Fkbp1b (FKBP prolyl isomerase 1B)

Gene: Fkbp1b (FKBP prolyl isomerase 1B) Rattus norvegicus

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Symbol:

Fkbp1b

Name:

FKBP prolyl isomerase 1B

Description:

Exhibits FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Localizes to the intracellular membrane-bounded organelle. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B); INTERACTS WITH ammonium chloride; bisphenol A; cocaine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

12.6 kDa FK506-binding protein; 12.6 kDa FKBP; calstabin-2; FK506 binding protein 1B; FK506 binding protein 1b (12.6 kDa); FK506-binding protein 1B; FKBP-12.6; FKBP-1B; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B; PPIase FKBP1B; rotamase

Orthologs:

Homo sapiens (human) : FKBP1B (FKBP prolyl isomerase 1B) HGNC Alliance
Mus musculus (house mouse) : Fkbp1b (FK506 binding protein 1b) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fkbp1b (FKBP prolyl isomerase 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : FKBP1B (FKBP prolyl isomerase 1B)
Canis lupus familiaris (dog) : FKBP1B (FKBP prolyl isomerase 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fkbp1b (FKBP prolyl isomerase 1B)
Sus scrofa (pig) : FKBP1B (FKBP prolyl isomerase 1B)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FKBP1B (FKBP prolyl isomerase 1B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Fkbp1b (FK506 binding protein 1b)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fkbp1b (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fkbp1b (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FKBP1B (FKBP prolyl isomerase 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FKBP1A (FKBP prolyl isomerase 1A)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Fkbp1b (FK506 binding protein 1b)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):	FKBP1B (FKBP prolyl isomerase 1B)	Alliance	DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):	fkbp1b (FKBP prolyl isomerase 1B)	Alliance	DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	FPR1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):	Fkbp12	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):	fkb-2	Alliance	DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):	fkb-8	Alliance	DIOPT (OrthoInspector, PANTHER, PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	6	29,975,863 - 29,987,252 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	39,899,242 - 39,908,337 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	27,309,253 - 27,318,232 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

Position Markers

QTLs in Region (Rnor_6.0)

miRNA Target Status

Sequence

Nucleotide Sequences

Protein Sequences

Transcriptome

Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links

Nomenclature History

RGD Curation Notes

More on Fkbp1b
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	61835
Created:	2001-04-11
Species:	Rattus norvegicus
Last Modified:	2019-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

Gene Enrichment unavailable	Ortholog Finder unavailable
Gene Enrichment	Ortholog Finder

RGD Manual Annotations

Imported Annotations - MGI