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Gene: Uba1 (ubiquitin-like modifier activating enzyme 1) Rattus norvegicus
Symbol: Uba1
Name: ubiquitin-like modifier activating enzyme 1
RGD ID: 1359327
Description: Predicted to have ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to colocalize with bounding membrane of organelle; desmosome; and heterochromatin. Human ortholog(s) of this gene implicated in X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1); PARTICIPATES IN Parkinson's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,5-hexanedione; 4-phenylbutyric acid.
Type: protein-coding
Also known as: LOC314432; similar to ubiquitin-protein ligase (EC E1 - mouse; Ube1x; ubiquitin-activating enzyme E1, Chr X; ubiquitin-like modifier-activating enzyme 1
Homo sapiens (human) : UBA1 (ubiquitin like modifier activating enzyme 1)  HGNC  Alliance
Mus musculus (house mouse) : Uba1 (ubiquitin-like modifier activating enzyme 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uba1 (ubiquitin like modifier activating enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UBA1 (ubiquitin like modifier activating enzyme 1)
Canis lupus familiaris (dog) : UBA1 (ubiquitin like modifier activating enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uba1 (ubiquitin like modifier activating enzyme 1)
Sus scrofa (pig) : UBA1 (ubiquitin like modifier activating enzyme 1)
Chlorocebus sabaeus (African green monkey) : UBA1 (ubiquitin like modifier activating enzyme 1)
Heterocephalus glaber (naked mole-rat) : Uba1 (ubiquitin like modifier activating enzyme 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X1,723,135 - 1,745,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,723,174 - 1,741,701 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,516,602 - 2,538,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,926,049 - 12,944,522 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X12,931,605 - 12,950,078 (-)NCBI
CeleraX2,072,832 - 2,091,181 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Uba1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359327
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.