Dixdc1 (DIX domain containing 1) - Rat Genome Database

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Gene: Dixdc1 (DIX domain containing 1) Rattus norvegicus
Analyze
Symbol: Dixdc1
Name: DIX domain containing 1
RGD ID: 1309902
Description: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in cerebellar cortex development; positive regulation of JNK cascade; and positive regulation of axonogenesis. Located in axon terminus and neuronal cell body. Part of protein-containing complex. Orthologous to human DIXDC1 (DIX domain containing 1); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccd1; coiled-coil protein DIX1; coiled-coil-DIX1; DIX domain-containing protein 1; dixin; LOC363062
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,904,218 - 59,977,595 (-)NCBIGRCr8
mRatBN7.2851,007,835 - 51,081,191 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,007,838 - 51,081,090 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,513,683 - 56,575,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,792,617 - 54,854,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,656,859 - 52,718,900 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,091,232 - 55,164,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,091,235 - 55,162,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,688,638 - 53,761,215 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,018,179 - 54,073,235 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,040,712 - 54,112,412 (-)NCBI
Celera850,555,793 - 50,608,269 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
mercury dichloride  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. Ikeuchi Y, etal., J Neurosci. 2009 Apr 1;29(13):4312-21.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15579909   PMID:17554179   PMID:19375513   PMID:20624590   PMID:21189423   PMID:27521891   PMID:27873129  


Genomics

Comparative Map Data
Dixdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,904,218 - 59,977,595 (-)NCBIGRCr8
mRatBN7.2851,007,835 - 51,081,191 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,007,838 - 51,081,090 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,513,683 - 56,575,716 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,792,617 - 54,854,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,656,859 - 52,718,900 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,091,232 - 55,164,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,091,235 - 55,162,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,688,638 - 53,761,215 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,018,179 - 54,073,235 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1854,040,712 - 54,112,412 (-)NCBI
Celera850,555,793 - 50,608,269 (-)NCBICelera
Cytogenetic Map8q23NCBI
DIXDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,927,315 - 112,022,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,927,144 - 112,022,653 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,798,039 - 111,893,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,313,137 - 111,398,518 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,353,285 - 111,397,913NCBI
Celera11108,961,135 - 109,046,522 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,721,826 - 107,817,397 (+)NCBIHuRef
CHM1_111111,680,944 - 111,776,629 (+)NCBICHM1_1
T2T-CHM13v2.011111,937,556 - 112,032,895 (+)NCBIT2T-CHM13v2.0
Dixdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,574,052 - 50,650,900 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,574,052 - 50,650,817 (-)EnsemblGRCm39 Ensembl
GRCm38950,662,752 - 50,739,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,662,752 - 50,739,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,470,857 - 50,536,089 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,414,982 - 50,480,205 (-)NCBIMGSCv36mm8
Celera947,949,270 - 48,015,116 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Dixdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,642,078 - 13,711,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,640,693 - 13,713,926 (+)NCBIChiLan1.0ChiLan1.0
DIXDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,677,661 - 112,773,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,771,936 - 113,865,921 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,813,905 - 106,908,898 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,657,803 - 110,753,119 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,657,803 - 110,753,114 (+)Ensemblpanpan1.1panPan2
DIXDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,097,000 - 21,168,470 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,100,045 - 21,167,166 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,019,330 - 21,090,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,119,943 - 21,191,396 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,119,955 - 21,190,088 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,181,292 - 21,252,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,081,791 - 21,153,169 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,130,502 - 21,201,971 (-)NCBIUU_Cfam_GSD_1.0
Dixdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,186,983 - 94,265,252 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,443,525 - 2,517,114 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,440,357 - 2,518,596 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIXDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1939,666,454 - 39,734,909 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,446,249 - 44,526,107 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIXDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,276,780 - 103,377,110 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,286,346 - 103,378,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,605,417 - 22,704,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dixdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,094,736 - 7,175,072 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,093,457 - 7,178,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dixdc1
239 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:354
Count of miRNA genes:227
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000039045
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
RH139711  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,007,856 - 51,008,020 (+)MAPPERmRatBN7.2
Rnor_6.0855,091,254 - 55,091,417NCBIRnor6.0
Rnor_5.0853,688,660 - 53,688,823UniSTSRnor5.0
RGSC_v3.4854,018,201 - 54,018,364UniSTSRGSC3.4
Celera850,555,815 - 50,555,978UniSTS
RH 3.4 Map8548.2UniSTS
Cytogenetic Map8q23UniSTS
RH128680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,009,346 - 51,009,496 (+)MAPPERmRatBN7.2
Rnor_6.0855,092,743 - 55,092,892NCBIRnor6.0
Rnor_5.0853,690,149 - 53,690,298UniSTSRnor5.0
RGSC_v3.4854,019,690 - 54,019,839UniSTSRGSC3.4
Celera850,557,304 - 50,557,453UniSTS
RH 3.4 Map8545.1UniSTS
Cytogenetic Map8q23UniSTS
RH137617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,030,952 - 51,031,109 (+)MAPPERmRatBN7.2
Rnor_6.0855,114,350 - 55,114,506NCBIRnor6.0
Rnor_5.0853,711,756 - 53,711,912UniSTSRnor5.0
RGSC_v3.4854,041,297 - 54,041,453UniSTSRGSC3.4
Celera850,578,915 - 50,579,071UniSTS
Cytogenetic Map8q23UniSTS
RH139339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2851,009,090 - 51,009,237 (+)MAPPERmRatBN7.2
Rnor_6.0855,092,488 - 55,092,634NCBIRnor6.0
Rnor_5.0853,689,894 - 53,690,040UniSTSRnor5.0
RGSC_v3.4854,019,435 - 54,019,581UniSTSRGSC3.4
Celera850,557,049 - 50,557,195UniSTS
Cytogenetic Map8q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 74 12 34 10
Low 3 43 53 37 19 37 8 10 23 7 1 8
Below cutoff 1

Sequence


Ensembl Acc Id: ENSRNOT00000039045   ⟹   ENSRNOP00000037500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,009,336 - 51,069,883 (-)Ensembl
Rnor_6.0 Ensembl855,091,235 - 55,144,087 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083102   ⟹   ENSRNOP00000073690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,009,336 - 51,081,090 (-)Ensembl
Rnor_6.0 Ensembl855,094,514 - 55,162,421 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100212   ⟹   ENSRNOP00000085938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,007,838 - 51,060,690 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109900   ⟹   ENSRNOP00000084790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,019,825 - 51,036,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114265   ⟹   ENSRNOP00000095631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl851,007,838 - 51,060,690 (-)Ensembl
RefSeq Acc Id: NM_001395147   ⟹   NP_001382076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,966,300 (-)NCBI
mRatBN7.2851,007,835 - 51,069,917 (-)NCBI
RefSeq Acc Id: XM_008766295   ⟹   XP_008764517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,968,334 (-)NCBI
mRatBN7.2851,007,835 - 51,070,826 (-)NCBI
Rnor_6.0855,091,232 - 55,153,671 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766296   ⟹   XP_008764518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,939,185 (-)NCBI
mRatBN7.2851,007,835 - 51,042,210 (-)NCBI
Rnor_6.0855,091,232 - 55,125,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595731   ⟹   XP_017451220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,977,585 (-)NCBI
mRatBN7.2851,007,835 - 51,081,191 (-)NCBI
Rnor_6.0855,091,232 - 55,164,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595732   ⟹   XP_017451221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,968,334 (-)NCBI
mRatBN7.2851,007,835 - 51,070,825 (-)NCBI
Rnor_6.0855,091,232 - 55,153,671 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595733   ⟹   XP_017451222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,977,548 (-)NCBI
mRatBN7.2851,007,835 - 51,079,032 (-)NCBI
Rnor_6.0855,091,232 - 55,162,404 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081729   ⟹   XP_038937657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,938,084 (-)NCBI
mRatBN7.2851,007,835 - 51,041,690 (-)NCBI
RefSeq Acc Id: XM_039081730   ⟹   XP_038937658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,932,621 (-)NCBI
mRatBN7.2851,007,835 - 51,036,392 (-)NCBI
RefSeq Acc Id: XM_063265744   ⟹   XP_063121814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,977,554 (-)NCBI
RefSeq Acc Id: XM_063265745   ⟹   XP_063121815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,977,595 (-)NCBI
RefSeq Acc Id: XM_063265746   ⟹   XP_063121816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,904,218 - 59,975,346 (-)NCBI
RefSeq Acc Id: XP_008764517   ⟸   XM_008766295
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764518   ⟸   XM_008766296
- Peptide Label: isoform X7
- UniProtKB: A6J4E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451220   ⟸   XM_017595731
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K662 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451222   ⟸   XM_017595733
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K662 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451221   ⟸   XM_017595732
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QJF6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073690   ⟸   ENSRNOT00000083102
Ensembl Acc Id: ENSRNOP00000037500   ⟸   ENSRNOT00000039045
RefSeq Acc Id: XP_038937657   ⟸   XM_039081729
- Peptide Label: isoform X6
- UniProtKB: A6J4E9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937658   ⟸   XM_039081730
- Peptide Label: isoform X8
- UniProtKB: A6J4E9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095631   ⟸   ENSRNOT00000114265
Ensembl Acc Id: ENSRNOP00000085938   ⟸   ENSRNOT00000100212
Ensembl Acc Id: ENSRNOP00000084790   ⟸   ENSRNOT00000109900
RefSeq Acc Id: NP_001382076   ⟸   NM_001395147
- UniProtKB: Q2VUH7 (UniProtKB/Swiss-Prot),   A0A8L2QJF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121815   ⟸   XM_063265745
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K662 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121814   ⟸   XM_063265744
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K662 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121816   ⟸   XM_063265746
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K662 (UniProtKB/TrEMBL)
Protein Domains
Calponin-homology (CH)   DIX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2VUH7-F1-model_v2 AlphaFold Q2VUH7 1-684 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309902 AgrOrtholog
BioCyc Gene G2FUF-30555 BioCyc
Ensembl Genes ENSRNOG00000010260 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039045.6 UniProtKB/TrEMBL
  ENSRNOT00000083102.2 UniProtKB/TrEMBL
  ENSRNOT00000100212.1 UniProtKB/TrEMBL
  ENSRNOT00000109900.1 UniProtKB/TrEMBL
  ENSRNOT00000114265.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dsh/Dvl-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363062 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 363062 ENTREZGENE
PANTHER PTHR10878 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10878:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dixdc1 PhenoGen
PROSITE DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010260 RatGTEx
SMART DAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K662 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4R3_RAT UniProtKB/TrEMBL
  A0A8I6ANQ8_RAT UniProtKB/TrEMBL
  A0A8I6GB10_RAT UniProtKB/TrEMBL
  A0A8L2QJF6 ENTREZGENE, UniProtKB/TrEMBL
  A6J4E9 ENTREZGENE, UniProtKB/TrEMBL
  DIXC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-07 Dixdc1  DIX domain containing 1  Dixdc1_predicted  DIX domain containing 1 (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Dixdc1_predicted  DIX domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED