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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | ISO | RGD:1604274 | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of LRRC8C mRNA, [Estradiol co-treated with TGFB1 protein] results in increased expression of LRRC8C mRNA | CTD | PMID:20660070, PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1550691 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LRRC8C promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LRRC8C mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1550691 | 6480464 | Tetrachlorodibenzodioxin affects the expression of LRRC8C mRNA | CTD | PMID:21570461, PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1550691 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LRRC8C mRNA | CTD | PMID:21889950, PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LRRC8C mRNA | CTD | PMID:22298810, PMID:34747641 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2, 6-dinitrotoluene affects the expression of LRRC8C mRNA | CTD | PMID:21346803 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1550691 | 6480464 | Fenretinide results in increased expression of LRRC8C mRNA | CTD | PMID:28973697 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of LRRC8C mRNA | CTD | PMID:31881176 | acrylamide | increases expression | ISO | RGD:1604274 | 6480464 | Acrylamide results in increased expression of LRRC8C mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | RGD:1604274 | 6480464 | Aflatoxin B1 results in decreased methylation of LRRC8C gene | CTD | PMID:27153756 | aflatoxin B1 | increases methylation | ISO | RGD:1604274 | 6480464 | Aflatoxin B1 results in increased methylation of LRRC8C intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | RGD:1604274 | 6480464 | Tretinoin results in decreased expression of LRRC8C mRNA | CTD | PMID:33167477 | aristolochic acid | decreases expression | ISO | RGD:1604274 | 6480464 | aristolochic acid I results in decreased expression of LRRC8C mRNA | CTD | PMID:33212167 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of LRRC8C gene | CTD | PMID:28931070 | benzo[a]pyrene | increases expression | ISO | RGD:1550691 | 6480464 | Benzo(a)pyrene results in increased expression of LRRC8C mRNA | CTD | PMID:21569818, PMID:32417428 | benzo[a]pyrene | affects methylation | ISO | RGD:1604274 | 6480464 | Benzo(a)pyrene affects the methylation of LRRC8C intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RGD:1604274 | 6480464 | Benzo(a)pyrene results in decreased methylation of LRRC8C 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:1604274 | 6480464 | benzo(e)pyrene results in increased methylation of LRRC8C intron | CTD | PMID:30157460 | bis(2-chloroethyl) sulfide | increases phosphorylation | ISO | RGD:1604274 | 6480464 | Mustard Gas results in increased phosphorylation of LRRC8C protein | CTD | PMID:19845377 | bisphenol A | decreases expression | ISO | RGD:1604274 | 6480464 | bisphenol A results in decreased expression of LRRC8C mRNA | CTD | PMID:29275510 | cadmium atom | increases expression | ISO | RGD:1604274 | 6480464 | Cadmium results in increased expression of LRRC8C mRNA | CTD | PMID:24376830 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of LRRC8C promoter | CTD | PMID:22457795 | carbon nanotube | increases expression | ISO | RGD:1550691 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroprene | decreases expression | ISO | RGD:1550691 | 6480464 | Chloroprene results in decreased expression of LRRC8C mRNA | CTD | PMID:23125180 | cisplatin | multiple interactions | ISO | RGD:1604274 | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of LRRC8C mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | RGD:1604274 | 6480464 | Cisplatin results in decreased expression of LRRC8C mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | RGD:1604274 | 6480464 | Cisplatin results in increased expression of LRRC8C mRNA | CTD | PMID:27594783 | cobalt dichloride | decreases expression | ISO | RGD:1604274 | 6480464 | cobaltous chloride results in decreased expression of LRRC8C mRNA | CTD | PMID:19320972 | copper(II) sulfate | increases expression | ISO | RGD:1604274 | 6480464 | Copper Sulfate results in increased expression of LRRC8C mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | ISO | RGD:1604274 | 6480464 | Asbestos, Crocidolite results in increased expression of LRRC8C mRNA | CTD | PMID:18687144 | dibutyl phthalate | increases expression | ISO | RGD:1550691 | 6480464 | Dibutyl Phthalate results in increased expression of LRRC8C mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | RGD:1604274 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | RGD:1604274 | 6480464 | Doxorubicin results in decreased expression of LRRC8C mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of LRRC8C mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | RGD:1604274 | 6480464 | entinostat results in decreased expression of LRRC8C mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | RGD:1604274 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA | CTD | PMID:27188386 | entinostat | increases expression | ISO | RGD:1604274 | 6480464 | entinostat results in increased expression of LRRC8C mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | RGD:1550691 | 6480464 | Ethanol affects the expression of LRRC8C mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | RGD:1550691 | 6480464 | Ethanol results in increased expression of LRRC8C mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | RGD:1604274 | 6480464 | Ethyl Methanesulfonate results in decreased expression of LRRC8C mRNA | CTD | PMID:23649840 | fluoranthene | multiple interactions | ISO | RGD:1550691 | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of LRRC8C mRNA | CTD | PMID:28329830 | formaldehyde | decreases expression | ISO | RGD:1604274 | 6480464 | Formaldehyde results in decreased expression of LRRC8C mRNA | CTD | PMID:23649840 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of LRRC8C mRNA | CTD | PMID:33387578 | isoprenaline | increases expression | ISO | RGD:1550691 | 6480464 | Isoproterenol results in increased expression of LRRC8C mRNA | CTD | PMID:20003209 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of LRRC8C mRNA | CTD | PMID:19564919 | methapyrilene | increases methylation | ISO | RGD:1604274 | 6480464 | Methapyrilene results in increased methylation of LRRC8C intron | CTD | PMID:30157460 | methoxychlor | increases methylation | EXP | | 6480464 | Methoxychlor results in increased methylation of LRRC8C gene | CTD | PMID:23303685 | methyl methanesulfonate | decreases expression | ISO | RGD:1604274 | 6480464 | Methyl Methanesulfonate results in decreased expression of LRRC8C mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | RGD:1604274 | 6480464 | methylmercuric chloride results in decreased expression of LRRC8C mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | RGD:1604274 | 6480464 | Nickel results in increased expression of LRRC8C mRNA | CTD | PMID:24768652, PMID:25583101 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LRRC8C mRNA | CTD | PMID:33387578 | phenobarbital | increases expression | ISO | RGD:1604274 | 6480464 | Phenobarbital results in increased expression of LRRC8C mRNA | CTD | PMID:19084549 | phenylmercury acetate | increases expression | ISO | RGD:1604274 | 6480464 | Phenylmercuric Acetate results in increased expression of LRRC8C mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1604274 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC8C mRNA | CTD | PMID:27188386 | progesterone | multiple interactions | ISO | RGD:1604274 | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of LRRC8C mRNA | CTD | PMID:20660070 | SB 431542 | multiple interactions | ISO | RGD:1604274 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | succimer | multiple interactions | ISO | RGD:1550691 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of LRRC8C mRNA | CTD | PMID:21641980 | sunitinib | decreases expression | ISO | RGD:1604274 | 6480464 | Sunitinib results in decreased expression of LRRC8C mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | RGD:1604274 | 6480464 | Temozolomide results in increased expression of LRRC8C mRNA | CTD | PMID:31758290 | thapsigargin | decreases expression | ISO | RGD:1604274 | 6480464 | Thapsigargin results in decreased expression of LRRC8C mRNA | CTD | PMID:22378314 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of LRRC8C mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | ISO | RGD:1604274 | 6480464 | trichostatin A results in increased expression of LRRC8C mRNA | CTD | PMID:24935251 | trichostatin A | multiple interactions | ISO | RGD:1604274 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRRC8C mRNA | CTD | PMID:27188386 | trichostatin A | decreases expression | ISO | RGD:1604274 | 6480464 | trichostatin A results in decreased expression of LRRC8C mRNA | CTD | PMID:24935251, PMID:26272509 | triclosan | decreases expression | ISO | RGD:1604274 | 6480464 | Triclosan results in decreased expression of LRRC8C mRNA | CTD | PMID:30510588 | troglitazone | decreases expression | ISO | RGD:1550691 | 6480464 | troglitazone results in decreased expression of LRRC8C mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | RGD:1550691 | 6480464 | Tungsten results in decreased expression of LRRC8C mRNA | CTD | PMID:30912803 | tunicamycin | decreases expression | ISO | RGD:1604274 | 6480464 | Tunicamycin results in decreased expression of LRRC8C mRNA | CTD | PMID:22378314 | valproic acid | decreases methylation | ISO | RGD:1604274 | 6480464 | Valproic Acid results in decreased methylation of LRRC8C gene | CTD | PMID:29154799 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of LRRC8C mRNA | CTD | PMID:29427782 | valproic acid | increases expression | ISO | RGD:1604274 | 6480464 | Valproic Acid results in increased expression of LRRC8C mRNA | CTD | PMID:23179753, PMID:24935251 | valproic acid | affects expression | ISO | RGD:1604274 | 6480464 | Valproic Acid affects the expression of LRRC8C mRNA | CTD | PMID:25979313 | vincristine | decreases expression | ISO | RGD:1604274 | 6480464 | Vincristine results in decreased expression of LRRC8C mRNA | CTD | PMID:23649840 | zinc atom | multiple interactions | ISO | RGD:1604274 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of LRRC8C mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1604274 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of LRRC8C mRNA | CTD | PMID:18593933 | |