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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDIsoproterenol results in increased expression of NCF2 mRNA, Isoproterenol results in increased expression of NCF2 protein

PMID:20723002
multiple interactionsEXP 6480464CTD1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA], 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein], dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA], dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]

PMID:20723002
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.