Myl3 (myosin light chain 3) - Rat Genome Database

Name: Myl3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Myl3 (myosin light chain 3) Rattus norvegicus

Analyze

Symbol:

Myl3

Name:

myosin light chain 3

RGD ID:

3142

Description:

Enables cytoskeletal motor activity. Involved in cardiac muscle contraction and skeletal muscle tissue development. Part of myosin complex. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3); PARTICIPATES IN prostaglandin I2 signaling pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC93574; MLC1SB; MLClV; Mylc1v; myosin alkali light chain 1, ventricular; myosin light chain 1, slow-twitch muscle B/ventricular isoform; Myosin light chain 3 alkali cardiac ventricles; Myosin light chain 3, alkali, cardiac ventricles; myosin, light chain 3, alkali; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3; rVMLC1; ventricular myosin light chain 1; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYL3 (myosin light chain 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Myl3 (myosin, light polypeptide 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Myl3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYL3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYL3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myl3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYL3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYL3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Myl3 (myosin light chain 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MYL3 (myosin light chain 3)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Myl3 (myosin, light polypeptide 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	myl4 (myosin, light chain 4, alkali; atrial, embryonic)	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	myl13 (myosin, light chain 13)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	MLC1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Mlc-c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mlc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mlc-7	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	mlc-3	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	mlc-6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Candidate Gene For:

Vetf5

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	110,738,669 - 110,744,814 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	110,738,661 - 110,744,816 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	116,353,285 - 116,359,407 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	114,552,491 - 114,558,613 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	112,395,292 - 112,401,414 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	119,030,852 - 119,036,996 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,030,875 - 119,036,996 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	118,370,030 - 118,376,218 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,140,705 - 115,146,827 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,160,166 - 115,166,273 (+)	NCBI
Celera	8	110,021,445 - 110,027,566 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cardiomyopathy (ISO)

familial hypertrophic cardiomyopathy (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

hypertrophic cardiomyopathy 8 (ISO)

Left Ventricular Hypertrophy (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

restrictive cardiomyopathy (ISO)

restrictive cardiomyopathy 1 (ISO)

transthyretin amyloidosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,6-di-tert-butyl-4-methylphenol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

7H-xanthine (EXP)

9H-xanthine (EXP)

acrolein (ISO)

all-trans-retinoic acid (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

calcium atom (EXP)

calcium(0) (EXP)

carbon nanotube (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

dextran sulfate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

ethanol (EXP)

etoposide (ISO)

fulvestrant (ISO)

graphite (ISO)

isoprenaline (EXP)

lead diacetate (ISO)

ozone (EXP,ISO)

sodium fluoride (EXP)

sodium nitrate (ISO)

sulforaphane (ISO)

sunitinib (ISO)

thalidomide (ISO)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (ISO)

zinc atom (EXP)

zinc(0) (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac muscle contraction (IDA,ISO)

muscle contraction (TAS)

regulation of striated muscle contraction (ISO)

regulation of the force of heart contraction (ISO)

skeletal muscle tissue development (IEP)

ventricular cardiac muscle tissue morphogenesis (ISO)

Cellular Component

A band (ISO)

I band (ISO)

myosin complex (IDA)

myosin II complex (IBA)

Molecular Function

actin monomer binding (ISO)

calcium ion binding (IEA)

cytoskeletal motor activity (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

dilated cardiomyopathy pathway (IEA)

hypertrophic cardiomyopathy pathway (IEA)

prostaglandin I2 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.	Andersen PS, etal., J Med Genet. 2001 Dec;38(12):E43.
2.	Differential synthesis by cultured atrial and ventricular rat cardiac myocytes of myosin light chain isoforms.	Brand T, etal., FEBS Lett. 1991 Jun 3;283(2):289-90.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis.	Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
6.	Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.	McNally EM, etal., Nucleic Acids Res 1989 Apr 11;17(7):2753-67.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.	Yamashita H, etal., Cardiovasc Res. 2003 Dec 1;60(3):580-8.

Additional References at PubMed

PMID:2798124	PMID:8673105	PMID:12477932	PMID:15489334	PMID:16675844	PMID:16754800	PMID:17494635	PMID:26316108	PMID:29476059

Genomics

Comparative Map Data

Myl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	110,738,669 - 110,744,814 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	110,738,661 - 110,744,816 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	116,353,285 - 116,359,407 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	114,552,491 - 114,558,613 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	112,395,292 - 112,401,414 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	119,030,852 - 119,036,996 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,030,875 - 119,036,996 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	118,370,030 - 118,376,218 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,140,705 - 115,146,827 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,160,166 - 115,166,273 (+)	NCBI
Celera	8	110,021,445 - 110,027,566 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

MYL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	46,857,872 - 46,882,182 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	46,835,111 - 46,882,172 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	46,899,362 - 46,904,934 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	46,874,361 - 46,879,977 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	46,874,370 - 46,879,935	NCBI
Celera	3	46,837,863 - 46,843,479 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	46,942,461 - 46,948,077 (-)	NCBI		HuRef
CHM1_1	3	46,849,457 - 46,855,073 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	46,874,270 - 46,898,580 (-)	NCBI		T2T-CHM13v2.0

Myl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	110,592,746 - 110,598,870 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	110,570,929 - 110,598,866 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	110,763,678 - 110,769,802 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	110,741,861 - 110,769,798 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	110,666,185 - 110,672,298 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	110,608,497 - 110,614,610 (+)	NCBI		MGSCv36	mm8
Celera	9	110,493,398 - 110,499,489 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	60.69	NCBI

Myl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	25,305,759 - 25,312,271 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	25,308,513 - 25,311,959 (+)	NCBI	ChiLan1.0	ChiLan1.0

MYL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	47,859,467 - 47,865,084 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,859,467 - 47,865,084 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	46,758,058 - 46,782,425 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MYL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	41,941,617 - 41,947,085 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	41,933,105 - 42,073,779 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	41,857,795 - 41,863,262 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	42,424,129 - 42,429,604 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	42,423,791 - 42,429,606 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	41,665,759 - 41,671,226 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	42,066,707 - 42,072,174 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	42,347,703 - 42,353,170 (+)	NCBI		UU_Cfam_GSD_1.0

Myl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	201,100,747 - 201,105,928 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	649,875 - 655,110 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936596	649,887 - 655,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	29,707,371 - 29,735,586 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	29,730,271 - 29,735,616 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	32,978,399 - 32,983,747 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	8,263,536 - 8,272,229 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	8,261,206 - 8,269,185 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	158,859,015 - 158,883,595 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	74,404,915 - 74,408,752 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	74,405,054 - 74,408,567 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Myl3
26 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	35
Count of miRNA genes:	33
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000028458
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088624	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088624	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

D8Wox8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,738,340 - 110,738,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,030,521 - 119,030,650	NCBI	Rnor6.0
Rnor_5.0	8	118,369,739 - 118,369,868	UniSTS	Rnor5.0
RGSC_v3.4	8	115,140,350 - 115,140,480	RGD	RGSC3.4
RGSC_v3.4	8	115,140,351 - 115,140,480	UniSTS	RGSC3.4
Celera	8	110,021,091 - 110,021,220	UniSTS
Cytogenetic Map	8	q32	UniSTS

D8Wox9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,738,340 - 110,738,550 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,030,521 - 119,030,732	NCBI	Rnor6.0
Rnor_5.0	8	118,369,739 - 118,369,950	UniSTS	Rnor5.0
RGSC_v3.4	8	115,140,350 - 115,140,562	RGD	RGSC3.4
RGSC_v3.4	8	115,140,351 - 115,140,562	UniSTS	RGSC3.4
RGSC_v3.1	8	115,159,805 - 115,160,017	RGD
Celera	8	110,021,091 - 110,021,302	UniSTS
RH 3.4 Map	8	1191.3	UniSTS
RH 3.4 Map	8	1191.3	RGD
RH 2.0 Map	8	935.5	RGD
Cytogenetic Map	8	q32	UniSTS

D8Arb21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,738,338 - 110,738,575 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,030,519 - 119,030,757	NCBI	Rnor6.0
Rnor_5.0	8	118,369,737 - 118,369,975	UniSTS	Rnor5.0
RGSC_v3.4	8	115,140,348 - 115,140,587	RGD	RGSC3.4
RGSC_v3.4	8	115,140,349 - 115,140,587	UniSTS	RGSC3.4
RGSC_v3.1	8	115,159,803 - 115,160,042	RGD
Celera	8	110,021,089 - 110,021,327	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH138771

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,744,192 - 110,744,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,036,375 - 119,036,818	NCBI	Rnor6.0
Rnor_5.0	8	118,375,597 - 118,376,040	UniSTS	Rnor5.0
RGSC_v3.4	8	115,146,206 - 115,146,649	UniSTS	RGSC3.4
Celera	8	110,026,945 - 110,027,388	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH94602

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	110,744,610 - 110,744,791 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,036,793 - 119,036,973	NCBI	Rnor6.0
Rnor_5.0	8	118,376,015 - 118,376,195	UniSTS	Rnor5.0
RGSC_v3.4	8	115,146,624 - 115,146,804	UniSTS	RGSC3.4
Celera	8	110,027,363 - 110,027,543	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	49					3	3					3
Medium		1	1		1	5	7			2	7	5
Low		33	17	17	17		1	44	35	29	1
Below cutoff		20	20	1	20			30		7	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X14812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X16325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X16326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000028458 ⟹ ENSRNOP00000028458

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	110,738,661 - 110,744,815 (+)	Ensembl
Rnor_6.0 Ensembl	8	119,030,875 - 119,036,996 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117250 ⟹ ENSRNOP00000079091

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	110,738,661 - 110,744,816 (+)	Ensembl

RefSeq Acc Id:

NM_012606 ⟹ NP_036738

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	110,738,693 - 110,744,814 (+)	NCBI
Rnor_6.0	8	119,030,875 - 119,036,996 (+)	NCBI
Rnor_5.0	8	118,370,030 - 118,376,218 (+)	NCBI
RGSC_v3.4	8	115,140,705 - 115,146,827 (+)	RGD
Celera	8	110,021,445 - 110,027,566 (+)	RGD

Sequence:

show sequence

CTATCTCACTCTCTTCTCTCCTTCTTCCCGCCTCTCTGTGATTACAGCTCCAATGGCCCCCAAA
AAGCCAGAGCCCAAGAAGGACGATGCCAAAACCGCTGCCCCCAAAGCAGCTCCGGCCCCTGCGG
CTGCACCTGCGGCTGCACCTGAGCCCGAACGCCCTAAGGAAGCAGAGTTTGATGCCTCCAAGAT
TAAGATTGAGTTCACGCCTGAACAGATTGAAGAGTTCAAGGAGGCCTTCCAACTGTTTGACCGC
ACACCTAAGGGCGAGATGAAGATCACGTACGGGCAGTGTGGGGATGTCCTGCGGGCTCTGGGAC
AGAATCCTACCCAGGCAGAGGTGCTCCGCGTCTTGGGGAAGCCCAAACAGGAAGAGCTCAACTC
CAAGATGATGGATTTTGAAACATTCCTGCCCATGCTGCAGCACATCTCCAAGAACAAAGACACG
GGCACATATGAGGACTTCGTGGAGGGGCTGCGGGTCTTCGACAAGGAGGGCAACGGAACTGTTA
TGGGTGCAGAGCTCCGTCATGTGCTGGCCACGCTGGGTGAGAGGCTGACAGAAGACGAGGTAGA
GAAACTGATGGCTGGTCAAGAAGACTCCAATGGCTGCATCAACTATGAAGCATTTGTGAAGCAC
ATCATGGCCAGCTGAGCCTCTCAGGAAGCCCAGGGCAGGCCAAGCTGGGGACATGCCATCTCCC
AACCATAATGCTGACACCATGTCTGGAGCTTCGGGAAGGAAAGGAGTGTCCCAGACTCCAGCAC
ATGGTCGCAGATCACTCCGTGTGCGGTGGTCCTCCCTGGCCCCTGCTAGGATGTGCTTGCCTAC
CCGTGGTACCCTTTCTGTCTCCACCCTGCGGCCTTATGAATAAATGATTTCCTTCCTTCTGCTC
TCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243917 ⟹ XP_006243979

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	110,738,675 - 110,744,814 (+)	NCBI
Rnor_6.0	8	119,030,852 - 119,036,987 (+)	NCBI
Rnor_5.0	8	118,370,030 - 118,376,218 (+)	NCBI

Sequence:

show sequence

CCCAGGGTGGCAGTAAGGCTCACCTATCTCACTCTCTTCTCTCCTTCTTCCCGCCTCTCTGTGA
TTACAGCTCCAATGGCCCCCAAAAAGCCAGAGCCCAAGAAGGACGATGCCAAAACCGCTGCCCC
CAAAGCAGCTCCGGCCCCTGCGGCTGCACCTGCGGCTGCACCTGAGCCCGAACGCCCTAAGGAA
GCAGAGTTTGATGCCTCCAAGATTAAGATTGAGTTCACGCCTGAACAGATTGAAGAGTTCAAGG
AGGCCTTCCAACTGTTTGACCGCACACCTAAGGGCGAGATGAAGATCACGTACGGGCAGTGTGG
GGATGTCCTGCGGGCTCTGGGACAGAATCCTACCCAGGCAGAGGTGCTCCGCGTCTTGGGGAAG
CCCAAACAGGAAGAGCTCAACTCCAAGATGATGGATTTTGAAACATTCCTGCCCATGCTGCAGC
ACATCTCCAAGAACAAAGACACGGGCACATATGAGGACTTCGTGGAGGGGCTGCGGGTCTTCGA
CAAGGAGGGCAACGGAACTGTTATGGGTGCAGAGCTCCGTCATGTGCTGGCCACGCTGGGTGAG
AGGCTGACAGAAGACGAGGTAGAGAAACTGATGGCTGGTCAAGAAGACTCCAATGGCTGCATCA
ACTATGAAGCATTTGTGAAGCACATCATGGCCAGCTGAGCCTCTCAGTCCTTCCTCCATAACCT
GAGGCTGCTTTTGCTTCAGGAAGCCCAGGGCAGGCCAAGCTGGGGACATGCCATCTCCCAACCA
TAATGCTGACACCATGTCTGGAGCTTCGGGAAGGAAAGGAGTGTCCCAGACTCCAGCACATGGT
CGCAGATCACTCCGTGTGCGGTGGTCCTCCCTGGCCCCTGCTAGGATGTGCTTGCCTACCCGTG
GTACCCTTTCTGTCTCCACCCTGCGGCCTTATGAATAAATGATTTCCTTCCTTCTG

hide sequence

RefSeq Acc Id:

XM_039080803 ⟹ XP_038936731

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	110,738,671 - 110,744,814 (+)	NCBI

RefSeq Acc Id:

XM_039080804 ⟹ XP_038936732

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	110,738,669 - 110,744,814 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036738	(Get FASTA)	NCBI Sequence Viewer
	XP_006243979	(Get FASTA)	NCBI Sequence Viewer
	XP_038936731	(Get FASTA)	NCBI Sequence Viewer
	XP_038936732	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81832	(Get FASTA)	NCBI Sequence Viewer
	CAA32917	(Get FASTA)	NCBI Sequence Viewer
	CAA34388	(Get FASTA)	NCBI Sequence Viewer
	EDL77060	(Get FASTA)	NCBI Sequence Viewer
	P16409	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_036738 ⟸ NM_012606

- UniProtKB:

P16409 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFQ
LFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISK
NKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEA
FVKHIMAS

hide sequence

RefSeq Acc Id:	XP_006243979 ⟸ XM_006243917
- Peptide Label:	isoform X1
- UniProtKB:	P16409 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFQ LFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISK NKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEA FVKHIMAS hide sequence

RefSeq Acc Id:

ENSRNOP00000028458 ⟸ ENSRNOT00000028458

RefSeq Acc Id:	XP_038936732 ⟸ XM_039080804
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038936731 ⟸ XM_039080803
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000079091 ⟸ ENSRNOT00000117250

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P16409-F1-model_v2	AlphaFold	P16409	1-200	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696336

Promoter ID:

EPDNEW_R6860

Type:

single initiation site

Name:

Myl3_1

Description:

myosin light chain 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	119,030,866 - 119,030,926	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3142	AgrOrtholog
BioCyc Gene	G2FUF-29058	BioCyc
Ensembl Genes	ENSRNOG00000020955	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000028458	ENTREZGENE
	ENSRNOP00000028458.2	UniProtKB/Swiss-Prot
	ENSRNOP00000079091.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028458	ENTREZGENE
	ENSRNOT00000028458.6	UniProtKB/Swiss-Prot
	ENSRNOT00000117250.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7192037	IMAGE-MGC_LOAD
InterPro	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24585	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93574	IMAGE-MGC_LOAD
NCBI Gene	24585	ENTREZGENE
PANTHER	MYOSIN LIGHT CHAIN 1, 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MYOSIN LIGHT CHAIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Myl3	PhenoGen
PROSITE	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZM89_RAT	UniProtKB/TrEMBL
	MYL3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-11	Myl3	myosin light chain 3	Myl3	myosin, light chain 3, alkali; ventricular, skeletal, slow	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-14	Myl3	myosin, light chain 3, alkali; ventricular, skeletal, slow	Myl3	myosin, light polypeptide 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Myl3	Myosin light chain 3, alkali, cardiac ventricles			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	displays low expression during development with increased expression after birth and in adult heart	633422

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)