Ptpn12 (protein tyrosine phosphatase, non-receptor type 12) - Rat Genome Database

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Gene: Ptpn12 (protein tyrosine phosphatase, non-receptor type 12) Rattus norvegicus
Analyze
Symbol: Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
RGD ID: 620894
Description: Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ptpg1; RKPTP; tyrosine-protein phosphatase non-receptor type 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,913,071 - 14,985,084 (+)NCBIGRCr8
mRatBN7.2414,020,997 - 14,092,931 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,021,052 - 14,092,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,158,307 - 19,230,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,960,328 - 15,032,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,343,956 - 13,415,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,631,129 - 10,702,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,631,073 - 10,702,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,623,632 - 10,695,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,517,642 - 9,589,954 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.149,517,585 - 9,574,832 (+)NCBI
Celera49,582,368 - 9,654,126 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
3',5'-cyclic GMP  (EXP)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N(6)-dimethylallyladenine  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
nucleus  (IBA)
podosome  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. Kitamura T, etal., Jpn J Cancer Res. 1995 Sep;86(9):811-8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney. Moriyama T, etal., FEBS Lett 1994 Oct 24;353(3):305-8.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7772023   PMID:9285683   PMID:12674328   PMID:16354758   PMID:21376233   PMID:24791697   PMID:27061092   PMID:27134172  


Genomics

Comparative Map Data
Ptpn12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,913,071 - 14,985,084 (+)NCBIGRCr8
mRatBN7.2414,020,997 - 14,092,931 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,021,052 - 14,092,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,158,307 - 19,230,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,960,328 - 15,032,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,343,956 - 13,415,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,631,129 - 10,702,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,631,073 - 10,702,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,623,632 - 10,695,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,517,642 - 9,589,954 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.149,517,585 - 9,574,832 (+)NCBI
Celera49,582,368 - 9,654,126 (+)NCBICelera
Cytogenetic Map4q11NCBI
PTPN12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38777,537,295 - 77,640,069 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl777,537,295 - 77,640,069 (+)EnsemblGRCh38hg38GRCh38
GRCh37777,166,612 - 77,269,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36777,004,771 - 77,107,322 (+)NCBINCBI36Build 36hg18NCBI36
Build 34776,811,485 - 76,914,037NCBI
Celera771,867,421 - 71,970,039 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef771,768,818 - 71,871,494 (+)NCBIHuRef
CHM1_1777,097,083 - 77,199,758 (+)NCBICHM1_1
T2T-CHM13v2.0778,789,201 - 78,891,996 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2776,499,836 - 76,602,451 (+)NCBI
Ptpn12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,191,643 - 21,261,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,191,643 - 21,260,909 (-)EnsemblGRCm39 Ensembl
GRCm38520,986,645 - 21,055,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl520,986,645 - 21,055,911 (-)EnsemblGRCm38mm10GRCm38
MGSCv37520,492,463 - 20,561,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36520,498,469 - 20,567,621 (-)NCBIMGSCv36mm8
Celera517,944,646 - 18,014,696 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.83NCBI
Ptpn12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554107,557,103 - 7,599,139 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554107,556,283 - 7,599,170 (-)NCBIChiLan1.0ChiLan1.0
PTPN12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2695,387,345 - 95,490,209 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17143,651,984 - 143,754,849 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0769,457,158 - 69,560,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1783,268,834 - 83,371,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl783,268,834 - 83,371,120 (+)Ensemblpanpan1.1panPan2
PTPN12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11817,608,665 - 17,692,543 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1817,607,936 - 17,692,219 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1817,266,233 - 17,315,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01817,927,205 - 18,011,994 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,927,265 - 18,011,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11817,677,847 - 17,762,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01817,617,247 - 17,702,020 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,886,436 - 17,971,250 (+)NCBIUU_Cfam_GSD_1.0
Ptpn12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,785,782 - 59,892,793 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,909,551 - 21,016,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,909,557 - 21,016,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9102,480,924 - 102,563,751 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19102,480,914 - 102,563,969 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29112,920,939 - 112,961,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12171,285,917 - 71,389,645 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2171,285,736 - 71,389,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604232,533,869 - 32,637,803 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473926,747,830 - 26,828,535 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn12
280 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:188
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000017907
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat

Markers in Region
RH143589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,067,650 - 14,067,779 (+)MAPPERmRatBN7.2
Rnor_6.0410,677,559 - 10,677,687NCBIRnor6.0
Rnor_5.0410,670,289 - 10,670,417UniSTSRnor5.0
RGSC_v3.449,564,180 - 9,564,308UniSTSRGSC3.4
Celera49,628,900 - 9,629,028UniSTS
RH 3.4 Map459.2UniSTS
Cytogenetic Map4q11UniSTS
PTPN12_1837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,092,075 - 14,092,706 (+)MAPPERmRatBN7.2
Rnor_6.0410,701,535 - 10,702,165NCBIRnor6.0
Rnor_5.0410,694,273 - 10,694,903UniSTSRnor5.0
RGSC_v3.449,589,103 - 9,589,733UniSTSRGSC3.4
Celera49,653,275 - 9,653,905UniSTS
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017907   ⟹   ENSRNOP00000017907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,108 - 14,092,927 (+)Ensembl
Rnor_6.0 Ensembl410,631,129 - 10,702,386 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081939   ⟹   ENSRNOP00000075346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,052 - 14,079,703 (+)Ensembl
Rnor_6.0 Ensembl410,631,073 - 10,688,211 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106350   ⟹   ENSRNOP00000079518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,108 - 14,092,927 (+)Ensembl
RefSeq Acc Id: NM_057115   ⟹   NP_476456
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,274 - 14,985,080 (+)NCBI
mRatBN7.2414,021,108 - 14,092,927 (+)NCBI
Rnor_6.0410,631,129 - 10,702,386 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
RGSC_v3.449,517,642 - 9,589,954 (+)RGD
Celera49,582,368 - 9,654,126 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235868   ⟹   XP_006235930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,071 - 14,985,084 (+)NCBI
mRatBN7.2414,020,997 - 14,092,931 (+)NCBI
Rnor_6.0410,631,139 - 10,702,390 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235870   ⟹   XP_006235932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,187 - 14,985,084 (+)NCBI
mRatBN7.2414,021,021 - 14,092,931 (+)NCBI
Rnor_6.0410,631,253 - 10,702,390 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285423   ⟹   XP_063141493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,176 - 14,985,084 (+)NCBI
RefSeq Acc Id: XM_063285424   ⟹   XP_063141494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,667 - 14,985,084 (+)NCBI
RefSeq Acc Id: NP_476456   ⟸   NM_057115
- UniProtKB: G3V7Q4 (UniProtKB/TrEMBL),   A6K5C4 (UniProtKB/TrEMBL),   A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235930   ⟸   XM_006235868
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235932   ⟸   XM_006235870
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075346   ⟸   ENSRNOT00000081939
Ensembl Acc Id: ENSRNOP00000017907   ⟸   ENSRNOT00000017907
Ensembl Acc Id: ENSRNOP00000079518   ⟸   ENSRNOT00000106350
RefSeq Acc Id: XP_063141493   ⟸   XM_063285423
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141494   ⟸   XM_063285424
- Peptide Label: isoform X3
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7Q4-F1-model_v2 AlphaFold G3V7Q4 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692813
Promoter ID:EPDNEW_R3337
Type:initiation region
Name:Ptpn12_1
Description:protein tyrosine phosphatase, non-receptor type 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0410,631,133 - 10,631,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620894 AgrOrtholog
BioCyc Gene G2FUF-45963 BioCyc
Ensembl Genes ENSRNOG00000013135 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017907.6 UniProtKB/TrEMBL
  ENSRNOT00000081939.2 UniProtKB/TrEMBL
  ENSRNOT00000106350.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTN12/18/22 UniProtKB/TrEMBL
  PTN12_cat UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-12 UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:117255 UniProtKB/TrEMBL
NCBI Gene 117255 ENTREZGENE
PANTHER TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpn12 PhenoGen
PIRSF Tyr-Ptase_nr12 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013135 RatGTEx
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2KAC5_RAT UniProtKB/TrEMBL
  A0A8I5ZN71 ENTREZGENE, UniProtKB/TrEMBL
  A6K5C4 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Q4 ENTREZGENE, UniProtKB/TrEMBL
  Q63745_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ptpn12  protein tyrosine phosphatase, non-receptor type 12      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ptpn12  protein tyrosine phosphatase, non-receptor type 12      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein a 382 amino acid protein with a M(r) of 44,438 633766