Cops3 (COP9 signalosome subunit 3) - Rat Genome Database

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Gene: Cops3 (COP9 signalosome subunit 3) Rattus norvegicus
Analyze
Symbol: Cops3
Name: COP9 signalosome subunit 3
RGD ID: 1303002
Description: Predicted to be involved in protein deneddylation; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COP9 (constitutive photomorphogenic) homolog, subunit 3; COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana); COP9 constitutive photomorphogenic homolog subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 signalosome complex subunit 3; MGC94156; SGN3; signalosome subunit 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,117,664 - 45,151,868 (-)NCBIGRCr8
mRatBN7.21044,618,115 - 44,652,807 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,618,115 - 44,641,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,318,474 - 49,341,861 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,808,835 - 48,832,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,312,440 - 44,335,827 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,182,680 - 46,206,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,182,687 - 46,206,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,938,610 - 45,962,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,139,837 - 46,163,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,153,461 - 46,176,869 (-)NCBI
Celera1043,879,656 - 43,903,024 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
COP9 signalosome  (IBA,IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
perinuclear region of cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6. COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Yan J, etal., Mol Cell Biol 2003 Oct;23(19):6798-808.
Additional References at PubMed
PMID:9707402   PMID:18850735   PMID:19141280   PMID:22871113  


Genomics

Comparative Map Data
Cops3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,117,664 - 45,151,868 (-)NCBIGRCr8
mRatBN7.21044,618,115 - 44,652,807 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,618,115 - 44,641,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,318,474 - 49,341,861 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,808,835 - 48,832,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,312,440 - 44,335,827 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,182,680 - 46,206,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,182,687 - 46,206,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,938,610 - 45,962,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,139,837 - 46,163,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,153,461 - 46,176,869 (-)NCBI
Celera1043,879,656 - 43,903,024 (-)NCBICelera
Cytogenetic Map10q22NCBI
COPS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,246,616 - 17,281,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,246,616 - 17,281,273 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,149,930 - 17,184,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,090,864 - 17,125,316 (-)NCBINCBI36Build 36hg18NCBI36
Build 341717,090,865 - 17,125,316NCBI
Celera1718,089,725 - 18,124,196 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,902,830 - 16,937,477 (-)NCBIHuRef
CHM1_11717,159,638 - 17,194,346 (-)NCBICHM1_1
T2T-CHM13v2.01717,192,637 - 17,227,324 (-)NCBIT2T-CHM13v2.0
Cops3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,708,621 - 59,739,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,708,621 - 59,730,664 (-)EnsemblGRCm39 Ensembl
GRCm381159,817,795 - 59,848,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,817,795 - 59,839,838 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,631,306 - 59,653,269 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,354,384 - 60,376,347 (-)NCBIMGSCv36mm8
MGSCv361159,633,999 - 59,655,962 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.8NCBI
Cops3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577638,749 - 664,390 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577639,616 - 664,390 (+)NCBIChiLan1.0ChiLan1.0
COPS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21951,764,384 - 51,799,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11756,476,072 - 56,510,971 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,013,180 - 34,047,546 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,944,506 - 38,978,514 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,944,618 - 38,978,235 (+)Ensemblpanpan1.1panPan2
COPS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,143,397 - 42,169,509 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,143,474 - 42,169,517 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,283,352 - 42,309,239 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,251,785 - 42,277,904 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,251,786 - 42,280,691 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,218,758 - 42,244,870 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,166,098 - 42,192,196 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,358,201 - 42,384,316 (+)NCBIUU_Cfam_GSD_1.0
Cops3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,936,099 - 61,961,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741905,252 - 931,408 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936741905,593 - 931,148 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COPS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,994,310 - 61,024,846 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,000,562 - 61,023,920 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,034,590 - 63,057,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COPS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,280,490 - 16,331,538 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660594,596,000 - 4,632,806 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cops3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248494,124,586 - 4,150,933 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248494,125,188 - 4,150,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cops3
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:131
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000004438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat

Markers in Region
RH137040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,618,270 - 44,618,429 (+)MAPPERmRatBN7.2
Rnor_6.01046,182,827 - 46,182,985NCBIRnor6.0
Rnor_5.01045,938,758 - 45,938,916UniSTSRnor5.0
RGSC_v3.41046,139,984 - 46,140,142UniSTSRGSC3.4
Celera1043,879,805 - 43,879,963UniSTS
Cytogenetic Map10q22UniSTS
RH129531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,618,165 - 44,618,382 (+)MAPPERmRatBN7.2
Rnor_6.01046,182,722 - 46,182,938NCBIRnor6.0
Rnor_5.01045,938,653 - 45,938,869UniSTSRnor5.0
RGSC_v3.41046,139,879 - 46,140,095UniSTSRGSC3.4
Celera1043,879,698 - 43,879,916UniSTS
RH 3.4 Map10525.9UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000091471   ⟹   ENSRNOP00000069208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,618,115 - 44,641,597 (-)Ensembl
Rnor_6.0 Ensembl1046,182,687 - 46,206,135 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113689   ⟹   ENSRNOP00000078108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,618,115 - 44,639,442 (-)Ensembl
RefSeq Acc Id: NM_001004200   ⟹   NP_001004200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,117,664 - 45,141,071 (-)NCBI
mRatBN7.21044,618,124 - 44,641,533 (-)NCBI
Rnor_6.01046,182,680 - 46,206,083 (-)NCBI
Rnor_5.01045,938,610 - 45,962,047 (-)NCBI
RGSC_v3.41046,139,837 - 46,163,246 (-)RGD
Celera1043,879,656 - 43,903,024 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597079   ⟹   XP_017452568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,117,664 - 45,134,584 (-)NCBI
mRatBN7.21044,618,115 - 44,638,568 (-)NCBI
Rnor_6.01046,182,680 - 46,203,118 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085398   ⟹   XP_038941326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,117,664 - 45,151,868 (-)NCBI
mRatBN7.21044,618,115 - 44,652,807 (-)NCBI
RefSeq Acc Id: XM_039085399   ⟹   XP_038941327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,117,664 - 45,141,112 (-)NCBI
mRatBN7.21044,618,115 - 44,641,605 (-)NCBI
RefSeq Acc Id: XM_063268611   ⟹   XP_063124681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,117,664 - 45,141,095 (-)NCBI
RefSeq Acc Id: XM_063268612   ⟹   XP_063124682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,123,149 - 45,141,136 (-)NCBI
RefSeq Acc Id: XR_005489723
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,123,149 - 45,141,136 (-)NCBI
mRatBN7.21044,618,115 - 44,641,603 (-)NCBI
RefSeq Acc Id: NP_001004200   ⟸   NM_001004200
- UniProtKB: Q68FW9 (UniProtKB/Swiss-Prot),   A0A8I5Y8F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452568   ⟸   XM_017597079
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000069208   ⟸   ENSRNOT00000091471
RefSeq Acc Id: XP_038941326   ⟸   XM_039085398
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941327   ⟸   XM_039085399
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y8F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078108   ⟸   ENSRNOT00000113689
RefSeq Acc Id: XP_063124681   ⟸   XM_063268611
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124682   ⟸   XM_063268612
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FW9-F1-model_v2 AlphaFold Q68FW9 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697240
Promoter ID:EPDNEW_R7765
Type:initiation region
Name:Cops3_1
Description:COP9 signalosome subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,206,124 - 46,206,184EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303002 AgrOrtholog
BioCyc Gene G2FUF-24872 BioCyc
Ensembl Genes ENSRNOG00000053943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026801 UniProtKB/Swiss-Prot
  ENSRNOG00060030239 UniProtKB/Swiss-Prot
  ENSRNOG00065007921 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091471 ENTREZGENE
  ENSRNOT00000091471.2 UniProtKB/Swiss-Prot
  ENSRNOT00000113689.1 UniProtKB/TrEMBL
  ENSRNOT00055046438 UniProtKB/Swiss-Prot
  ENSRNOT00060052722 UniProtKB/Swiss-Prot
  ENSRNOT00065012476 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128107 IMAGE-MGC_LOAD
InterPro CSN3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287367 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94156 IMAGE-MGC_LOAD
NCBI Gene 287367 ENTREZGENE
PANTHER 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10758:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CSN3-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cops3 PhenoGen
PROSITE PCI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053943 RatGTEx
  ENSRNOG00055026801 RatGTEx
  ENSRNOG00060030239 RatGTEx
  ENSRNOG00065007921 RatGTEx
SMART PINT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y8F4 ENTREZGENE, UniProtKB/TrEMBL
  A6HF17_RAT UniProtKB/TrEMBL
  A6HF18_RAT UniProtKB/TrEMBL
  A6HF19_RAT UniProtKB/TrEMBL
  CSN3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Cops3  COP9 signalosome subunit 3  Cops3  COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Cops3  COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)  Cops3  COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cops3  COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)    COP9 constitutive photomorphogenic homolog subunit 3  Name updated 1299863 APPROVED
2005-02-14 Cops3  COP9 constitutive photomorphogenic homolog subunit 3      Symbol and Name status set to provisional 70820 PROVISIONAL