Cd163 (CD163 molecule) - Rat Genome Database

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Gene: Cd163 (CD163 molecule) Rattus norvegicus
Analyze
Symbol: Cd163
Name: CD163 molecule
RGD ID: 1310382
Description: Predicted to enable scaffold protein binding activity. Involved in multicellular organism aging. Located in cell surface. Biomarker of uveitis. Orthologous to human CD163 (CD163 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD163 antigen; cluster of differentiation 163; ED2; LOC312701; scavenger receptor cysteine-rich type 1 protein M130
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,085,080 - 157,118,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,085,093 - 157,117,878 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,335,769 - 163,369,111 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,118,672 - 159,152,022 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04157,764,068 - 157,797,421 (+)NCBIRnor_WKY
Rnor_6.04156,752,063 - 156,785,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4156,752,082 - 156,785,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04223,769,336 - 223,802,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,394,833 - 160,428,208 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,639,152 - 160,669,269 (+)NCBI
Celera4145,861,321 - 145,894,692 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abdominal Obesity  (ISO)
Actinobacillus Infections  (ISO)
acute pancreatitis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
autosomal dominant familial periodic fever  (ISO)
brucellosis  (ISO)
carotid artery disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
developmental and epileptic encephalopathy 21  (ISO)
diverticulitis of colon  (ISO)
Ebola hemorrhagic fever  (ISO)
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 9  (ISO)
Epstein-Barr Virus Infections  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
glomerulonephritis  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
hepatocellular carcinoma  (ISO)
hidradenitis suppurativa  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Viral Hepatitis  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
Klippel-Feil syndrome 3  (ISO)
lepromatous leprosy  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
malaria  (ISO)
Metabolic Syndrome  (ISO)
multisystem inflammatory syndrome in children  (ISO)
nasopharynx carcinoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
peroxisome biogenesis disorder 2B  (ISO)
pneumonia  (ISO)
Porcine Reproductive and Respiratory Syndrome  (ISO)
pulmonary tuberculosis  (ISO)
Sepsis  (ISO)
Spinal Cord Compression  (IEP)
Spontaneous Abortions  (ISO)
Staphylococcal Infections  (ISO)
Temtamy syndrome  (ISO)
Traumatic Brain Injuries  (IEP)
uveitis  (IEP)
visceral leishmaniasis  (ISO)
Whipple disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butoxyethanol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
deguelin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (EXP)
ethanol  (ISO)
flutamide  (EXP)
fructose  (EXP,ISO)
gadolinium trichloride  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CD163 levels, pro- and anti-inflammatory cytokine secretion of monocytes in children with pulmonary tuberculosis. Aktas Cetin E, etal., Pediatr Pulmonol. 2017 May;52(5):675-683. doi: 10.1002/ppul.23617. Epub 2016 Sep 29.
2. Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma. Azambuja D, etal., Ann Oncol. 2012 Mar;23(3):736-742. doi: 10.1093/annonc/mdr157. Epub 2011 May 20.
3. Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. Beltrán LM, etal., PLoS One. 2014 Mar 4;9(3):e90541. doi: 10.1371/journal.pone.0090541. eCollection 2014.
4. Collagen deposition in chronic hidradenitis suppurativa: potential role for CD163+ macrophages. Byrd AS, etal., Br J Dermatol. 2018 Sep;179(3):792-794. doi: 10.1111/bjd.16600. Epub 2018 Jun 29.
5. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
6. Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis. Dighal A, etal., PLoS Negl Trop Dis. 2020 Feb 5;14(2):e0007991. doi: 10.1371/journal.pntd.0007991. eCollection 2020 Feb.
7. The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-α production. Dimitrijević M, etal., Exp Gerontol. 2013 Nov;48(11):1243-54. doi: 10.1016/j.exger.2013.07.001. Epub 2013 Jul 11.
8. The macrophage activation marker CD163 is associated with IL28B genotype and hepatic inflammation in chronic hepatitis C virus infected patients. Dultz G, etal., J Viral Hepat. 2016 Apr;23(4):267-73. doi: 10.1111/jvh.12488. Epub 2015 Nov 10.
9. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. Etzerodt A, etal., J Exp Med. 2020 Apr 6;217(4). pii: 133611. doi: 10.1084/jem.20191869.
10. CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. Fischer-Riepe L, etal., J Allergy Clin Immunol. 2020 Nov;146(5):1137-1151. doi: 10.1016/j.jaci.2020.02.034. Epub 2020 Mar 19.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Serum soluble CD163 levels in patients with influenza-associated encephalopathy. Hasegawa S, etal., Brain Dev. 2013 Aug;35(7):626-9. doi: 10.1016/j.braindev.2012.10.005. Epub 2012 Nov 11.
13. Soluble CD163-Associated Dietary Patterns and the Risk of Metabolic Syndrome. Hu TY, etal., Nutrients. 2019 Apr 25;11(4). pii: nu11040940. doi: 10.3390/nu11040940.
14. M2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and Epstein-Barr viral infection in nasopharyngeal carcinoma. Huang H, etal., Acta Otolaryngol. 2017 Aug;137(8):888-894. doi: 10.1080/00016489.2017.1296585. Epub 2017 Apr 10.
15. Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C. Kazankov K, etal., Hepatology. 2014 Aug;60(2):521-30. doi: 10.1002/hep.27129. Epub 2014 May 6.
16. Monocyte expression and soluble levels of the haemoglobin receptor (CD163/sCD163) and the mannose receptor (MR/sMR) in septic and critically ill non-septic ICU patients. Kjærgaard AG, etal., PLoS One. 2014 Mar 17;9(3):e92331. doi: 10.1371/journal.pone.0092331. eCollection 2014.
17. Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma. Komohara Y, etal., Cancer Sci. 2013 Jul;104(7):945-51. doi: 10.1111/cas.12167. Epub 2013 May 9.
18. Levels of soluble CD163 and severity of malaria in children in Ghana. Kusi KA, etal., Clin Vaccine Immunol. 2008 Sep;15(9):1456-60. doi: 10.1128/CVI.00506-07. Epub 2008 Jul 16.
19. Expression of CD206 and CD163 on intermediate CD14++CD16+ monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. Li X, etal., Virus Res. 2018 Jul 15;253:92-102. doi: 10.1016/j.virusres.2018.05.021. Epub 2018 May 29.
20. Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1. McElroy AK, etal., Emerg Infect Dis. 2019 Feb;25(2):290-298. doi: 10.3201/eid2502.181326.
21. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Mendonça VR, etal., Infect Immun. 2012 Apr;80(4):1445-54. doi: 10.1128/IAI.05933-11. Epub 2012 Jan 30.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Impaired immune functions of monocytes and macrophages in Whipple's disease. Moos V, etal., Gastroenterology. 2010 Jan;138(1):210-20. doi: 10.1053/j.gastro.2009.07.066. Epub 2009 Aug 5.
24. CD163 favors Mycobacterium leprae survival and persistence by promoting anti-inflammatory pathways in lepromatous macrophages. Moura DF, etal., Eur J Immunol. 2012 Nov;42(11):2925-36. doi: 10.1002/eji.201142198. Epub 2012 Sep 14.
25. Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis. Nagai M, etal., Scand J Rheumatol. 2016 Oct;45(5):397-403. doi: 10.3109/03009742.2015.1127410. Epub 2016 Apr 20.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. Schaer DJ, etal., Eur J Haematol. 2005 Jan;74(1):6-10. doi: 10.1111/j.1600-0609.2004.00318.x.
30. sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. Silva RL, etal., PLoS Negl Trop Dis. 2017 Mar 29;11(3):e0005486. doi: 10.1371/journal.pntd.0005486. eCollection 2017 Mar.
31. Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology. Spitsin S, etal., J Neurol Sci. 2013 Nov 15;334(1-2):18-23. doi: 10.1016/j.jns.2013.07.008. Epub 2013 Aug 2.
32. Serum levels of soluble CD163 and soluble CD14 following antibiotic therapy of patients with acute brucellosis. Sun H, etal., J Infect Dev Ctries. 2019 Aug 31;13(8):714-719. doi: 10.3855/jidc.10602.
33. Utility of Macrophage-activated Marker CD163 for Diagnosis and Prognosis in Pulmonary Tuberculosis. Suzuki Y, etal., Ann Am Thorac Soc. 2017 Jan;14(1):57-64. doi: 10.1513/AnnalsATS.201607-528OC.
34. Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder. Underwood ML, etal., AIDS. 2020 Feb 1;34(2):177-188. doi: 10.1097/QAD.0000000000002416.
35. Cellular neuroinflammation in a lateral forceps compression model of spinal cord injury. Vaughn CN, etal., Anat Rec (Hoboken). 2013 Aug;296(8):1229-46. doi: 10.1002/ar.22730. Epub 2013 Jun 17.
36. Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages. von Rahden BH, etal., Langenbecks Arch Surg. 2011 Aug;396(6):759-68. doi: 10.1007/s00423-011-0797-4. Epub 2011 May 7.
37. Expression of serum sCD163 in patients with liver diseases and inflammatory disorders. Wang J, etal., Int J Clin Exp Pathol. 2015 Jul 1;8(7):8419-25. eCollection 2015.
38. Elevated soluble CD163 plasma levels are associated with disease severity in patients with hemorrhagic fever with renal syndrome. Wang J, etal., PLoS One. 2014 Nov 13;9(11):e112127. doi: 10.1371/journal.pone.0112127. eCollection 2014.
39. Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure. Ye H, etal., World J Gastroenterol. 2013 May 14;19(18):2818-25. doi: 10.3748/wjg.v19.i18.2818.
40. Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure. Zhang M, etal., J Transl Med. 2014 Mar 6;12:60. doi: 10.1186/1479-5876-12-60.
41. Soluble Scavenger Receptor CD163 Is Associated with Severe Acute Kidney Injury in Patients with Hantaan Virus Infection. Zhang Y, etal., Viral Immunol. 2015 May;28(4):241-6. doi: 10.1089/vim.2014.0112. Epub 2015 Mar 19.
42. Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury. Zhang Z, etal., Brain Res. 2012 Jun 21;1461:102-10. doi: 10.1016/j.brainres.2012.04.038. Epub 2012 Apr 27.
Additional References at PubMed
PMID:16434690   PMID:16920481   PMID:17353345   PMID:23326413   PMID:24942581  


Genomics

Comparative Map Data
Cd163
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,085,080 - 157,118,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,085,093 - 157,117,878 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,335,769 - 163,369,111 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,118,672 - 159,152,022 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04157,764,068 - 157,797,421 (+)NCBIRnor_WKY
Rnor_6.04156,752,063 - 156,785,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4156,752,082 - 156,785,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04223,769,336 - 223,802,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,394,833 - 160,428,208 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,639,152 - 160,669,269 (+)NCBI
Celera4145,861,321 - 145,894,692 (+)NCBICelera
Cytogenetic Map4q42NCBI
CD163
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,470,811 - 7,503,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl127,470,811 - 7,503,893 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,623,407 - 7,656,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,514,676 - 7,547,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,515,020 - 7,547,639NCBI
Celera129,198,918 - 9,231,725 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,436,319 - 7,469,334 (-)NCBIHuRef
CHM1_1127,622,379 - 7,655,379 (-)NCBICHM1_1
T2T-CHM13v2.0127,484,506 - 7,517,489 (-)NCBIT2T-CHM13v2.0
Cd163
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,281,596 - 124,307,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,281,615 - 124,307,486 (+)EnsemblGRCm39 Ensembl
GRCm386124,304,636 - 124,330,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,304,656 - 124,330,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,254,669 - 124,280,545 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,270,275 - 124,296,146 (+)NCBIMGSCv36mm8
Celera6125,994,313 - 126,020,180 (+)NCBICelera
Cytogenetic Map6F2NCBI
CD163
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,779,244 - 7,812,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,775,343 - 7,810,023 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,616,714 - 7,649,768 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD163
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,669,757 - 37,700,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,669,827 - 37,753,106 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,915,837 - 8,946,494 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,023,513 - 38,054,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,023,571 - 38,105,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,898,042 - 37,928,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,939,566 - 37,969,977 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,402,538 - 8,433,169 (-)NCBIUU_Cfam_GSD_1.0
CD163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,300,231 - 63,334,498 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,300,200 - 63,334,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD163
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,501,562 - 7,536,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,501,150 - 7,536,295 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666063667,595 - 702,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd163
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,975,747 - 4,000,349 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,976,746 - 4,000,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd163
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:348
Count of miRNA genes:219
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000068407
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
731178Oia7Oil induced arthritis QTL 70.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4156050654157232313Rat

Markers in Region
RH140276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,117,692 - 157,117,847 (+)MAPPERmRatBN7.2
Rnor_6.04156,784,690 - 156,784,844NCBIRnor6.0
Rnor_5.04223,801,948 - 223,802,102UniSTSRnor5.0
RGSC_v3.44160,427,431 - 160,427,585UniSTSRGSC3.4
Celera4145,893,915 - 145,894,069UniSTS
RH 3.4 Map41002.7UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 35 26 18 26 2 2
Low 3 28 14 7 1 7 8 11 45 20 28 9 8
Below cutoff 2 2 2 2 7 11 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068407   ⟹   ENSRNOP00000058828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,085,093 - 157,117,877 (+)Ensembl
Rnor_6.0 Ensembl4156,752,093 - 156,785,467 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084588   ⟹   ENSRNOP00000069665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,085,093 - 157,117,878 (+)Ensembl
Rnor_6.0 Ensembl4156,752,082 - 156,784,869 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096376   ⟹   ENSRNOP00000080333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,085,590 - 157,117,877 (+)Ensembl
RefSeq Acc Id: NM_001107887   ⟹   NP_001101357
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,085,093 - 157,118,470 (+)NCBI
Rnor_6.04156,752,093 - 156,785,467 (+)NCBI
Rnor_5.04223,769,336 - 223,802,725 (+)NCBI
RGSC_v3.44160,394,833 - 160,428,208 (+)RGD
Celera4145,861,321 - 145,894,692 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237352   ⟹   XP_006237414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,085,080 - 157,117,877 (+)NCBI
Rnor_6.04156,752,063 - 156,784,874 (+)NCBI
Rnor_5.04223,769,336 - 223,802,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592650   ⟹   XP_017448139
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,085,080 - 157,117,877 (+)NCBI
Rnor_6.04156,752,063 - 156,784,874 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592651   ⟹   XP_017448140
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,085,080 - 157,117,877 (+)NCBI
Rnor_6.04156,752,063 - 156,784,874 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101357 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237414 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448139 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448140 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM01961 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101357   ⟸   NM_001107887
- UniProtKB: D3Z9U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237414   ⟸   XM_006237352
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448139   ⟸   XM_017592650
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448140   ⟸   XM_017592651
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069665   ⟸   ENSRNOT00000084588
RefSeq Acc Id: ENSRNOP00000058828   ⟸   ENSRNOT00000068407
RefSeq Acc Id: ENSRNOP00000080333   ⟸   ENSRNOT00000096376
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9U2-F1-model_v2 AlphaFold D3Z9U2 1-1120 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693376
Promoter ID:EPDNEW_R3901
Type:initiation region
Name:Cd163_1
Description:CD163 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04156,752,107 - 156,752,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310382 AgrOrtholog
BioCyc Gene G2FUF-43112 BioCyc
Ensembl Genes ENSRNOG00000010253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000058828 ENTREZGENE
  ENSRNOP00000058828.2 UniProtKB/TrEMBL
  ENSRNOP00000069665 ENTREZGENE
  ENSRNOP00000069665.2 UniProtKB/TrEMBL
  ENSRNOP00000080333.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068407 ENTREZGENE
  ENSRNOT00000068407.2 UniProtKB/TrEMBL
  ENSRNOT00000084588 ENTREZGENE
  ENSRNOT00000084588.2 UniProtKB/TrEMBL
  ENSRNOT00000096376.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
  Srcr_rcpt-rel UniProtKB/TrEMBL
KEGG Report rno:312701 UniProtKB/TrEMBL
NCBI Gene 312701 ENTREZGENE
Pfam SRCR UniProtKB/TrEMBL
PhenoGen Cd163 PhenoGen
PRINTS SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Srcr_receptor UniProtKB/TrEMBL
UniProt A0A0G2JVY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQF0_RAT UniProtKB/TrEMBL
  D3Z9U2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd163  Cd163 molecule  Cd163  CD163 antigen   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Cd163  CD163 molecule  Cd163  Cd163 molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cd163  CD163 antigen   Cd163_predicted  CD163 antigen (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cd163_predicted  CD163 antigen (predicted)      Symbol and Name status set to approved 70820 APPROVED