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Gene: Calca (calcitonin-related polypeptide alpha) Rattus norvegicus
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Symbol: Calca
Name: calcitonin-related polypeptide alpha
Description: Predicted to have calcitonin receptor binding activity and identical protein binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; cellular response to tumor necrosis factor; and vasodilation. Localizes to several cellular components, including axon; extracellular space; and neuronal cell body. Used to study brain disease; ischemia; and stomach disease. Biomarker of prediabetes syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in migraine and osteoporosis. Orthologous to human CALCA (calcitonin related polypeptide alpha); INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-type CGRP; Cal1; CAL6; Calc; calcitonin; calcitonin gene-related peptide 1; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP; CGRP-I; RATCAL6
Orthologs:
Homo sapiens (human) : CALCA (calcitonin related polypeptide alpha)  HGNC  Alliance
Mus musculus (house mouse) : Calca (calcitonin/calcitonin-related polypeptide, alpha)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CALCA (calcitonin related polypeptide alpha)
Canis lupus familiaris (dog) : CRSP-3 (calcitonin receptor-stimulating peptide 3)
Sus scrofa (pig) : CALCB (calcitonin-related polypeptide beta)
Chlorocebus sabaeus (African green monkey) : CALCA (calcitonin related polypeptide alpha)
Heterocephalus glaber (naked mole-rat) : Calca (calcitonin related polypeptide alpha)
more info ...
Is Marker For: Strains:   SHRSP.WKY-(Calca-D1Arb21)/IzmTkyo  
QTLs:   Bp138  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01184,184,018 - 184,188,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,184,020 - 184,188,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,158,061 - 191,162,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,686,168 - 172,691,061 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11172,824,299 - 172,827,127 (-)NCBI
Celera1166,711,610 - 166,716,491 (-)NCBICelera
Cytogenetic Map1q35NCBI
RH 3.4 Map11317.6RGD
RH 2.0 Map1757.3RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Calca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2254
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.