Mcf2l (MCF.2 cell line derived transforming sequence-like) - Rat Genome Database

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Gene: Mcf2l (MCF.2 cell line derived transforming sequence-like) Rattus norvegicus
Analyze
Symbol: Mcf2l
Name: MCF.2 cell line derived transforming sequence-like
RGD ID: 619782
Description: Enables guanyl-nucleotide exchange factor activity. Involved in intracellular signal transduction. Located in cytoplasm. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DBL's big sister; guanine nucleotide exchange factor DBS; LOC100361711; mcf 2l; mcf.2 transforming sequence-like; MCF2-transforming sequence-like protein; Ost; OST oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,209,277 - 83,355,683 (-)NCBIGRCr8
mRatBN7.21676,507,133 - 76,652,893 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,507,133 - 76,652,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,788,448 - 81,893,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,241,025 - 85,345,705 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,490,494 - 80,594,784 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,839,686 - 81,986,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,839,653 - 81,980,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,325,603 - 81,471,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,365,090 - 81,469,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,365,289 - 81,386,688NCBI
Celera1674,314,419 - 74,419,162 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrogen dioxide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. Horii Y, etal., EMBO J 1994 Oct 17;13(20):4776-86.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12637522   PMID:15157669   PMID:17000758   PMID:22664934  


Genomics

Comparative Map Data
Mcf2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,209,277 - 83,355,683 (-)NCBIGRCr8
mRatBN7.21676,507,133 - 76,652,893 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,507,133 - 76,652,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,788,448 - 81,893,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,241,025 - 85,345,705 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,490,494 - 80,594,784 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,839,686 - 81,986,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,839,653 - 81,980,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,325,603 - 81,471,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,365,090 - 81,469,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,365,289 - 81,386,688NCBI
Celera1674,314,419 - 74,419,162 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
MCF2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813112,894,335 - 113,099,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13112,894,378 - 113,099,742 (+)EnsemblGRCh38hg38GRCh38
GRCh3713113,623,528 - 113,754,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,704,069 - 112,792,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413112,704,068 - 112,792,495NCBI
Celera1394,447,310 - 94,578,431 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,064,614 - 94,192,511 (+)NCBIHuRef
CHM1_113113,592,716 - 113,722,761 (+)NCBICHM1_1
T2T-CHM13v2.013112,144,372 - 112,351,082 (+)NCBIT2T-CHM13v2.0
Mcf2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39812,923,806 - 13,070,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl812,923,806 - 13,070,905 (+)EnsemblGRCm39 Ensembl
GRCm38812,873,806 - 13,020,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl812,873,806 - 13,020,905 (+)EnsemblGRCm38mm10GRCm38
MGSCv37812,915,893 - 13,020,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36812,915,935 - 13,020,479 (+)NCBIMGSCv36mm8
Celera813,083,766 - 13,188,308 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Mcf2l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404696,056 - 787,563 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404697,917 - 787,145 (-)NCBIChiLan1.0ChiLan1.0
MCF2L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,386,260 - 114,601,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,071,013 - 113,287,378 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,024,030 - 94,239,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,104,151 - 113,310,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,111,066 - 113,309,224 (+)Ensemblpanpan1.1panPan2
MCF2L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,441,249 - 60,570,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,441,938 - 60,606,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,154,082 - 60,283,316 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,067,610 - 61,196,177 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,162,229 - 61,196,170 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12260,565,665 - 60,694,793 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02260,563,111 - 60,696,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02260,598,080 - 60,727,816 (+)NCBIUU_Cfam_GSD_1.0
Mcf2l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,289,463 - 195,432,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936472519,944 - 659,111 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936472520,129 - 629,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCF2L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,408,056 - 78,505,493 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,407,525 - 78,505,495 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,230,288 - 86,244,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCF2L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1390,902,306 - 91,103,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl390,979,152 - 91,106,377 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604647,890,024 - 48,119,358 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcf2l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793794,435 - 894,963 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793794,435 - 900,033 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcf2l
765 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:123
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000023352, ENSRNOT00000043170
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 4 2 2 2 2 74 34 28 11 2
Low 1 13 53 39 19 39 6 9 1 11 6
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z35654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000023352   ⟹   ENSRNOP00000023352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,900 - 76,578,507 (-)Ensembl
Rnor_6.0 Ensembl1681,840,453 - 81,945,127 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000043170   ⟹   ENSRNOP00000047024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,900 - 76,602,218 (-)Ensembl
Rnor_6.0 Ensembl1681,841,450 - 81,980,027 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079096   ⟹   ENSRNOP00000068993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,900 - 76,652,733 (-)Ensembl
Rnor_6.0 Ensembl1681,840,453 - 81,880,502 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087095   ⟹   ENSRNOP00000075224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,133 - 76,580,518 (-)Ensembl
Rnor_6.0 Ensembl1681,839,653 - 81,912,738 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100402   ⟹   ENSRNOP00000083374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,133 - 76,613,050 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101752   ⟹   ENSRNOP00000077897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,133 - 76,580,518 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111168   ⟹   ENSRNOP00000085354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,507,133 - 76,615,686 (-)Ensembl
RefSeq Acc Id: NM_001413769   ⟹   NP_001400698
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,280 - 83,314,762 (-)NCBI
mRatBN7.21676,507,141 - 76,612,629 (-)NCBI
RefSeq Acc Id: NM_053951   ⟹   NP_446403
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,210,039 - 83,314,715 (-)NCBI
mRatBN7.21676,507,900 - 76,612,582 (-)NCBI
Rnor_6.01681,840,453 - 81,945,127 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
RGSC_v3.41681,365,090 - 81,469,766 (-)RGD
Celera1674,314,419 - 74,419,162 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253416   ⟹   XP_006253478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
Rnor_6.01681,839,686 - 81,945,572 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253421   ⟹   XP_006253483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
Rnor_6.01681,839,686 - 81,945,571 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253423   ⟹   XP_006253485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,304,035 (-)NCBI
mRatBN7.21676,507,133 - 76,602,555 (-)NCBI
Rnor_6.01681,839,686 - 81,934,372 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253424   ⟹   XP_006253486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,282,533 (-)NCBI
mRatBN7.21676,507,133 - 76,580,415 (-)NCBI
Rnor_6.01681,839,686 - 81,914,643 (-)NCBI
Rnor_5.01681,325,603 - 81,471,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599979   ⟹   XP_017455468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,304 (-)NCBI
Rnor_6.01681,839,686 - 81,948,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094159   ⟹   XP_038950087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094160   ⟹   XP_038950088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094162   ⟹   XP_038950090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094163   ⟹   XP_038950091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
mRatBN7.21676,507,133 - 76,613,003 (-)NCBI
RefSeq Acc Id: XM_039094165   ⟹   XP_038950093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,355,683 (-)NCBI
mRatBN7.21676,507,133 - 76,652,893 (-)NCBI
RefSeq Acc Id: XM_039094166   ⟹   XP_038950094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,355,671 (-)NCBI
mRatBN7.21676,507,133 - 76,652,887 (-)NCBI
RefSeq Acc Id: XM_039094167   ⟹   XP_038950095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,304,029 (-)NCBI
mRatBN7.21676,507,133 - 76,602,553 (-)NCBI
RefSeq Acc Id: XM_039094169   ⟹   XP_038950097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,250,277 (-)NCBI
mRatBN7.21676,507,133 - 76,548,145 (-)NCBI
RefSeq Acc Id: XM_063275040   ⟹   XP_063131110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,298,261 (-)NCBI
RefSeq Acc Id: XM_063275041   ⟹   XP_063131111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,282,522 (-)NCBI
RefSeq Acc Id: XM_063275042   ⟹   XP_063131112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,282,529 (-)NCBI
RefSeq Acc Id: XM_063275044   ⟹   XP_063131114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,209,277 - 83,317,707 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001400698 (Get FASTA)   NCBI Sequence Viewer  
  NP_446403 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253478 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253483 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253485 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253486 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455468 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950087 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950090 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950091 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950093 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950094 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950095 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950097 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131110 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131111 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131112 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131114 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA84713 (Get FASTA)   NCBI Sequence Viewer  
  EDM08865 (Get FASTA)   NCBI Sequence Viewer  
  EDM08866 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023352
  ENSRNOP00000023352.6
  ENSRNOP00000047024
  ENSRNOP00000047024.5
  ENSRNOP00000068993
  ENSRNOP00000068993.2
  ENSRNOP00000075224
  ENSRNOP00000075224.1
  ENSRNOP00000077897.1
  ENSRNOP00000083374
  ENSRNOP00000083374.1
  ENSRNOP00000085354
  ENSRNOP00000085354.1
  ENSRNOP00055021158
  ENSRNOP00060029819
  ENSRNOP00065011193
GenBank Protein Q63406 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446403   ⟸   NM_053951
- Peptide Label: isoform 1
- UniProtKB: D4A7F3 (UniProtKB/TrEMBL),   A6IWK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253478   ⟸   XM_006253416
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253483   ⟸   XM_006253421
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZZZ7 (UniProtKB/TrEMBL),   D4A7F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253485   ⟸   XM_006253423
- Peptide Label: isoform X9
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253486   ⟸   XM_006253424
- Peptide Label: isoform X10
- UniProtKB: A0A0G2KA20 (UniProtKB/TrEMBL),   A0A8I5Y6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455468   ⟸   XM_017599979
- Peptide Label: isoform X11
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068993   ⟸   ENSRNOT00000079096
RefSeq Acc Id: ENSRNOP00000047024   ⟸   ENSRNOT00000043170
RefSeq Acc Id: ENSRNOP00000075224   ⟸   ENSRNOT00000087095
RefSeq Acc Id: ENSRNOP00000023352   ⟸   ENSRNOT00000023352
RefSeq Acc Id: XP_038950093   ⟸   XM_039094165
- Peptide Label: isoform X8
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950094   ⟸   XM_039094166
- Peptide Label: isoform X12
- UniProtKB: Q63406 (UniProtKB/Swiss-Prot),   D4A7F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950091   ⟸   XM_039094163
- Peptide Label: isoform X7
- UniProtKB: D4A7F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950090   ⟸   XM_039094162
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZWU6 (UniProtKB/TrEMBL),   A0A8I5Y6G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950088   ⟸   XM_039094160
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950087   ⟸   XM_039094159
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950095   ⟸   XM_039094167
- Peptide Label: isoform X13
- UniProtKB: A0A8L2QMZ3 (UniProtKB/TrEMBL),   D4A7F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950097   ⟸   XM_039094169
- Peptide Label: isoform X17
- UniProtKB: A0A8I5Y6G8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077897   ⟸   ENSRNOT00000101752
RefSeq Acc Id: ENSRNOP00000083374   ⟸   ENSRNOT00000100402
RefSeq Acc Id: ENSRNOP00000085354   ⟸   ENSRNOT00000111168
RefSeq Acc Id: NP_001400698   ⟸   NM_001413769
- Peptide Label: isoform 2
- UniProtKB: D4A7F3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131114   ⟸   XM_063275044
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063131110   ⟸   XM_063275040
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063131112   ⟸   XM_063275042
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063131111   ⟸   XM_063275041
- Peptide Label: isoform X14
Protein Domains
CRAL-TRIO   DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63406-F1-model_v2 AlphaFold Q63406 1-1149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619782 AgrOrtholog
BioCyc Gene G2FUF-10695 BioCyc
Ensembl Genes ENSRNOG00000028426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015089 UniProtKB/Swiss-Prot
  ENSRNOG00060020542 UniProtKB/Swiss-Prot
  ENSRNOG00065009338 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023352 ENTREZGENE
  ENSRNOT00000023352.7 UniProtKB/TrEMBL
  ENSRNOT00000043170.7 UniProtKB/TrEMBL
  ENSRNOT00000079096 UniProtKB/TrEMBL
  ENSRNOT00000079096.2 UniProtKB/Swiss-Prot
  ENSRNOT00000087095.2 UniProtKB/TrEMBL
  ENSRNOT00000100402.1 UniProtKB/TrEMBL
  ENSRNOT00000101752.1 UniProtKB/TrEMBL
  ENSRNOT00000111168.1 UniProtKB/TrEMBL
  ENSRNOT00055025955 UniProtKB/Swiss-Prot
  ENSRNOT00060036252 UniProtKB/Swiss-Prot
  ENSRNOT00065014967 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBS_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBS_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117020 UniProtKB/TrEMBL
NCBI Gene 117020 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE EXCHANGE FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRAL_TRIO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcf2l PhenoGen
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028426 RatGTEx
  ENSRNOG00055015089 RatGTEx
  ENSRNOG00060020542 RatGTEx
  ENSRNOG00065009338 RatGTEx
SMART RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU75_RAT UniProtKB/TrEMBL
  A0A0G2KA20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y6G8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QMZ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IWK6 ENTREZGENE, UniProtKB/TrEMBL
  A6IWK7_RAT UniProtKB/TrEMBL
  D4A7F3 ENTREZGENE, UniProtKB/TrEMBL
  MCF2L_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Mcf2l  MCF.2 cell line derived transforming sequence-like  LOC100361711  MCF.2 cell line derived transforming sequence-like  Data merged from RGD:2319563 737654 PROVISIONAL
2010-05-05 LOC100361711  MCF.2 cell line derived transforming sequence-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-31 Mcf2l  MCF.2 cell line derived transforming sequence-like  mcf 2l  mcf.2 cell line derived transforming sequence-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Mcf2l  mcf.2 transforming sequence-like    MCF.2 cell line derived transforming sequence-like  Name updated 1299863 APPROVED
2002-08-07 Mcf2l  MCF.2 cell line derived transforming sequence-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains Db1 homology and PH (pleckstrin homology) domains 729022
gene_function catalyzed guanine nucleotide exchange on RhoA and Cdc4 729022