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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDIsoproterenol results in increased expression of MMP9 mRNAPMID:18594475 PMID:35608392
Mmp9multiple interactionsEXP 6480464CTDCPU0213 inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]PMID:18594475 PMID:35608392
Mmp9increases activityISOMmp9 (Mus musculus)6480464CTDIsoproterenol results in increased activity of MMP9PMID:18089841
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDIsoproterenol results in increased expression of MMP9 mRNAPMID:16574429 PMID:24929186
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDPropranolol inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]PMID:16574429
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDDoxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]PMID:18089841
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