Lrat (lecithin retinol acyltransferase) - Rat Genome Database

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Gene: Lrat (lecithin retinol acyltransferase) Rattus norvegicus
Analyze
Symbol: Lrat
Name: lecithin retinol acyltransferase
RGD ID: 68362
Description: Enables phosphatidylcholine-retinol O-acyltransferase activity; retinoic acid binding activity; and retinol binding activity. Involved in response to retinoic acid; response to vitamin A; and retinol metabolic process. Located in multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase); lecithin-retinol acyltransferase; lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); phosphatidylcholine--retinol O-acyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,264,093 - 168,273,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,454,144 - 175,463,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,475,076 - 173,484,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,076,492 - 168,085,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,896,304 - 181,905,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,896,305 - 181,905,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,310,924 - 201,319,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,636,382 - 174,645,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,586,488 - 174,595,550 (-)NCBI
Celera2162,290,825 - 162,299,887 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (EXP)
arachidonic acid  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
clorgyline  (ISO)
cyproconazole  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
glafenine  (EXP)
iron dichloride  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
linoleic acid  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methidathion  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Distribution of lecithin-retinol acyltransferase activity in different types of rat liver cells and subcellular fractions. Blaner WS, etal., FEBS Lett. 1990 Nov 12;274(1-2):89-92.
2. Uptake and esterification of vitamin A by RCS rat retinal pigment epithelial cells in primary culture. Cia D, etal., Vision Res. 2004 Feb;44(3):247-55.
3. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
7. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
8. Regulation of hepatic lecithin: retinol acyltransferase activity by retinoic acid. Matsuura T and Ross AC, Arch Biochem Biophys. 1993 Mar;301(2):221-7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver. Nagatsuma K, etal., Liver Int. 2009 Jan;29(1):47-54. Epub 2008 Jun 9.
11. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids. Shimada T, etal., Arch Biochem Biophys. 1997 Aug 1;344(1):220-7.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. Thompson DA, etal., Nat Genet. 2001 Jun;28(2):123-4.
22. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
23. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
24. Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid. Zolfaghari R and Ross AC, J Lipid Res 2000 Dec;41(12):2024-34.
25. Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats. Zolfaghari R, etal., Biochem J 2002 Dec 1;368(Pt 2):621-31.
Additional References at PubMed
PMID:1885578   PMID:3410848   PMID:10819989   PMID:18093970   PMID:19665987   PMID:20439489   PMID:21512299   PMID:23012479   PMID:23105095   PMID:34281288  


Genomics

Comparative Map Data
Lrat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,264,093 - 168,273,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,454,144 - 175,463,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,475,076 - 173,484,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,076,492 - 168,085,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,896,304 - 181,905,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,896,305 - 181,905,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,310,924 - 201,319,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,636,382 - 174,645,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,586,488 - 174,595,550 (-)NCBI
Celera2162,290,825 - 162,299,887 (-)NCBICelera
Cytogenetic Map2q34NCBI
LRAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,740,838 - 154,753,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,626,945 - 154,753,120 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,661,990 - 155,674,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,884,613 - 155,893,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 344156,022,767 - 156,031,875NCBI
Celera4152,996,143 - 153,005,248 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,405,746 - 151,414,958 (+)NCBIHuRef
CHM1_14155,643,059 - 155,652,147 (+)NCBICHM1_1
T2T-CHM13v2.04158,072,645 - 158,084,927 (+)NCBIT2T-CHM13v2.0
Lrat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
Lrat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554712,603,678 - 2,609,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554712,603,395 - 2,610,988 (+)NCBIChiLan1.0ChiLan1.0
LRAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan14153,008,750 - 153,021,026 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04147,110,568 - 147,119,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,928,607 - 158,937,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,928,607 - 158,937,747 (+)Ensemblpanpan1.1panPan2
LRAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,399,773 - 52,409,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,399,544 - 52,406,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,744,532 - 52,752,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01553,086,516 - 53,094,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,087,735 - 53,096,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,341,249 - 52,349,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,447,030 - 52,454,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,762,096 - 52,769,963 (+)NCBIUU_Cfam_GSD_1.0
Lrat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,044,997 - 38,054,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,492,297 - 1,501,917 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,491,480 - 1,498,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,409,461 - 74,419,681 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,412,226 - 74,428,713 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,710,192 - 78,726,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,297,114 - 101,304,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248532,936,109 - 2,945,101 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248532,936,426 - 2,941,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrat
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:62
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000035411
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat

Markers in Region
RH128305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,264,370 - 168,264,560 (+)MAPPERmRatBN7.2
Rnor_6.02181,896,582 - 181,896,771NCBIRnor6.0
Rnor_5.02201,311,202 - 201,311,391UniSTSRnor5.0
RGSC_v3.42174,636,660 - 174,636,849UniSTSRGSC3.4
Celera2162,291,103 - 162,291,292UniSTS
RH 3.4 Map21098.7UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 18 18 2 2
Low 3 25 34 23 16 23 8 8 12 34 31 9 8
Below cutoff 12 3 3 44 1 7

Sequence


RefSeq Acc Id: ENSRNOT00000035411   ⟹   ENSRNOP00000035053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)Ensembl
Rnor_6.0 Ensembl2181,900,499 - 181,905,300 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082156   ⟹   ENSRNOP00000073664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2181,896,305 - 181,900,856 (-)Ensembl
RefSeq Acc Id: NM_022280   ⟹   NP_071616
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22168,264,093 - 168,273,155 (-)NCBI
Rnor_6.02181,896,304 - 181,905,366 (-)NCBI
Rnor_5.02201,310,924 - 201,319,986 (-)NCBI
RGSC_v3.42174,636,382 - 174,645,444 (-)RGD
Celera2162,290,825 - 162,299,887 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071616 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF97786 (Get FASTA)   NCBI Sequence Viewer  
  EDM00844 (Get FASTA)   NCBI Sequence Viewer  
  EDM00845 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035053
  ENSRNOP00000035053.3
  ENSRNOP00055030674
  ENSRNOP00060009123
  ENSRNOP00065043780
GenBank Protein Q9JI61 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071616   ⟸   NM_022280
- UniProtKB: Q9JI61 (UniProtKB/Swiss-Prot),   A6J5U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073664   ⟸   ENSRNOT00000082156
RefSeq Acc Id: ENSRNOP00000035053   ⟸   ENSRNOT00000035411
Protein Domains
LRAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI61-F1-model_v2 AlphaFold Q9JI61 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691394
Promoter ID:EPDNEW_R1919
Type:single initiation site
Name:Lrat_1
Description:lecithin retinol acyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02181,905,365 - 181,905,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68362 AgrOrtholog
BioCyc Gene G2FUF-52664 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
  PWY-6861 [the visual cycle I (vertebrates)] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
  PWY-6861 BioCyc
Ensembl Genes ENSRNOG00000025608 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021938 UniProtKB/Swiss-Prot
  ENSRNOG00060007355 UniProtKB/Swiss-Prot
  ENSRNOG00065030920 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035411 ENTREZGENE
  ENSRNOT00000035411.5 UniProtKB/Swiss-Prot
  ENSRNOT00055037620 UniProtKB/Swiss-Prot
  ENSRNOT00060012100 UniProtKB/Swiss-Prot
  ENSRNOT00065053284 UniProtKB/Swiss-Prot
Gene3D-CATH endopeptidase domain like (from Nostoc punctiforme) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRAT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64047 ENTREZGENE
PANTHER LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/Swiss-Prot
  LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/TrEMBL
  LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/TrEMBL
  PTHR46678 UniProtKB/Swiss-Prot
Pfam LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrat PhenoGen
PROSITE LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025608 RatGTEx
  ENSRNOG00055021938 RatGTEx
  ENSRNOG00060007355 RatGTEx
  ENSRNOG00065030920 RatGTEx
TIGR TC209483
UniProt A6J5U5 ENTREZGENE, UniProtKB/TrEMBL
  LRAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Lrat  lecithin retinol acyltransferase  Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)    lecithin-retinol acyltransferase  Name updated 1299863 APPROVED
2002-06-10 Lrat  lecithin-retinol acyltransferase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in liver 68273
gene_protein 231 amino acids; 25.8 kDa 68273