Pnp (purine nucleoside phosphorylase)

Gene: Pnp (purine nucleoside phosphorylase) Rattus norvegicus

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Symbol:

Pnp

Name:

purine nucleoside phosphorylase

Description:

Exhibits purine-nucleoside phosphorylase activity. Involved in purine nucleoside metabolic process. Localizes to the cytoplasm; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

inosine phosphorylase; inosine-guanosine phosphorylase; Np; Np_mapped; nucleoside phosphorylase; nucleoside phosphorylase (mapped)

Orthologs:

Homo sapiens (human) : PNP (purine nucleoside phosphorylase) HGNC Alliance
Mus musculus (house mouse) : Pnp2 (purine-nucleoside phosphorylase 2) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pnp (purine nucleoside phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PNP (purine nucleoside phosphorylase)
Canis lupus familiaris (dog) : PNP (purine nucleoside phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pnp (purine nucleoside phosphorylase)
Sus scrofa (pig) : PNP (purine nucleoside phosphorylase)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PNP (purine nucleoside phosphorylase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Pnp2 (purine-nucleoside phosphorylase 2)	HGNC	EggNOG, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Pnp (purine nucleoside phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PNP (purine nucleoside phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PNP (purine nucleoside phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pnp (purine nucleoside phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PNP (purine nucleoside phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pnp (purine-nucleoside phosphorylase)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):	PNP (purine nucleoside phosphorylase)	Alliance	DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):	Pnp2 (purine-nucleoside phosphorylase 2)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):	pnp5b (purine nucleoside phosphorylase 5b)	Alliance	DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):	pnp5a (purine nucleoside phosphorylase 5a)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):	pnp4b (purine nucleoside phosphorylase 4b)	Alliance	DIOPT (OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):	pnp6 (purine nucleoside phosphorylase 6)	Alliance	DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB)
Drosophila melanogaster (fruit fly):	CG16758	Alliance	DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Caenorhabditis elegans (roundworm):	K02D7.1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	PNP1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):	CG18128	Alliance	DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	15	27,875,883 - 27,883,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	15	31,708,604 - 31,716,285 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	26,929,784 - 26,937,434 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	15	24,490,737 - 24,498,388 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

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Strain Variation

Strain Sequence Variants (Rnor 5.0)

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Additional Information

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Nomenclature History

RGD Curation Notes

More on Pnp
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1597189
Created:	2006-11-20
Species:	Rattus norvegicus
Last Modified:	2019-04-23
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

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Imported Annotations - SMPDB