694 - 58,999,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097956   ⟹   XP_038953884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,597,585 - 60,622,145 (-)NCBI
mRatBN7.21943,685,801 - 43,713,162 (-)NCBI
RefSeq Acc Id: XM_039097957   ⟹   XP_038953885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,597,585 - 60,622,145 (-)NCBI
mRatBN7.21943,685,801 - 43,713,162 (-)NCBI
RefSeq Acc Id: XM_039097958   ⟹   XP_038953886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,259,200 - 60,622,145 (-)NCBI
mRatBN7.21943,353,867 - 43,713,162 (-)NCBI
RefSeq Acc Id: XM_063278262   ⟹   XP_063134332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,606,455 - 60,622,145 (-)NCBI
RefSeq Acc Id: XR_010060023
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,259,200 - 60,322,178 (-)NCBI
RefSeq Acc Id: XR_010060024
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,259,200 - 60,330,549 (-)NCBI
RefSeq Acc Id: XR_010060025
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81960,259,200 - 60,330,549 (-)NCBI
RefSeq Acc Id: NP_062191   ⟸   NM_019318
- UniProtKB: P54844 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255758   ⟸   XM_006255696
- Peptide Label: isoform X3
- UniProtKB: P54844 (UniProtKB/Swiss-Prot),   A0A8I6B690 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016577   ⟸   ENSRNOT00000016577
RefSeq Acc Id: XP_038953886   ⟸   XM_039097958
- Peptide Label: isoform X2
- UniProtKB: P54844 (UniProtKB/Swiss-Prot),   F1LSV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953884   ⟸   XM_039097956
- Peptide Label: isoform X1
- UniProtKB: P54844 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038953885   ⟸   XM_039097957
- Peptide Label: isoform X2
- UniProtKB: P54844 (UniProtKB/Swiss-Prot),   F1LSV1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097791   ⟸   ENSRNOT00000095407
RefSeq Acc Id: XP_063134332   ⟸   XM_063278262
- Peptide Label: isoform X2
- UniProtKB: P54844 (UniProtKB/Swiss-Prot),   F1LSV1 (UniProtKB/TrEMBL)
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54844-F1-model_v2 AlphaFold P54844 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701164
Promoter ID:EPDNEW_R11688
Type:multiple initiation site
Name:Maf_1
Description:MAF bZIP transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01948,196,686 - 48,196,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3034 AgrOrtholog
BioCyc Gene G2FUF-5577 BioCyc
Ensembl Genes ENSRNOG00000012428 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016577.6 UniProtKB/TrEMBL
  ENSRNOT00000095407.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_Maf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Maf_TF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transciption_factor_Maf_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54267 UniProtKB/Swiss-Prot
NCBI Gene 54267 ENTREZGENE
PANTHER PTHR10129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10129:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_Maf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Maf_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Maf PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012428 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6B690 ENTREZGENE, UniProtKB/TrEMBL
  F1LSV1 ENTREZGENE, UniProtKB/TrEMBL
  MAF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Maf  MAF bZIP transcription factor  LOC108348985  uncharacterized LOC108348985  Data merged from RGD:11390626 737654 PROVISIONAL
2016-08-02 LOC108348985  uncharacterized LOC108348985      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-05-18 Maf  MAF bZIP transcription factor  Maf  v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Maf  v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog  Maf  v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Maf  v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)    v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf)  Name updated 1299863 APPROVED
2002-06-10 Maf  v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog (c-maf)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in chondrocytes, lens, and spinal cord 69874