Fkbp1b (FKBP prolyl isomerase 1B)

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Gene: Fkbp1b (FKBP prolyl isomerase 1B) Rattus norvegicus

Analyze

Symbol:

Fkbp1b

Name:

FKBP prolyl isomerase 1B

RGD ID:

61835

Description:

Enables FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Located in intracellular membrane-bounded organelle. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

12.6 kDa FK506-binding protein; 12.6 kDa FKBP; calstabin-2; FK506 binding protein 1B; FK506 binding protein 1b (12.6 kDa); FK506-binding protein 1B; FKBP-12.6; FKBP-1B; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B; PPIase FKBP1B; rotamase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FKBP1B (FKBP prolyl isomerase 1B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Fkbp1b (FK506 binding protein 1b)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fkbp1b (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fkbp1b (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fkbp1b (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FKBP1A (FKBP prolyl isomerase 1A)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Fkbp1b (FK506 binding protein 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	FKBP1B (FKBP prolyl isomerase 1B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	fkbp1b (FKBP prolyl isomerase 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	FPR1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Fkbp12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	fkb-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	fkb-8	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	27,832,128 - 27,850,600 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	6	27,838,802 - 27,848,653 (-)	Ensembl
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	29,977,797 - 29,987,451 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	27,309,253 - 27,318,232 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiac Arrhythmias (IEP)

cardiomyopathy (IEP)

catecholaminergic polymorphic ventricular tachycardia (ISS)

congestive heart failure (IEP)

Graves' disease (ISO)

Ventricular Fibrillation (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-dichloroaniline (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetylcholine (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atenolol (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

calcitriol (ISO)

calcium atom (ISO)

calcium(0) (ISO)

carbon nanotube (ISO)

carvedilol (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dantrolene (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

diisopropyl fluorophosphate (EXP)

diuron (ISO)

dofetilide (EXP)

dorsomorphin (ISO)

folic acid (ISO)

halothane (ISO)

indometacin (ISO)

isoprenaline (EXP)

L-methionine (ISO)

metoprolol (ISO)

nickel sulfate (ISO)

ochratoxin A (EXP)

paracetamol (ISO)

phenylmercury acetate (ISO)

propanal (ISO)

resveratrol (ISO)

rotenone (ISO)

ryanodine (ISO)

SB 431542 (ISO)

streptozocin (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chaperone-mediated protein folding (IBA)

insulin secretion (ISO)

insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

negative regulation of heart rate (ISO)

negative regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

negative regulation of phosphoprotein phosphatase activity (ISO)

negative regulation of release of sequestered calcium ion into cytosol (ISO)

negative regulation of ryanodine-sensitive calcium-release channel activity (ISO)

neuronal action potential propagation (ISO)

positive regulation of axon regeneration (IDA)

positive regulation of cytosolic calcium ion concentration (IDA,ISO)

positive regulation of sequestering of calcium ion (ISO)

protein peptidyl-prolyl isomerization (IBA,ISO)

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (IBA,ISO)

regulation of cytosolic calcium ion concentration (ISO)

regulation of heart rate (ISO)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (ISO)

regulation of ryanodine-sensitive calcium-release channel activity (ISO)

release of sequestered calcium ion into cytosol (ISO)

response to glucose (ISO)

response to hydrogen peroxide (IEP)

response to organic substance (IEP)

response to redox state (ISO)

response to vitamin E (IEP)

smooth muscle contraction (ISO)

T cell proliferation (ISO)

Cellular Component

calcium channel complex (ISO)

cytoplasm (IBA,ISO)

intracellular membrane-bounded organelle (IDA,ISO)

membrane (ISO)

sarcoplasmic reticulum (ISO)

sarcoplasmic reticulum membrane (IBA,ISO)

Z disc (ISO)

Molecular Function

calcium channel inhibitor activity (ISO)

cyclic nucleotide binding (IDA)

FK506 binding (IDA,ISO)

peptidyl-prolyl cis-trans isomerase activity (IBA,ISO)

protein binding (ISO)

signaling receptor binding (ISO)

transmembrane transporter binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Gold BG, etal., Neuroreport. 1998 Feb 16;9(3):553-8.
3.	He H, etal., Phytother Res. 2008 Aug;22(8):1115-24.
4.	He HB, etal., J Pharm Pharmacol. 2007 Jul;59(7):977-84.
5.	Li N, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):211-8. Epub 2008 Jun 27.
6.	Maalej A, etal., Autoimmunity. 2004 May;37(3):237-9.
7.	MGD data from the GO Consortium
8.	Na T, etal., Acta Pharmacol Sin. 2007 Jun;28(6):773-82.
9.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Noguchi N, etal., J Biol Chem 1997 Feb 7;272(6):3133-6.
11.	Online Mendelian Inheritance in Man, OMIM (TM).
12.	Qi MY, etal., J Pharm Pharmacol. 2008 Dec;60(12):1687-94.
13.	RGD automated data pipeline
14.	RGD automated import pipeline for gene-chemical interactions
15.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:7513996	PMID:7592869	PMID:10830164	PMID:11237759	PMID:12443530	PMID:12837242	PMID:14592808	PMID:14605212	PMID:15024040	PMID:16213210	PMID:16481613	PMID:16672364
PMID:17921453	PMID:18466757	PMID:19226252	PMID:19578067	PMID:19805579	PMID:20080623	PMID:20431056	PMID:21289178	PMID:21788490	PMID:22087651	PMID:22363773	PMID:24053175
PMID:26224869	PMID:29255009

Genomics

Comparative Map Data

Fkbp1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	27,832,128 - 27,850,600 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	6	27,838,802 - 27,848,653 (-)	Ensembl
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	29,977,797 - 29,987,451 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	27,309,253 - 27,318,232 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

FKBP1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	24,033,206 - 24,063,681 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	24,049,701 - 24,063,681 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	24,272,611 - 24,286,551 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	24,126,132 - 24,140,055 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	24,184,278 - 24,198,199	NCBI
Celera	2	24,112,915 - 24,126,882 (+)	NCBI
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	24,011,446 - 24,025,414 (+)	NCBI		HuRef
CHM1_1	2	24,201,974 - 24,215,941 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	24,084,432 - 24,098,366 (+)	NCBI

Fkbp1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	4,883,174 - 4,891,736 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	12	4,883,174 - 4,891,591 (-)	Ensembl
GRCm38	12	4,833,176 - 4,841,573 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	4,833,174 - 4,841,591 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	4,839,980 - 4,848,401 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	4,855,524 - 4,863,925 (-)	NCBI			mm8
Celera	12	4,764,579 - 4,773,000 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI

Fkbp1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	6,263,271 - 6,277,767 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	6,263,271 - 6,274,823 (+)	NCBI	ChiLan1.0	ChiLan1.0

FKBP1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	24,145,893 - 24,162,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	24,145,893 - 24,159,082 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	24,047,287 - 24,065,765 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

FKBP1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	18,534,295 - 18,544,973 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	18,534,741 - 18,544,943 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	18,433,090 - 18,443,766 (+)	NCBI
ROS_Cfam_1.0	17	18,809,188 - 18,819,365 (+)	NCBI
UMICH_Zoey_3.1	17	18,545,586 - 18,556,272 (+)	NCBI
UU_Cfam_GSD_1.0	17	18,595,511 - 18,606,198 (+)	NCBI

Fkbp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	62,916,727 - 62,923,563 (+)	NCBI
SpeTri2.0	NW_004936493	7,916,002 - 7,922,747 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FKBP1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	114,623,529 - 114,634,628 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	114,623,529 - 114,636,200 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	121,888,309 - 121,899,459 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FKBP1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	83,606,511 - 83,620,289 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	14	83,606,454 - 83,620,205 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666045	28,546,085 - 28,559,863 (+)	NCBI	Vero_WHO_p1.0

Fkbp1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	6,382,983 - 6,394,051 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624738	6,383,003 - 6,394,051 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH133671

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	27,839,107 - 27,839,321 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	29,986,997 - 29,987,210	NCBI	Rnor6.0
Rnor_5.0	6	39,899,284 - 39,899,497	UniSTS	Rnor5.0
Celera	6	27,308,799 - 27,309,012	UniSTS
RH 3.4 Map	6	117.7	UniSTS

RH94771

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	27,840,723 - 27,840,788 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	29,985,530 - 29,985,594	NCBI	Rnor6.0
Rnor_5.0	6	39,900,900 - 39,900,964	UniSTS	Rnor5.0
Celera	6	27,310,415 - 27,310,479	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	49
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000071784
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		4							54	17
Low	3	26	23	14	7	14	4	4	20	18	40	10	4
Below cutoff		13	20	13	12	13	4	5			1	1	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D86642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000071784 ⟹ ENSRNOP00000067023

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	27,838,802 - 27,848,653 (-)	Ensembl
Rnor_6.0 Ensembl	6	29,977,797 - 29,987,451 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119856 ⟹ ENSRNOP00000092320

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	27,839,691 - 27,848,653 (-)	Ensembl

RefSeq Acc Id:

NM_022675 ⟹ NP_073166

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,562 - 27,848,543 (-)	NCBI
Rnor_6.0	6	29,977,893 - 29,986,756 (+)	NCBI
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI
Celera	6	27,309,253 - 27,318,232 (-)	RGD

Sequence:

show sequence

ATGGGCGTGGAGATCGAGACCATCTCCCCGGGAGACGGAAGGACATTCCCTAAGAAGGGTCAGA
TATGCGTGGTGCACTACACAGGGATGCTCCAGAATGGCAAGAAATTCGATTCGTCCAGAGACAG
AAACAAACCCTTCAAGTTCAGAATTGGCAAGCAGGAAGTCATCAAAGGTTTTGAAGAAGGCGCT
GCCCAGATGAGCTTGGGGCAGAGGGCGAAGCTGACCTGCACCCCTGATGTGGCATATGGAGCTA
CTGGCCACCCCGGTGTCATCCCTCCCAATGCCACCCTCATCTTTGACGTGGAGCTGCTCAACTT
AGAGTGA

hide sequence

RefSeq Acc Id:

XM_006239860 ⟹ XP_006239922

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,066 - 27,848,792 (-)	NCBI
Rnor_6.0	6	29,977,669 - 29,987,252 (+)	NCBI
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI

Sequence:

show sequence

CTCGGGCCCCGCCCCGGCCGACCCCACCTTGTCGCACAGCTCCACCCCGCCGCCCCCTTCCCGG
CGGCCCCTCCCCGCGCAGGTCCTGACTCCAGCCGCACCTCCTCCGGCTCTGCAGTGGCGGCAAG
AAGACGAGCCGGAGCGCCTGCGGGGTCCGGCCTGAGCAGAGCCGGGGTCGGGGCAGCCGCGAGG
ACCCCCTTGGAGGCGGGGCCTGTGGGACCGCGATGGGCGTGGAGATCGAGACCATCTCCCCGGG
AGACGGGATGCTCCAGAATGGCAAGAAATTCGATTCGTCCAGAGACAGAAACAAACCCTTCAAG
TTCAGAATTGGCAAGCAGGAAGTCATCAAAGGTTTTGAAGAAGGCGCTGCCCAGATGAGCTTGG
GGCAGAGGGCGAAGCTGACCTGCACCCCTGATGTGGCATATGGAGCTACTGGCCACCCCGGTGT
CATCCCTCCCAATGCCACCCTCATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAGGCAGGAA
GGAAGTCGAGGTGGCTGGAGAAGGCTCCTGCTCTGTCCTAGCCTGCTCTCTCTGCCACTGGGAC
GGCTCCTCCAATGTAGGGCTCTTGATCAGTGTGCTGACCCCACCGCCCCTTGACATTATCTGTT
CTTTCTGCCCAACTTGCTCTGTATGTGTCGGCCACTTAACCGTCCCCATACATCTTTGCTTGAG
GAAACTTTTAGTTGCAGATCCAAACATTTCAGACTGCATTTTGTGTGATGCATGTGGTAGCCAT
TCCTGATCATAGGACACAGATCTCGTTTGCACAATCTATATTGCCTTACCTGCACTTAAGCCAG
ATATACAAGGTGCTCAGACATGCGCTGTACATGGTTACCTGGAGGGACTTGAGCCAGTTACCTT
TGCTGTCACTTTCTTATCTTCTGTTGGCTGCTCACTTTAAGCACTGCCCTCTTTGGAAATACTA
TGTAAAATAAAGGCTCTGTGCTTGGCATCTTCCTGTCCA

hide sequence

RefSeq Acc Id:

