LGALS3 (galectin 3) - Rat Genome Database

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Gene: LGALS3 (galectin 3) Homo sapiens
Analyze
Symbol: LGALS3
Name: galectin 3
RGD ID: 736304
HGNC Page HGNC:6563
Description: Enables several functions, including IgE binding activity; molecular condensate scaffold activity; and receptor ligand inhibitor activity. Involved in several processes, including leukocyte chemotaxis; regulation of T cell activation; and regulation of apoptotic process. Located in several cellular components, including immunological synapse; mitochondrial inner membrane; and nucleoplasm. Is active in extracellular space. Implicated in asthma. Biomarker of COVID-19; aortic valve stenosis; and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 35 kDa lectin; advanced glycation end-product receptor 3; carbohydrate-binding protein 35; CBP35; GAL3; galactose-specific lectin 3; GALBP; galectin-3; GALIG; IgE-binding protein; L31; laminin-binding protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside binding soluble 3; lectin, galactoside-binding, soluble, 3; LGALS2; MAC-2 antigen; MAC2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GeneID 3958 had the official symbol LGALS2 and was identified as the human homolog of mouse Mac-2 (macrophage galactose-specific lectin) in M35368.1 and PMID: 2402511. The official symbol for this gene is now LGALS3. [30 Mar 2010]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381455,129,252 - 55,145,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1455,124,110 - 55,145,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371455,595,970 - 55,612,148 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,665,625 - 54,681,901 (+)NCBINCBI36Build 36hg18NCBI36
Build 341454,665,757 - 54,681,881NCBI
Celera1435,645,428 - 35,661,641 (+)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1435,758,537 - 35,774,750 (+)NCBIHuRef
CHM1_11455,534,573 - 55,550,756 (+)NCBICHM1_1
T2T-CHM13v2.01449,334,442 - 49,350,620 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,4-dichlorobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bucladesine  (EXP)
buspirone  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calyculin a  (ISO)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chloroform  (ISO)
choline  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
Dibutyl phosphate  (EXP)
diclofenac  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
erythromycin estolate  (ISO)
etoposide  (EXP)
fenamidone  (ISO)
ferric oxide  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactose  (EXP)
leflunomide  (EXP)
LY294002  (EXP)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
monocrotaline  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetylsphingosine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
naloxone  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP)
Nonylphenol  (EXP)
Nutlin-3  (EXP)
ochratoxin A  (ISO)
oxycodone  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenacetin  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (EXP)
quinoline  (EXP)
rac-lactic acid  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA)
cell differentiation  (IEA)
eosinophil chemotaxis  (IBA,IDA)
epithelial cell differentiation  (IEP)
extracellular matrix organization  (ISO)
innate immune response  (IEA)
macrophage chemotaxis  (IBA,IDA)
maintenance of protein location  (ISO)
monocyte chemotaxis  (IBA,IDA)
mononuclear cell migration  (IDA)
mRNA processing  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell proliferation in bone marrow  (ISO)
negative regulation of endocytosis  (IBA,IDA)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,IDA)
negative regulation of immunological synapse formation  (ISS)
negative regulation of NK T cell activation  (IDA)
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISS)
negative regulation of T cell receptor signaling pathway  (ISS)
neutrophil chemotaxis  (IBA,IDA)
positive chemotaxis  (IBA,IDA)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium ion import  (IBA,IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendritic cell differentiation  (IDA)
positive regulation of mononuclear cell migration  (IDA)
positive regulation of protein localization to plasma membrane  (IDA)
positive regulation of protein-containing complex assembly  (IDA)
positive regulation of serotonin secretion  (ISO)
regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IMP)
regulation of T cell apoptotic process  (IDA)
regulation of T cell proliferation  (IMP)
response to quercetin  (ISO)
RNA splicing  (IEA)
skeletal system development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer Ahmed HH, etal., Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4991-4998. doi: 10.22034/APJCP.2016.17.11.4991.
2. Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells. Arar C, etal., FEBS Lett. 1998 Jul 3;430(3):307-11.
3. Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis. Bellac CL, etal., Neurobiol Dis. 2007 Nov;28(2):175-83. Epub 2007 Jul 10.
4. Galectin-3 in preneoplastic lesions of glioma. Binh NH, etal., J Neurooncol. 2013 Jan;111(2):123-32. doi: 10.1007/s11060-012-1005-2. Epub 2012 Nov 23.
5. Galectin-3 mediates aldosterone-induced vascular fibrosis. Calvier L, etal., Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75. doi: 10.1161/ATVBAHA.112.300569. Epub 2012 Nov 1.
6. Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients. Cervantes-Alvarez E, etal., Sci Rep. 2022 Feb 3;12(1):1856. doi: 10.1038/s41598-022-05968-4.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Henderson NC, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5060-5. Epub 2006 Mar 20.
9. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
10. Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. Karlsen AE, etal., Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. Epub 2006 Mar 29.
11. Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model. Lopez E, etal., J Immunol. 2006 Feb 1;176(3):1943-50.
12. Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. Maeda N, etal., J Biol Chem. 2003 May 23;278(21):18938-44. Epub 2003 Mar 19.
13. Up-regulation of galectin-3 in acute renal failure of the rat. Nishiyama J, etal., Am J Pathol. 2000 Sep;157(3):815-23.
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Sharma UC, etal., Circulation. 2004 Nov 9;110(19):3121-8. Epub 2004 Nov 1.
18. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
19. Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. VanGuilder HD, etal., PLoS One. 2011 Jan 13;6(1):e16271. doi: 10.1371/journal.pone.0016271.
20. Galectin-3 is upregulated in microglial cells in response to ischemic brain lesions, but not to facial nerve axotomy. Walther M, etal., J Neurosci Res. 2000 Aug 15;61(4):430-5.
21. A novel function of microRNA let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain. Wu L, etal., Brain Pathol. 2010 Nov;20(6):1042-54. doi: 10.1111/j.1750-3639.2010.00410.x. Epub 2010 Jun 14.
22. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
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PMID:8063692   PMID:8253805   PMID:8253806   PMID:8390986   PMID:8449510   PMID:8581828   PMID:8692888   PMID:8813152   PMID:8889548   PMID:9162064   PMID:9271684   PMID:9439577  
PMID:9447709   PMID:9501082   PMID:9520085   PMID:9582341   PMID:10089212   PMID:10536372   PMID:10704522   PMID:10745073   PMID:10925302   PMID:10961987   PMID:11146440   PMID:11160123  
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PMID:15181153   PMID:15205467   PMID:15279903   PMID:15326483   PMID:15362030   PMID:15386597   PMID:15489334   PMID:15501810   PMID:15555581   PMID:15561101   PMID:15579437   PMID:15604089  
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PMID:18676377   PMID:18695044   PMID:18757439   PMID:18836743   PMID:18942707   PMID:18951731   PMID:18988806   PMID:18997617   PMID:19016746   PMID:19020721   PMID:19020999   PMID:19053747  
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PMID:19633306   PMID:19690136   PMID:19699526   PMID:19706535   PMID:19723119   PMID:19747906   PMID:19755493   PMID:19781269   PMID:19798881   PMID:19799084   PMID:19818774   PMID:19818782  
PMID:19830550   PMID:19843071   PMID:19913121   PMID:19940114   PMID:19946888   PMID:20014549   PMID:20040515   PMID:20056110   PMID:20080851   PMID:20130888   PMID:20144269   PMID:20156641  
PMID:20198455   PMID:20204403   PMID:20363921   PMID:20372914   PMID:20384870   PMID:20401558   PMID:20450430   PMID:20451577   PMID:20490454   PMID:20551380   PMID:20565834   PMID:20600357  
PMID:20622331   PMID:20628086   PMID:20635166   PMID:20682656   PMID:20695889   PMID:20698585   PMID:20711594   PMID:20713592   PMID:20729207   PMID:20800603   PMID:20807768   PMID:20812334  
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PMID:24909114   PMID:24924396   PMID:24940712   PMID:24940913   PMID:24945728   PMID:24947099   PMID:24981072   PMID:24984218   PMID:24996823   PMID:25007045   PMID:25014520   PMID:25034653  
PMID:25037231   PMID:25041837   PMID:25054620   PMID:25069762   PMID:25095870   PMID:25101304   PMID:25138305   PMID:25169435   PMID:25177969   PMID:25180794   PMID:25214264   PMID:25221953  
PMID:25222780   PMID:25254965   PMID:25260879   PMID:25268020   PMID:25274119   PMID:25282685   PMID:25303959   PMID:25307291   PMID:25315772   PMID:25316666   PMID:25339127   PMID:25369125  
PMID:25369297   PMID:25373317   PMID:25416956   PMID:25418979   PMID:25425968   PMID:25456698   PMID:25463412   PMID:25578395   PMID:25614283   PMID:25616863   PMID:25622682   PMID:25658354  
PMID:25662390   PMID:25684038   PMID:25684095   PMID:25684565   PMID:25689620   PMID:25697876   PMID:25703476   PMID:25753178   PMID:25765552   PMID:25788032   PMID:25814534   PMID:25819524  
PMID:25857722   PMID:25869013   PMID:25869099   PMID:25875367   PMID:25875595   PMID:25887000   PMID:25921557   PMID:25942420   PMID:25976729   PMID:25980453   PMID:25985013   PMID:25990624  
PMID:26116899   PMID:26118042   PMID:26129647   PMID:26142116   PMID:26142180   PMID:26158764   PMID:26165519   PMID:26168351   PMID:26173257   PMID:26186194   PMID:26224120   PMID:26264495  
PMID:26289852   PMID:26312551   PMID:26337870   PMID:26342075   PMID:26344197   PMID:26355912   PMID:26359845   PMID:26429330   PMID:26438086   PMID:26447186   PMID:26479349   PMID:26496610  
PMID:26525848   PMID:26546635   PMID:26571149   PMID:26582585   PMID:26582946   PMID:26589797   PMID:26656543   PMID:26663797   PMID:26693954   PMID:26708131   PMID:26718452   PMID:26722123  
PMID:26752347   PMID:26755550   PMID:26760037   PMID:26771117   PMID:26781273   PMID:26786981   PMID:26787685   PMID:26808993   PMID:26828748   PMID:26860036   PMID:26869635   PMID:26880404  
PMID:26885508   PMID:26891020   PMID:26894286   PMID:26896466   PMID:26911284   PMID:26912009   PMID:26934444   PMID:26944570   PMID:27012551   PMID:27013611   PMID:27035870   PMID:27059733  
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PMID:27512958   PMID:27538613   PMID:27559042   PMID:27566192   PMID:27590897   PMID:27591049   PMID:27603703   PMID:27614937   PMID:27617577   PMID:27626163   PMID:27629834   PMID:27630169  
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PMID:27900991   PMID:27917818   PMID:27926873   PMID:27939933   PMID:27959409   PMID:27981746   PMID:27982117   PMID:27983996   PMID:28002441   PMID:28011482   PMID:28068900   PMID:28079145  
PMID:28094123   PMID:28104787   PMID:28112232   PMID:28146425   PMID:28150280   PMID:28185839   PMID:28215640   PMID:28238096   PMID:28262193   PMID:28262838   PMID:28288987   PMID:28327460  
PMID:28360193   PMID:28364041   PMID:28390192   PMID:28406038   PMID:28430337   PMID:28431936   PMID:28438975   PMID:28446218   PMID:28456545   PMID:28468272   PMID:28469279   PMID:28514442  
PMID:28515276   PMID:28533486   PMID:28554765   PMID:28576849   PMID:28594391   PMID:28627758   PMID:28675297   PMID:28675934   PMID:28695825   PMID:28698921   PMID:28705047   PMID:28731466  
PMID:28743815   PMID:28775154   PMID:28795637   PMID:28822790   PMID:28826890   PMID:28828226   PMID:28830298   PMID:28848207   PMID:28865675   PMID:28869606   PMID:28870921   PMID:28872212  
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PMID:31511537   PMID:31514240   PMID:31515488   PMID:31521826   PMID:31527615   PMID:31536960   PMID:31540324   PMID:31586073   PMID:31593356   PMID:31594818   PMID:31682868   PMID:31687050  
PMID:31737173   PMID:31777257   PMID:31782085   PMID:31798282   PMID:31842510   PMID:31870801   PMID:31881201   PMID:31917884   PMID:31929564   PMID:32022821   PMID:32023902   PMID:32138174  
PMID:32144274   PMID:32157924   PMID:32159713   PMID:32196999   PMID:32221384   PMID:32295421   PMID:32296183   PMID:32312639   PMID:32343887   PMID:32398681   PMID:32416067   PMID:32457281  
PMID:32501939   PMID:32521226   PMID:32538210   PMID:32555606   PMID:32573308   PMID:32573962   PMID:32579956   PMID:32639409   PMID:32664510   PMID:32671973   PMID:32687490   PMID:32690320  
PMID:32695112   PMID:32703931   PMID:32754725   PMID:32755098   PMID:32770187   PMID:32784491   PMID:32801345   PMID:32838557   PMID:32852752   PMID:32886424   PMID:32893848   PMID:32901511  
PMID:32915505   PMID:32927397   PMID:32928962   PMID:32936667   PMID:32940080   PMID:33013832   PMID:33020562   PMID:33028850   PMID:33060727   PMID:33065093   PMID:33154744   PMID:33158139  
PMID:33167787   PMID:33203036   PMID:33277362   PMID:33300056   PMID:33308024   PMID:33309338   PMID:33352408   PMID:33398681   PMID:33408220   PMID:33484019   PMID:33486675   PMID:33566456  
PMID:33573443   PMID:33641161   PMID:33693708   PMID:33709179   PMID:33733487   PMID:33736691   PMID:33760180   PMID:33782343   PMID:33801193   PMID:33834359   PMID:33845483   PMID:33869196  
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PMID:35320524   PMID:35320554   PMID:35366371   PMID:35467088   PMID:35491999   PMID:35516420   PMID:35599381   PMID:35608796   PMID:35635536   PMID:35676659   PMID:35718316   PMID:35789267  
PMID:35812455   PMID:35817157   PMID:35831314   PMID:35900535   PMID:35906200   PMID:35917725   PMID:35934654   PMID:35941108   PMID:35944360   PMID:35955408   PMID:35976444   PMID:36113868  
PMID:36114006   PMID:36141752   PMID:36175599   PMID:36215168   PMID:36220879   PMID:36221351   PMID:36223831   PMID:36225252   PMID:36318198   PMID:36332381   PMID:36332898   PMID:36388167  
PMID:36449214   PMID:36481721   PMID:36499646   PMID:36504105   PMID:36527092   PMID:36537046   PMID:36546745   PMID:36583779   PMID:36591819   PMID:36624336   PMID:36633201   PMID:36656189  
PMID:36672849   PMID:36745560   PMID:36803120   PMID:36807052   PMID:36880731   PMID:36901846   PMID:36959138   PMID:36960864   PMID:36975419   PMID:36979345   PMID:37001908   PMID:37017753  
PMID:37055381   PMID:37070727   PMID:37079165   PMID:37112643   PMID:37127515   PMID:37129844   PMID:37164154   PMID:37175392   PMID:37175823   PMID:37180150   PMID:37202527   PMID:37298447  
PMID:37298569   PMID:37352334   PMID:37380081   PMID:37499664   PMID:37574746   PMID:37626284   PMID:37628961   PMID:37638704   PMID:37685918   PMID:37686069   PMID:37750426   PMID:37815932  
PMID:37849915   PMID:37875993   PMID:37958814   PMID:37988169   PMID:38070861   PMID:38113892   PMID:38151436   PMID:38172822   PMID:38201234   PMID:38216266   PMID:38237765   PMID:38251657  
PMID:38310085   PMID:38310352   PMID:38332916   PMID:38371379   PMID:38438589   PMID:38471823   PMID:38474141   PMID:38474195   PMID:38496616   PMID:38561725   PMID:38613883   PMID:38636895  
PMID:38641066   PMID:38674175   PMID:38693121   PMID:38755574   PMID:38787309   PMID:38840496   PMID:38878854   PMID:38930833   PMID:38951854   PMID:39084257   PMID:39097896   PMID:39193673  


Genomics

Comparative Map Data
LGALS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381455,129,252 - 55,145,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1455,124,110 - 55,145,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371455,595,970 - 55,612,148 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,665,625 - 54,681,901 (+)NCBINCBI36Build 36hg18NCBI36
Build 341454,665,757 - 54,681,881NCBI
Celera1435,645,428 - 35,661,641 (+)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1435,758,537 - 35,774,750 (+)NCBIHuRef
CHM1_11455,534,573 - 55,550,756 (+)NCBICHM1_1
T2T-CHM13v2.01449,334,442 - 49,350,620 (+)NCBIT2T-CHM13v2.0
Lgals3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,611,317 - 47,623,624 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,605,208 - 47,623,617 (+)EnsemblGRCm39 Ensembl
GRCm381447,373,860 - 47,386,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,367,751 - 47,386,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,993,535 - 48,005,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,295,795 - 46,308,037 (+)NCBIMGSCv36mm8
Celera1443,562,063 - 43,575,064 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
Lgals3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81523,099,795 - 23,111,731 (+)NCBIGRCr8
mRatBN7.21520,620,083 - 20,632,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,607,692 - 20,632,025 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1523,400,729 - 23,412,663 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,358,692 - 24,370,626 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,609,201 - 22,621,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01524,153,602 - 24,165,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1524,141,651 - 24,165,537 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01528,094,344 - 28,106,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,327,071 - 23,339,006NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1521,014,742 - 21,026,522 (+)NCBICelera
Cytogenetic Map15p14NCBI
Lgals3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,447,774 - 8,452,438 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,448,120 - 8,452,437 (-)NCBIChiLan1.0ChiLan1.0
LGALS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21556,250,524 - 56,266,924 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,467,032 - 55,483,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,715,850 - 35,732,263 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,990,023 - 54,006,412 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,990,023 - 54,006,412 (+)Ensemblpanpan1.1panPan2
LGALS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,977,438 - 30,994,711 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,983,633 - 30,994,705 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,752,177 - 30,763,224 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0831,236,480 - 31,254,738 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl831,236,550 - 31,254,723 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,846,505 - 30,857,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,923,589 - 30,934,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,288,737 - 31,299,778 (+)NCBIUU_Cfam_GSD_1.0
Lgals3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,252,712 - 74,264,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493669727,145 - 38,586 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493669720,861 - 38,568 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,478,710 - 184,497,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11184,478,639 - 184,496,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,956,478 - 204,974,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGALS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,311,343 - 32,328,335 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,311,271 - 32,328,339 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,546,585 - 20,562,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,298,201 - 14,304,637 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,300,138 - 14,307,843 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LGALS3
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002306.3(LGALS3):c.431+499G>A single nucleotide variant Lung cancer [RCV000098937] Chr14:55140862 [GRCh38]
Chr14:55607580 [GRCh37]
Chr14:14q22.3
uncertain significance
GRCh38/hg38 14q22.1-22.3(chr14:50591011-56286919)x1 copy number loss See cases [RCV000051519] Chr14:50591011..56286919 [GRCh38]
Chr14:51057729..56753637 [GRCh37]
Chr14:50127479..55823390 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q22.1-22.3(chr14:51544846-55320598)x1 copy number loss See cases [RCV000135883] Chr14:51544846..55320598 [GRCh38]
Chr14:52011564..55787316 [GRCh37]
Chr14:51081314..54857069 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q21.1-22.3(chr14:39196172-56714461)x3 copy number gain See cases [RCV000140717] Chr14:39196172..56714461 [GRCh38]
Chr14:39665376..57181179 [GRCh37]
Chr14:38735127..56250932 [NCBI36]
Chr14:14q21.1-22.3
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.2-22.3(chr14:54530302-55812050)x3 copy number gain not provided [RCV000683621] Chr14:54530302..55812050 [GRCh37]
Chr14:14q22.2-22.3
uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.2-22.3(chr14:55440068-55655692)x3 copy number gain not provided [RCV000751018] Chr14:55440068..55655692 [GRCh37]
Chr14:14q22.2-22.3
benign
NM_002306.4(LGALS3):c.30G>A (p.Ala10=) single nucleotide variant not provided [RCV000884254] Chr14:55138056 [GRCh38]
Chr14:55604774 [GRCh37]
Chr14:14q22.3
likely benign
NM_002306.4(LGALS3):c.498C>T (p.Asn166=) single nucleotide variant not provided [RCV000936426] Chr14:55142650 [GRCh38]
Chr14:55609368 [GRCh37]
Chr14:14q22.3
likely benign
NM_002306.4(LGALS3):c.24T>C (p.His8=) single nucleotide variant not provided [RCV000901280] Chr14:55138050 [GRCh38]
Chr14:55604768 [GRCh37]
Chr14:14q22.3
benign
NM_002306.4(LGALS3):c.548G>A (p.Arg183Lys) single nucleotide variant not provided [RCV000947568] Chr14:55142700 [GRCh38]
Chr14:55609418 [GRCh37]
Chr14:14q22.3
benign
NM_002306.4(LGALS3):c.18+7G>A single nucleotide variant not provided [RCV000879862] Chr14:55137398 [GRCh38]
Chr14:55604116 [GRCh37]
Chr14:14q22.3
benign
NM_002306.4(LGALS3):c.294C>T (p.Thr98=) single nucleotide variant not provided [RCV000957223] Chr14:55138320 [GRCh38]
Chr14:55605038 [GRCh37]
Chr14:14q22.3
benign
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3
likely pathogenic
GRCh37/hg19 14q22.1-22.3(chr14:53241194-55803026) copy number loss not specified [RCV002053104] Chr14:53241194..55803026 [GRCh37]
Chr14:14q22.1-22.3
pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33
pathogenic
NM_002306.4(LGALS3):c.485G>A (p.Arg162His) single nucleotide variant not specified [RCV004106171] Chr14:55142637 [GRCh38]
Chr14:55609355 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.386G>A (p.Arg129His) single nucleotide variant not specified [RCV004210078] Chr14:55140318 [GRCh38]
Chr14:55607036 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.545G>A (p.Gly182Glu) single nucleotide variant not specified [RCV004158150] Chr14:55142697 [GRCh38]
Chr14:55609415 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.89C>G (p.Pro30Arg) single nucleotide variant not specified [RCV004210854] Chr14:55138115 [GRCh38]
Chr14:55604833 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.422A>G (p.Asn141Ser) single nucleotide variant not specified [RCV004237905] Chr14:55140354 [GRCh38]
Chr14:55607072 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.671G>A (p.Arg224Gln) single nucleotide variant not specified [RCV004182479] Chr14:55145189 [GRCh38]
Chr14:55611907 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.72C>T (p.Gly24=) single nucleotide variant not provided [RCV003393440] Chr14:55138098 [GRCh38]
Chr14:55604816 [GRCh37]
Chr14:14q22.3
likely benign
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1
pathogenic
NM_002306.4(LGALS3):c.18G>A (p.Ser6=) single nucleotide variant not provided [RCV003393439] Chr14:55137391 [GRCh38]
Chr14:55604109 [GRCh37]
Chr14:14q22.3
likely benign
GRCh38/hg38 14q22.2-22.3(chr14:53949639-56297420)x1 copy number loss Dystonia 5 [RCV003984308] Chr14:53949639..56297420 [GRCh38]
Chr14:14q22.2-22.3
pathogenic
NM_002306.4(LGALS3):c.320A>G (p.Tyr107Cys) single nucleotide variant not specified [RCV004412834] Chr14:55138346 [GRCh38]
Chr14:55605064 [GRCh37]
Chr14:14q22.3
uncertain significance
NM_002306.4(LGALS3):c.576T>G (p.Phe192Leu) single nucleotide variant not specified [RCV004642381] Chr14:55142728 [GRCh38]
Chr14:55609446 [GRCh37]
Chr14:14q22.3
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR424hsa-miR-424-3pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI17889671

Predicted Target Of
Summary Value
Count of predictions:1004
Count of miRNA genes:666
Interacting mature miRNAs:753
Transcripts:ENST00000254301, ENST00000553493, ENST00000553755, ENST00000554715, ENST00000556263, ENST00000556322, ENST00000556438
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406899200GWAS548176_Hgalectin-3 measurement QTL GWAS548176 (human)1e-08galectin-3 measurement145514352455143525Human
407014645GWAS663621_Hblood protein measurement QTL GWAS663621 (human)3e-45blood protein measurementblood protein measurement (CMO:0000028)145513422155134222Human

Markers in Region
D14S878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371455,601,201 - 55,601,332UniSTSGRCh37
Build 361454,670,954 - 54,671,085RGDNCBI36
Celera1435,650,694 - 35,650,825RGD
Cytogenetic Map14q22.3UniSTS
HuRef1435,763,803 - 35,763,934UniSTS
Whitehead-YAC Contig Map14 UniSTS
G35459  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371455,601,951 - 55,602,089UniSTSGRCh37
Build 361454,671,704 - 54,671,842RGDNCBI36
Celera1435,651,444 - 35,651,582RGD
Cytogenetic Map14q22.3UniSTS
HuRef1435,764,553 - 35,764,691UniSTS
RH70554  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371455,604,532 - 55,604,668UniSTSGRCh37
Build 361454,674,285 - 54,674,421RGDNCBI36
Celera1435,654,025 - 35,654,161RGD
Cytogenetic Map14q22.3UniSTS
HuRef1435,767,134 - 35,767,270UniSTS
GeneMap99-GB4 RH Map14124.97UniSTS
WI-15390  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371455,611,853 - 55,612,003UniSTSGRCh37
Build 361454,681,606 - 54,681,756RGDNCBI36
Celera1435,661,346 - 35,661,496RGD
Cytogenetic Map14q22.3UniSTS
HuRef1435,774,455 - 35,774,605UniSTS
GeneMap99-GB4 RH Map14125.07UniSTS
Whitehead-RH Map14195.4UniSTS
RH69221  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371455,600,260 - 55,600,425UniSTSGRCh37
Build 361454,670,013 - 54,670,178RGDNCBI36
Celera1435,649,753 - 35,649,918RGD
Cytogenetic Map14q22.3UniSTS
HuRef1435,762,862 - 35,763,027UniSTS
GeneMap99-GB4 RH Map14124.97UniSTS
NCBI RH Map14559.2UniSTS
RH69146  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q22.3UniSTS
GeneMap99-GB4 RH Map14124.97UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2436 2788 2250 4948 1723 2349 5 623 1946 465 2269 7291 6461 53 3711 1 850 1741 1614 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_017089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_003225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB086821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF266280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX496996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX496998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG332134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ645629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU681070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX161455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD518618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ900920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S59012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000254301   ⟹   ENSP00000254301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,129,252 - 55,145,423 (+)Ensembl
Ensembl Acc Id: ENST00000553493   ⟹   ENSP00000451526
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,124,110 - 55,138,292 (+)Ensembl
Ensembl Acc Id: ENST00000553755
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,129,256 - 55,142,755 (+)Ensembl
Ensembl Acc Id: ENST00000554715   ⟹   ENSP00000451381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,129,260 - 55,143,721 (+)Ensembl
Ensembl Acc Id: ENST00000556263
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,138,044 - 55,140,440 (+)Ensembl
Ensembl Acc Id: ENST00000556322
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,137,369 - 55,142,678 (+)Ensembl
Ensembl Acc Id: ENST00000556438
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1455,137,188 - 55,145,413 (+)Ensembl
RefSeq Acc Id: NM_001357678   ⟹   NP_001344607
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381455,129,252 - 55,145,423 (+)NCBI
T2T-CHM13v2.01449,334,442 - 49,350,613 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002306   ⟹   NP_002297
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381455,129,252 - 55,145,423 (+)NCBI
GRCh371455,595,935 - 55,612,148 (+)ENTREZGENE
Build 361454,665,625 - 54,681,901 (+)NCBI Archive
HuRef1435,758,537 - 35,774,750 (+)ENTREZGENE
CHM1_11455,534,573 - 55,550,756 (+)NCBI
T2T-CHM13v2.01449,334,442 - 49,350,613 (+)NCBI
Sequence:
RefSeq Acc Id: NR_003225
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381455,136,983 - 55,145,430 (+)NCBI
GRCh371455,595,935 - 55,612,148 (+)ENTREZGENE
Build 361454,673,659 - 54,681,901 (+)NCBI Archive
HuRef1435,758,537 - 35,774,750 (+)ENTREZGENE
CHM1_11455,542,309 - 55,550,756 (+)NCBI
T2T-CHM13v2.01449,342,173 - 49,350,620 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001344607 (Get FASTA)   NCBI Sequence Viewer  
  NP_002297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35607 (Get FASTA)   NCBI Sequence Viewer  
  AAA36163 (Get FASTA)   NCBI Sequence Viewer  
  AAA88086 (Get FASTA)   NCBI Sequence Viewer  
  AAB26229 (Get FASTA)   NCBI Sequence Viewer  
  AAG44701 (Get FASTA)   NCBI Sequence Viewer  
  AAG44702 (Get FASTA)   NCBI Sequence Viewer  
  AAH01120 (Get FASTA)   NCBI Sequence Viewer  
  AAH53667 (Get FASTA)   NCBI Sequence Viewer  
  AAH68068 (Get FASTA)   NCBI Sequence Viewer  
  ADO22437 (Get FASTA)   NCBI Sequence Viewer  
  BAA22164 (Get FASTA)   NCBI Sequence Viewer  
  BAC45249 (Get FASTA)   NCBI Sequence Viewer  
  BAD92628 (Get FASTA)   NCBI Sequence Viewer  
  BAG37435 (Get FASTA)   NCBI Sequence Viewer  
  CAD48745 (Get FASTA)   NCBI Sequence Viewer  
  CAD48746 (Get FASTA)   NCBI Sequence Viewer  
  CAD61918 (Get FASTA)   NCBI Sequence Viewer  
  CAE46042 (Get FASTA)   NCBI Sequence Viewer  
  CAG33178 (Get FASTA)   NCBI Sequence Viewer  
  CAG46894 (Get FASTA)   NCBI Sequence Viewer  
  CBX53892 (Get FASTA)   NCBI Sequence Viewer  
  EAW80658 (Get FASTA)   NCBI Sequence Viewer  
  EAW80660 (Get FASTA)   NCBI Sequence Viewer  
  EAW80661 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000254301
  ENSP00000254301.9
  ENSP00000451381.1
  ENSP00000451526.1
GenBank Protein P17931 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_002297   ⟸   NM_002306
- Peptide Label: isoform 1
- UniProtKB: Q6IBA7 (UniProtKB/Swiss-Prot),   Q16005 (UniProtKB/Swiss-Prot),   B2RC38 (UniProtKB/Swiss-Prot),   Q96J47 (UniProtKB/Swiss-Prot),   P17931 (UniProtKB/Swiss-Prot),   A0A024R693 (UniProtKB/TrEMBL),   Q6FGL0 (UniProtKB/TrEMBL),   Q6NVH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344607   ⟸   NM_001357678
- Peptide Label: isoform 3
- UniProtKB: Q6FGL0 (UniProtKB/TrEMBL),   Q6NVH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000254301   ⟸   ENST00000254301
Ensembl Acc Id: ENSP00000451526   ⟸   ENST00000553493
Ensembl Acc Id: ENSP00000451381   ⟸   ENST00000554715
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17931-F1-model_v2 AlphaFold P17931 1-250 view protein structure

Promoters
RGD ID:6791718
Promoter ID:HG_KWN:19421
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001177388,   UC001XBR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361454,665,626 - 54,666,126 (+)MPROMDB
RGD ID:6851776
Promoter ID:EP73692
Type:multiple initiation site
Name:HS_LGALS3
Description:Lectin, galactoside-binding, soluble, 3 (galectin 3).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361454,665,720 - 54,665,780EPD
RGD ID:6791719
Promoter ID:HG_KWN:19422
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:ENST00000399106,   NR_003225
Position:
Human AssemblyChrPosition (strand)Source
Build 361454,672,636 - 54,674,737 (+)MPROMDB
RGD ID:7227683
Promoter ID:EPDNEW_H19587
Type:initiation region
Name:LGALS3_1
Description:galectin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381455,129,252 - 55,129,312EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6563 AgrOrtholog
COSMIC LGALS3 COSMIC
Ensembl Genes ENSG00000131981 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000254301 ENTREZGENE
  ENST00000254301.14 UniProtKB/Swiss-Prot
  ENST00000553493.5 UniProtKB/TrEMBL
  ENST00000554715.1 UniProtKB/TrEMBL
  ENST00000556438 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000131981 GTEx
HGNC ID HGNC:6563 ENTREZGENE
Human Proteome Map LGALS3 Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galectin_CRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3958 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3958 ENTREZGENE
OMIM 153619 OMIM
PANTHER PTHR11346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11346:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30340 PharmGKB
PROSITE GALECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Gal-bind_lectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R693 ENTREZGENE, UniProtKB/TrEMBL
  B2RC38 ENTREZGENE
  G3V3R6_HUMAN UniProtKB/TrEMBL
  G3V407_HUMAN UniProtKB/TrEMBL
  LEG3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q16005 ENTREZGENE
  Q6FGL0 ENTREZGENE, UniProtKB/TrEMBL
  Q6IBA7 ENTREZGENE
  Q6NVH9 ENTREZGENE, UniProtKB/TrEMBL
  Q96J47 ENTREZGENE
UniProt Secondary B2RC38 UniProtKB/Swiss-Prot
  Q16005 UniProtKB/Swiss-Prot
  Q6IBA7 UniProtKB/Swiss-Prot
  Q96J47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-23 LGALS3  galectin 3    lectin, galactoside binding soluble 3  Symbol and/or name change 5135510 APPROVED
2016-04-12 LGALS3  lectin, galactoside binding soluble 3    lectin, galactoside-binding, soluble, 3  Symbol and/or name change 5135510 APPROVED