Hexa (hexosaminidase subunit alpha) - Rat Genome Database

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Gene: Hexa (hexosaminidase subunit alpha) Rattus norvegicus
Analyze
Symbol: Hexa
Name: hexosaminidase subunit alpha
RGD ID: 2792
Description: Predicted to enable acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; and protein heterodimerization activity. Predicted to be involved in ganglioside catabolic process and glycosaminoglycan metabolic process. Predicted to act upstream of or within several processes, including adult walking behavior; nervous system development; and sensory perception of sound. Predicted to be located in azurophil granule and cytosol. Predicted to be part of beta-N-acetylhexosaminidase complex. Predicted to be active in lysosome and membrane. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-hexosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; hexosaminidase A; hexosaminidase subunit A; Hexose aminidase A (alpha polypeptide); MGC95289; N-acetyl-beta-glucosaminidase subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2859,936,526 - 59,961,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,936,660 - 59,962,013 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx865,458,741 - 65,483,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,731,762 - 63,756,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0861,601,107 - 61,626,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0864,325,435 - 64,350,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,325,435 - 64,350,773 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0864,087,247 - 64,112,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4863,363,219 - 63,388,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1863,382,272 - 63,407,200 (+)NCBI
Celera859,378,288 - 59,403,211 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
compound 48/80  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
flunarizine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
Mibefradil  (EXP)
N,O-dimethyltyramine  (ISO)
nefazodone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Pharmacological modification of the serotonergic transmitter system and beta-N-acetylhexosaminidase activity in rats. Casal JA, etal., Life Sci 2000 Sep 29;67(19):2369-74.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis. Hermo L, etal., J Androl 2004 Jan-Feb;25(1):69-81.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease. Seyrantepe V, etal., Exp Neurol. 2018 Jan;299(Pt A):26-41. doi: 10.1016/j.expneurol.2017.09.012. Epub 2017 Sep 30.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Structural organization, sequence, and expression of the mouse HEXA gene encoding the alpha subunit of hexosaminidase A. Wakamatsu N, etal., Genomics 1994 Nov 1;24(1):110-9.
Additional References at PubMed
PMID:1914521   PMID:6230359   PMID:7937929   PMID:8747922   PMID:8789434   PMID:8896570   PMID:9103204   PMID:9184660   PMID:9223328   PMID:9302266   PMID:9417048   PMID:9645704  
PMID:10021458   PMID:10196372   PMID:10591619   PMID:11854359   PMID:14972652   PMID:15489334   PMID:19946888   PMID:23376485   PMID:23390484   PMID:23533145   PMID:25645918  


Genomics

Comparative Map Data
Hexa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2859,936,526 - 59,961,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,936,660 - 59,962,013 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx865,458,741 - 65,483,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,731,762 - 63,756,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0861,601,107 - 61,626,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0864,325,435 - 64,350,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,325,435 - 64,350,773 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0864,087,247 - 64,112,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4863,363,219 - 63,388,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1863,382,272 - 63,407,200 (+)NCBI
Celera859,378,288 - 59,403,211 (+)NCBICelera
Cytogenetic Map8q24NCBI
HEXA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381572,340,924 - 72,376,014 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1572,340,924 - 72,376,420 (-)EnsemblGRCh38hg38GRCh38
GRCh371572,633,265 - 72,668,355 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361570,422,832 - 70,455,457 (-)NCBINCBI36Build 36hg18NCBI36
Build 341570,422,832 - 70,455,393NCBI
Celera1549,521,918 - 49,554,688 (-)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1549,466,005 - 49,498,776 (-)NCBIHuRef
CHM1_11572,753,786 - 72,786,527 (-)NCBICHM1_1
T2T-CHM13v2.01570,157,399 - 70,192,818 (-)NCBIT2T-CHM13v2.0
Hexa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39959,446,966 - 59,472,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl959,446,823 - 59,472,392 (+)EnsemblGRCm39 Ensembl
GRCm38959,539,540 - 59,565,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl959,539,540 - 59,565,109 (+)EnsemblGRCm38mm10GRCm38
MGSCv37959,387,474 - 59,412,912 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36959,337,673 - 59,363,111 (+)NCBIMGSCv36mm8
Celera956,766,853 - 56,792,230 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.02NCBI
Hexa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,790,268 - 4,806,734 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554504,790,342 - 4,806,862 (+)NCBIChiLan1.0ChiLan1.0
LOC100986229
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11565,707,784 - 65,807,320 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01551,235,123 - 51,326,832 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11570,034,232 - 70,090,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1570,057,943 - 70,090,688 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1569,998,866 - 70,033,749 (-)Ensemblpanpan1.1panPan2
HEXA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13035,836,788 - 35,862,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3035,772,553 - 35,799,681 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03036,041,265 - 36,068,396 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3036,039,878 - 36,068,382 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13035,993,838 - 36,020,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03036,021,266 - 36,048,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03036,277,065 - 36,304,204 (-)NCBIUU_Cfam_GSD_1.0
Hexa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640113,863,160 - 113,890,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647131,709,491 - 31,738,245 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647131,712,485 - 31,738,273 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEXA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl760,878,284 - 60,913,339 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1760,878,531 - 60,911,537 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2765,420,894 - 65,453,741 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEXA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12611,081,985 - 11,130,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2611,082,468 - 11,116,075 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048130,463,174 - 130,496,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hexa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247811,686,384 - 1,714,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247811,686,818 - 1,706,044 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hexa
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:124
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000013747
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
RH134318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2859,955,830 - 59,957,479 (+)MAPPERmRatBN7.2
Rnor_6.0864,344,952 - 64,346,600NCBIRnor6.0
Rnor_5.0864,106,764 - 64,108,412UniSTSRnor5.0
RGSC_v3.4863,382,334 - 63,383,982UniSTSRGSC3.4
Celera859,397,399 - 59,399,047UniSTS
Cytogenetic Map8q24UniSTS
RH136740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2859,961,726 - 59,961,912 (+)MAPPERmRatBN7.2
Rnor_6.0864,350,848 - 64,351,033NCBIRnor6.0
Rnor_5.0864,112,660 - 64,112,845UniSTSRnor5.0
RGSC_v3.4863,388,230 - 63,388,415UniSTSRGSC3.4
Celera859,403,295 - 59,403,480UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000013747   ⟹   ENSRNOP00000013747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl859,936,726 - 59,961,640 (+)Ensembl
Rnor_6.0 Ensembl864,325,435 - 64,350,773 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105014   ⟹   ENSRNOP00000085099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl859,936,660 - 59,961,657 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108506   ⟹   ENSRNOP00000084550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl859,936,707 - 59,962,013 (+)Ensembl
RefSeq Acc Id: NM_001004443   ⟹   NP_001004443
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2859,936,714 - 59,961,643 (+)NCBI
Rnor_6.0864,325,435 - 64,350,764 (+)NCBI
Rnor_5.0864,087,247 - 64,112,587 (+)NCBI
RGSC_v3.4863,363,219 - 63,388,146 (+)RGD
Celera859,378,288 - 59,403,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_017595561   ⟹   XP_017451050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2859,936,859 - 59,961,654 (+)NCBI
Rnor_6.0864,335,255 - 64,350,775 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005487769
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2859,936,526 - 59,961,654 (+)NCBI
RefSeq Acc Id: NP_001004443   ⟸   NM_001004443
- Peptide Label: precursor
- UniProtKB: Q641X3 (UniProtKB/Swiss-Prot),   A6J526 (UniProtKB/TrEMBL),   A0A8L2Q7B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451050   ⟸   XM_017595561
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q7B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013747   ⟸   ENSRNOT00000013747
RefSeq Acc Id: ENSRNOP00000084550   ⟸   ENSRNOT00000108506
RefSeq Acc Id: ENSRNOP00000085099   ⟸   ENSRNOT00000105014
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641X3-F1-model_v2 AlphaFold Q641X3 1-528 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696040
Promoter ID:EPDNEW_R6564
Type:initiation region
Name:Hexa_1
Description:hexosaminidase subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0864,325,425 - 64,325,485EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2792 AgrOrtholog
BioCyc Gene G2FUF-30238 BioCyc
BioCyc Pathway PWY-6902 [chitin degradation II (Vibrio)] BioCyc
BioCyc Pathway Image PWY-6902 BioCyc
Ensembl Genes ENSRNOG00000010252 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027102 UniProtKB/Swiss-Prot
  ENSRNOG00060016046 UniProtKB/Swiss-Prot
  ENSRNOG00065007034 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013747.5 UniProtKB/TrEMBL
  ENSRNOT00000105014.1 UniProtKB/TrEMBL
  ENSRNOT00000108506 ENTREZGENE
  ENSRNOT00000108506.1 UniProtKB/Swiss-Prot
  ENSRNOT00055046863 UniProtKB/Swiss-Prot
  ENSRNOT00060027496 UniProtKB/Swiss-Prot
  ENSRNOT00065010982 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.379.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134440 IMAGE-MGC_LOAD
InterPro Beta_hexosaminidase_sua/sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_20_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hex-like_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEX_eukaryotic_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300757 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95289 IMAGE-MGC_LOAD
NCBI Gene 300757 ENTREZGENE
PANTHER BETA-HEXOSAMINIDASE SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycohydro_20b2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hexa PhenoGen
PIRSF B-hxosamndse_ab_euk UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010252 RatGTEx
  ENSRNOG00055027102 RatGTEx
  ENSRNOG00060016046 RatGTEx
  ENSRNOG00065007034 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55545 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZD2_RAT UniProtKB/TrEMBL
  A0A8L2Q7B4 ENTREZGENE, UniProtKB/TrEMBL
  A6J526 ENTREZGENE, UniProtKB/TrEMBL
  A6J527_RAT UniProtKB/TrEMBL
  HEXA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Hexa  hexosaminidase subunit alpha  Hexa  hexosaminidase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hexa  Hexose aminidase A (alpha polypeptide)      Symbol and Name status set to approved 70586 APPROVED