Gas6 (growth arrest specific 6) - Rat Genome Database

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Gene: Gas6 (growth arrest specific 6) Rattus norvegicus
Analyze
Symbol: Gas6
Name: growth arrest specific 6
RGD ID: 61913
Description: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including activation of protein kinase B activity; positive regulation of intracellular signal transduction; and regulation of renal system process. Located in extracellular space. Used to study glomerulonephritis. Orthologous to human GAS6 (growth arrest specific 6); PARTICIPATES IN Gas6 - Axl signaling axis; INTERACTS WITH 11-deoxycorticosterone; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AXL receptor tyrosine kinase ligand; GAS-6; GPF; growth arrest-specific protein 6; growth-potentiating factor
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,045,430 - 76,075,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,045,426 - 76,075,904 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,326,082 - 81,356,495 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,779,051 - 84,809,465 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01680,027,812 - 80,058,245 (+)NCBIRnor_WKY
Rnor_6.01681,213,364 - 81,243,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,213,364 - 81,243,757 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,701,559 - 80,732,410 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,900,159 - 80,930,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,900,528 - 80,930,916 (+)NCBI
Celera1673,852,900 - 73,883,275 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
aldosterone  (EXP)
alpha-pinene  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chrysene  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
curcumin  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
graphite  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
menaquinone  (EXP)
methapyrilene  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
spironolactone  (EXP)
streptozocin  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vitamin K  (EXP)
warfarin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IDA)
animal organ regeneration  (IEP)
apoptotic cell clearance  (ISO,ISS)
apoptotic process  (ISO)
B cell chemotaxis  (ISO,ISS)
blood coagulation  (ISO)
calcium ion transmembrane transport  (ISO)
cell-substrate adhesion  (ISO)
cellular response to glucose stimulus  (IDA)
cellular response to growth factor stimulus  (ISO)
cellular response to interferon-alpha  (ISO,ISS)
cellular response to starvation  (ISO)
cellular response to vitamin K  (ISO,ISS)
cellular response to xenobiotic stimulus  (IDA,ISO)
dendritic cell differentiation  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
extracellular matrix assembly  (IEP)
fibroblast apoptotic process  (ISO)
fusion of virus membrane with host plasma membrane  (ISO,ISS)
hematopoietic stem cell migration to bone marrow  (ISO,ISS)
myeloid cell apoptotic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of biomineral tissue development  (ISO,ISS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
negative regulation of dendritic cell apoptotic process  (ISO,ISS)
negative regulation of DNA-binding transcription factor activity  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of endothelial cell apoptotic process  (ISO,ISS)
negative regulation of fibroblast apoptotic process  (ISO,ISS)
negative regulation of interleukin-1 production  (ISO,ISS)
negative regulation of interleukin-6 production  (ISO,ISS)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of oligodendrocyte apoptotic process  (ISO,ISS)
negative regulation of renal albumin absorption  (IEP)
negative regulation of tumor necrosis factor production  (ISO,ISS)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO,ISS)
negative regulation of type II interferon production  (ISO,ISS)
neuron migration  (ISO)
peptidyl-serine phosphorylation  (ISO,ISS)
phagocytosis  (ISO,ISS)
positive regulation of cytokine-mediated signaling pathway  (ISO,ISS)
positive regulation of dendritic cell chemotaxis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of glomerular filtration  (IDA)
positive regulation of natural killer cell differentiation  (ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (ISO,ISS)
positive regulation of phagocytosis  (ISO,ISS)
positive regulation of protein export from nucleus  (ISO,ISS)
positive regulation of protein kinase activity  (ISO,ISS)
positive regulation of protein kinase B signaling  (IDA,ISO)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of protein tyrosine kinase activity  (ISO,ISS)
positive regulation of TOR signaling  (IDA)
protein kinase B signaling  (IBA,ISO,ISS)
protein localization to plasma membrane  (ISO,ISS)
protein phosphorylation  (ISO,ISS)
receptor-mediated virion attachment to host cell  (ISO,ISS)
signal transduction  (IDA,ISO)
tissue regeneration  (TAS)
tissue remodeling  (TAS)
viral entry into host cell  (ISO,ISS)
viral genome replication  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of growth arrest-specific gene 6 in diabetic nephropathy. Arai H, etal., Vitam Horm. 2008;78:375-92. doi: 10.1016/S0083-6729(07)00015-5.
2. Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. Borgel D, etal., Crit Care Med. 2006 Jan;34(1):219-22.
3. Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat. Couchie D, etal., Gastroenterology. 2005 Nov;129(5):1633-42.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Melaragno MG, etal., Circ Res 1998 Oct 5;83(7):697-704.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. Munoz X, etal., Hum Mutat. 2004 May;23(5):506-12.
9. Vascular smooth muscle cell-derived, Gla-containing growth-potentiating factor for Ca(2+)-mobilizing growth factors. Nakano T, etal., J Biol Chem 1995 Mar 17;270(11):5702-5.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Structural basis for Gas6-Axl signalling. Sasaki T, etal., EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosis. Yagami T, etal., Neuropharmacology 2002 Dec;43(8):1289-96.
16. Gas6, warfarin, and kidney diseases. Yanagita M Clin Exp Nephrol. 2004 Dec;8(4):304-9.
17. Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. Yanagita M, etal., Am J Pathol. 2001 Apr;158(4):1423-32.
Additional References at PubMed
PMID:7559388   PMID:7634325   PMID:7854420   PMID:8336730   PMID:8939948   PMID:9163328   PMID:9395235   PMID:10648841   PMID:12644472   PMID:15184064   PMID:15380678   PMID:15561781  
PMID:15650770   PMID:16014032   PMID:16359517   PMID:16723520   PMID:16799993   PMID:18159085   PMID:18188450   PMID:18292389   PMID:18395422   PMID:18680538   PMID:18760998   PMID:18787040  
PMID:18840707   PMID:19657094   PMID:19922767   PMID:20048160   PMID:20088931   PMID:20103767   PMID:21501828   PMID:23334461   PMID:23376485   PMID:23533145   PMID:24006456   PMID:28386842  
PMID:29196212   PMID:30365934   PMID:32307774   PMID:34678434  


Genomics

Comparative Map Data
Gas6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,045,430 - 76,075,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,045,426 - 76,075,904 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,326,082 - 81,356,495 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,779,051 - 84,809,465 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01680,027,812 - 80,058,245 (+)NCBIRnor_WKY
Rnor_6.01681,213,364 - 81,243,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,213,364 - 81,243,757 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,701,559 - 80,732,410 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,900,159 - 80,930,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,900,528 - 80,930,916 (+)NCBI
Celera1673,852,900 - 73,883,275 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
GAS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,820,549 - 113,864,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13113,820,549 - 113,864,076 (-)EnsemblGRCh38hg38GRCh38
GRCh3713114,523,522 - 114,567,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,546,913 - 113,590,396 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413113,546,912 - 113,590,396NCBI
Celera1395,265,581 - 95,312,916 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,864,702 - 94,908,220 (+)NCBIHuRef
CHM1_113114,491,807 - 114,536,236 (-)NCBICHM1_1
T2T-CHM13v2.013113,029,283 - 113,074,357 (-)NCBIT2T-CHM13v2.0
Gas6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,515,374 - 13,544,535 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,515,374 - 13,544,490 (-)EnsemblGRCm39 Ensembl
GRCm38813,465,374 - 13,494,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,465,374 - 13,494,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,465,374 - 13,494,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,465,351 - 13,494,483 (-)NCBIMGSCv36mm8
Celera813,633,535 - 13,662,710 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.06NCBI
Gas6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404275,946 - 304,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404276,397 - 303,864 (+)NCBIChiLan1.0ChiLan1.0
GAS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,975,196 - 61,005,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,974,849 - 61,005,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,684,745 - 60,717,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,659,911 - 61,692,783 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,659,911 - 61,692,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,097,815 - 61,130,605 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,099,052 - 61,131,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,131,260 - 61,164,234 (-)NCBIUU_Cfam_GSD_1.0
Gas6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,897,815 - 195,920,260 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647232,123 - 54,028 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647227,116 - 57,158 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,848,797 - 78,881,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,848,797 - 78,880,733 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,582,221 - 86,614,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103214855
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,720,871 - 91,762,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604648,879,389 - 48,960,473 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793385,812 - 410,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793385,846 - 410,934 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gas6
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000024677
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH144400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,052,207 - 76,052,399 (-)MAPPERmRatBN7.2
Rnor_6.01681,236,868 - 81,237,059NCBIRnor6.0
Rnor_5.01680,725,063 - 80,725,254UniSTSRnor5.0
RGSC_v3.41680,907,234 - 80,907,425UniSTSRGSC3.4
Celera1673,859,585 - 73,859,776UniSTS
RH 3.4 Map16743.8UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 39 23 19 23 8 11 64 35 37 11 8
Low 18 18 18 10 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024677   ⟹   ENSRNOP00000024677
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,045,426 - 76,075,904 (+)Ensembl
Rnor_6.0 Ensembl1681,213,364 - 81,243,757 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076356
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,230,796 - 81,233,365 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076763   ⟹   ENSRNOP00000068052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,230,096 - 81,243,221 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106117   ⟹   ENSRNOP00000087634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,045,426 - 76,059,952 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106628   ⟹   ENSRNOP00000081977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,045,491 - 76,075,897 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120129   ⟹   ENSRNOP00000091430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,048,523 - 76,075,904 (+)Ensembl
RefSeq Acc Id: NM_057100   ⟹   NP_476441
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,045,490 - 76,075,904 (+)NCBI
Rnor_6.01681,213,364 - 81,243,757 (-)NCBI
Rnor_5.01680,701,559 - 80,732,410 (-)NCBI
RGSC_v3.41680,900,159 - 80,930,929 (+)RGD
Celera1673,852,900 - 73,883,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_017600238   ⟹   XP_017455727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,045,430 - 76,073,468 (+)NCBI
Rnor_6.01681,214,830 - 81,243,824 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476441   ⟸   NM_057100
- Peptide Label: precursor
- UniProtKB: Q6IRL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455727   ⟸   XM_017600238
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000024677   ⟸   ENSRNOT00000024677
RefSeq Acc Id: ENSRNOP00000068052   ⟸   ENSRNOT00000076763
RefSeq Acc Id: ENSRNOP00000091430   ⟸   ENSRNOT00000120129
RefSeq Acc Id: ENSRNOP00000081977   ⟸   ENSRNOT00000106628
RefSeq Acc Id: ENSRNOP00000087634   ⟸   ENSRNOT00000106117
Protein Domains
EGF-like   Gla   LAM_G_DOMAIN   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63772-F1-model_v2 AlphaFold Q63772 1-674 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700224
Promoter ID:EPDNEW_R10748
Type:initiation region
Name:Gas6_1
Description:growth arrest specific 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,243,791 - 81,243,851EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61913 AgrOrtholog
BioCyc Gene G2FUF-10724 BioCyc
Ensembl Genes ENSRNOG00000018233 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000081977.1 UniProtKB/TrEMBL
  ENSRNOP00000087634.1 UniProtKB/TrEMBL
  ENSRNOP00000091430.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000106117.1 UniProtKB/TrEMBL
  ENSRNOT00000106628.1 UniProtKB/TrEMBL
  ENSRNOT00000120129.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096665 IMAGE-MGC_LOAD
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58935 UniProtKB/TrEMBL
MGC_CLONE MGC:91537 IMAGE-MGC_LOAD
NCBI Gene 58935 ENTREZGENE
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GAS6 RGD
PhenoGen Gas6 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZSS9_RAT UniProtKB/TrEMBL
  A0A8I6A8C7_RAT UniProtKB/TrEMBL
  A0A8I6AC16_RAT UniProtKB/TrEMBL
  GAS6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IRL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gas6  growth arrest specific 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process protects cortical neurons from amyloid beta protein (Abeta)-induced apoptosis 632769