Ccr1 (C-C motif chemokine receptor 1) - Rat Genome Database

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Gene: Ccr1 (C-C motif chemokine receptor 1) Rattus norvegicus
Analyze
Symbol: Ccr1
Name: C-C motif chemokine receptor 1
RGD ID: 708446
Description: Enables C-C chemokine binding activity. Involved in cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; and cerebellum development. Located in neuronal cell body. Used to study colitis. Biomarker of anterior uveitis. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C chemokine receptor type 1; chemokine (C-C motif) receptor 1; LOC57301; macrophage inflammatory protein-1 alpha receptor; macrophage inflammatory protein-1 alpha receptor gene
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,433,711 - 132,439,266 (-)NCBIGRCr8
mRatBN7.28123,556,286 - 123,561,841 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx8129,152,874 - 129,158,441 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,352,003 - 127,357,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,170,253 - 125,175,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,996,646 - 133,002,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,996,649 - 133,002,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,147,926 - 132,153,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,693,658 - 128,699,213 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,713,397 - 128,718,950 (-)NCBI
Celera8122,658,153 - 122,663,708 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-arachidonoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methyl methanesulfonate  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sterigmatocystin  (ISO)
styrene  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trans-caffeic acid  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE. Adamus G, etal., Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2894-903.
2. CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver. Ajuebor MN, etal., Eur J Immunol. 2004 Oct;34(10):2907-18.
3. Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Amat M, etal., Br J Pharmacol. 2006 Nov;149(6):666-75. Epub 2006 Oct 3.
4. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. Anders HJ, etal., J Am Soc Nephrol. 2004 Jun;15(6):1504-13.
5. Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo. Bonville CA, etal., J Virol. 2004 Aug;78(15):7984-9.
6. Gene expression profiles at different stages of collagen-induced arthritis. Booth G, etal., Autoimmunity. 2008 Nov;41(7):512-21.
7. Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects. Borregaard J, etal., Contact Dermatitis. 2008 Oct;59(4):212-9.
8. Therapeutic targeting of CCR1 attenuates established chronic fungal asthma in mice. Carpenter KJ, etal., Br J Pharmacol. 2005 Aug;145(8):1160-72.
9. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Choi SW, etal., Blood. 2007 Nov 1;110(9):3447-55. Epub 2007 Jul 19.
10. Developmental changes in the expression of chemokine receptor CCR1 in the rat cerebellum. Cowell RM and Silverstein FS, J Comp Neurol. 2003 Feb 24;457(1):7-23.
11. Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages. Di Marzio P, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):909-16.
12. Effector stage CC chemokine receptor-1 selective antagonism reduces multiple sclerosis-like rat disease. Eltayeb S, etal., J Neuroimmunol. 2003 Sep;142(1-2):75-85.
13. Expression of cytokine signaling genes in morbidly obese patients with non-alcoholic steatohepatitis and hepatic fibrosis. Estep JM, etal., Obes Surg. 2009 May;19(5):617-24. Epub 2009 Mar 12.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. Gladue RP, etal., J Immunol. 2006 Mar 1;176(5):3141-8.
16. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
17. CCR1 is an early and specific marker of Alzheimer's disease. Halks-Miller M, etal., Ann Neurol. 2003 Nov;54(5):638-46.
18. Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis. Haringman JJ, etal., Ann Rheum Dis. 2003 Aug;62(8):715-21.
19. A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds. Havaux X, etal., Clin Exp Immunol. 2005 Feb;139(2):179-88.
20. Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. He M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1173-80. Epub 2007 Jan 18.
21. Treatment with BX471, a nonpeptide CCR1 antagonist, protects mice against acute pancreatitis-associated lung injury by modulating neutrophil recruitment. He M, etal., Pancreas. 2007 Mar;34(2):233-41.
22. CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Hickey MJ, etal., Viral Immunol. 2007 Dec;20(4):599-608.
23. Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis. Ji J, etal., Infect Immun. 2003 Aug;71(8):4278-88.
24. Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses. John AE, etal., Eur J Immunol. 2005 Jan;35(1):108-16.
25. Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell-cell communication. Kanno M, etal., J Neuroimmunol. 2005 Oct;167(1-2):72-80.
26. Spatiotemporal CCR1, CCL3(MIP-1alpha), CXCR4, CXCL12(SDF-1alpha) expression patterns in a rat spinal cord injury model of posttraumatic neuropathic pain. Knerlich-Lukoschus F, etal., J Neurosurg Spine. 2011 May;14(5):583-97. Epub 2011 Feb 18.
27. Treatment with Met-RANTES decreases bacterial translocation in experimental colitis. Kucuk C, etal., Am J Surg. 2006 Jan;191(1):77-83.
28. Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression. LaCasse RA, etal., J Neuroimmunol. 2008 May 30;196(1-2):16-26. Epub 2008 Apr 8.
29. Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction. Liehn EA, etal., J Cell Mol Med. 2008 Apr;12(2):496-506. Epub 2007 Dec 14.
30. Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis. Lionakis MS, etal., PLoS Pathog. 2012;8(8):e1002865. doi: 10.1371/journal.ppat.1002865. Epub 2012 Aug 16.
31. CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats. Machado RR, etal., Brain Res. 2007 Jun 9;.
32. Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. Manczak M, etal., J Autoimmun. 2002 Jun;18(4):259-70.
33. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, etal., PLoS One. 2012;7(10):e47930. doi: 10.1371/journal.pone.0047930. Epub 2012 Oct 24.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Morteau O, etal., Gastroenterology. 2002 Mar;122(3):725-33.
36. Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. Ninichuk V, etal., J Am Soc Nephrol. 2005 Apr;16(4):977-85. Epub 2005 Feb 16.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Repeke CE, etal., Bone. 2010 Apr;46(4):1122-30. Epub 2010 Jan 4.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83.
42. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
43. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
44. Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase. Stroo I, etal., Int Immunol. 2010 Jun;22(6):433-42. Epub 2010 Apr 21.
45. Differential expression of the chemokine receptors CX3CR1 and CCR1 by microglia and macrophages in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis. Sunnemark D, etal., Brain Pathol. 2003 Oct;13(4):617-29.
46. Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease. Waehre T, etal., J Am Coll Cardiol. 2003 May 7;41(9):1460-7.
47. Identification and characterization of a rat macrophage inflammatory protein-1alpha receptor. Waller A, etal., J Hematother Stem Cell Res. 2000 Oct;9(5):703-9.
48. Selective expression and cellular localization of pro-inflammatory chemokine ligand/receptor pairs in the sciatic nerves of a severe murine experimental autoimmune neuritis model of Guillain-Barre syndrome. Xia RH, etal., Neuropathol Appl Neurobiol. 2010 Aug;36(5):388-98. Epub 2010 May 25.
49. Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro. Yang M, etal., Blood. 2006 Mar 15;107(6):2262-70. doi: 10.1182/blood-2005-08-3365. Epub 2005 Nov 22.
50. The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis. Yang X, etal., Am J Respir Cell Mol Biol. 2011 Jul;45(1):127-35. Epub 2010 Sep 24.
51. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Zhang N, etal., Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4536-41. Epub 2005 Mar 11.
Additional References at PubMed
PMID:7545673   PMID:7594543   PMID:8699119   PMID:9166425   PMID:10660125   PMID:10706735   PMID:10734056   PMID:15001559   PMID:15474493   PMID:15557190   PMID:17484785   PMID:18587271  
PMID:21403648   PMID:22417871   PMID:22752444   PMID:24056371   PMID:31919846   PMID:34413501  


Genomics

Comparative Map Data
Ccr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,433,711 - 132,439,266 (-)NCBIGRCr8
mRatBN7.28123,556,286 - 123,561,841 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx8129,152,874 - 129,158,441 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,352,003 - 127,357,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,170,253 - 125,175,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,996,646 - 133,002,201 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,996,649 - 133,002,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,147,926 - 132,153,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,693,658 - 128,699,213 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,713,397 - 128,718,950 (-)NCBI
Celera8122,658,153 - 122,663,708 (-)NCBICelera
Cytogenetic Map8q32NCBI
CCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,201,711 - 46,208,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,201,711 - 46,208,313 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,243,202 - 46,249,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,218,204 - 46,224,836 (-)NCBINCBI36Build 36hg18NCBI36
Build 34346,218,203 - 46,224,836NCBI
Celera346,180,543 - 46,187,174 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,286,913 - 46,293,545 (-)NCBIHuRef
CHM1_1346,193,211 - 46,199,842 (-)NCBICHM1_1
T2T-CHM13v2.0346,217,573 - 46,224,175 (-)NCBIT2T-CHM13v2.0
Ccr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,762,163 - 123,768,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,762,161 - 123,768,729 (-)EnsemblGRCm39 Ensembl
GRCm389123,962,126 - 123,968,692 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,962,124 - 123,968,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv379123,876,959 - 123,883,525 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,810,922 - 123,817,364 (-)NCBIMGSCv36mm8
Celera9125,030,694 - 125,037,264 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
CCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,164,661 - 46,171,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,169,429 - 46,176,130 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,107,526 - 46,114,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,213,167 - 47,219,832 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,214,688 - 47,215,755 (-)Ensemblpanpan1.1panPan2
CCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,421,356 - 42,427,177 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,421,356 - 42,426,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,337,281 - 42,341,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,903,724 - 42,909,542 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,903,713 - 42,909,543 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,144,885 - 42,149,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,552,456 - 42,557,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,827,348 - 42,831,924 (+)NCBIUU_Cfam_GSD_1.0
LOC101964209
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,628,576 - 200,633,955 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596177,812 - 183,186 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596177,774 - 183,186 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,227,222 - 29,233,960 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,227,218 - 29,233,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,323,642 - 32,330,286 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,634,205 - 7,641,380 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,517,175 - 159,523,723 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724812
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,826,659 - 74,827,726 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,822,848 - 74,828,614 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr1
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000008772
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 43 107 91 90 59 25 59 6 212 91 87 45 57 31

Sequence


Ensembl Acc Id: ENSRNOT00000008772   ⟹   ENSRNOP00000008772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8132,996,649 - 133,002,201 (-)Ensembl
RefSeq Acc Id: NM_020542   ⟹   NP_065417
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,433,711 - 132,439,266 (-)NCBI
mRatBN7.28123,556,286 - 123,561,841 (-)NCBI
Rnor_6.08132,996,646 - 133,002,201 (-)NCBI
Rnor_5.08132,147,926 - 132,153,481 (-)NCBI
RGSC_v3.48128,693,658 - 128,699,213 (-)RGD
Celera8122,658,153 - 122,663,708 (-)RGD
Sequence:
RefSeq Acc Id: XM_063266045   ⟹   XP_063122115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,433,711 - 132,438,976 (-)NCBI
Protein Sequences
Protein RefSeqs NP_065417 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122115 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF34340 (Get FASTA)   NCBI Sequence Viewer  
  AAH79207 (Get FASTA)   NCBI Sequence Viewer  
  EDL76748 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_065417   ⟸   NM_020542
- UniProtKB: Q9JLY8 (UniProtKB/TrEMBL),   A6I4C9 (UniProtKB/TrEMBL),   Q6AY38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008772   ⟸   ENSRNOT00000008772
RefSeq Acc Id: XP_063122115   ⟸   XM_063266045
- Peptide Label: isoform X1
- UniProtKB: A6I4C9 (UniProtKB/TrEMBL),   Q6AY38 (UniProtKB/TrEMBL),   Q9JLY8 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLY8-F1-model_v2 AlphaFold Q9JLY8 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696415
Promoter ID:EPDNEW_R6940
Type:single initiation site
Name:Ccr1_1
Description:C-C motif chemokine receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08133,002,213 - 133,002,273EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708446 AgrOrtholog
BioCyc Gene G2FUF-28600 BioCyc
Ensembl Genes ENSRNOG00000006715 Ensembl
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131790 IMAGE-MGC_LOAD
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  CC_1_rcpt UniProtKB/TrEMBL
  Chmkine_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:57301 UniProtKB/TrEMBL
MGC_CLONE MGC:94269 IMAGE-MGC_LOAD
NCBI Gene 57301 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/TrEMBL
  PTHR10489:SF711 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Ccr1 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER1 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006715 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6I4C9 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY38 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLY8 ENTREZGENE
UniProt Secondary Q9JLY8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr1  C-C motif chemokine receptor 1  Ccr1  chemokine (C-C motif) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ccr1  chemokine (C-C motif) receptor 1    macrophage inflammatory protein-1 alpha receptor gene  Name updated 1299863 APPROVED
2004-09-10 Ccr1  macrophage inflammatory protein-1 alpha receptor gene  LOC57301    Symbol and Name updated 1299863 APPROVED