Gene: Grk5 (G protein-coupled receptor kinase 5) Rattus norvegicus
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Symbol: Grk5
Name: G protein-coupled receptor kinase 5
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH hypertension; Parkinson's disease; Alzheimer's disease (ortholog); FOUND IN cytosol (ortholog); nuclear membrane (ortholog); nuclear speck (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil
AGR Description: Predicted to have beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity; involved in negative regulation of signal transduction, oligodendrocyte differentiation, and response to alkaloid; predicted to localize to the cytosol, intracellular organelle, and plasma membrane; biomarker of Parkinson's disease and hypertension; orthologous to human GRK5 (G protein-coupled receptor kinase 5).
Merged Description: Predicted to have beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity; involved in negative regulation of signal transduction, oligodendrocyte differentiation, and response to alkaloid; predicted to localize to the cytosol, intracellular organelle, and plasma membrane; biomarker of Parkinson's disease and hypertension; orthologous to human GRK5 (G protein-coupled receptor kinase 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: g protein-coupled receptor kinase GRK5; Gprk5; MGC93405
Orthologs:
Homo sapiens (human) : GRK5 (G protein-coupled receptor kinase 5)  HGNC  Alliance
Mus musculus (house mouse) : Grk5 (G protein-coupled receptor kinase 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk5 (G protein-coupled receptor kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK5 (G protein-coupled receptor kinase 5)
Canis lupus familiaris (dog) : GRK5 (G protein-coupled receptor kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk5 (G protein-coupled receptor kinase 5)
Sus scrofa (pig) : GRK5 (G protein-coupled receptor kinase 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Celera1255,668,943 - 255,859,242 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grk5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61985
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.