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Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells.

Authors: Arar, C  Gaudin, JC  Capron, L  Legrand, A 
Citation: Arar C, etal., FEBS Lett. 1998 Jul 3;430(3):307-11.
Pubmed: (View Article at PubMed) PMID:9688561

The galectin-3 gene (LGALS3) encodes a beta-galactose binding lectin. LGALS3 expression is associated with neoplastic transformation and with differentiation of monocytes to macrophages. Factors involved in migration, proliferation, adhesion and differentiation of vascular smooth muscle cells (SMC) play a major role during atherosclerosis development. Expression of the galectin-3 gene was not detected in quiescent SMC but was activated in aortas of hypercholesterolemic rabbits, in aortas of rats after balloon injury and in cultured SMC. These results suggest that galectin-3 production is involved in the developmental process of atherogenesis.


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RGD Object Information
RGD ID: 9685205
Created: 2014-12-29
Species: All species
Last Modified: 2014-12-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.