Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) Rattus norvegicus
Analyze
Symbol: Lrrc8c
Name: leucine rich repeat containing 8 VRAC subunit C
RGD ID: 1306585
Description: Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Is integral component of plasma membrane. Part of ion channel complex. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine rich repeat containing 8 family, member C; leucine-rich repeat-containing protein 8C; LOC289443; MGC112653; RGD1306585; similar to hypothetical protein AD158; volume-regulated anion channel subunit LRRC8C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,223,901 - 4,315,590 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)Ensembl
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:15184384   PMID:15489334   PMID:19946888   PMID:24790029   PMID:26824658   PMID:29769723  


Genomics

Comparative Map Data
Lrrc8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,223,901 - 4,315,590 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)Ensembl
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
LRRC8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,615,824 - 89,719,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl189,633,072 - 89,769,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,098,679 - 90,185,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,871,350 - 89,953,169 (+)NCBINCBI36hg18NCBI36
Celera188,344,351 - 88,430,780 (+)NCBI
Cytogenetic Map1p22.2NCBI
HuRef188,215,951 - 88,302,419 (+)NCBIHuRef
CHM1_1190,213,622 - 90,300,056 (+)NCBICHM1_1
T2T-CHM13v2.0189,476,355 - 89,562,765 (+)NCBI
Lrrc8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,666,850 - 105,760,884 (+)NCBIGRCm39mm39
GRCm39 Ensembl5105,667,254 - 105,760,884 (+)Ensembl
GRCm385105,519,345 - 105,613,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,519,388 - 105,613,018 (+)EnsemblGRCm38mm10GRCm38
MGSCv375105,948,490 - 106,037,973 (+)NCBIGRCm37mm9NCBIm37
MGSCv365105,759,773 - 105,849,256 (+)NCBImm8
Celera5102,631,726 - 102,729,227 (+)NCBICelera
Cytogenetic Map5E5NCBI
Lrrc8c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,460,212 - 4,494,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,460,212 - 4,494,317 (-)NCBIChiLan1.0ChiLan1.0
LRRC8C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,001,695 - 91,134,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,105,551 - 91,138,447 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,299,691 - 92,384,733 (+)NCBIMhudiblu_PPA_v0panPan3
LRRC8C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,895,769 - 58,932,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,899,996 - 58,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,605,421 - 61,690,225 (-)NCBI
ROS_Cfam_1.0659,407,523 - 59,492,055 (-)NCBI
ROS_Cfam_1.0 Ensembl659,409,555 - 59,493,796 (-)Ensembl
UMICH_Zoey_3.1658,981,235 - 59,065,445 (-)NCBI
UNSW_CanFamBas_1.0658,934,585 - 59,019,172 (-)NCBI
UU_Cfam_GSD_1.0659,414,770 - 59,499,275 (-)NCBI
Lrrc8c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,823,337 - 99,897,484 (+)NCBI
SpeTri2.0NW_0049365379,050,495 - 9,124,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,931,849 - 127,079,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,996,955 - 139,119,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,752,341 - 43,842,958 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,752,370 - 43,842,766 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603374,090,984 - 74,181,626 (+)NCBIVero_WHO_p1.0
Lrrc8c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247428,009,901 - 8,096,652 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AI326115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,228,029 - 4,228,206 (+)MAPPERmRatBN7.2
Rnor_6.0145,287,784 - 5,287,960NCBIRnor6.0
Rnor_5.0145,278,501 - 5,278,677UniSTSRnor5.0
RGSC_v3.4145,306,420 - 5,306,596UniSTSRGSC3.4
Celera144,390,868 - 4,391,044UniSTS
Cytogenetic Map14p22UniSTS
RH135313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,266,065 - 4,266,285 (+)MAPPERmRatBN7.2
Rnor_6.0145,325,890 - 5,326,109NCBIRnor6.0
Rnor_5.0145,316,607 - 5,316,826UniSTSRnor5.0
RGSC_v3.4145,344,454 - 5,344,673UniSTSRGSC3.4
Celera144,428,886 - 4,429,105UniSTS
RH 3.4 Map1480.7UniSTS
Cytogenetic Map14p22UniSTS
RH137556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,255,709 - 4,255,833 (+)MAPPERmRatBN7.2
Rnor_6.0145,315,461 - 5,315,584NCBIRnor6.0
Rnor_5.0145,306,178 - 5,306,301UniSTSRnor5.0
RGSC_v3.4145,334,097 - 5,334,220UniSTSRGSC3.4
Celera144,418,530 - 4,418,653UniSTS
Cytogenetic Map14p22UniSTS
BE096967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,268,264 - 4,268,429 (+)MAPPERmRatBN7.2
Rnor_6.0145,328,088 - 5,328,252NCBIRnor6.0
Rnor_5.0145,318,805 - 5,318,969UniSTSRnor5.0
RGSC_v3.4145,346,652 - 5,346,816UniSTSRGSC3.4
Celera144,431,084 - 4,431,248UniSTS
RH 3.4 Map1484.7UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:70
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000002896
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 9 2 18 2 54 16 28 8
Low 3 27 48 39 1 39 8 11 20 19 13 3 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002896   ⟹   ENSRNOP00000002896
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104559   ⟹   ENSRNOP00000082962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)Ensembl
RefSeq Acc Id: NM_001037179   ⟹   NP_001032256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2144,227,837 - 4,315,205 (-)NCBI
Rnor_6.0145,287,591 - 5,378,698 (-)NCBI
Rnor_5.0145,274,372 - 5,369,435 (-)NCBI
RGSC_v3.4145,306,227 - 5,393,820 (-)RGD
Celera144,390,675 - 4,477,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250542   ⟹   XP_006250604
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2144,223,901 - 4,315,588 (-)NCBI
Rnor_6.0145,283,655 - 5,378,738 (-)NCBI
Rnor_5.0145,274,372 - 5,369,435 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091660   ⟹   XP_038947588
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2144,223,901 - 4,315,590 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001032256 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250604 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947588 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00077 (Get FASTA)   NCBI Sequence Viewer  
  EDL99473 (Get FASTA)   NCBI Sequence Viewer  
  Q498T9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001032256   ⟸   NM_001037179
- UniProtKB: Q498T9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250604   ⟸   XM_006250542
- Peptide Label: isoform X1
- UniProtKB: Q498T9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002896   ⟸   ENSRNOT00000002896
RefSeq Acc Id: XP_038947588   ⟸   XM_039091660
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000082962   ⟸   ENSRNOT00000104559

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498T9-F1-model_v2 AlphaFold Q498T9 1-803 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699166
Promoter ID:EPDNEW_R9691
Type:initiation region
Name:Lrrc8c_1
Description:leucine rich repeat containing 8 VRAC subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0145,378,670 - 5,378,730EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306585 AgrOrtholog
BioCyc Gene G2FUF-16553 BioCyc
Ensembl Genes ENSRNOG00000002122 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000065000 Ensembl, ENTREZGENE
Ensembl Protein ENSRNOP00000002896 UniProtKB/Swiss-Prot
  ENSRNOP00000082962 ENTREZGENE
Ensembl Transcript ENSRNOT00000002896 UniProtKB/Swiss-Prot
  ENSRNOT00000104559 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7386007 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRC8_Pannexin-like UniProtKB/Swiss-Prot
KEGG Report rno:289443 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112653 IMAGE-MGC_LOAD
NCBI Gene 289443 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot
  Pannexin_like UniProtKB/Swiss-Prot
PhenoGen Lrrc8c PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
SMART LRR_TYP UniProtKB/Swiss-Prot
UniProt LRC8C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Lrrc8c  leucine rich repeat containing 8 VRAC subunit C  Lrrc8c  leucine rich repeat containing 8 family, member C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrrc8c  leucine rich repeat containing 8 family, member C  RGD1306585  similar to hypothetical protein AD158  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1306585  similar to hypothetical protein AD158  RGD1306585_predicted  similar to hypothetical protein AD158 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306585_predicted  similar to hypothetical protein AD158 (predicted)  LOC289443_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289443_predicted  similar to hypothetical protein AD158 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL