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Gene: Hexa (hexosaminidase A) Mus musculus
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Symbol: Hexa
Name: hexosaminidase A
RGD ID: 10707
Description: Exhibits beta-N-acetylhexosaminidase activity. Involved in several processes, including SMAD protein signal transduction; adult walking behavior; and nervous system development. Localizes to lysosome and membrane. Is expressed in brain; mandible; and maxilla. Used to study Tay-Sachs disease. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-hexosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; Hex-1; hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha
Orthologs:
Homo sapiens (human) : HEXA (hexosaminidase subunit alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hexa (hexosaminidase subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hexa (hexosaminidase subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100986229 (CUGBP Elav-like family member 6)
Canis lupus familiaris (dog) : HEXA (hexosaminidase subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hexa (hexosaminidase subunit alpha)
Sus scrofa (pig) : HEXA (hexosaminidase subunit alpha)
Chlorocebus sabaeus (African green monkey) : HEXA (hexosaminidase subunit alpha)
Heterocephalus glaber (naked mole-rat) : Hexa (hexosaminidase subunit alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl959,539,540 - 59,565,109 (+)EnsemblGRCm38mm10GRCm38
GRCm38959,539,540 - 59,565,109 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37959,387,474 - 59,412,912 (+)NCBIGRCm37mm9NCBIm37
MGSCv36959,337,673 - 59,363,111 (+)NCBImm8
Celera956,766,853 - 56,792,230 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hexa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10707
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.