RGD Reference Report - Treatment with Met-RANTES decreases bacterial translocation in experimental colitis. - Rat Genome Database

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Treatment with Met-RANTES decreases bacterial translocation in experimental colitis.

Authors: Kucuk, C  Sozuer, E  Gursoy, S  Canoz, O  Artis, T  Akcan, A  Akyildiz, H  Muhtaroglu, S 
Citation: Kucuk C, etal., Am J Surg. 2006 Jan;191(1):77-83.
RGD ID: 2307162
Pubmed: PMID:16399111   (View Abstract at PubMed)
DOI: DOI:10.1016/j.amjsurg.2005.10.005   (Journal Full-text)

BACKGROUND: During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation, normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis. METHODS: Rats were randomly assigned to 3 groups. Group 1 = control, group 2 = experimental colitis, and group 3 = colitis plus Met-RANTES treatment. On day 7 after colitis was induced, plasma tumor necrosis factor-alpha colon tissue myeloperoxidase and portal blood endotoxin levels were measured. Lymph node, liver, and spleen culture quantified bacterial translocation. RESULTS: Met-RANTES treatment resulted in significant decreases in colonic damage as well as bacterial translocation in experimental colitis. CONCLUSIONS: These results suggest that chemokine receptor antagonists may potentially be useful in the treatment of IBDs.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCR1Humancolitis  ISOCcr1 (Rattus norvegicus) RGD 
Ccr1Ratcolitis  IMP  RGD 
Ccr1Mousecolitis  ISOCcr1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccr1  (C-C motif chemokine receptor 1)

Genes (Mus musculus)
Ccr1  (C-C motif chemokine receptor 1)

Genes (Homo sapiens)
CCR1  (C-C motif chemokine receptor 1)


Additional Information