Yy1 (YY1 transcription factor) - Rat Genome Database

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Gene: Yy1 (YY1 transcription factor) Rattus norvegicus
Analyze
Symbol: Yy1
Name: YY1 transcription factor
RGD ID: 3982
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to interleukin-1; negative regulation of cell growth involved in cardiac muscle cell development; and regulation of transcription by RNA polymerase II. Located in nuclear matrix. Part of transcription regulator complex. Used to study type 1 diabetes mellitus. Biomarker of type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; mTOR signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NF-E1; NMP-1; NMP1; transcriptional repressor protein YY1; UCRBP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,471,615 - 133,500,875 (+)NCBIGRCr8
mRatBN7.26127,706,739 - 127,736,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,707,596 - 127,732,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,830,843 - 127,855,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,125,889 - 128,150,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,484,792 - 127,509,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,702,443 - 132,726,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,702,448 - 132,727,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,872,505 - 141,896,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,132,419 - 133,156,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,138,605 - 133,162,873 (+)NCBI
Celera6125,273,530 - 125,282,803 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium sulfate  (ISO)
calyculin A  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diethyldithiocarbamic acid  (ISO)
Diosbulbin B  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
Jujuboside A  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
lithocholic acid  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methapyrilene  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium chloride  (ISO)
rotenone  (EXP)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
B cell differentiation  (IEA,ISO)
camera-type eye morphogenesis  (IEA,ISO)
cellular response to interleukin-1  (IDA)
cellular response to UV  (IEA,ISO)
chromatin remodeling  (IEA,ISO)
chromosome organization  (IEA,ISO)
DNA damage response  (IEA,ISO)
double-strand break repair via homologous recombination  (IEA,ISO)
gene expression  (IEA,ISO)
hemopoiesis  (IEA,ISO)
immunoglobulin heavy chain V-D-J recombination  (IEA,ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of interferon-beta production  (IEA,ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
positive regulation of DNA repair  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of telomere maintenance in response to DNA damage  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
regulation of cell cycle  (IEA,ISO)
regulation of chromosome organization  (IEA,ISO)
regulation of DNA repair  (IEA,ISO)
regulation of DNA replication  (IEA,ISO)
regulation of DNA strand elongation  (IEA,ISO)
regulation of DNA-templated transcription  (IDA,IEA,ISO)
regulation of embryonic development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to prostaglandin F  (IEP)
response to UV-C  (IEA,ISO)
RNA localization  (IEA,ISO)
spermatogenesis  (IEA,ISO)
telomere maintenance  (IEA,ISO)

Cellular Component
chromatin  (IBA,IEA,ISO)
chromatin silencing complex  (IEA,ISO)
Ino80 complex  (IEA,ISO)
nuclear matrix  (IDA)
nucleus  (IEA,ISO)
PcG protein complex  (IBA,IEA,ISO)
transcription regulator complex  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia. Beck K, etal., Circ Res. 2010 Dec 10;107(12):1490-7. doi: 10.1161/CIRCRESAHA.110.231985. Epub 2010 Oct 28.
2. Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene. Bergad PL, etal., J Biol Chem. 2000 Mar 17;275(11):8114-20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Karki P, etal., Mol Cell Biol. 2014 Apr;34(7):1280-9. doi: 10.1128/MCB.01176-13. Epub 2014 Jan 27.
6. Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat. Kloting N and Kloting I, Mol Genet Metab. 2004 Jul;82(3):255-9.
7. Diabetes per se and metabolic state influence gene expression in tissue-dependent manner of BB/OK rats. Kloting N, etal., Diabetes Metab Res Rev. 2005 May-Jun;21(3):281-7.
8. Subcellular partitioning of transcription factors during osteoblast differentiation: developmental association of the AML/CBF alpha/PEBP2 alpha-related transcription factor-NMP-2 with the nuclear matrix. Lindenmuth DM, etal., J Cell Biochem. 1997 Jul 1;66(1):123-32.
9. Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Mariner PD, etal., Biochem Biophys Res Commun. 2005 Jan 7;326(1):79-86.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding. Mizuno D, etal., Biochim Biophys Acta 2003 Jun 19;1627(2-3):121-8.
12. Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1. Nackley AC, etal., Endocrinology 2002 Mar;143(3):1085-96.
13. The transcription factor Yin Yang 1 is an activator of BACE1 expression. Nowak K, etal., J Neurochem. 2006 Mar;96(6):1696-707.
14. IL-1 beta increases abundance and activity of the negative transcriptional regulator yin yang-1 (YY1) in neonatal rat cardiac myocytes. Patten M, etal., J Mol Cell Cardiol. 2000 Jul;32(7):1341-52.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2. Santiago FS, etal., J Biol Chem 2001 Nov 2;276(44):41143-9.
20. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. Sucharov CC, etal., J Biol Chem. 2003 Aug 15;278(33):31233-9. Epub 2003 May 16.
21. YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5. Sucharov CC, etal., Mol Biol Cell. 2008 Oct;19(10):4141-53. doi: 10.1091/mbc.E07-12-1217. Epub 2008 Jul 16.
22. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.
Additional References at PubMed
PMID:9857059   PMID:10791971   PMID:11861914   PMID:12527199   PMID:12723621   PMID:15161869   PMID:15329343   PMID:15369764   PMID:15574595   PMID:16099430   PMID:16260628   PMID:16624538  
PMID:17001316   PMID:17107999   PMID:17556661   PMID:17702849   PMID:18026119   PMID:18584324   PMID:18940814   PMID:19139378   PMID:19786570   PMID:20720167   PMID:20843790   PMID:21303910  
PMID:21729784   PMID:22005459   PMID:22065573   PMID:23531880   PMID:23555743   PMID:23942234   PMID:24101522   PMID:24137001   PMID:24675724   PMID:26269591   PMID:26658965   PMID:28065881  
PMID:30998979   PMID:32590621   PMID:33300076   PMID:33498722   PMID:36436207   PMID:38264929   PMID:38353379  


Genomics

Comparative Map Data
Yy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,471,615 - 133,500,875 (+)NCBIGRCr8
mRatBN7.26127,706,739 - 127,736,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,707,596 - 127,732,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,830,843 - 127,855,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,125,889 - 128,150,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,484,792 - 127,509,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,702,443 - 132,726,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,702,448 - 132,727,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,872,505 - 141,896,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,132,419 - 133,156,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,138,605 - 133,162,873 (+)NCBI
Celera6125,273,530 - 125,282,803 (+)NCBICelera
Cytogenetic Map6q32NCBI
YY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,239,144 - 100,282,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,238,298 - 100,282,788 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,705,481 - 100,749,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,774,855 - 99,814,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,774,854 - 99,814,557NCBI
Celera1480,759,739 - 80,799,431 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,888,079 - 80,926,725 (+)NCBIHuRef
CHM1_114100,642,915 - 100,683,150 (+)NCBICHM1_1
T2T-CHM13v2.01494,472,191 - 94,515,818 (+)NCBIT2T-CHM13v2.0
Yy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,758,841 - 108,786,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,758,899 - 108,786,074 (+)EnsemblGRCm39 Ensembl
GRCm3812108,792,945 - 108,820,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,792,973 - 108,820,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,031,521 - 110,054,842 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,241,118 - 109,264,439 (+)NCBIMGSCv36mm8
Celera12110,029,534 - 110,052,930 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.58NCBI
Yy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543821,341,374 - 21,377,674 (+)NCBIChiLan1.0ChiLan1.0
YY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,390,655 - 101,434,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,607,371 - 100,650,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,859,491 - 80,903,651 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,173,287 - 100,217,651 (+)NCBIpanpan1.1PanPan1.1panPan2
YY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,539,511 - 68,572,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,539,353 - 68,568,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,058,331 - 68,091,508 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,823,410 - 68,856,669 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,823,416 - 68,851,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,485,332 - 68,518,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,551,498 - 68,584,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,948,873 - 68,982,099 (+)NCBIUU_Cfam_GSD_1.0
Yy1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,137,064 - 6,171,061 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366043,911,407 - 3,945,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,132,191 - 121,170,697 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,132,168 - 121,170,699 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,602,231 - 128,613,935 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,199,172 - 78,243,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,199,039 - 78,237,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,338,296 - 65,383,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yy1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,846,765 - 3,875,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,846,753 - 3,875,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Yy1
116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:33
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000005743
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
AW488674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,734,241 - 127,734,334 (+)MAPPERmRatBN7.2
Rnor_6.06132,729,183 - 132,729,275NCBIRnor6.0
Rnor_5.06141,899,259 - 141,899,351UniSTSRnor5.0
RGSC_v3.46133,159,021 - 133,159,113UniSTSRGSC3.4
Celera6125,285,138 - 125,285,230UniSTS
Cytogenetic Map6q32UniSTS
RH131280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,706,741 - 127,706,961 (+)MAPPERmRatBN7.2
Rnor_6.06132,701,686 - 132,701,905NCBIRnor6.0
Rnor_5.06141,871,762 - 141,871,981UniSTSRnor5.0
RGSC_v3.46133,131,523 - 133,131,742UniSTSRGSC3.4
Celera6125,258,019 - 125,258,238UniSTS
Cytogenetic Map6q32UniSTS
RH139545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,734,146 - 127,734,334 (+)MAPPERmRatBN7.2
Rnor_6.06132,729,088 - 132,729,275NCBIRnor6.0
Rnor_5.06141,899,164 - 141,899,351UniSTSRnor5.0
RGSC_v3.46133,158,926 - 133,159,113UniSTSRGSC3.4
Celera6125,285,043 - 125,285,230UniSTS
RH 3.4 Map6788.1UniSTS
Cytogenetic Map6q32UniSTS
RH140410  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86133,470,356 - 133,470,550 (+)Marker Load Pipeline
mRatBN7.26127,705,978 - 127,706,172 (+)MAPPERmRatBN7.2
Rnor_6.06132,700,923 - 132,701,116NCBIRnor6.0
Rnor_5.06141,870,999 - 141,871,192UniSTSRnor5.0
RGSC_v3.46133,130,760 - 133,130,953UniSTSRGSC3.4
Celera6125,257,256 - 125,257,449UniSTS
RH 3.4 Map6787.5UniSTS
Cytogenetic Map6q32UniSTS
AI231795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,736,071 - 127,736,204 (+)MAPPERmRatBN7.2
Rnor_6.06132,731,013 - 132,731,145NCBIRnor6.0
Rnor_5.06141,901,089 - 141,901,221UniSTSRnor5.0
RGSC_v3.46133,160,851 - 133,160,983UniSTSRGSC3.4
Celera6125,286,968 - 125,287,100UniSTS
RH 3.4 Map6787.0UniSTS
Cytogenetic Map6q32UniSTS
G36215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,722,669 - 127,722,765 (+)MAPPERmRatBN7.2
Rnor_6.06132,717,611 - 132,717,706NCBIRnor6.0
Rnor_5.06141,887,687 - 141,887,782UniSTSRnor5.0
RGSC_v3.46133,147,449 - 133,147,544UniSTSRGSC3.4
Celera6125,273,566 - 125,273,661UniSTS
Cytogenetic Map6q32UniSTS
PMC84716P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,707,884 - 127,708,096 (+)MAPPERmRatBN7.2
Rnor_6.06132,702,828 - 132,703,039NCBIRnor6.0
Rnor_5.06141,872,904 - 141,873,115UniSTSRnor5.0
RGSC_v3.46133,132,666 - 133,132,877UniSTSRGSC3.4
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005743   ⟹   ENSRNOP00000005743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,707,596 - 127,731,999 (+)Ensembl
Rnor_6.0 Ensembl6132,702,448 - 132,727,046 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097604   ⟹   ENSRNOP00000089643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,707,596 - 127,732,747 (+)Ensembl
RefSeq Acc Id: NM_173290   ⟹   NP_775412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,471,615 - 133,500,875 (+)NCBI
mRatBN7.26127,707,237 - 127,736,499 (+)NCBI
Rnor_6.06132,702,581 - 132,726,848 (+)NCBI
Rnor_5.06141,872,505 - 141,896,924 (+)NCBI
RGSC_v3.46133,132,419 - 133,156,686 (+)RGD
Celera6125,273,530 - 125,282,803 (+)RGD
Sequence:
RefSeq Acc Id: NP_775412   ⟸   NM_173290
- UniProtKB: Q8CHJ4 (UniProtKB/TrEMBL),   A0A8I6A7Q7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005743   ⟸   ENSRNOT00000005743
Ensembl Acc Id: ENSRNOP00000089643   ⟸   ENSRNOT00000097604
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHJ4-F1-model_v2 AlphaFold Q8CHJ4 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694821
Promoter ID:EPDNEW_R5345
Type:initiation region
Name:Yy1_1
Description:YY1 transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06132,702,480 - 132,702,540EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3982 AgrOrtholog
BioCyc Gene G2FUF-36279 BioCyc
Ensembl Genes ENSRNOG00000004339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005743 ENTREZGENE
  ENSRNOT00000005743.4 UniProtKB/TrEMBL
  ENSRNOT00000097604.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro YY-1-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:24919 UniProtKB/TrEMBL
NCBI Gene 24919 ENTREZGENE
PANTHER TRANSCRIPTION FACTOR YY1-RELATED UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PharmGKB YY1 RGD
PhenoGen Yy1 PhenoGen
PIRSF TF_Yin_yang UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004339 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6A7Q7 ENTREZGENE, UniProtKB/TrEMBL
  A6KBH3_RAT UniProtKB/TrEMBL
  A6KBH4_RAT UniProtKB/TrEMBL
  Q8CHJ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Yy1  YY1 transcription factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the rat vascular smooth muscle cells after injury 628455
gene_function GL1-Kruppel-type zinc finger nuclear factor 628455
gene_process represses or activates the expression of many growth factors and inhibits smooth muscle growth 628455
gene_regulation mRNA and protein expression increased by growth factors which stimulate binding and transcription and expression blocked by neutralizing antibodies against fibroblast growth factors 628455