Myl3 (myosin, light polypeptide 3) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Myl3 (myosin, light polypeptide 3) Mus musculus
Analyze
Symbol: Myl3
Name: myosin, light polypeptide 3
RGD ID: 736457
MGI Page MGI
Description: Predicted to have actin monomer binding activity and motor activity. Predicted to be involved in several processes, including cardiac muscle contraction; regulation of the force of heart contraction; and ventricular cardiac muscle tissue morphogenesis. Predicted to localize to A band; I band; and myosin complex. Is expressed in several structures, including diaphragm; heart; limb segment; skeletal musculature; and tail mesenchyme. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3); PARTICIPATES IN prostaglandin I2 signaling pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 1,2-dichloroethane; 2,6-di-tert-butyl-4-methylphenol; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: a; MLC; MLC1s; MLC1SB; MLC1v; Myl; Mylc; myosin alkali light chain 1, ventricular/slow skeletal muscle isoform; myosin light chain 1, slow-twitch muscle B/ventricular isoform; myosin light chain 3; myosin light chain, alkali, cardiac ventricles; myosin, light polypeptide 3, alkali; slow skeletal; vent; ventricular; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain; VLC1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,592,746 - 110,598,870 (+)NCBIGRCm39mm39
GRCm389110,763,678 - 110,769,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,741,861 - 110,769,798 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,666,185 - 110,672,298 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,608,497 - 110,614,610 (+)NCBImm8
Celera9110,493,398 - 110,499,489 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
A band  (ISO)
I band  (ISO)
myosin complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1429837   PMID:1525038   PMID:1901785   PMID:2211821   PMID:2277065   PMID:2534378   PMID:2983233   PMID:3194193   PMID:3839241   PMID:7628699   PMID:7797078   PMID:8136524  
PMID:8268655   PMID:8404542   PMID:8406508   PMID:8689583   PMID:9400381   PMID:9422794   PMID:9489771   PMID:9500550   PMID:9758703   PMID:10021345   PMID:10220415   PMID:10349636  
PMID:10399364   PMID:10679931   PMID:11042159   PMID:11076861   PMID:11238910   PMID:11668599   PMID:12140191   PMID:12477932   PMID:14727813   PMID:15472070   PMID:15489334   PMID:15513965  
PMID:15687484   PMID:16141072   PMID:16141073   PMID:16494860   PMID:16649168   PMID:17289022   PMID:17468400   PMID:17559643   PMID:18554416   PMID:19035347   PMID:21267068   PMID:21278135  
PMID:22589735   PMID:23063798   PMID:23375831   PMID:24335282   PMID:24457600   PMID:24835278   PMID:25172430   PMID:28346476   PMID:29509905   PMID:30787001   PMID:31923383   PMID:32094117  


Genomics

Comparative Map Data
Myl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,592,746 - 110,598,870 (+)NCBIGRCm39mm39
GRCm389110,763,678 - 110,769,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,741,861 - 110,769,798 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,666,185 - 110,672,298 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,608,497 - 110,614,610 (+)NCBImm8
Celera9110,493,398 - 110,499,489 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.69NCBI
MYL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,835,111 - 46,882,172 (-)EnsemblGRCh38hg38GRCh38
GRCh38346,857,872 - 46,863,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,899,357 - 46,904,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,874,361 - 46,879,977 (-)NCBINCBI36hg18NCBI36
Build 34346,874,370 - 46,879,935NCBI
Celera346,837,863 - 46,843,479 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,942,461 - 46,948,077 (-)NCBIHuRef
CHM1_1346,849,457 - 46,855,073 (-)NCBICHM1_1
Myl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08119,030,852 - 119,036,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,030,875 - 119,036,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,370,030 - 118,376,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,140,705 - 115,146,827 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,160,166 - 115,166,273 (+)NCBI
Celera8110,021,445 - 110,027,566 (+)NCBICelera
Cytogenetic Map8q32NCBI
Myl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,305,759 - 25,312,271 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,308,513 - 25,311,959 (+)NCBIChiLan1.0ChiLan1.0
MYL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,859,467 - 47,865,084 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,859,467 - 47,865,084 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,758,058 - 46,782,425 (-)NCBIMhudiblu_PPA_v0panPan3
MYL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2041,933,105 - 42,073,779 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12041,941,617 - 41,947,085 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Myl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936596649,887 - 655,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,699,304 - 29,735,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,730,271 - 29,735,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,978,399 - 32,983,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,263,536 - 8,272,229 (-)NCBI
ChlSab1.1 Ensembl228,261,206 - 8,269,185 (-)Ensembl
Myl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,405,054 - 74,408,567 (+)NCBI

Position Markers
D9Mit37  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,762,590 - 110,762,646UniSTSGRCm38
GRCm389110,762,590 - 110,762,727UniSTSGRCm38
MGSCv379110,665,094 - 110,665,150UniSTSGRCm37
MGSCv379110,665,094 - 110,665,231UniSTSGRCm37
Celera9110,492,303 - 110,492,359UniSTS
Celera9110,492,303 - 110,492,444UniSTS
Cytogenetic Map9F3UniSTS
cM Map961.0UniSTS
cM Map9 UniSTS
Whitehead Genetic960.1UniSTS
Whitehead_YAC9 UniSTS
RH138771  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,769,153 - 110,769,632UniSTSGRCm38
MGSCv379110,671,657 - 110,672,136UniSTSGRCm37
Celera9110,498,847 - 110,499,326UniSTS
Cytogenetic Map9F3UniSTS
cM Map961.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:573
Count of miRNA genes:286
Interacting mature miRNAs:308
Transcripts:ENSMUST00000079784, ENSMUST00000124267, ENSMUST00000136695, ENSMUST00000153142
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079784   ⟹   ENSMUSP00000078715
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,763,646 - 110,769,798 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124267   ⟹   ENSMUSP00000142424
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,765,861 - 110,769,620 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136695   ⟹   ENSMUSP00000142791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,766,156 - 110,769,671 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153142
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,768,435 - 110,769,794 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200011   ⟹   ENSMUSP00000142530
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,741,861 - 110,769,147 (+)Ensembl
RefSeq Acc Id: NM_001364484   ⟹   NP_001351413
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,592,746 - 110,598,870 (+)NCBI
GRCm389110,763,678 - 110,769,802 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010859   ⟹   NP_034989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,592,746 - 110,598,870 (+)NCBI
GRCm389110,763,678 - 110,769,802 (+)NCBI
MGSCv379110,666,185 - 110,672,298 (+)RGD
Celera9110,493,398 - 110,499,489 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034989   ⟸   NM_010859
- UniProtKB: P09542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001351413   ⟸   NM_001364484
RefSeq Acc Id: ENSMUSP00000078715   ⟸   ENSMUST00000079784
RefSeq Acc Id: ENSMUSP00000142424   ⟸   ENSMUST00000124267
RefSeq Acc Id: ENSMUSP00000142791   ⟸   ENSMUST00000136695
RefSeq Acc Id: ENSMUSP00000142530   ⟸   ENSMUST00000200011
Protein Domains
EF-hand

Promoters
RGD ID:6844840
Promoter ID:MM_KWN:58933
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000039826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,665,996 - 110,666,496 (+)MPROMDB
RGD ID:6844846
Promoter ID:MM_KWN:58935
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000039829
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,670,381 - 110,670,881 (+)MPROMDB
RGD ID:8671068
Promoter ID:EPDNEW_M13541
Type:initiation region
Name:Myl3_1
Description:Mus musculus myosin, light polypeptide 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,763,678 - 110,763,738EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97268 AgrOrtholog
Ensembl Genes ENSMUSG00000059741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000078715 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142424 UniProtKB/TrEMBL
  ENSMUSP00000142530 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000142791 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079784 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000124267 UniProtKB/TrEMBL
  ENSMUST00000136695 UniProtKB/TrEMBL
  ENSMUST00000200011 ENTREZGENE, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17897 UniProtKB/Swiss-Prot
MGD MGI:97268 ENTREZGENE
NCBI Gene 17897 ENTREZGENE
PhenoGen Myl3 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDM3_MOUSE UniProtKB/TrEMBL
  A0A0G2JDW2_MOUSE UniProtKB/TrEMBL
  MYL3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61935_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UIF4 UniProtKB/Swiss-Prot
  Q9CQZ2 UniProtKB/Swiss-Prot