XM_017594336 ⟹ XP_017449825

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,066 - 27,850,600 (-)	NCBI
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI

Sequence:

show sequence

CCCGTAAACCTTCACAATCTTCTCAAGTGCTTCAACCTCTTCTCCCACGCAGGTCTCATCCGTT
CTCTTAGAAGAGGGATGCTCCAGAATGGCAAGAAATTCGATTCGTCCAGAGACAGAAACAAACC
CTTCAAGTTCAGAATTGGCAAGCAGGAAGTCATCAAAGGTTTTGAAGAAGGCGCTGCCCAGATG
AGCTTGGGGCAGAGGGCGAAGCTGACCTGCACCCCTGATGTGGCATATGGAGCTACTGGCCACC
CCGGTGTCATCCCTCCCAATGCCACCCTCATCTTTGACGTGGAGCTGCTCAACTTAGAGTGAAG
GCAGGAAGGAAGTCGAGGTGGCTGGAGAAGGCTCCTGCTCTGTCCTAGCCTGCTCTCTCTGCCA
CTGGGACGGCTCCTCCAATGTAGGGCTCTTGATCAGTGTGCTGACCCCACCGCCCCTTGACATT
ATCTGTTCTTTCTGCCCAACTTGCTCTGTATGTGTCGGCCACTTAACCGTCCCCATACATCTTT
GCTTGAGGAAACTTTTAGTTGCAGATCCAAACATTTCAGACTGCATTTTGTGTGATGCATGTGG
TAGCCATTCCTGATCATAGGACACAGATCTCGTTTGCACAATCTATATTGCCTTACCTGCACTT
AAGCCAGATATACAAGGTGCTCAGACATGCGCTGTACATGGTTACCTGGAGGGACTTGAGCCAG
TTACCTTTGCTGTCACTTTCTTATCTTCTGTTGGCTGCTCACTTTAAGCACTGCCCTCTTTGGA
AATACTATGTAAAATAAAGGCTCTGTGCTTGGCATCTTCCTGTCCA

hide sequence

RefSeq Acc Id:

XM_039112798 ⟹ XP_038968726

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,832,128 - 27,848,833 (-)	NCBI

RefSeq Acc Id:

XM_039112799 ⟹ XP_038968727

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,748 - 27,848,830 (-)	NCBI

RefSeq Acc Id:

XM_039112800 ⟹ XP_038968728

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,744 - 27,850,224 (-)	NCBI

RefSeq Acc Id:

XM_039112801 ⟹ XP_038968729

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,744 - 27,844,365 (-)	NCBI

RefSeq Acc Id:

XM_039112802 ⟹ XP_038968730

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,833,180 - 27,848,809 (-)	NCBI

RefSeq Acc Id:

XM_039112803 ⟹ XP_038968731

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,832,749 - 27,848,810 (-)	NCBI

RefSeq Acc Id:

XM_039112804 ⟹ XP_038968732

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,066 - 27,844,347 (-)	NCBI

RefSeq Acc Id:

XM_039112805 ⟹ XP_038968733

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,601 - 27,848,800 (-)	NCBI

RefSeq Acc Id:

XM_039112806 ⟹ XP_038968734

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,833,180 - 27,850,219 (-)	NCBI

RefSeq Acc Id:

XM_039112807 ⟹ XP_038968735

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,839,066 - 27,849,818 (-)	NCBI

RefSeq Acc Id:

XR_005505573

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	27,832,128 - 27,848,808 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388191	(Get FASTA)	NCBI Sequence Viewer
	NP_001388192	(Get FASTA)	NCBI Sequence Viewer
	NP_073166	(Get FASTA)	NCBI Sequence Viewer
	XP_006239922	(Get FASTA)	NCBI Sequence Viewer
	XP_017449825	(Get FASTA)	NCBI Sequence Viewer
	XP_038968726	(Get FASTA)	NCBI Sequence Viewer
	XP_038968727	(Get FASTA)	NCBI Sequence Viewer
	XP_038968728	(Get FASTA)	NCBI Sequence Viewer
	XP_038968729	(Get FASTA)	NCBI Sequence Viewer
	XP_038968730	(Get FASTA)	NCBI Sequence Viewer
	XP_038968731	(Get FASTA)	NCBI Sequence Viewer
	XP_038968732	(Get FASTA)	NCBI Sequence Viewer
	XP_038968733	(Get FASTA)	NCBI Sequence Viewer
	XP_038968734	(Get FASTA)	NCBI Sequence Viewer
	XP_038968735	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA13154	(Get FASTA)	NCBI Sequence Viewer
	EDM03049	(Get FASTA)	NCBI Sequence Viewer
	P97534	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_073166 ⟸ NM_022675
- UniProtKB:	P97534 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGVEIETISPGDGRTFPKKGQICVVHYTGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGA AQMSLGQRAKLTCTPDVAYGATGHPGVIPPNATLIFDVELLNLE hide sequence

RefSeq Acc Id:	XP_006239922 ⟸ XM_006239860
- Peptide Label:	isoform X7
- Sequence:	show sequence MGVEIETISPGDGMLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPD VAYGATGHPGVIPPNATLIFDVELLNLE hide sequence

RefSeq Acc Id:	XP_017449825 ⟸ XM_017594336
- Peptide Label:	isoform X10
- Sequence:	show sequence MLQNGKKFDSSRDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPDVAYGATGHPGVIP PNATLIFDVELLNLE hide sequence

RefSeq Acc Id:

ENSRNOP00000067023 ⟸ ENSRNOT00000071784

RefSeq Acc Id:	XP_038968726 ⟸ XM_039112798
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038968731 ⟸ XM_039112803
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038968734 ⟸ XM_039112806
- Peptide Label:	isoform X11

RefSeq Acc Id:	XP_038968730 ⟸ XM_039112802
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038968735 ⟸ XM_039112807
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038968732 ⟸ XM_039112804
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_038968733 ⟸ XM_039112805
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038968728 ⟸ XM_039112800
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038968729 ⟸ XM_039112801
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038968727 ⟸ XM_039112799
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000092320 ⟸ ENSRNOT00000119856

Protein Domains

PPIase FKBP-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97534-F1-model_v2	AlphaFold	P97534	1-108	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694479

Promoter ID:

EPDNEW_R5002

Type:

initiation region

Name:

Fkbp1b_1

Description:

FK506 binding protein 1B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	29,977,785 - 29,977,845	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61835	AgrOrtholog
BioCyc Gene	G2FUF-38263	BioCyc
Ensembl Genes	ENSRNOG00000047143	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000067023	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000092320	ENTREZGENE
Ensembl Transcript	ENSRNOT00000071784	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000119856	ENTREZGENE
InterPro	PPIase_FKBP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:58950	UniProtKB/Swiss-Prot
NCBI Gene	58950	ENTREZGENE
Pfam	FKBP_C	UniProtKB/Swiss-Prot
PharmGKB	FKBP1B	RGD
PhenoGen	Fkbp1b	PhenoGen
PROSITE	FKBP_PPIASE	UniProtKB/Swiss-Prot
TIGR	TC208795
UniProt	FKB1B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-09	Fkbp1b	FKBP prolyl isomerase 1B	Fkbp1b	FK506 binding protein 1B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-01	Fkbp1b	FK506 binding protein 1B	Fkbp1b	FK506 binding protein 1b	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Fkbp1b	FK506 binding protein 1b			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	found in pancreatic islets of Langerhans	61587
gene_physical_interaction	binds selectively to ryanodine receptor 2(RyR2), also binds cyclic ADP-ribose	61587
gene_process	effects the release of intracellular calcium, my be important for insulin secretion	61587

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI