Myl3 (myosin light chain 3) - Rat Genome Database

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Gene: Myl3 (myosin light chain 3) Rattus norvegicus
Analyze
Symbol: Myl3
Name: myosin light chain 3
RGD ID: 3142
Description: Enables cytoskeletal motor activity. Involved in cardiac muscle contraction and skeletal muscle tissue development. Part of myosin complex. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3); PARTICIPATES IN prostaglandin I2 signaling pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93574; MLC1SB; MLClV; Mylc1v; myosin alkali light chain 1, ventricular; myosin light chain 1, slow-twitch muscle B/ventricular isoform; Myosin light chain 3 alkali cardiac ventricles; Myosin light chain 3, alkali, cardiac ventricles; myosin, light chain 3, alkali; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3; rVMLC1; ventricular myosin light chain 1; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Vetf5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28110,738,669 - 110,744,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,738,661 - 110,744,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,353,285 - 116,359,407 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08114,552,491 - 114,558,613 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08112,395,292 - 112,401,414 (+)NCBIRnor_WKY
Rnor_6.08119,030,852 - 119,036,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,030,875 - 119,036,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,370,030 - 118,376,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,140,705 - 115,146,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,160,166 - 115,166,273 (+)NCBI
Celera8110,021,445 - 110,027,566 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
A band  (IBA,ISO)
I band  (ISO)
myosin complex  (IDA)
myosin II complex  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations. Andersen PS, etal., J Med Genet. 2001 Dec;38(12):E43.
2. Differential synthesis by cultured atrial and ventricular rat cardiac myocytes of myosin light chain isoforms. Brand T, etal., FEBS Lett. 1991 Jun 3;283(2):289-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
6. Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension. McNally EM, etal., Nucleic Acids Res 1989 Apr 11;17(7):2753-67.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction. Yamashita H, etal., Cardiovasc Res. 2003 Dec 1;60(3):580-8.
Additional References at PubMed
PMID:2798124   PMID:8673105   PMID:12477932   PMID:15489334   PMID:16675844   PMID:16754800   PMID:17494635   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Myl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28110,738,669 - 110,744,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,738,661 - 110,744,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,353,285 - 116,359,407 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08114,552,491 - 114,558,613 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08112,395,292 - 112,401,414 (+)NCBIRnor_WKY
Rnor_6.08119,030,852 - 119,036,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,030,875 - 119,036,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,370,030 - 118,376,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,140,705 - 115,146,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,160,166 - 115,166,273 (+)NCBI
Celera8110,021,445 - 110,027,566 (+)NCBICelera
Cytogenetic Map8q32NCBI
MYL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,857,872 - 46,863,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl346,835,111 - 46,882,172 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,899,362 - 46,904,934 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,874,361 - 46,879,977 (-)NCBINCBI36Build 36hg18NCBI36
Build 34346,874,370 - 46,879,935NCBI
Celera346,837,863 - 46,843,479 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,942,461 - 46,948,077 (-)NCBIHuRef
CHM1_1346,849,457 - 46,855,073 (-)NCBICHM1_1
T2T-CHM13v2.0346,874,270 - 46,879,842 (-)NCBIT2T-CHM13v2.0
Myl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,592,746 - 110,598,870 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,570,929 - 110,598,866 (+)EnsemblGRCm39 Ensembl
GRCm389110,763,678 - 110,769,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,741,861 - 110,769,798 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,666,185 - 110,672,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,608,497 - 110,614,610 (+)NCBIMGSCv36mm8
Celera9110,493,398 - 110,499,489 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.69NCBI
Myl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,305,759 - 25,312,271 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,308,513 - 25,311,959 (+)NCBIChiLan1.0ChiLan1.0
MYL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,859,467 - 47,865,084 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,859,467 - 47,865,084 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,758,058 - 46,782,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MYL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,941,617 - 41,947,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2041,933,105 - 42,073,779 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,857,795 - 41,863,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,424,129 - 42,429,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,423,791 - 42,429,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,665,759 - 41,671,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,066,707 - 42,072,174 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,347,703 - 42,353,170 (+)NCBIUU_Cfam_GSD_1.0
Myl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,100,747 - 201,105,928 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596649,875 - 655,110 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936596649,887 - 655,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,707,371 - 29,735,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,730,271 - 29,735,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,978,399 - 32,983,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,263,536 - 8,272,229 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,261,206 - 8,269,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041158,859,015 - 158,883,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,404,915 - 74,408,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,405,054 - 74,408,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myl3
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000028458
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
D8Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,738,340 - 110,738,468 (+)MAPPERmRatBN7.2
Rnor_6.08119,030,521 - 119,030,650NCBIRnor6.0
Rnor_5.08118,369,739 - 118,369,868UniSTSRnor5.0
RGSC_v3.48115,140,350 - 115,140,480RGDRGSC3.4
RGSC_v3.48115,140,351 - 115,140,480UniSTSRGSC3.4
Celera8110,021,091 - 110,021,220UniSTS
Cytogenetic Map8q32UniSTS
D8Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,738,340 - 110,738,550 (+)MAPPERmRatBN7.2
Rnor_6.08119,030,521 - 119,030,732NCBIRnor6.0
Rnor_5.08118,369,739 - 118,369,950UniSTSRnor5.0
RGSC_v3.48115,140,350 - 115,140,562RGDRGSC3.4
RGSC_v3.48115,140,351 - 115,140,562UniSTSRGSC3.4
RGSC_v3.18115,159,805 - 115,160,017RGD
Celera8110,021,091 - 110,021,302UniSTS
RH 3.4 Map81191.3UniSTS
RH 3.4 Map81191.3RGD
RH 2.0 Map8935.5RGD
Cytogenetic Map8q32UniSTS
D8Arb21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,738,338 - 110,738,575 (+)MAPPERmRatBN7.2
Rnor_6.08119,030,519 - 119,030,757NCBIRnor6.0
Rnor_5.08118,369,737 - 118,369,975UniSTSRnor5.0
RGSC_v3.48115,140,348 - 115,140,587RGDRGSC3.4
RGSC_v3.48115,140,349 - 115,140,587UniSTSRGSC3.4
RGSC_v3.18115,159,803 - 115,160,042RGD
Celera8110,021,089 - 110,021,327UniSTS
Cytogenetic Map8q32UniSTS
RH138771  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,744,192 - 110,744,636 (+)MAPPERmRatBN7.2
Rnor_6.08119,036,375 - 119,036,818NCBIRnor6.0
Rnor_5.08118,375,597 - 118,376,040UniSTSRnor5.0
RGSC_v3.48115,146,206 - 115,146,649UniSTSRGSC3.4
Celera8110,026,945 - 110,027,388UniSTS
Cytogenetic Map8q32UniSTS
RH94602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,744,610 - 110,744,791 (+)MAPPERmRatBN7.2
Rnor_6.08119,036,793 - 119,036,973NCBIRnor6.0
Rnor_5.08118,376,015 - 118,376,195UniSTSRnor5.0
RGSC_v3.48115,146,624 - 115,146,804UniSTSRGSC3.4
Celera8110,027,363 - 110,027,543UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 43 3 3 3
Medium 1 1 1 5 7 2 7 5
Low 33 17 17 17 1 44 35 29 1
Below cutoff 20 20 1 20 30 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028458   ⟹   ENSRNOP00000028458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,738,661 - 110,744,815 (+)Ensembl
Rnor_6.0 Ensembl8119,030,875 - 119,036,996 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117250   ⟹   ENSRNOP00000079091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,738,661 - 110,744,816 (+)Ensembl
RefSeq Acc Id: NM_012606   ⟹   NP_036738
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28110,738,693 - 110,744,814 (+)NCBI
Rnor_6.08119,030,875 - 119,036,996 (+)NCBI
Rnor_5.08118,370,030 - 118,376,218 (+)NCBI
RGSC_v3.48115,140,705 - 115,146,827 (+)RGD
Celera8110,021,445 - 110,027,566 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243917   ⟹   XP_006243979
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28110,738,675 - 110,744,814 (+)NCBI
Rnor_6.08119,030,852 - 119,036,987 (+)NCBI
Rnor_5.08118,370,030 - 118,376,218 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080803   ⟹   XP_038936731
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28110,738,671 - 110,744,814 (+)NCBI
RefSeq Acc Id: XM_039080804   ⟹   XP_038936732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28110,738,669 - 110,744,814 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036738   ⟸   NM_012606
- UniProtKB: P16409 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243979   ⟸   XM_006243917
- Peptide Label: isoform X1
- UniProtKB: P16409 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028458   ⟸   ENSRNOT00000028458
RefSeq Acc Id: XP_038936732   ⟸   XM_039080804
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936731   ⟸   XM_039080803
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000079091   ⟸   ENSRNOT00000117250
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16409-F1-model_v2 AlphaFold P16409 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696336
Promoter ID:EPDNEW_R6860
Type:single initiation site
Name:Myl3_1
Description:myosin light chain 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,030,866 - 119,030,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3142 AgrOrtholog
BioCyc Gene G2FUF-29058 BioCyc
Ensembl Genes ENSRNOG00000020955 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028458 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000079091.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028458 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000117250.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192037 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24585 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93574 IMAGE-MGC_LOAD
NCBI Gene 24585 ENTREZGENE
PhenoGen Myl3 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZM89_RAT UniProtKB/TrEMBL
  MYL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-11 Myl3  myosin light chain 3  Myl3  myosin, light chain 3, alkali; ventricular, skeletal, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Myl3  myosin, light chain 3, alkali; ventricular, skeletal, slow  Myl3  myosin, light polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Myl3  Myosin light chain 3, alkali, cardiac ventricles      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression displays low expression during development with increased expression after birth and in adult heart 633422