Sox17 (SRY-box transcription factor 17)

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Gene: Sox17 (SRY-box transcription factor 17) Rattus norvegicus

Analyze

Symbol:

Sox17

Name:

SRY-box transcription factor 17

RGD ID:

1305371

Description:

Enables sequence-specific double-stranded DNA binding activity. Involved in response to alkaloid. Located in nucleus. Biomarker of cholangiocarcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in intracranial aneurysm; patent ductus arteriosus; and vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC312936; SRY (sex determining region Y)-box 17; SRY box 17; SRY-box containing gene 17; transcription factor SOX-17

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SOX17 (SRY-box transcription factor 17)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Sox17 (SRY (sex determining region Y)-box 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sox17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SOX17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SOX17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sox17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SOX17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SOX17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sox17 (SRY-box transcription factor 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PTPN5 (protein tyrosine phosphatase non-receptor type 5)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SOX17 (SRY-box transcription factor 17)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sox17 (SRY (sex determining region Y)-box 17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sox17 (SRY (sex determining region Y)-box 17)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	D	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Sox15	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	sox17a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sox17b.1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	15,016,660 - 15,022,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	15,016,731 - 15,022,228 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	17,215,894 - 17,221,391 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	18,819,700 - 18,825,180 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	18,550,534 - 18,556,035 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	14,890,318 - 14,895,907 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	14,890,408 - 14,895,907 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	19,675,563 - 19,681,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	15,241,405 - 15,246,904 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	15,244,440 - 15,246,899 (+)	NCBI
Celera	5	14,398,084 - 14,403,591 (+)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

biliary atresia (ISS)

cholangiocarcinoma (IEP)

Colorectal Neoplasms (ISO)

genetic disease (ISO)

hypertensive retinopathy (ISO)

intracranial aneurysm (ISO)

patent ductus arteriosus (ISO)

primary pulmonary hypertension (ISO)

Primary Pulmonary Hypertension, 1 (ISO)

Pulmonary Arterial Hypertension (ISO)

pulmonary hypertension (IEP)

Pulmonary Hypertension, Hypoxia-Induced (ISO)

Teratogenesis (ISO)

vesicoureteral reflux (ISO)

Vesicoureteral Reflux 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-bromo-2'-deoxyuridine (ISO)

5-fluorouracil (ISO)

6-aminonicotinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetic acid (ISO)

actinomycin D (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

all-trans-retinol (ISO)

angiotensin II (ISO)

Aroclor 1254 (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

C60 fullerene (EXP)

calciol (ISO)

camptothecin (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

CHIR 99021 (ISO)

Chlorophacinone (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

columbamine (ISO)

Cuprizon (EXP)

diethylstilbestrol (ISO)

dimethyl sulfoxide (ISO)

diniconazole (ISO)

dinoseb (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fenvalerate (EXP)

fluazinam (ISO)

flusilazole (ISO)

folic acid (ISO)

gefitinib (ISO)

genistein (EXP,ISO)

gentamycin (EXP)

hexaconazole (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

isoprenaline (ISO)

isotretinoin (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

maleic acid (ISO)

methamphetamine (EXP)

mianserin (ISO)

mifepristone (EXP)

monocrotaline (EXP)

N-acetyl-L-cysteine (ISO)

N-nitrosodiethylamine (ISO)

naphthalene (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

remdesivir (ISO)

resveratrol (EXP,ISO)

ritanserin (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (ISO)

sorafenib (ISO)

sunitinib (ISO)

tetrachloroethene (ISO)

tetraphene (ISO)

thalidomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

trichloroethene (EXP,ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vandetanib (ISO)

vinclozolin (EXP)

ziprasidone (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure morphogenesis (IBA)

angiogenesis (IBA,ISO)

cardiac cell fate determination (ISO)

cardiogenic plate morphogenesis (ISO)

cell migration involved in gastrulation (ISO)

cellular response to leukemia inhibitory factor (ISO)

common bile duct development (ISO)

embryonic foregut morphogenesis (ISO)

embryonic heart tube development (ISO)

embryonic heart tube morphogenesis (ISO)

embryonic organ development (ISO)

endocardial cell differentiation (ISO)

endocardium formation (ISO)

endoderm development (ISO)

endoderm formation (ISO)

