Rad52 (RAD52 homolog, DNA repair protein) - Rat Genome Database

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Gene: Rad52 (RAD52 homolog, DNA repair protein) Rattus norvegicus
Analyze
Symbol: Rad52
Name: RAD52 homolog, DNA repair protein
RGD ID: 1304975
Description: Predicted to enable identical protein binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; double-strand break repair via single-strand annealing; and mitotic recombination. Predicted to act upstream of or within DNA double-strand break processing involved in repair via single-strand annealing; cellular response to oxidative stress; and regulation of nucleotide-excision repair. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung cancer (multiple); mucoepidermoid carcinoma; and nicotine dependence. Orthologous to human RAD52 (RAD52 homolog, DNA repair protein); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA repair protein RAD52 homolog; LOC297561; RAD52 homolog; RAD52 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,778,320 - 154,802,002 (+)NCBIGRCr8
mRatBN7.24153,106,062 - 153,128,598 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4153,106,062 - 153,128,207 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,382,308 - 159,403,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04155,166,037 - 155,187,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,789,386 - 153,810,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,429,826 - 152,451,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,430,187 - 152,451,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,515,666 - 219,536,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,281,973 - 156,295,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,519,008 - 156,540,079 (+)NCBI
Celera4141,966,210 - 141,979,264 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. Danoy P, etal., Int J Cancer. 2008 Jul 15;123(2):457-463. doi: 10.1002/ijc.23524.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population. Han S, etal., Int J Clin Exp Med. 2015 Sep 15;8(9):16528-35. eCollection 2015.
5. Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. Kazma R, etal., Carcinogenesis. 2012 May;33(5):1059-64. doi: 10.1093/carcin/bgs116. Epub 2012 Mar 1.
6. [Genetic variation in DNA repair gene RAD52 is associated with the response to platinum-based chemotherapy in SCLC patients]. Li HM, etal., Zhonghua Zhong Liu Za Zhi. 2016 Jul;38(7):504-9. doi: 10.3760/cma.j.issn.0253-3766.2016.07.005.
7. RAD52 variants influence NSCLC risk in the Chinese population in a high altitude area. Li M, etal., Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620918192. doi: 10.1177/1753466620918192.
8. Evaluating the role of RAD52 and its interactors as novel potential molecular targets for hepatocellular carcinoma. Li P, etal., Cancer Cell Int. 2019 Nov 6;19:279. doi: 10.1186/s12935-019-0996-6. eCollection 2019.
9. Association of a functional RAD52 genetic variant locating in a miRNA binding site with risk of HBV-related hepatocellular carcinoma. Li Z, etal., Mol Carcinog. 2015 Sep;54(9):853-8. doi: 10.1002/mc.22156. Epub 2014 Apr 11.
10. Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance. Lieberman R, etal., Oncotarget. 2017 May 23;8(21):34032-34044. doi: 10.18632/oncotarget.16371.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma. Shi J, etal., Cancer Discov. 2012 Feb;2(2):131-9. doi: 10.1158/2159-8290.CD-11-0246. Epub 2011 Dec 7.
17. Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks. Sotiriou SK, etal., Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.
18. [Expression and significance of gene Rad52 in nasopharyngeal carcinoma]. Wei L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Apr;28(7):486-9.
19. Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control study. Xu L, etal., PLoS One. 2015 Jun 2;10(6):e0128753. doi: 10.1371/journal.pone.0128753. eCollection 2015.
20. RAD52 gene polymorphisms are associated with risk of colorectal cancer in a Chinese Han population. Zhang L, etal., Medicine (Baltimore). 2017 Dec;96(49):e8994. doi: 10.1097/MD.0000000000008994.
Additional References at PubMed
PMID:8702565   PMID:10744977   PMID:12370410   PMID:12379650   PMID:12750383   PMID:19506022   PMID:21804533   PMID:22912580   PMID:29217771  


Genomics

Comparative Map Data
Rad52
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,778,320 - 154,802,002 (+)NCBIGRCr8
mRatBN7.24153,106,062 - 153,128,598 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4153,106,062 - 153,128,207 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4159,382,308 - 159,403,320 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04155,166,037 - 155,187,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,789,386 - 153,810,390 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04152,429,826 - 152,451,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4152,430,187 - 152,451,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04219,515,666 - 219,536,494 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44156,281,973 - 156,295,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14156,519,008 - 156,540,079 (+)NCBI
Celera4141,966,210 - 141,979,264 (+)NCBICelera
Cytogenetic Map4q42NCBI
RAD52
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812911,736 - 991,122 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12911,736 - 990,053 (-)EnsemblGRCh38hg38GRCh38
GRCh37121,020,902 - 1,099,207 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612891,516 - 929,124 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412891,503 - 929,109NCBI
Celera122,627,552 - 2,665,203 (-)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef12872,427 - 910,057 (-)NCBIHuRef
CHM1_1121,020,392 - 1,057,188 (-)NCBICHM1_1
T2T-CHM13v2.012907,492 - 985,932 (-)NCBIT2T-CHM13v2.0
Rad52
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,878,781 - 119,899,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,879,659 - 119,899,789 (+)EnsemblGRCm39 Ensembl
GRCm386119,901,722 - 119,922,827 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,902,698 - 119,922,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv376119,852,716 - 119,872,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,868,333 - 119,888,441 (+)NCBIMGSCv36mm8
Celera6121,739,874 - 121,759,754 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.86NCBI
Rad52
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554546,215,129 - 6,231,726 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554546,206,195 - 6,227,859 (+)NCBIChiLan1.0ChiLan1.0
RAD52
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2106,410,061 - 6,489,983 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,403,853 - 6,486,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012986,372 - 1,066,708 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112946,717 - 1,027,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12946,825 - 985,668 (-)Ensemblpanpan1.1panPan2
RAD52
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12742,915,334 - 43,032,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2742,915,634 - 42,951,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,651,092 - 3,768,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02743,276,387 - 43,393,660 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2743,276,400 - 43,309,769 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,215,107 - 43,332,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,186,962 - 43,304,084 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,010,268 - 3,127,255 (+)NCBIUU_Cfam_GSD_1.0
Rad52
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945108,084,397 - 108,112,640 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,066,905 - 1,099,703 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366061,070,336 - 1,099,684 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD52
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,143,646 - 68,169,670 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,140,846 - 68,223,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,410,118 - 70,490,100 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD52
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111893,984 - 989,119 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11895,292 - 927,430 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660637,412,292 - 7,447,005 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad52
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247359,123,599 - 9,153,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rad52
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:383
Count of miRNA genes:207
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000013070
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat

Markers in Region
RH128843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24153,126,853 - 153,127,057 (+)MAPPERmRatBN7.2
Rnor_6.04152,451,368 - 152,451,571NCBIRnor6.0
Rnor_5.04219,535,987 - 219,536,190UniSTSRnor5.0
RGSC_v3.44156,294,731 - 156,294,934UniSTSRGSC3.4
Celera4141,978,757 - 141,978,960UniSTS
RH 3.4 Map4982.7UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 15 8 17 8 67 21 34 8
Low 3 33 42 33 2 33 8 11 7 14 7 3 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013070   ⟹   ENSRNOP00000013070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,106,062 - 153,128,207 (+)Ensembl
Rnor_6.0 Ensembl4152,437,966 - 152,451,304 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076062   ⟹   ENSRNOP00000068161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4152,430,509 - 152,447,922 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076733   ⟹   ENSRNOP00000068082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4152,449,270 - 152,451,599 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076930   ⟹   ENSRNOP00000068411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4152,450,126 - 152,451,609 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084520   ⟹   ENSRNOP00000073295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4153,106,062 - 153,127,361 (+)Ensembl
Rnor_6.0 Ensembl4152,430,187 - 152,451,499 (+)Ensembl
RefSeq Acc Id: NM_001354109   ⟹   NP_001341038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,320 - 154,799,617 (+)NCBI
mRatBN7.24153,106,062 - 153,127,361 (+)NCBI
RefSeq Acc Id: XM_008763232   ⟹   XP_008761454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,084 - 153,128,598 (+)NCBI
Rnor_6.04152,429,828 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763233   ⟹   XP_008761455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,370 - 154,802,002 (+)NCBI
mRatBN7.24153,106,083 - 153,128,598 (+)NCBI
Rnor_6.04152,429,828 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763234   ⟹   XP_008761456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,079 - 153,128,598 (+)NCBI
Rnor_6.04152,429,828 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763235   ⟹   XP_008761457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,798,413 (+)NCBI
mRatBN7.24153,106,084 - 153,126,690 (+)NCBI
Rnor_6.04152,429,828 - 152,451,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763237   ⟹   XP_008761459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,085 - 153,128,598 (+)NCBI
Rnor_6.04152,429,829 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763238   ⟹   XP_008761460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,083 - 153,128,598 (+)NCBI
Rnor_6.04152,429,828 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592585   ⟹   XP_017448074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,073 - 153,128,598 (+)NCBI
Rnor_6.04152,429,826 - 152,451,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107433   ⟹   XP_038963361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,081 - 153,128,598 (+)NCBI
RefSeq Acc Id: XM_039107434   ⟹   XP_038963362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
mRatBN7.24153,106,085 - 153,128,598 (+)NCBI
RefSeq Acc Id: XM_063285892   ⟹   XP_063141962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,370 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285893   ⟹   XP_063141963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285894   ⟹   XP_063141964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285895   ⟹   XP_063141965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285896   ⟹   XP_063141966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285897   ⟹   XP_063141967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,370 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285898   ⟹   XP_063141968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,370 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285899   ⟹   XP_063141969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285900   ⟹   XP_063141970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XM_063285901   ⟹   XP_063141971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,778,360 - 154,802,002 (+)NCBI
RefSeq Acc Id: XP_008761455   ⟸   XM_008763233
- Peptide Label: isoform X1
- UniProtKB: D3ZZL1 (UniProtKB/TrEMBL),   A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761456   ⟸   XM_008763234
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761454   ⟸   XM_008763232
- Peptide Label: isoform X1
- UniProtKB: D3ZZL1 (UniProtKB/TrEMBL),   A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761459   ⟸   XM_008763237
- Peptide Label: isoform X9
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761460   ⟸   XM_008763238
- Peptide Label: isoform X11
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761457   ⟸   XM_008763235
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448074   ⟸   XM_017592585
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: ENSRNOP00000073295   ⟸   ENSRNOT00000084520
RefSeq Acc Id: ENSRNOP00000068411   ⟸   ENSRNOT00000076930
RefSeq Acc Id: ENSRNOP00000068161   ⟸   ENSRNOT00000076062
RefSeq Acc Id: ENSRNOP00000013070   ⟸   ENSRNOT00000013070
RefSeq Acc Id: ENSRNOP00000068082   ⟸   ENSRNOT00000076733
RefSeq Acc Id: NP_001341038   ⟸   NM_001354109
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963361   ⟸   XM_039107433
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963362   ⟸   XM_039107434
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K552 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141965   ⟸   XM_063285895
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063141966   ⟸   XM_063285896
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063141963   ⟸   XM_063285893
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063141964   ⟸   XM_063285894
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063141969   ⟸   XM_063285899
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063141971   ⟸   XM_063285901
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063141970   ⟸   XM_063285900
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063141962   ⟸   XM_063285892
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141967   ⟸   XM_063285897
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063141968   ⟸   XM_063285898
- Peptide Label: isoform X13

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZL1-F1-model_v2 AlphaFold D3ZZL1 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693351
Promoter ID:EPDNEW_R3876
Type:initiation region
Name:Rad52_1
Description:RAD52 homolog, DNA repair protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04152,430,497 - 152,430,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304975 AgrOrtholog
BioCyc Gene G2FUF-43209 BioCyc
Ensembl Genes ENSRNOG00000009742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013070.9 UniProtKB/TrEMBL
  ENSRNOT00000084520 ENTREZGENE
  ENSRNOT00000084520.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.80 UniProtKB/TrEMBL
InterPro DNA_recomb/repair_Rad52 UniProtKB/TrEMBL
  Rad52_fam UniProtKB/TrEMBL
  Rad52_Rad22 UniProtKB/TrEMBL
  Rad52_Rad59_Rad22_sf UniProtKB/TrEMBL
NCBI Gene 297561 ENTREZGENE
PANTHER DNA REPAIR PROTEIN RAD52 HOMOLOG UniProtKB/TrEMBL
  Rad52_Rad22 UniProtKB/TrEMBL
Pfam Rad52_Rad22 UniProtKB/TrEMBL
PhenoGen Rad52 PhenoGen
RatGTEx ENSRNOG00000009742 RatGTEx
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
UniProt A0A0G2K552 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-17 Rad52  RAD52 homolog, DNA repair protein  Rad52  RAD52 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rad52  RAD52 homolog (S. cerevisiae)   Rad52_predicted  RAD52 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rad52_predicted  RAD52 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED