C9 (complement C9) - Rat Genome Database

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Gene: C9 (complement C9) Rattus norvegicus
Analyze
Symbol: C9
Name: complement C9
RGD ID: 620319
Description: Predicted to be involved in several processes, including complement activation; innate immune response; and protein homooligomerization. Predicted to be located in plasma membrane. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Biomarker of polycystic kidney disease. Human ortholog(s) of this gene implicated in age related macular degeneration 15; complement component 9 deficiency; and opiate dependence. Orthologous to human C9 (complement C9); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: complement component 9; complement component C9; LOC360336
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,300,510 - 57,348,759 (+)NCBIGRCr8
mRatBN7.2255,573,094 - 55,621,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,572,992 - 55,621,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx262,673,026 - 62,721,273 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0260,746,574 - 60,794,844 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0255,749,037 - 55,797,274 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0255,775,562 - 55,823,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,775,274 - 55,823,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,517,644 - 75,565,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,743,084 - 55,791,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,671,316 - 55,719,381 (+)NCBI
Celera251,194,591 - 51,242,839 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bosentan  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciprofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
lead diacetate  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Fischetti F, etal., Blood. 2005 Oct 1;106(7):2340-6. Epub 2005 Jun 14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. The membrane attack complex of complement induces caspase activation and apoptosis. Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. Su Z, etal., J Intern Med. 2014 Feb 4. doi: 10.1111/joim.12214.
13. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, etal., Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.
Additional References at PubMed
PMID:9212048   PMID:9688553   PMID:12477932   PMID:16034134   PMID:18178252   PMID:19056867   PMID:22516433   PMID:22832194   PMID:23376485   PMID:23533145   PMID:26841934   PMID:30111885  


Genomics

Comparative Map Data
C9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,300,510 - 57,348,759 (+)NCBIGRCr8
mRatBN7.2255,573,094 - 55,621,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,572,992 - 55,621,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx262,673,026 - 62,721,273 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0260,746,574 - 60,794,844 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0255,749,037 - 55,797,274 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0255,775,562 - 55,823,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,775,274 - 55,823,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,517,644 - 75,565,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,743,084 - 55,791,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,671,316 - 55,719,381 (+)NCBI
Celera251,194,591 - 51,242,839 (+)NCBICelera
Cytogenetic Map2q16NCBI
C9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38539,284,140 - 39,364,495 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl539,284,140 - 39,371,324 (-)EnsemblGRCh38hg38GRCh38
GRCh37539,284,242 - 39,364,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36539,320,758 - 39,400,412 (-)NCBINCBI36Build 36hg18NCBI36
Build 34539,320,764 - 39,400,412NCBI
Celera539,170,963 - 39,251,580 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef539,235,660 - 39,316,262 (-)NCBIHuRef
CHM1_1539,286,294 - 39,366,561 (-)NCBICHM1_1
T2T-CHM13v2.0539,533,654 - 39,614,008 (-)NCBIT2T-CHM13v2.0
C9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,474,827 - 6,528,306 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,474,808 - 6,528,232 (+)EnsemblGRCm39 Ensembl
GRCm38156,445,346 - 6,498,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,445,327 - 6,498,751 (+)EnsemblGRCm38mm10GRCm38
MGSCv37156,395,333 - 6,448,476 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,392,548 - 6,445,691 (+)NCBIMGSCv36mm8
Celera156,294,488 - 6,347,559 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map152.79NCBI
C9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542623,790,792 - 23,824,117 (-)NCBIChiLan1.0ChiLan1.0
C9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2470,971,579 - 71,054,978 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,128,522 - 69,208,611 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0571,011,961 - 71,090,243 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1576,051,911 - 76,130,725 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,051,911 - 76,130,725 (+)Ensemblpanpan1.1panPan2
C9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1469,660,861 - 69,719,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl469,660,907 - 69,719,562 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha469,337,298 - 69,397,077 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0470,176,511 - 70,236,336 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,176,550 - 70,235,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1469,925,818 - 69,985,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0470,038,157 - 70,097,881 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0470,577,290 - 70,637,100 (+)NCBIUU_Cfam_GSD_1.0
C9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213228,373,978 - 228,423,999 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365182,958,995 - 2,994,880 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365182,947,956 - 2,994,892 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1624,520,634 - 24,590,338 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11624,521,318 - 24,575,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21625,800,236 - 25,823,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1438,082,751 - 38,165,886 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl438,082,457 - 38,164,164 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607128,458,276 - 28,543,866 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475915,534,660 - 15,624,381 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475915,534,743 - 15,623,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C9
145 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:8
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000018545
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH137381  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8257,348,585 - 57,348,739 (+)Marker Load Pipeline
mRatBN7.2255,621,171 - 55,621,325 (+)MAPPERmRatBN7.2
Rnor_6.0255,823,634 - 55,823,787NCBIRnor6.0
Rnor_5.0275,565,393 - 75,565,546UniSTSRnor5.0
RGSC_v3.4255,790,975 - 55,791,128UniSTSRGSC3.4
Celera251,242,666 - 51,242,819UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 24 57 90 89 59 25 59 6 172 71 37 25 54 30

Sequence


Ensembl Acc Id: ENSRNOT00000018545   ⟹   ENSRNOP00000018545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,572,992 - 55,621,338 (+)Ensembl
Rnor_6.0 Ensembl255,775,274 - 55,823,826 (+)Ensembl
RefSeq Acc Id: NM_057146   ⟹   NP_476487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,300,510 - 57,348,759 (+)NCBI
mRatBN7.2255,573,094 - 55,621,345 (+)NCBI
Rnor_6.0255,775,562 - 55,823,807 (+)NCBI
Rnor_5.0275,517,644 - 75,565,566 (+)NCBI
RGSC_v3.4255,743,084 - 55,791,148 (+)RGD
Celera251,194,591 - 51,242,839 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA96528 (Get FASTA)   NCBI Sequence Viewer  
  AAB38023 (Get FASTA)   NCBI Sequence Viewer  
  AAH91127 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018545
  ENSRNOP00000018545.4
GenBank Protein Q62930 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476487   ⟸   NM_057146
- Peptide Label: precursor
- UniProtKB: Q5BKC4 (UniProtKB/TrEMBL),   A6KGF3 (UniProtKB/TrEMBL),   F7F389 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018545   ⟸   ENSRNOT00000018545
Protein Domains
EGF-like   LDL-receptor class A   MACPF   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62930-F1-model_v2 AlphaFold Q62930 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691170
Promoter ID:EPDNEW_R1695
Type:single initiation site
Name:C9_1
Description:complement C9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0255,775,364 - 55,775,424EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620319 AgrOrtholog
BioCyc Gene G2FUF-54156 BioCyc
Ensembl Genes ENSRNOG00000013736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018545 ENTREZGENE
  ENSRNOT00000018545.6 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324872 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAC_perforin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108614 IMAGE-MGC_LOAD
NCBI Gene 117512 ENTREZGENE
PANTHER COMPLEMENT COMPONENT C6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45742:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen C9 PhenoGen
PRINTS COMPLEMENTC9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013736 RatGTEx
SMART LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KGF3 ENTREZGENE, UniProtKB/TrEMBL
  CO9_RAT UniProtKB/Swiss-Prot
  F7F389 ENTREZGENE, UniProtKB/TrEMBL
  Q5BKC4 ENTREZGENE, UniProtKB/TrEMBL
  Q62930 ENTREZGENE
UniProt Secondary Q62957 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C9  complement C9  C9  complement component 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 C9  complement component 9  C9_predicted  complement component 9 (predicted)  Data merged from RGD:1310023 737654 APPROVED
2005-01-20 C9  complement component 9      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 C9_predicted  complement component 9 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 C9  complement component 9      Symbol and Name status set to provisional 70820 PROVISIONAL