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Gene: Lgals3 (galectin 3) Rattus norvegicus
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Symbol: Lgals3
Name: galectin 3
Description: Exhibits several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of angiogenesis; and positive regulation of serotonin secretion. Localizes to several cellular components, including the cell surface; extracellular space; and nucleus. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; congestive heart failure; and hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 35 kDa lectin; AGE-R3; carbohydrate-binding protein 35; CBP 35; CBP30; epsilon BP; gal-3; galactose-specific lectin 3; galectin-3; IgE binding protein; L-34; laminin-binding protein; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; mac-2 antigen; MGC105387
Orthologs:
Homo sapiens (human) : LGALS3 (galectin 3)  HGNC  Alliance
Mus musculus (house mouse) : Lgals3 (lectin, galactose binding, soluble 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lgals3 (galectin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LGALS3 (galectin 3)
Canis lupus familiaris (dog) : LGALS3 (galectin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lgals3 (galectin 3)
Sus scrofa (pig) : LGALS3 (galectin 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01524,153,602 - 24,165,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01528,094,344 - 28,106,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,327,071 - 23,339,006NCBIRGSC3.4rn4RGSC3.4
Celera1521,014,742 - 21,026,522 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lgals3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69356
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.