Lrrc8c (leucine rich repeat containing 8 VRAC subunit C)

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Gene: Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) Rattus norvegicus

Analyze

Symbol:

Lrrc8c

Name:

leucine rich repeat containing 8 VRAC subunit C

RGD ID:

1306585

Description:

Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Is integral component of plasma membrane. Part of ion channel complex. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leucine rich repeat containing 8 family, member C; leucine-rich repeat-containing protein 8C; LOC289443; MGC112653; RGD1306585; similar to hypothetical protein AD158; volume-regulated anion channel subunit LRRC8C

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	4,223,901 - 4,315,590 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	14	4,227,832 - 4,315,249 (-)	Ensembl
Rnor_6.0	14	5,283,655 - 5,378,738 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,283,647 - 5,378,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	5,274,372 - 5,369,435 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	5,306,227 - 5,393,820 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	5,306,353 - 5,393,463 (-)	NCBI
Celera	14	4,390,675 - 4,477,877 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

multiple sclerosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chloroprene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

formaldehyde (ISO)

gentamycin (EXP)

isoprenaline (ISO)

methamphetamine (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

paracetamol (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

progesterone (ISO)

SB 431542 (ISO)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triclosan (ISO)

troglitazone (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anion transmembrane transport (ISO,ISS)

aspartate transmembrane transport (IMP)

cellular response to osmotic stress (IMP)

cyclic-GMP-AMP transmembrane import across plasma membrane (ISO,ISS)

fat cell differentiation (ISO)

inorganic anion transport (IEA)

protein hexamerization (ISO,ISS)

taurine transport (IMP)

Cellular Component

cytoplasm (ISO,ISS)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

integral component of plasma membrane (IMP,ISO,ISS)

ion channel complex (IMP,ISO,ISS)

plasma membrane (ISO,ISS)

Molecular Function

protein binding (ISO)

volume-sensitive anion channel activity (IMP,ISO,ISS)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MGD data from the GO Consortium
3.	RGD automated data pipeline
4.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	RGD automated import pipeline for gene-chemical interactions
6.	Schober AL, etal., J Physiol. 2017 Nov 15;595(22):6939-6951. doi: 10.1113/JP275053. Epub 2017 Sep 12.

Additional References at PubMed

PMID:12477932	PMID:15184384	PMID:15489334	PMID:19946888	PMID:24790029	PMID:26824658	PMID:29769723

Genomics

Comparative Map Data

Lrrc8c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	4,223,901 - 4,315,590 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	14	4,227,832 - 4,315,249 (-)	Ensembl
Rnor_6.0	14	5,283,655 - 5,378,738 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,283,647 - 5,378,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	5,274,372 - 5,369,435 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	5,306,227 - 5,393,820 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	5,306,353 - 5,393,463 (-)	NCBI
Celera	14	4,390,675 - 4,477,877 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

LRRC8C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,615,824 - 89,719,533 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	89,633,072 - 89,769,903 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	90,098,679 - 90,185,092 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,871,350 - 89,953,169 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	1	88,344,351 - 88,430,780 (+)	NCBI
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	88,215,951 - 88,302,419 (+)	NCBI		HuRef
CHM1_1	1	90,213,622 - 90,300,056 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	89,476,355 - 89,562,765 (+)	NCBI

Lrrc8c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	105,666,850 - 105,760,884 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	105,667,254 - 105,760,884 (+)	Ensembl
GRCm38	5	105,519,345 - 105,613,018 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	105,519,388 - 105,613,018 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	105,948,490 - 106,037,973 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	105,759,773 - 105,849,256 (+)	NCBI			mm8
Celera	5	102,631,726 - 102,729,227 (+)	NCBI		Celera
Cytogenetic Map	5	E5	NCBI

Lrrc8c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	4,460,212 - 4,494,317 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	4,460,212 - 4,494,317 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC8C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	91,001,695 - 91,134,865 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	91,105,551 - 91,138,447 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	92,299,691 - 92,384,733 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

LRRC8C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	58,895,769 - 58,932,729 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	58,899,996 - 58,932,729 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	61,605,421 - 61,690,225 (-)	NCBI
ROS_Cfam_1.0	6	59,407,523 - 59,492,055 (-)	NCBI
ROS_Cfam_1.0 Ensembl	6	59,409,555 - 59,493,796 (-)	Ensembl
UMICH_Zoey_3.1	6	58,981,235 - 59,065,445 (-)	NCBI
UNSW_CanFamBas_1.0	6	58,934,585 - 59,019,172 (-)	NCBI
UU_Cfam_GSD_1.0	6	59,414,770 - 59,499,275 (-)	NCBI

Lrrc8c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	99,823,337 - 99,897,484 (+)	NCBI
SpeTri2.0	NW_004936537	9,050,495 - 9,124,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC8C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	126,931,849 - 127,079,843 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	126,957,099 - 127,079,042 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	138,996,955 - 139,119,829 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC8C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	43,752,341 - 43,842,958 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	20	43,752,370 - 43,842,766 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666033	74,090,984 - 74,181,626 (+)	NCBI	Vero_WHO_p1.0

Lrrc8c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	8,009,901 - 8,096,652 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624742	8,010,849 - 8,096,567 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

AI326115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,228,029 - 4,228,206 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,287,784 - 5,287,960	NCBI	Rnor6.0
Rnor_5.0	14	5,278,501 - 5,278,677	UniSTS	Rnor5.0
RGSC_v3.4	14	5,306,420 - 5,306,596	UniSTS	RGSC3.4
Celera	14	4,390,868 - 4,391,044	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH135313

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,266,065 - 4,266,285 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,325,890 - 5,326,109	NCBI	Rnor6.0
Rnor_5.0	14	5,316,607 - 5,316,826	UniSTS	Rnor5.0
RGSC_v3.4	14	5,344,454 - 5,344,673	UniSTS	RGSC3.4
Celera	14	4,428,886 - 4,429,105	UniSTS
RH 3.4 Map	14	80.7	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH137556

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,255,709 - 4,255,833 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,315,461 - 5,315,584	NCBI	Rnor6.0
Rnor_5.0	14	5,306,178 - 5,306,301	UniSTS	Rnor5.0
RGSC_v3.4	14	5,334,097 - 5,334,220	UniSTS	RGSC3.4
Celera	14	4,418,530 - 4,418,653	UniSTS
Cytogenetic Map	14	p22	UniSTS

BE096967

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,268,264 - 4,268,429 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,328,088 - 5,328,252	NCBI	Rnor6.0
Rnor_5.0	14	5,318,805 - 5,318,969	UniSTS	Rnor5.0
RGSC_v3.4	14	5,346,652 - 5,346,816	UniSTS	RGSC3.4
Celera	14	4,431,084 - 4,431,248	UniSTS
RH 3.4 Map	14	84.7	UniSTS
Cytogenetic Map	14	p22	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3813074	9088978	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	94
Count of miRNA genes:	70
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000002896
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		16	9	2	18	2			54	16	28	8
Low	3	27	48	39	1	39	8	11	20	19	13	3	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002896 ⟹ ENSRNOP00000002896

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	5,283,647 - 5,378,726 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104559 ⟹ ENSRNOP00000082962

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,227,832 - 4,315,249 (-)	Ensembl

RefSeq Acc Id:

NM_001037179 ⟹ NP_001032256

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	4,227,837 - 4,315,205 (-)	NCBI
Rnor_6.0	14	5,287,591 - 5,378,698 (-)	NCBI
Rnor_5.0	14	5,274,372 - 5,369,435 (-)	NCBI
RGSC_v3.4	14	5,306,227 - 5,393,820 (-)	RGD
Celera	14	4,390,675 - 4,477,877 (-)	RGD

Sequence:

show sequence

AGCTGGGGCGTTAGCTGCGTCCCGGCTCAGAGCCCGCGAAGAGGACGAGGACCGAGGCGCCGCC
GCGTCCCTGGCCGTAGCACTCTGGTCGCGACAAGCCATGAGCAGCGACGCCGCGGTCGCTGGCC
GTCGCTGAGCCCAACCCGGACACAGCTCGCCGCGCCCTGGCATCCTGTTTTGCGGACACCCTCG
CCCCCAGAGATTAATGTGGCTGCTTATGACTAAGAATTCTGGGACCACAGATGTTCAGAGAAGT
AACATATACATATAAGAAACATGATTCCAGTGACCGAGTTCCGGCAGTTCTCCGAGCAGCAGCC
TGCCTTCCGGGTGCTGAAGCCGTGGTGGGATGTGTTCACGGACTACCTCTCGGTGGCCATGCTG
ATGATCGGGGTGTTTGGATGTACTTTACAAGTCATGCAAGACAAGATCATCTGCCTCCCAAAAA
GAGTGCAGCCTGCTCAGAACCACTCTTCCCTCTCCAACGTCTCCCAGACTGTGATCAATACCAC
CCCGCTGCCCCCACCTAAACCCTCTCCGACCAACCCGGCGACCGTGGAGATGAAGGGACTGAAG
ACAGACCTGGACCTCCAGCAGTACAGTTTCATCAACCAGATGTGCTACGAGCGAGCCCTCCACT
GGTATGCCAAGTACTTCCCGTACCTTGTGCTCATCCACACCCTGGTCTTCATGCTCTGCAGCAA
CTTCTGGTTCAAGTTCCCTGGATCTAGTTCCAAAATAGAACATTTCATCTCCATCCTGGGGAAG
TGCTTCGACTCCCCGTGGACCACTCGGGCTCTCTCCGAGGTGTCTGGCGAGGACTCCGAAGAGA
AGGACAATAGGAAGAACAACATGAACAGGTCCAACACCATCCAGTCCGGTCCGGAAGGCAGCCT
GGTCAAGTCCCAGTCTCTCAAGTCAATTCCCGAGAAGTTCGTGGTTGACAAATCCACTGCGGGG
GCTCTGGACAAGAAGGAAGGTGAACAGGCCAAGGCCTTGTTCGAGAAGGTTAAGAAGTTCAGAC
TGCACGTGGAGGAAGGTGACATCCTGTATGCCATGTATGTGCGGCAGACTGTGCTTAAGGTCAT
CAAGTTCCTGATCATCATCGCCTACAACAGTGCTCTGGTTTCCAAAGTCCAGTTCACCGTGGAC
TGCAATGTGGACATCCAGGACATGACGGGCTATAAGAACTTTTCCTGCAATCACACCATGGCTC
ATTTGTTCTCCAAACTCTCCTTTTGCTACCTGTGCTTTGTAAGCATCTACGGCCTGACGTGCCT
TTATACCTTGTACTGGCTGTTCTACCGTTCTCTGAGGGAGTACTCTTTTGAGTATGTCCGGCAG
GAGACTGGAATCGATGACATTCCGGACGTGAAAAATGACTTTGCCTTTATGCTCCATATGATAG
ACCAGTATGACCCTCTCTATTCCAAGAGGTTTGCGGTGTTCCTCTCTGAGGTCAGCGAGAACAA
GTTAAAGCAGCTCAACTTAAATAACGAGTGGACCCCCGACAAGCTGCGGCAGAAGCTGCAGACG
AATGCCCACAACCGCCTGGAGCTGCCTCTCATCATGCTGTCTGGCCTCCCAGACACCGTGTTCG
AGATCACGGAGTTACAGTCCCTGAAGCTGGAGATCATTAAGAACGTCATGATACCCGCCACCAT
CGCCCAGCTAGACAACCTTCAGGAGCTCTCCCTCCACCAGTGCTCCGTCAAGATCCACAGTGCG
GCACTCTCCTTCCTGAAGGAGAATCTCAAGGTCTTGAGCGTCAAGTTCGATGACATGAGGGAGC
TGCCCCCCTGGATGTACGGCCTCCGGAATCTGGAAGAGCTCTATCTGGTTGGCTCTCTGAGTCA
CGACATCTCCAAAAACGTCACCCTGGAGTCCCTGCGGGACCTCAAAAGCCTTAAAATCCTTTCC
ATCAAGAGCAACGTCTCCAAGATCCCTCAGGCCGTGGTGGATGTGTCCAGCCACCTCCAGAAGA
TGTGCATTCACAACGACGGCACCAAGCTGGTAATGCTCAACAACCTGAAGAAGATGACCAACCT
GACCGAGCTGGAACTGGTCCACTGCGACCTGGAACGCATTCCCCACGCCGTGTTCAGCCTGCTC
AGTCTCCAGGAGCTGGACCTGAAGGAGAACAACCTGAAGTCCATAGAGGAGATCGTGAGTTTCC
AGCACTTGAGAAAGCTAACCGTGCTCAAACTGTGGTATAACAGCATCGCTTACATCCCAGAGCA
CATCAAGAAACTGACCAGCCTGGAGCGACTGTTTTTCAGCCACAATAAGGTAGAAGTGCTTCCC
TCCCACCTCTTCCTGTGCAACAAAATCAGATACCTGGACCTGTCCTATAACGACATTCGCTTCA
TCCCGCCCGAAATCGGGGTTCTGCAAAGTTTACAGTATTTCTCCATCACCTGTAACAAAGTGGA
GAGCCTCCCGGATGAACTCTACTTCTGCAAGAAACTTAAAACATTGAAGATCGGGAAAAACAGC
CTCTCTGTACTTTCACCAAAAATTGGAAACTTACTATTTCTTTCCTACTTAGACATCAAAGGCA
ATCACTTTGAAGTCCTCCCTCCCGAGCTGGGAGACTGCCGGGCTCTGAAACGAGCCGGGCTGGT
TGTGGAAGACGCTCTGTTTGAGACTCTGCCCTCAGATGTCCGGGAGCAAATGAAAGCAGACTAA
CTTATTTTTCATCAAAATATGACTGAAACATGCTTCTACCAAATACAATATAAAGAATTAGGTA
GTCCTAATGCCTTTCCTATATTATTTTTTTTCTTTTCCACACCAAGACATGTACACAAAGATCG
AGTAAGGAGTATGTATTTTTTAATAAAAGTTTAATTGTAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

RefSeq Acc Id:

XM_006250542 ⟹ XP_006250604

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	4,223,901 - 4,315,588 (-)	NCBI
Rnor_6.0	14	5,283,655 - 5,378,738 (-)	NCBI
Rnor_5.0	14	5,274,372 - 5,369,435 (-)	NCBI

Sequence:

show sequence

GCAGGCGGGGAGGCACCGGGGAGGAGGAACAGGGCTGCGGAGCTGGGGCGTTAGCTGCGTCCCG
GCTCAGAGCCCGCGAAGAGGACGAGGACCGAGGCGCCGCCGCGTCCCTGGCCGTAGCACTCTGG
TCGCGACAAGCCATGAGCAGCGACGCCGCGGTCGCTGGCCGTCGCTGAGCCCAACCCGGACACA
GCTCGCCGCGCCCTGGCATCCTGTTTTGCGGACACCCTCGCCCCCAGAGAAACATGATTCCAGT
GACCGAGTTCCGGCAGTTCTCCGAGCAGCAGCCTGCCTTCCGGGTGCTGAAGCCGTGGTGGGAT
GTGTTCACGGACTACCTCTCGGTGGCCATGCTGATGATCGGGGTGTTTGGATGTACTTTACAAG
TCATGCAAGACAAGATCATCTGCCTCCCAAAAAGAGTGCAGCCTGCTCAGAACCACTCTTCCCT
CTCCAACGTCTCCCAGACTGTGATCAATACCACCCCGCTGCCCCCACCTAAACCCTCTCCGACC
AACCCGGCGACCGTGGAGATGAAGGGACTGAAGACAGACCTGGACCTCCAGCAGTACAGTTTCA
TCAACCAGATGTGCTACGAGCGAGCCCTCCACTGGTATGCCAAGTACTTCCCGTACCTTGTGCT
CATCCACACCCTGGTCTTCATGCTCTGCAGCAACTTCTGGTTCAAGTTCCCTGGATCTAGTTCC
AAAATAGAACATTTCATCTCCATCCTGGGGAAGTGCTTCGACTCCCCGTGGACCACTCGGGCTC
TCTCCGAGGTGTCTGGCGAGGACTCCGAAGAGAAGGACAATAGGAAGAACAACATGAACAGGTC
CAACACCATCCAGTCCGGTCCGGAAGGCAGCCTGGTCAAGTCCCAGTCTCTCAAGTCAATTCCC
GAGAAGTTCGTGGTTGACAAATCCACTGCGGGGGCTCTGGACAAGAAGGAAGGTGAACAGGCCA
AGGCCTTGTTCGAGAAGGTTAAGAAGTTCAGACTGCACGTGGAGGAAGGTGACATCCTGTATGC
CATGTATGTGCGGCAGACTGTGCTTAAGGTCATCAAGTTCCTGATCATCATCGCCTACAACAGT
GCTCTGGTTTCCAAAGTCCAGTTCACCGTGGACTGCAATGTGGACATCCAGGACATGACGGGCT
ATAAGAACTTTTCCTGCAATCACACCATGGCTCATTTGTTCTCCAAACTCTCCTTTTGCTACCT
GTGCTTTGTAAGCATCTACGGCCTGACGTGCCTTTATACCTTGTACTGGCTGTTCTACCGTTCT
CTGAGGGAGTACTCTTTTGAGTATGTCCGGCAGGAGACTGGAATCGATGACATTCCGGACGTGA
AAAATGACTTTGCCTTTATGCTCCATATGATAGACCAGTATGACCCTCTCTATTCCAAGAGGTT
TGCGGTGTTCCTCTCTGAGGTCAGCGAGAACAAGTTAAAGCAGCTCAACTTAAATAACGAGTGG
ACCCCCGACAAGCTGCGGCAGAAGCTGCAGACGAATGCCCACAACCGCCTGGAGCTGCCTCTCA
TCATGCTGTCTGGCCTCCCAGACACCGTGTTCGAGATCACGGAGTTACAGTCCCTGAAGCTGGA
GATCATTAAGAACGTCATGATACCCGCCACCATCGCCCAGCTAGACAACCTTCAGGAGCTCTCC
CTCCACCAGTGCTCCGTCAAGATCCACAGTGCGGCACTCTCCTTCCTGAAGGAGAATCTCAAGG
TCTTGAGCGTCAAGTTCGATGACATGAGGGAGCTGCCCCCCTGGATGTACGGCCTCCGGAATCT
GGAAGAGCTCTATCTGGTTGGCTCTCTGAGTCACGACATCTCCAAAAACGTCACCCTGGAGTCC
CTGCGGGACCTCAAAAGCCTTAAAATCCTTTCCATCAAGAGCAACGTCTCCAAGATCCCTCAGG
CCGTGGTGGATGTGTCCAGCCACCTCCAGAAGATGTGCATTCACAACGACGGCACCAAGCTGGT
AATGCTCAACAACCTGAAGAAGATGACCAACCTGACCGAGCTGGAACTGGTCCACTGCGACCTG
GAACGCATTCCCCACGCCGTGTTCAGCCTGCTCAGTCTCCAGGAGCTGGACCTGAAGGAGAACA
ACCTGAAGTCCATAGAGGAGATCGTGAGTTTCCAGCACTTGAGAAAGCTAACCGTGCTCAAACT
GTGGTATAACAGCATCGCTTACATCCCAGAGCACATCAAGAAACTGACCAGCCTGGAGCGACTG
TTTTTCAGCCACAATAAGGTAGAAGTGCTTCCCTCCCACCTCTTCCTGTGCAACAAAATCAGAT
ACCTGGACCTGTCCTATAACGACATTCGCTTCATCCCGCCCGAAATCGGGGTTCTGCAAAGTTT
ACAGTATTTCTCCATCACCTGTAACAAAGTGGAGAGCCTCCCGGATGAACTCTACTTCTGCAAG
AAACTTAAAACATTGAAGATCGGGAAAAACAGCCTCTCTGTACTTTCACCAAAAATTGGAAACT
TACTATTTCTTTCCTACTTAGACATCAAAGGCAATCACTTTGAAGTCCTCCCTCCCGAGCTGGG
AGACTGCCGGGCTCTGAAACGAGCCGGGCTGGTTGTGGAAGACGCTCTGTTTGAGACTCTGCCC
TCAGATGTCCGGGAGCAAATGAAAGCAGACTAACTTATTTTTCATCAAAATATGACTGAAACAT
GCTTCTACCAAATACAATATAAAGAATTAGGTAGTCCTAATGCCTTTCCTATATTATTTTTTTT
CTTTTCCACACCAAGACATGTACACAAAGATCGAGTAAGGAGTATGTATTTTTTAATAAAAGTT
TAATTGTATTTTTTCAATATTAATATTTTAAAGTTTTATTTATCCTGGAAGCTGACTCATCTGT
TACTGCTTTCTGCCAGCAGGGATGGGTAGTTCCAACTGGCCTTGGGTTTTGCTTGAGAGCTTGA
GCTCATTCTTGTAAGAGGAAAGGGATCGTAGGTCGCGTGCATTTTGGCATAGTCTGAATGGGTA
GAGATATTCCGCCAACACCACCCTTAGTTCTTTCTACCCGTCAGAGCCCTTGGCGTGTTTCACC
GTGTGCACTGAGGCGAGGAGTCTATGCCAGCTGTTTTACTGTGAGCCTCCGCCTTCACGGGTCA
GGTGGTGCTACTCTGTAGGAAACCCTAGACTGTGAGCTCACACAAGTGCACTGTCACAGAGTAT
TACCCTGAGAAATCCCCTGCCTCTGACAGCGTTAATTGTATTATTTCCTAAACAGTTTCAGTTA
ACCTCGGCCCGGCTTTGTAAGTGGGTGAAGAAAGGAACCCCCTGTGGTTGCCGTCCTTGCGCGC
ATGCGTGCATTGTTTGCTGTCTAACTGATTCGTGTTTTTACCACCATCCTAAAATATGCCATCA
AAAATTAAATACAACCACCGCCACCCCCATCCGCCTCAGTATTGCCATATGGTACTGTTGAACA
ACCTTGGGGAAATTAGATTTATTTCAATATTCTGGCAGATAATTAAATTTTAAATCATAGAATT
AGAAGCCCTGTTTTGAGTAATTTAATCATTTTTGATGCCTTGATATGTGGATGCCTCCGATGGA
AAACAATCTTGCTACTAAGGCACTCTGTTAGAAAGCTGATGTATTCCGCACAGACCCCATCCCA
TCCCCTCCCCGGACCCTGTGCCGAGATATCAGTTCACTTTCTGCCTGCTGAACAAAACAGCCCA
CTGTATACAGAAGCACAGCCATCAGTTTCCCGCAAGCCTGCCCTCGAGGCCGATGCCAGTGCGG
CAAGCATGGGAACTCCTCGGCTGTCTGCTTAAGGATGCACCTCACTTAGAGCTGACTAACCTCT
CGGTGTTCTCGCTTAGCAATAGTTCCTGCCTAGTGTCGGGTGAAGCTTTTGTGTGGAGACATGA
GTGACACACTCCACCGACTGGCCTAGGGAAAAATTTAACACCGACAGTGGGAAGATGATTTGAC
TTCCAAAACCCTGTTTTGAAGATCGTTTTCTTGGCCCCCATGACCTTGCCTAGACCTGTTTTTT
TGTGACACGTAGACATGGACAAGGCCTGGGAAACACATGGTCCTCCTCGTCTGAGTTAAGACAG
AGAGCTGTGAGGGTGTAGCTCAGTGACGAAGCGCTTGTCCAGCGCTGTGCCCGGAGTCTGAGTT
TAGTGACCTGGGGGACGGGATTCATGGCGGTGGGTGGAGGAAGAGCAGTGAACAATCGTGCGAG
GGGCCAGCCATGTGCAAGCACTTCTGTCTTCTGCTTAAAGTTTCAGTCATGATTTCTTTAAACC
TGGAATTAAGATAATAATATTTTGAAATACTATTATGGCTTATATGTCTTATATGAAGAAATAT
TCAGTTTCAGAATATTAAATCATATGAATCACGTGCCATGTTCAGAAAAGCTCTGTCTTAAAGA
ACTTACGGGCAGATTGTCTGTTATTGAGCATGGGTAGCCTGTTGTGGAAATGTAAATTGAACCA
ATGAATGCACTGTGTTGATTGTTAAGACTTGTGGTTATTTCTAACATCACCCTTCCAAGGGGAC
CTATTAGAGTTAAACACCATAGCTAAACTGAAGTCTTTCTCTGGCATTAACTGAAAATTAACCC
ATAGGGGTTCCTAACTGAAGCAAATCGCCAATAATTCAGTTTTATCAAGCTTCCAAATAATTTG
ATTTGTTTTCATAGTGATTGTTTTTTTGCAGGCTCACTCCCAACCTAGGTTGTAAATATCATTC
AATAAACCAGAATAATCCCAAGACTAAAAGGGAAATGTTCATAGATCTTTCTATTAGATTTTTA
TAAAAAAACTTCCAAAGCCTCACAAACTCTGAAGAGTTTGGATTTTCTGACTCCCGTCCTTTTT
AACACGGTAAGCTTTTGTTCGCGTTCTCGCTTTCAGTTACTGTCCAGCCTTCCAACAGGAAACT
CAGGTACCTGAACTGCTGGCTTCTCTAATGTTCTCTGATCTAACTCAGCACAGAGAGGCTGTCT
GCCTCCTCTCTCTGTGTTTTCCAAGTGCTCTTCCTGAGAAGGATCAGCTCTGTCCAACCTCCGA
CTCACAACAAACTGCTGTATAAATCACAAATGTGCCATCTGTACTCTCAACTCCGGGGCTCGCT
TCAAGCTCAAGGTGGCCACGCTGCACAGTGAGGTTTACTAACAGAGTACAGAACAGCCGTCTGG
TGGTGCTGTGGTTGGAAGGTCCTAATAGAACCCCACCTAAGGGACCAGCAAGATGGCTCTGTGG
GGGAATGGCACTTGCCATCCACCTGAGGTCCTGAGCTTGCTCTCCAGGATCCACACAGTGGAAC
AGAGAACCAACTCCCATAAGTCGTCCTCTGACAGGTGCCACGCCACGAGCCCCTACACAAAACG
TGCACAAACCAATTAATGAAAATTTTACACCCAAGAATGTAACACCTCAGAACAGAATTGTGTT
TTCTTATTATGTGATTTGATCTCGTTTTGAATATCAGAACTCTCGATGGGATAAAATTTGTGAT
GTACATGAGGTCCTTTGCATGGCCCACCCAGTCCTTGCCTGGTGTTACAATGAGCTCCAACCGT
CTCTGTGGCGTCCTAAATAGCAAGCAAGCCTGCCCTTTCAGGCTCTTTGGAAATGTCCCTGCCC
CAAAGATGGTGTTCATTTTAATCATAGGCCCTGCTCTGAAAGGTCTGAAACATGGACTCTTCCT
TGGGTTTCCTCAACAAAAGAAGCCCAGTTGTTTTGTTTTGTTTTGTTTTTCCAGTATGCTGGTT
TCTGGCTTTAGTTTATCTCACTCTCTAATCCAATTTTCACACCAAATACCTGATCAACAGTATT
GGCATTTCATCGATACAAAAAAATCTGTTAGCGCTACTCTTGTGAGTCTTGTTGATGTCATTTC
GGTCTTTCAGAGTGTTAGTGAGGACTACATTAAAGAGTTCACACTGGGGCAGAGTCTCAAGAAC
AGGGCTTCATACCCAAGTGGATAAAAATTGCTACCACTGAGGAGACTTCTGGAAGAGTCTATGG
GATGTTTGCACCTTTTCCATTTAGAGACATAGTAAGAAATCCCAGTCTTACCTAGAGCAGCCGT
GAGTTTTCAGGTTTATCTCTCAGTCTTCAATGATAATTATTATATCAGCCTCCCACCCCCACCC
CCAGCAAGTATCTGCTCCCATTCCCCTTCCCAAAGTCACCCACTAACAAAGATGACATTCTTAG
GATTATCTGAGGGAGAGAGAAGAGAGTCTCTGCCCCCAAGGAATTTATATTTTAATCAGAGAGA
TATAGAACATTGGACAGCTTGACTTACTGACCAGATAGCAGCCACTATGTGTTCAGGGTTTGGT
TTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGAGCCAGGGTCTTGCTTTTTAACCCAGGCT
GACCTTAAACTTGAGAGCCTCTTGCCTTGGCTTCCTGGACACTGGATTACAAGTGTTTACTGCA
CACCTGGCCCGAGTGGTTTCTAGTGCATTCGTTTTTGTGTCTTCATTCCCCTGCGACTCGGCTC
TTTGGGGTTGACGCCCCACGCCTTACGTGCTTGCTCGTGTTCGGTTCGCGTCTGTTTGCTATGT
TCATGTGCATTCAGATGGTCGAGGGCTGGCAAACTTCTTGGACTGCCGAGAGAAAGGACTGATG
GTTGGTTTGTCAGAATACATGTTCATGAAAGGAAACCGTCTTAATGTTACTTCGCTATGTAGTG
TACAGGAACAAAAATAAATAAAGTTGTTTTTGTAACGTAA

hide sequence

RefSeq Acc Id:

XM_039091660 ⟹ XP_038947588

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	4,223,901 - 4,315,590 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032256	(Get FASTA)	NCBI Sequence Viewer
	XP_006250604	(Get FASTA)	NCBI Sequence Viewer
	XP_038947588	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00077	(Get FASTA)	NCBI Sequence Viewer
	EDL99473	(Get FASTA)	NCBI Sequence Viewer
	Q498T9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001032256 ⟸ NM_001037179

- UniProtKB:

Q498T9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQN
HSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFP
YLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNN
MNRSNTIQSGPEGSLVKSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGD
ILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLS
FCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLY
SKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQS
LKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYG
LRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDG
TKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLT
VLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGV
LQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLP
PELGDCRALKRAGLVVEDALFETLPSDVREQMKAD

hide sequence

RefSeq Acc Id:	XP_006250604 ⟸ XM_006250542
- Peptide Label:	isoform X1
- UniProtKB:	Q498T9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQN HSSLSNVSQTVINTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFP YLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNN MNRSNTIQSGPEGSLVKSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEEGD ILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLS FCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLY SKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQS LKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYG LRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDG TKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLT VLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGV LQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLP PELGDCRALKRAGLVVEDALFETLPSDVREQMKAD hide sequence

RefSeq Acc Id:

ENSRNOP00000002896 ⟸ ENSRNOT00000002896

RefSeq Acc Id:	XP_038947588 ⟸ XM_039091660
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000082962 ⟸ ENSRNOT00000104559

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q498T9-F1-model_v2	AlphaFold	Q498T9	1-803	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699166

Promoter ID:

EPDNEW_R9691

Type:

initiation region

Name:

Lrrc8c_1

Description:

leucine rich repeat containing 8 VRAC subunit C

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	5,378,670 - 5,378,730	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306585	AgrOrtholog
BioCyc Gene	G2FUF-16553	BioCyc
Ensembl Genes	ENSRNOG00000002122	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00000065000	Ensembl, ENTREZGENE
Ensembl Protein	ENSRNOP00000002896	UniProtKB/Swiss-Prot
	ENSRNOP00000082962	ENTREZGENE
Ensembl Transcript	ENSRNOT00000002896	UniProtKB/Swiss-Prot
	ENSRNOT00000104559	ENTREZGENE
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7386007	IMAGE-MGC_LOAD
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
	LRRC8_Pannexin-like	UniProtKB/Swiss-Prot
KEGG Report	rno:289443	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112653	IMAGE-MGC_LOAD
NCBI Gene	289443	ENTREZGENE
Pfam	LRR_8	UniProtKB/Swiss-Prot
	Pannexin_like	UniProtKB/Swiss-Prot
PhenoGen	Lrrc8c	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot
SMART	LRR_TYP	UniProtKB/Swiss-Prot
UniProt	LRC8C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-16	Lrrc8c	leucine rich repeat containing 8 VRAC subunit C	Lrrc8c	leucine rich repeat containing 8 family, member C	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Lrrc8c	leucine rich repeat containing 8 family, member C	RGD1306585	similar to hypothetical protein AD158	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1306585	similar to hypothetical protein AD158	RGD1306585_predicted	similar to hypothetical protein AD158 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1306585_predicted	similar to hypothetical protein AD158 (predicted)	LOC289443_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC289443_predicted	similar to hypothetical protein AD158 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD