Grk5 (G protein-coupled receptor kinase 5) - Rat Genome Database
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Gene: Grk5 (G protein-coupled receptor kinase 5) Rattus norvegicus
Analyze
Symbol: Grk5
Name: G protein-coupled receptor kinase 5
RGD ID: 61985
Description: Predicted to have beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to alkaloid. Predicted to localize to cytosol; nucleus; and plasma membrane. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: g protein-coupled receptor kinase GRK5; Gprk5; MGC93405
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21260,028,269 - 260,223,699 (+)NCBI
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Celera1255,668,943 - 255,859,242 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
gamma-linolenic acid  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
melphalan  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methylseleninic acid  (ISO)
metoprolol  (ISO)
morphine  (EXP)
nitrobenzenes  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

References

References - curated
1. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. Arraes SM, etal., Blood. 2006 Nov 1;108(9):2906-13. Epub 2006 Jul 18.
3. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Bychkov ER, etal., Neurobiol Aging. 2008 Mar;29(3):379-96. Epub 2006 Nov 27.
5. Daniele S, etal., Cell Signal. 2014 Jun;26(6):1310-25. doi: 10.1016/j.cellsig.2014.02.016. Epub 2014 Mar 5.
6. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
7. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
8. Fan X, etal., Neuropharmacology 2002 Oct;43(5):809-16.
9. Franklin JM and Carrasco GA, J Mol Neurosci. 2015 Mar;55(3):770-7. doi: 10.1007/s12031-014-0419-z. Epub 2014 Sep 12.
10. GOA data from the GO Consortium
11. KEGG
12. Li L, etal., J Neuroinflammation. 2008 Jun 3;5:24.
13. Liu J, etal., J Biol Chem. 2009 Jul 17;284(29):19564-71. doi: 10.1074/jbc.M109.005959. Epub 2009 May 28.
14. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
15. MGD data from the GO Consortium
16. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
17. Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.
18. Nagayama Y, etal., J Biol Chem 1996 Apr 26;271(17):10143-8.
19. Nash CA, etal., Cell Signal. 2018 Nov;51:86-98. doi: 10.1016/j.cellsig.2018.07.013. Epub 2018 Jul 31.
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Patial S, etal., J Cell Physiol. 2011 May;226(5):1323-33. doi: 10.1002/jcp.22460.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. RGD comprehensive gene curation
27. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
28. Simon V, etal., Endocrinology 2003 Jul;144(7):3058-66.
29. Smith SB, etal., J Pain. 2011 Nov;12(11 Suppl):T92-101.
30. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
31. Tarantino P, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):104-7. doi: 10.1002/ajmg.b.31129. Epub 2010 Nov 2.
32. Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
33. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Walker JK, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L312-9. Epub 2003 Oct 17.
35. Yi XP, etal., Hypertension 2002 Jun;39(6):1058-63.
36. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:14976207   PMID:17986524   PMID:20038610   PMID:20124405   PMID:22099983   PMID:22389501   PMID:22507984   PMID:22753221   PMID:22888001   PMID:23139825   PMID:23472081   PMID:23592773  
PMID:27613164   PMID:29080472   PMID:29543709  


Genomics

Comparative Map Data
Grk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21260,028,269 - 260,223,699 (+)NCBI
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Celera1255,668,943 - 255,859,242 (+)NCBICelera
Cytogenetic Map1q55NCBI
GRK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10119,207,571 - 119,459,745 (+)EnsemblGRCh38hg38GRCh38
GRCh3810119,207,571 - 119,459,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710120,967,083 - 121,219,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,957,187 - 121,205,121 (+)NCBINCBI36hg18NCBI36
Build 3410120,957,186 - 121,205,120NCBI
Celera10114,696,799 - 114,943,133 (+)NCBI
Cytogenetic Map10q26.11NCBI
HuRef10114,596,405 - 114,842,644 (+)NCBIHuRef
CHM1_110121,251,583 - 121,499,541 (+)NCBICHM1_1
Grk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,877,995 - 61,084,406 (+)NCBIGRCm39mm39
GRCm39 Ensembl1960,878,187 - 61,084,406 (+)Ensembl
GRCm381960,889,560 - 61,095,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,889,749 - 61,095,968 (+)EnsemblGRCm38mm10GRCm38
MGSCv371960,965,652 - 61,168,459 (+)NCBIGRCm37mm9NCBIm37
MGSCv361960,945,139 - 61,147,005 (+)NCBImm8
Celera1963,189,741 - 63,294,504 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Grk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495555144,156 - 254,534 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495555143,918 - 255,118 (+)NCBIChiLan1.0ChiLan1.0
GRK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110119,200,901 - 119,448,006 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,200,688 - 119,450,809 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010115,776,236 - 116,026,221 (+)NCBIMhudiblu_PPA_v0panPan3
GRK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2829,424,593 - 29,632,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12829,424,350 - 29,636,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Grk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364868,720,036 - 8,830,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,113,602 - 129,347,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114129,113,933 - 129,351,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,638,292 - 140,875,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,996,780 - 112,249,247 (+)NCBI
ChlSab1.1 Ensembl9111,996,599 - 112,244,570 (+)Ensembl
Grk5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473727,379,114 - 27,600,132 (-)NCBI

Position Markers
D1Rat459  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01282,365,175 - 282,365,384NCBIRnor6.0
Rnor_5.01289,700,208 - 289,700,417UniSTSRnor5.0
RGSC_v3.41267,593,349 - 267,593,558UniSTSRGSC3.4
RGSC_v3.41267,593,348 - 267,593,558RGDRGSC3.4
RGSC_v3.11267,804,434 - 267,804,643RGD
Celera1255,762,929 - 255,763,138UniSTS
RH 3.4 Map11704.5RGD
RH 3.4 Map11704.5UniSTS
RH 2.0 Map11311.7999RGD
SHRSP x BN Map1148.19RGD
Cytogenetic Map1q55UniSTS
AU047024  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01282,365,150 - 282,365,370NCBIRnor6.0
Rnor_5.01289,700,183 - 289,700,403UniSTSRnor5.0
RGSC_v3.41267,593,324 - 267,593,544UniSTSRGSC3.4
Celera1255,762,904 - 255,763,124UniSTS
Cytogenetic Map1q55UniSTS
RH139164  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01282,462,915 - 282,463,040NCBIRnor6.0
Rnor_5.01289,797,987 - 289,798,112UniSTSRnor5.0
RGSC_v3.41267,693,447 - 267,693,572UniSTSRGSC3.4
Celera1255,859,545 - 255,859,670UniSTS
RH 3.4 Map11713.3UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:496009  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01282,456,515 - 282,456,617NCBIRnor6.0
Rnor_5.01289,791,587 - 289,791,689UniSTSRnor5.0
RGSC_v3.41267,687,047 - 267,687,149UniSTSRGSC3.4
Celera1255,853,145 - 255,853,247UniSTS
Cytogenetic Map1q55UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1281795624282763074Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1280850604282365384Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000015687
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 40 20 6 19 6 1 1 74 31 34 11 1
Low 3 3 37 35 35 7 10 4 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015687   ⟹   ENSRNOP00000015687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)Ensembl
RefSeq Acc Id: NM_030829   ⟹   NP_110456
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,293 - 260,218,701 (+)NCBI
Rnor_6.01282,265,422 - 282,462,612 (+)NCBI
Rnor_5.01289,603,922 - 289,802,914 (+)NCBI
RGSC_v3.41267,495,534 - 267,693,144 (+)RGD
Celera1255,668,943 - 255,859,242 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231686   ⟹   XP_006231748
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,265,371 - 282,467,842 (+)NCBI
Rnor_5.01289,603,922 - 289,802,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589632   ⟹   XP_017445121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,265,371 - 282,467,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589633   ⟹   XP_017445122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,384,533 - 282,467,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088800   ⟹   XP_038944728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,270 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088801   ⟹   XP_038944729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,080,658 - 260,223,699 (+)NCBI
RefSeq Acc Id: XM_039088806   ⟹   XP_038944734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,271 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088810   ⟹   XP_038944738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,272 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088820   ⟹   XP_038944748
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,269 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088827   ⟹   XP_038944755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,028,271 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088828   ⟹   XP_038944756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21260,195,667 - 260,223,699 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_110456   ⟸   NM_030829
- Sequence:
RefSeq Acc Id: XP_006231748   ⟸   XM_006231686
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017445121   ⟸   XM_017589632
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445122   ⟸   XM_017589633
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000015687   ⟸   ENSRNOT00000015687
RefSeq Acc Id: XP_038944748   ⟸   XM_039088820
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038944728   ⟸   XM_039088800
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944734   ⟸   XM_039088806
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944755   ⟸   XM_039088827
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038944738   ⟸   XM_039088810
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038944729   ⟸   XM_039088801
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944756   ⟸   XM_039088828
- Peptide Label: isoform X7
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691025
Promoter ID:EPDNEW_R1549
Type:single initiation site
Name:Grk5_1
Description:G protein-coupled receptor kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,265,327 - 282,265,387EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 282396616 282396617 A C snv WN/N (MCW), COP/CrCrl (MCW & UW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61985 AgrOrtholog
Ensembl Genes ENSRNOG00000011439 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015687 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015687 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123515 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59075 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93405 IMAGE-MGC_LOAD
NCBI Gene 59075 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grk5 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204836
UniProt GRK5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Grk5  G protein-coupled receptor kinase 5  Gprk5  G protein-coupled receptor kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gprk5  G protein-coupled receptor kinase 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference