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Gene: Npm1 (nucleophosmin 1) Rattus norvegicus
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Symbol: Npm1
Name: nucleophosmin 1
Description: Exhibits several functions, including anion binding activity; p53 binding activity; and protein kinase B binding activity. Involved in several processes, including RNA metabolic process; negative regulation of apoptotic process; and regulation of DNA replication. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: B23NP; MGC108517; NPM; nucleolar phosphoprotein B23; nucleolar protein B23.1; nucleolar protein NO38; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); Nucleoplasmin-related protein (Nuclear protein B23; numatrin
Orthologs:
Homo sapiens (human) : NPM1 (nucleophosmin 1)  HGNC  Alliance
Mus musculus (house mouse) : Npm1 (nucleophosmin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npm1 (nucleophosmin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPM1 (nucleophosmin 1)
Canis lupus familiaris (dog) : NPM1 (nucleophosmin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npm1 (nucleophosmin 1)
Sus scrofa (pig) : NPM1 (nucleophosmin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01018,080,949 - 18,091,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01017,965,977 - 17,975,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,051,990 - 18,062,714 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11018,053,038 - 18,063,763 (-)NCBI
Celera1017,382,029 - 17,392,033 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Npm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3192
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.