endodermal cell differentiation (ISO)

endodermal cell fate determination (ISO)

endodermal cell fate specification (ISO)

endodermal digestive tract morphogenesis (ISO)

gallbladder development (ISO)

gastrulation (ISO)

gene expression (ISO)

heart development (IBA)

heart looping (ISO)

inner cell mass cellular morphogenesis (ISO)

metanephros development (ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

negative regulation of cell growth (ISO)

negative regulation of Wnt signaling pathway (ISO)

negative regulation of Wnt signaling pathway involved in heart development (ISO)

outflow tract morphogenesis (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of endodermal cell differentiation (ISO)

positive regulation of gene expression (ISO)

positive regulation of protein catabolic process (ISO)

positive regulation of stem cell differentiation (ISO)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

protein destabilization (ISO)

protein stabilization (ISO)

regulation of cardiac cell fate specification (ISO)

regulation of cell differentiation (ISO)

regulation of DNA-templated transcription (ISO)

regulation of embryonic development (ISO)

regulation of stem cell division (ISO)

regulation of stem cell proliferation (ISO)

regulation of transcription by RNA polymerase II (ISO)

response to alkaloid (IEP)

rostrocaudal neural tube patterning (ISO)

signal transduction involved in regulation of gene expression (ISO)

spermatogenesis (ISO)

stem cell differentiation (ISO)

stem cell fate specification (ISO)

ureter development (ISO)

vasculogenesis (IBA,ISO)

Cellular Component

nucleus (IDA,ISO)

transcription regulator complex (ISO)

Molecular Function

beta-catenin binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (IMP)

transcription cis-regulatory region binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Susceptibility loci for intracranial aneurysm in European and Japanese populations.	Bilguvar K, etal., Nat Genet. 2008 Dec;40(12):1472-7. doi: 10.1038/ng.240. Epub 2008 Nov 9.
2.	Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.	Dumur CI, etal., Exp Mol Pathol. 2010 Dec;89(3):227-35. Epub 2010 Sep 9.
3.	Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.	Foroud T, etal., Stroke. 2012 Nov;43(11):2846-52. doi: 10.1161/STROKEAHA.112.656397. Epub 2012 Sep 6.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.	Gräf S, etal., Nat Commun. 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4.
6.	Common genetic variants in pulmonary arterial hypertension.	Gu S, etal., Lancet Respir Med. 2019 Mar;7(3):190-191. doi: 10.1016/S2213-2600(18)30448-X. Epub 2018 Dec 5.
7.	Association of SOX17 Gene Polymorphisms and Intracranial Aneurysm: A Case-Control Study and Meta-Analysis.	Hong EP, etal., World Neurosurg. 2018 Feb;110:e823-e829. doi: 10.1016/j.wneu.2017.11.108. Epub 2017 Nov 27.
8.	Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.	Lee S, etal., Circulation. 2015 Mar 17;131(11):995-1005. doi: 10.1161/CIRCULATIONAHA.114.012568. Epub 2015 Jan 16.
9.	Associations among Genetic Variants and Intracranial Aneurysm in a Chinese Population.	Li B, etal., Yonsei Med J. 2019 Jul;60(7):651-658. doi: 10.3349/ymj.2019.60.7.651.
10.	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study.	Li M, etal., Neuropsychiatr Dis Treat. 2019 Apr 2;15:779-783. doi: 10.2147/NDT.S193478. eCollection 2019.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
13.	Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling.	Park CS, etal., Circ Res. 2022 Oct 28;131(10):792-806. doi: 10.1161/CIRCRESAHA.122.320845. Epub 2022 Oct 7.
14.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.	Rodríguez-Flores JL, etal., Mamm Genome. 2010 Apr;21(3-4):195-204. doi: 10.1007/s00335-010-9253-y. Epub 2010 Mar 5.
19.	SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.	Sangam S, etal., Am J Respir Crit Care Med. 2023 Apr 15;207(8):1055-1069. doi: 10.1164/rccm.202203-0450OC.
20.	SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.	Walters R, etal., Circulation. 2023 May 23;147(21):1606-1621. doi: 10.1161/CIRCULATIONAHA.122.061940. Epub 2023 Apr 17.
21.	Upregulated miR-194-5p suppresses retinal microvascular endothelial cell dysfunction and mitigates the symptoms of hypertensive retinopathy in mice by targeting SOX17 and VEGF signaling.	Wan Q, etal., Cell Cycle. 2023 Feb;22(3):331-346. doi: 10.1080/15384101.2022.2119514. Epub 2022 Oct 5.
22.	SOX17 Loss-of-Function Mutation Underlying Familial Pulmonary Arterial Hypertension.	Wang TM, etal., Int Heart J. 2021 May 29;62(3):566-574. doi: 10.1536/ihj.20-711. Epub 2021 May 1.
23.	Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis.	Yang JM, etal., Circ Res. 2020 Mar 13;126(6):767-783. doi: 10.1161/CIRCRESAHA.119.316476. Epub 2020 Feb 12.
24.	Genome-wide association study of intracranial aneurysm identifies three new risk loci.	Yasuno K, etal., Nat Genet. 2010 May;42(5):420-5. doi: 10.1038/ng.563. Epub 2010 Apr 4.
25.	SOX17 loss-of-function variation underlying familial congenital heart disease.	Zhao L, etal., Eur J Med Genet. 2021 May;64(5):104211. doi: 10.1016/j.ejmg.2021.104211. Epub 2021 Mar 29.
26.	Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease.	Zhu N, etal., Genome Med. 2018 Jul 20;10(1):56. doi: 10.1186/s13073-018-0566-x.
27.	SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner.	Zou X, etal., Adv Sci (Weinh). 2023 May;10(14):e2206139. doi: 10.1002/advs.202206139. Epub 2023 Mar 15.

Additional References at PubMed

PMID:8636240	PMID:11973269	PMID:12477932	PMID:15082719	PMID:15220343	PMID:16574095	PMID:16895970	PMID:17360443	PMID:17610846	PMID:17655922	PMID:17875931	PMID:17940068
PMID:18413743	PMID:18462699	PMID:18682240	PMID:19328208	PMID:19515696	PMID:19619492	PMID:19736317	PMID:19913509	PMID:20123909	PMID:20228271	PMID:20308546	PMID:20439489
PMID:20802155	PMID:20960469	PMID:21146513	PMID:21305474	PMID:22292085	PMID:22344693	PMID:23824537	PMID:25209250

Genomics

Comparative Map Data

Sox17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	15,016,660 - 15,022,228 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	15,016,731 - 15,022,228 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	17,215,894 - 17,221,391 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	18,819,700 - 18,825,180 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	18,550,534 - 18,556,035 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	14,890,318 - 14,895,907 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	14,890,408 - 14,895,907 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	19,675,563 - 19,681,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	15,241,405 - 15,246,904 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	15,244,440 - 15,246,899 (+)	NCBI
Celera	5	14,398,084 - 14,403,591 (+)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

SOX17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	54,457,935 - 54,460,892 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	54,457,935 - 54,460,892 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	55,370,495 - 55,373,452 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	55,533,048 - 55,536,009 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	55,533,047 - 55,535,484	NCBI
Celera	8	51,361,039 - 51,364,000 (+)	NCBI		Celera
Cytogenetic Map	8	q11.23	NCBI
HuRef	8	50,838,617 - 50,841,578 (+)	NCBI		HuRef
CHM1_1	8	55,422,260 - 55,425,221 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	54,835,189 - 54,838,146 (+)	NCBI		T2T-CHM13v2.0

Sox17
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	4,561,151 - 4,567,624 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	4,561,154 - 4,567,577 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	4,490,928 - 4,497,426 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	4,490,931 - 4,497,354 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	4,481,009 - 4,486,494 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	4,481,009 - 4,486,494 (-)	NCBI		MGSCv36	mm8
Celera	1	4,507,797 - 4,513,282 (-)	NCBI		Celera
Cytogenetic Map	1	A1	NCBI
cM Map	1	1.65	NCBI

Sox17
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955454	13,689,403 - 13,690,019 (+)	NCBI	ChiLan1.0	ChiLan1.0

SOX17
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	45,819,721 - 45,822,171 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	50,883,088 - 50,885,542 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	48,257,287 - 48,259,808 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	48,257,287 - 48,259,808 (+)	Ensembl	panpan1.1		panPan2

SOX17
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	5,979,092 - 5,981,504 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	5,979,261 - 5,981,124 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	6,289,199 - 6,291,617 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	6,057,575 - 6,059,968 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	6,057,528 - 6,059,963 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	5,992,409 - 5,994,803 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	6,198,380 - 6,200,809 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	6,377,256 - 6,379,697 (+)	NCBI		UU_Cfam_GSD_1.0

Sox17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	73,534,065 - 73,536,600 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	1,248,577 - 1,251,430 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936496	1,248,582 - 1,251,406 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOX17
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	76,854,150 - 76,857,148 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	76,854,218 - 76,857,143 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	83,968,236 - 83,971,155 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SOX17
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	50,523,816 - 50,527,360 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	50,524,893 - 50,527,847 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	91,335,953 - 91,338,947 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sox17
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	1,276,302 - 1,279,181 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	1,276,382 - 1,278,584 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sox17
41 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	76
Count of miRNA genes:	61
Interacting mature miRNAs:	71
Transcripts:	ENSRNOT00000033116
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	3844018	26141981	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
631827	Alc4	Alcohol consumption QTL 4	3.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	5	8187501	18616199	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat

Markers in Region

RH130629

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	15,021,882 - 15,022,085 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	14,895,562 - 14,895,764	NCBI	Rnor6.0
Rnor_5.0	5	19,680,739 - 19,680,941	UniSTS	Rnor5.0
RGSC_v3.4	5	15,246,559 - 15,246,761	UniSTS	RGSC3.4
Celera	5	14,403,246 - 14,403,448	UniSTS
Cytogenetic Map	5	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										9	19	11
Low	3	43	56	40	19	40	8	11	74	26	21		8
Below cutoff			1	1		1					1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000033116 ⟹ ENSRNOP00000033962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	15,016,731 - 15,022,228 (+)	Ensembl
Rnor_6.0 Ensembl	5	14,890,408 - 14,895,907 (+)	Ensembl

RefSeq Acc Id:

NM_001107902 ⟹ NP_001101372

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,731 - 15,022,228 (+)	NCBI
Rnor_6.0	5	14,890,408 - 14,895,907 (+)	NCBI
Rnor_5.0	5	19,675,563 - 19,681,084 (+)	NCBI
RGSC_v3.4	5	15,241,405 - 15,246,904 (+)	RGD
Celera	5	14,398,084 - 14,403,591 (+)	RGD

Sequence:

show sequence

ACCCATTTAGTGAAGAAACTGAAACATGGTCCACTCACAACTGCTGGCGGGTCTGAAGTGCGGT
TGCCCCCAACACTTCTCCCAAAGTATCTATCAAGAGAATGGTCAGCAGAAATTAGATCTAGTGA
GCAATATCTCCAGACATTTGAATTTCAGCCGTCCTATTTCCCCGAGAGGACTTGGCGCCAGAGC
CCGGCTCCAGCCAGTTTTCCCCTGGCAGCTTCCCATCCCCGCCTCAGGGTCCGGGGAAGCGGCG
TGTCCCGTGGCCGTAGCAGAGCGCGGGGTCGGTCTGGAGCGCCATGAGCAGCCCGGATGCGGGA
TACGCCAGTGACGACCAGAGCCAGCCTCGGAGCGCGCAGCCCGCGGTGATGGCCGGGTTGGGCC
CCTGTCCCTGGGCCGAGTCCCTGAGCTCTCTCGGGGACGTAAAGGTGAAAGGAGAGGTGGTGGC
GAGTAGCGGGGCGCCAGCCGGGACCTCGAGTCGAGCCAAAGCCGAGTCTCGCATCCGGCGGCCG
ATGAATGCCTTTATGGTGTGGGCCAAAGACGAACGCAAGCGGCTGGCACAGCAGAACCCGGATC
TGCACAACGCAGAGCTGAGCAAGATGCTAGGCAAATCCTGGAAGGCGTTGACCTTGGCGGAGAA
GCGGCCCTTCGTGGAAGAGGCCGAGCGGCTGCGTGTGCAGCACATGCAGGACCATCCCAACTAC
AAGTACCGGCCGCGGCGGCGCAAGCAGGTGAAGCGCATGAAACGGGTGGAGGGAGGCTTCCTGC
ACGCTCTCGCCGAGCCTCAGGCCGGCGCGCTTGGTCCCGAGGGCGGCCGCGTGGCCATGGATGG
CCTGGGTCTGCCTTTCCCGGAGCCAGGCTATCCGGCCGGCCCGCCGCTGATGTCCCCGCACATG
GGCGCCCACTACCGTGACTGCCAGGGACTGGGCGCACCCGCGCTCGACGGCTACCCTCTGCCCA
CTCCGGACACATCCCCGTTGGATGGCGTGGAGCAGGACCCGGCTTTCTTTGCTGCCCCGCTGCC
AGGGGACTGCCCGGCGGCCGGAGCCTACACGTATGCTCAGGTCTCGGACTATGCGGTGCCCGCA
GAGCCGTCCGCTGGCCCCATGCGAGTGGGACCCGACCCCTCCGGCTCTGCGATGCCGGGGATCC
TGGCGCCCCCCAGTGCTCTGCACCTGTACTACGGCGCGATGGGCTCGCCCGCGGCAAGCGCCGG
GCGCGGTTTCCACGCTCAGCCCCAGCAGCCACTGCAACCGCAGCCACCGCCGCCACCACCACCG
CCTCCACCGCCGCAGCAGCACCCGACGCACGGTCCGGGGCAGCCTTCTCCACCTCCCGAGGCTC
TGCCCTGCCGGGATGGCACGGAACCCAACCAGCCCACTGAGCTACTAGGGGAGGTGGACCGCAC
GGAATTCGAACAGTATTTGCACTTTGTGTATAAGCCGGAGATGGGTCTTCCCTACCAGGGACAC
GACTGCGGTGTGAACCTCTCGGACAGCCACGGAGCCATTTCCTCCGTGGTGTCCGACGCTAGCT
CAGCGGTCTACTACTGCAACTACCCTGACATCTGACGGTTGCCGATTTGACCTGCGGGCCAGAA
GCAGTGTTACACACTTCCTGGAAGCGCTAAGGAAATCCTTAGCGTCACGCTGTTTTGTTTTTAA
GTTGCCTTGGCATATAATTTATGGTAATTTATTTTGTCTGCCACTTGAACAGTTGAAGGGCTAC
ATGAGATTCTCATTTCAAATGCCTCGAGGGGTTTGCTCCCCACCATCACTGTCCAGTTTTAGCC
AGTTTTTAATATCTCACCAACTTGATCCAAAGAAATTTTGTCACGATCTTAAAAAAATCCTGGA
ATCTTTTTTAAAAAAATCTCTATCACATTGGTTTTATCAAAGTAATTTAAAGATCAACAGTAAA
TATTACACAATTAGAAGTGTATAGTTAATTGTAAACTTTCTATTTTCTTACAAAATTTAAGAAA
CCCTAAATACAAACAGTGGGGTGTTCAGATGTGATATCGTTGTTCTCCTACGAAAAAAATTCTC
ACAGAATGAACTTGCTATGTACATTCCAAAATATTGGTTTCTAAAAATAATACTGTAAATGTTT
TTAATTCTGTATACTTTAATAAGGCTGTTCAAAAATTCTGGTTTTTTTTTTTGTCATCTTGATA
TCTGCCAAAAGAGCTTTTCAGATATATCTGTTTTCGTTTGTGTTTTCTTCCAAATGTCTTTATC
CCTTTCCCCACAAAATTTGCCTTTAATCCCCACATTTTTAGAGTCAGAGAAACTAATCAAAATA
AAATTTGTTGTGACTGTTAATC

hide sequence

RefSeq Acc Id:

XM_008763538 ⟹ XP_008761760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,018,030 - 15,022,226 (+)	NCBI
Rnor_6.0	5	14,890,318 - 14,895,905 (+)	NCBI

Sequence:

show sequence

AAGGCTTGCAGGAAGCCGCTCCGGATGTTTGCTTCTTTACATGTGGCATTTGTGGCTGGCTTTG
ATAACGTCGCGAACTCGGCTTCCAACACCCATTTAGTGAAGAAACTGAAACATGGTCCACTCAC
AACTGCTGGCGGGTCTGAAGTGCGGTTGCCCCCAACACTTCTCCCAAAGTATCTATCAAGAGAA
TGGTCAGCAGAAATTAGATCTAGACAGATCAGTAGTTAATCTTCCGGAATGAGTGTAAATGACT
CTGGCACCCCTGGGCTTTTAACCGCTTTCTCAGTATGCTGGGTTCCCTTCACGGAGCAAGAACA
GAACAAGTAACCAGGTAAAATGATGCAAATACATTTTTTAGACCTACACCTGAATTATATTTCC
GTTGTCTCTTAGCTTTCGGAGAAATCAACCAAGACAGTGAAGACAGAGAAAATGCATTCTGGAC
CCGCTACTGTTTCCAACCTTCATTTCAAATAAAGCCCATAGTTTATTAAAAAAAAAATTCACGG
AAAGAGAAAATTCGGCCCTGGGATCTTTAAAAAGATGTCGGTTACTAGATGCAAAAGAGAAAAG
TCACTGTGGAGGTGAGGGCCTGCGCCCTTGCTTCTGAGAGGCAGGAGAGCTACATGGGGAAATT
GCCTCAAAACAAACGGAAGAGATACGATTTTTTTCCCTTAAAGATTACCTGGCTAAGGAATTGA
TTGGTAATATGGCTATCTCTGCCCCTATAACCCCTTATAACCCCTTTGGTTAAACATCTGAAAT
GCATTTTTTTGTTTGTTTGTTTTACTTTCAAGCCAATGTTTTTCAGGGGAAAAAAAGCTTTGAG
AAAGAGCACATTATCAGTTAGATTTAAGACCAATTGCTTTTAAATCACCAATTTAAAATATTAT
TTTCTTCGATTTCTTAAAGCAGATTTAAATTTACCCCCTTTGTATGAATCTTAAGACCTGGAAC
TTTAAACACTCTCACGGATCTCTCTGCACAACATCCAGCTTTAAATGGGAGGGTCGCCATTGCT
TTATAACATAACAAATTCGAGAAAGAATGGCTTCTGTATGAGTTCTTTGGAGACAAGATAGTTC
CAGAAACTGCAGGCCAGGAGCTAGCAAAACCTCTGTGCGTTTTGGAACCTCCAGTAAGCCAGAC
TTGGTATCTGAAATAACACAAGGAAACCTCAGCATGTTACCTCATGGGCCACAAGTAAGTGATA
CTTTTTCAATCAGCCCTTCACCTTAAAGAAGTCTTGTTTTGGAAACTGATATGTTGAGTCTCTC
TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCTGTCTTTCTCTCCTTC
AAGGCAGGGTTGCATGTAGCCCAGGCTGGCCTCTAATTCTATATGTAGCCGAGGATGATCTTGA
ACATATTTTTCTGCCCCCATTTCTCAAGTGCTGGAATTACAGAATTACAGGCATTAGGCATCTC
ATAGACTGTCTTTTCTGAGGAATTGTGCTAGGTGAGCGTTCTAATTGTGCTATTTCACCAGTCC
TTGAATTTTCCTCCCTTAAAACCACAATTTTTCCTCCCTTAAAACTATGTGAGACTGACTGTTG
GAGCTCTTAGAAAACAACACAAACATGCAAATGCAACAACAGGGAGCTTTCGGAGCTTCTGGTC
TGAAGGAGGGCTGCTGCTAGGTGTGCTCCTAACACCCTCCAGTGTCTCTGCCTTAGCACGCAAG
CTTCCCATCCCCGCCTCAGGGTCCGGGGAAGCGGCGTGTCCCGTGGCCGTAGCAGAGCGCGGGG
TCGGTCTGGAGCGCCATGAGCAGCCCGGATGCGGGATACGCCAGTGACGACCAGAGCCAGCCTC
GGAGCGCGCAGCCCGCGGTGATGGCCGGGTTGGGCCCCTGTCCCTGGGCCGAGTCCCTGAGCTC
TCTCGGGGACGTAAAGGTGAAAGGAGAGGTGGTGGCGAGTAGCGGGGCGCCAGCCGGGACCTCG
AGTCGAGCCAAAGCCGAGTCTCGCATCCGGCGGCCGATGAATGCCTTTATGGTGTGGGCCAAAG
ACGAACGCAAGCGGCTGGCACAGCAGAACCCGGATCTGCACAACGCAGAGCTGAGCAAGATGCT
AGGCAAATCCTGGAAGGCGTTGACCTTGGCGGAGAAGCGGCCCTTCGTGGAAGAGGCCGAGCGG
CTGCGTGTGCAGCACATGCAGGACCATCCCAACTACAAGTACCGGCCGCGGCGGCGCAAGCAGG
TGAAGCGCATGAAACGGGTGGAGGGAGGCTTCCTGCACGCTCTCGCCGAGCCTCAGGCCGGCGC
GCTTGGTCCCGAGGGCGGCCGCGTGGCCATGGATGGCCTGGGTCTGCCTTTCCCGGAGCCAGGC
TATCCGGCCGGCCCGCCGCTGATGTCCCCGCACATGGGCGCCCACTACCGTGACTGCCAGGGAC
TGGGCGCACCCGCGCTCGACGGCTACCCTCTGCCCACTCCGGACACATCCCCGTTGGATGGCGT
GGAGCAGGACCCGGCTTTCTTTGCTGCCCCGCTGCCAGGGGACTGCCCGGCGGCCGGAGCCTAC
ACGTATGCTCAGGTCTCGGACTATGCGGTGCCCGCAGAGCCGTCCGCTGGCCCCATGCGAGTGG
GACCCGACCCCTCCGGCTCTGCGATGCCGGGGATCCTGGCGCCCCCCAGTGCTCTGCACCTGTA
CTACGGCGCGATGGGCTCGCCCGCGGCAAGCGCCGGGCGCGGTTTCCACGCTCAGCCCCAGCAG
CCACTGCAACCGCAGCCACCGCCGCCACCACCACCGCCTCCACCGCCGCAGCAGCACCCGACGC
ACGGTCCGGGGCAGCCTTCTCCACCTCCCGAGGCTCTGCCCTGCCGGGATGGCACGGAACCCAA
CCAGCCCACTGAGCTACTAGGGGAGGTGGACCGCACGGAATTCGAACAGTATTTGCACTTTGTG
TATAAGCCGGAGATGGGTCTTCCCTACCAGGGACACGACTGCGGTGTGAACCTCTCGGACAGCC
ACGGAGCCATTTCCTCCGTGGTGTCCGACGCTAGCTCAGCGGTCTACTACTGCAACTACCCTGA
CATCTGACGGTTGCCGATTTGACCTGCGGGCCAGAAGCAGTGTTACACACTTCCTGGAAGCGCT
AAGGAAATCCTTAGCGTCACGCTGTTTTGTTTTTAAGTTGCCTTGGCATATAATTTATGGTAAT
TTATTTTGTCTGCCACTTGAACAGTTGAAGGGCTACATGAGATTCTCATTTCAAATGCCTCGAG
GGGTTTGCTCCCCACCATCACTGTCCAGTTTTAGCCAGTTTTTAATATCTCACCAACTTGATCC
AAAGAAATTTTGTCACGATCTTAAAAAAATCCTGGAATCTTTTTTAAAAAAATCTCTATCACAT
TGGTTTTATCAAAGTAATTTAAAGATCAACAGTAAATATTACACAATTAGAAGTGTATAGTTAA
TTGTAAACTTTCTATTTTCTTACAAAATTTAAGAAACCCTAAATACAAACAGTGGGGTGTTCAG
ATGTGATATCGTTGTTCTCCTACGAAAAAAATTCTCACAGAATGAACTTGCTATGTACATTCCA
AAATATTGGTTTCTAAAAATAATACTGTAAATGTTTTTAATTCTGTATACTTTAATAAGGCTGT
TCAAAAATTCTGGTTTTTTTTTTTGTCATCTTGATATCTGCCAAAAGAGCTTTTCAGATATATC
TGTTTTCGTTTGTGTTTTCTTCCAAATGTCTTTATCCCTTTCCCCACAAAATTTGCCTTTAATC
CCCACATTTTTAGAGTCAGAGAAACTAATCAAAATAAAATTTGTTGTGACTGTTAA

hide sequence

RefSeq Acc Id:

XM_039109750 ⟹ XP_038965678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,660 - 15,022,226 (+)	NCBI

RefSeq Acc Id:

XM_039109751 ⟹ XP_038965679

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,660 - 15,022,226 (+)	NCBI

RefSeq Acc Id:

XM_039109752 ⟹ XP_038965680

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,660 - 15,022,226 (+)	NCBI

RefSeq Acc Id:

XM_039109753 ⟹ XP_038965681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,660 - 15,022,226 (+)	NCBI

RefSeq Acc Id:

XM_039109754 ⟹ XP_038965682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	15,016,660 - 15,022,226 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101372	(Get FASTA)	NCBI Sequence Viewer
	XP_008761760	(Get FASTA)	NCBI Sequence Viewer
	XP_038965678	(Get FASTA)	NCBI Sequence Viewer
	XP_038965679	(Get FASTA)	NCBI Sequence Viewer
	XP_038965680	(Get FASTA)	NCBI Sequence Viewer
	XP_038965681	(Get FASTA)	NCBI Sequence Viewer
	XP_038965682	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66978	(Get FASTA)	NCBI Sequence Viewer
	EDM11594	(Get FASTA)	NCBI Sequence Viewer
	EDM11595	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101372 ⟸ NM_001107902

- UniProtKB:

G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKVKGEVVASSGAPAGTSSRAKA
ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQH
MQDHPNYKYRPRRRKQVKRMKRVEGGFLHALAEPQAGALGPEGGRVAMDGLGLPFPEPGYPAGP
PLMSPHMGAHYRDCQGLGAPALDGYPLPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQV
SDYAVPAEPSAGPMRVGPDPSGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQ
PPPPPPPPPPPQQHPTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEM
GLPYQGHDCGVNLSDSHGAISSVVSDASSAVYYCNYPDI

hide sequence

RefSeq Acc Id:	XP_008761760 ⟸ XM_008763538
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKVKGEVVASSGAPAGTSSRAKA ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQH MQDHPNYKYRPRRRKQVKRMKRVEGGFLHALAEPQAGALGPEGGRVAMDGLGLPFPEPGYPAGP PLMSPHMGAHYRDCQGLGAPALDGYPLPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQV SDYAVPAEPSAGPMRVGPDPSGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQ PPPPPPPPPPPQQHPTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEM GLPYQGHDCGVNLSDSHGAISSVVSDASSAVYYCNYPDI hide sequence

RefSeq Acc Id:

ENSRNOP00000033962 ⟸ ENSRNOT00000033116

RefSeq Acc Id:	XP_038965681 ⟸ XM_039109753
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965680 ⟸ XM_039109752
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965682 ⟸ XM_039109754
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965679 ⟸ XM_039109751
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965678 ⟸ XM_039109750
- Peptide Label:	isoform X1
- UniProtKB:	G3V923 (UniProtKB/TrEMBL), A6JFJ9 (UniProtKB/TrEMBL)

Protein Domains

HMG box Sox C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V923-F1-model_v2	AlphaFold	G3V923	1-423	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305371	AgrOrtholog
BioCyc Gene	G2FUF-42146	BioCyc
Ensembl Genes	ENSRNOG00000027357	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000033962	ENTREZGENE
	ENSRNOP00000033962.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033116	ENTREZGENE
	ENSRNOT00000033116.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
InterPro	DUF3547	UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/TrEMBL
	HMG_superfamily	UniProtKB/TrEMBL
	Sox7/17/18_central	UniProtKB/TrEMBL
KEGG Report	rno:312936	UniProtKB/TrEMBL
NCBI Gene	312936	ENTREZGENE
PANTHER	SOX TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR SOX-17	UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/TrEMBL
	Sox_C_TAD	UniProtKB/TrEMBL
PhenoGen	Sox17	PhenoGen
PROSITE	HMG_BOX_2	UniProtKB/TrEMBL
	SOX_C	UniProtKB/TrEMBL
SMART	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	HMG-box	UniProtKB/TrEMBL
UniProt	A6JFJ9	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ07_RAT	UniProtKB/TrEMBL
	G3V923	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Sox17	SRY-box transcription factor 17	Sox17	SRY box 17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-12	Sox17	SRY box 17	Sox17	SRY (sex determining region Y)-box 17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Sox17	SRY (sex determining region Y)-box 17	Sox17	SRY-box containing gene 17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Sox17	SRY-box containing gene 17	Sox17_predicted	SRY-box containing gene 17 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sox17_predicted	SRY-box containing gene 17 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)