Mcf2l (MCF.2 cell line derived transforming sequence-like) - Rat Genome Database

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Gene: Mcf2l (MCF.2 cell line derived transforming sequence-like) Rattus norvegicus
Analyze
Symbol: Mcf2l
Name: MCF.2 cell line derived transforming sequence-like
RGD ID: 619782
Description: Exhibits guanyl-nucleotide exchange factor activity. Involved in positive regulation of Rho protein signal transduction. Localizes to cytoplasm and extrinsic component of membrane. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DBL's big sister; guanine nucleotide exchange factor DBS; LOC100361711; mcf 2l; mcf.2 transforming sequence-like; MCF2-transforming sequence-like protein; Ost; OST oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,507,133 - 76,652,893 (-)NCBI
Rnor_6.0 Ensembl1681,839,653 - 81,980,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01681,839,686 - 81,986,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01681,325,603 - 81,471,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,365,090 - 81,469,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11681,365,289 - 81,386,688NCBI
Celera1674,314,419 - 74,419,162 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrogen dioxide  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12637522   PMID:15157669   PMID:17000758   PMID:22664934  


Genomics

Comparative Map Data
Mcf2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,507,133 - 76,652,893 (-)NCBI
Rnor_6.0 Ensembl1681,839,653 - 81,980,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01681,839,686 - 81,986,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01681,325,603 - 81,471,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,365,090 - 81,469,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11681,365,289 - 81,386,688NCBI
Celera1674,314,419 - 74,419,162 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
MCF2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13112,894,378 - 113,099,742 (+)EnsemblGRCh38hg38GRCh38
GRCh3813112,894,378 - 113,099,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713113,623,528 - 113,754,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,704,069 - 112,792,498 (+)NCBINCBI36hg18NCBI36
Build 3413112,704,068 - 112,792,495NCBI
Celera1394,447,310 - 94,578,431 (+)NCBI
Cytogenetic Map13q34NCBI
HuRef1394,064,614 - 94,192,511 (+)NCBIHuRef
CHM1_113113,592,716 - 113,722,761 (+)NCBICHM1_1
Mcf2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39812,923,806 - 13,070,502 (+)NCBIGRCm39mm39
GRCm39 Ensembl812,923,806 - 13,070,905 (+)Ensembl
GRCm38812,873,806 - 13,020,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl812,873,806 - 13,020,905 (+)EnsemblGRCm38mm10GRCm38
MGSCv37812,915,893 - 13,020,509 (+)NCBIGRCm37mm9NCBIm37
MGSCv36812,915,935 - 13,020,479 (+)NCBImm8
Celera813,083,766 - 13,188,308 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Mcf2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404696,056 - 787,563 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404697,917 - 787,145 (-)NCBIChiLan1.0ChiLan1.0
MCF2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113113,104,151 - 113,310,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,111,066 - 113,309,224 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01394,024,030 - 94,239,491 (+)NCBIMhudiblu_PPA_v0panPan3
MCF2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,441,249 - 60,570,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,441,938 - 60,606,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,154,082 - 60,283,316 (+)NCBI
ROS_Cfam_1.02261,067,610 - 61,196,177 (+)NCBI
UMICH_Zoey_3.12260,565,665 - 60,694,793 (+)NCBI
UNSW_CanFamBas_1.02260,563,111 - 60,696,961 (+)NCBI
UU_Cfam_GSD_1.02260,598,080 - 60,727,816 (+)NCBI
Mcf2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,289,463 - 195,432,026 (+)NCBI
SpeTri2.0NW_004936472520,129 - 629,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCF2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,408,055 - 78,505,488 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,407,525 - 78,505,495 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,230,288 - 86,244,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCF2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1390,902,306 - 91,103,953 (+)NCBI
ChlSab1.1 Ensembl390,979,152 - 91,106,377 (+)Ensembl
Vero_WHO_p1.0NW_02366604647,890,024 - 48,119,358 (+)NCBI
Mcf2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624793794,435 - 900,033 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:123
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000023352, ENSRNOT00000043170
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 4 2 2 2 2 74 34 28 11 2
Low 1 13 53 39 19 39 6 9 1 11 6
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z35654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023352   ⟹   ENSRNOP00000023352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,840,453 - 81,945,127 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043170   ⟹   ENSRNOP00000047024
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,841,450 - 81,980,027 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079096   ⟹   ENSRNOP00000068993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,840,453 - 81,880,502 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087095   ⟹   ENSRNOP00000075224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,839,653 - 81,912,738 (-)Ensembl
RefSeq Acc Id: NM_053951   ⟹   NP_446403
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,900 - 76,612,582 (-)NCBI
Rnor_6.01681,840,453 - 81,945,127 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
RGSC_v3.41681,365,090 - 81,469,766 (-)RGD
Celera1674,314,419 - 74,419,162 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253416   ⟹   XP_006253478
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
Rnor_6.01681,839,686 - 81,945,572 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253421   ⟹   XP_006253483
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
Rnor_6.01681,839,686 - 81,945,571 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253423   ⟹   XP_006253485
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,602,555 (-)NCBI
Rnor_6.01681,839,686 - 81,934,372 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253424   ⟹   XP_006253486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,580,415 (-)NCBI
Rnor_6.01681,839,686 - 81,914,643 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771381   ⟹   XP_008769603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,839,686 - 81,986,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599979   ⟹   XP_017455468
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,304 (-)NCBI
Rnor_6.01681,839,686 - 81,948,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094159   ⟹   XP_038950087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094160   ⟹   XP_038950088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094161   ⟹   XP_038950089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094162   ⟹   XP_038950090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094163   ⟹   XP_038950091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094165   ⟹   XP_038950093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,652,893 (-)NCBI
RefSeq Acc Id: XM_039094166   ⟹   XP_038950094
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,652,887 (-)NCBI
RefSeq Acc Id: XM_039094167   ⟹   XP_038950095
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,602,553 (-)NCBI
RefSeq Acc Id: XM_039094168   ⟹   XP_038950096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,580,410 (-)NCBI
RefSeq Acc Id: XM_039094169   ⟹   XP_038950097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21676,507,133 - 76,548,145 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446403   ⟸   NM_053951
- UniProtKB: D4A7F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253478   ⟸   XM_006253416
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253483   ⟸   XM_006253421
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006253485   ⟸   XM_006253423
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006253486   ⟸   XM_006253424
- Peptide Label: isoform X10
- UniProtKB: A0A0G2KA20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769603   ⟸   XM_008771381
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455468   ⟸   XM_017599979
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: ENSRNOP00000068993   ⟸   ENSRNOT00000079096
RefSeq Acc Id: ENSRNOP00000047024   ⟸   ENSRNOT00000043170
RefSeq Acc Id: ENSRNOP00000075224   ⟸   ENSRNOT00000087095
RefSeq Acc Id: ENSRNOP00000023352   ⟸   ENSRNOT00000023352
RefSeq Acc Id: XP_038950093   ⟸   XM_039094165
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038950094   ⟸   XM_039094166
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038950091   ⟸   XM_039094163
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038950090   ⟸   XM_039094162
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038950088   ⟸   XM_039094160
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950087   ⟸   XM_039094159
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950089   ⟸   XM_039094161
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950095   ⟸   XM_039094167
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038950096   ⟸   XM_039094168
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038950097   ⟸   XM_039094169
- Peptide Label: isoform X15
Protein Domains
CRAL-TRIO   DH   PH   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619782 AgrOrtholog
Ensembl Genes ENSRNOG00000028426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023352 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000047024 UniProtKB/Swiss-Prot
  ENSRNOP00000068993 UniProtKB/TrEMBL
  ENSRNOP00000075224 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023352 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000043170 UniProtKB/Swiss-Prot
  ENSRNOT00000079096 UniProtKB/TrEMBL
  ENSRNOT00000087095 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBS_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBS_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117020 UniProtKB/TrEMBL
NCBI Gene 117020 ENTREZGENE
Pfam CRAL_TRIO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcf2l PhenoGen
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU75_RAT UniProtKB/TrEMBL
  A0A0G2KA20 ENTREZGENE, UniProtKB/TrEMBL
  D4A7F3 ENTREZGENE, UniProtKB/TrEMBL
  MCF2L_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Mcf2l  MCF.2 cell line derived transforming sequence-like  LOC100361711  MCF.2 cell line derived transforming sequence-like  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100361711  MCF.2 cell line derived transforming sequence-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-31 Mcf2l  MCF.2 cell line derived transforming sequence-like  mcf 2l  mcf.2 cell line derived transforming sequence-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Mcf2l  mcf.2 transforming sequence-like    MCF.2 cell line derived transforming sequence-like  Name updated 1299863 APPROVED
2002-08-07 Mcf2l  MCF.2 cell line derived transforming sequence-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains Db1 homology and PH (pleckstrin homology) domains 729022
gene_function catalyzed guanine nucleotide exchange on RhoA and Cdc4 729022