Pnp (purine nucleoside phosphorylase) - Rat Genome Database

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Gene: Pnp (purine nucleoside phosphorylase) Rattus norvegicus
Analyze
Symbol: Pnp
Name: purine nucleoside phosphorylase
RGD ID: 1597189
Description: Enables purine-nucleoside phosphorylase activity. Involved in purine nucleoside metabolic process. Located in cytoplasm; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inosine phosphorylase; inosine-guanosine phosphorylase; Np; Np_mapped; nucleoside phosphorylase; nucleoside phosphorylase (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21524,170,456 - 24,178,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,170,602 - 24,203,986 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,941,797 - 26,949,458 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01527,900,519 - 27,908,184 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01526,150,344 - 26,158,005 (+)NCBIRnor_WKY
Rnor_6.01527,875,883 - 27,883,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,875,911 - 27,883,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,708,604 - 31,716,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,929,784 - 26,937,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,490,737 - 24,498,388 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioscin  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
menadione  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
microcystin RR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Histochemical demonstration of purine nucleoside phosphorylase (PNPase) in microglial and astroglial cells of adult rat brain. Castellano B, etal., J Histochem Cytochem. 1990 Nov;38(11):1535-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Information Derived from GenBank Report RGD, Sept. 2003
9. Purine nucleoside phosphorylase activity in rat cerebrospinal fluid. Silva RG, etal., Neurochem Res. 2004 Oct;29(10):1831-5.
10. A human purine nucleoside phosphorylase deficiency caused by a single base change. Williams SR, etal., J Biol Chem. 1987 Feb 15;262(5):2332-8.
11. Deficiency of purine nucleoside phosphorylase activity in thymocytes from the immunodeficient diabetic BB rat. Wu G and Marliss EB, Clin Exp Immunol. 1991 Nov;86(2):260-5.
Additional References at PubMed
PMID:2104852   PMID:6771276   PMID:9305962   PMID:15047506   PMID:16930574   PMID:16964310   PMID:18938130   PMID:19001417   PMID:19056867   PMID:20212140   PMID:20458337   PMID:23376485  
PMID:23533145   PMID:25502805   PMID:31515488   PMID:32910805  


Genomics

Comparative Map Data
Pnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21524,170,456 - 24,178,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,170,602 - 24,203,986 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,941,797 - 26,949,458 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01527,900,519 - 27,908,184 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01526,150,344 - 26,158,005 (+)NCBIRnor_WKY
Rnor_6.01527,875,883 - 27,883,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,875,911 - 27,883,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,708,604 - 31,716,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,929,784 - 26,937,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,490,737 - 24,498,388 (+)NCBICelera
Cytogenetic Map15p14NCBI
PNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,469,406 - 20,477,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1420,461,992 - 20,477,094 (+)EnsemblGRCh38hg38GRCh38
GRCh371420,937,565 - 20,945,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,007,382 - 20,015,088 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,007,404 - 20,015,039NCBI
Celera14798,688 - 807,315 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,059,149 - 1,067,777 (+)NCBIHuRef
CHM1_11420,938,918 - 20,947,545 (+)NCBICHM1_1
T2T-CHM13v2.01414,666,309 - 14,673,992 (+)NCBIT2T-CHM13v2.0
Pnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,193,598 - 51,202,206 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,193,449 - 51,202,206 (+)EnsemblGRCm39 Ensembl
GRCm381450,956,141 - 50,964,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,955,992 - 50,964,749 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,575,816 - 51,584,424 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,877,941 - 49,888,626 (+)NCBIMGSCv36mm8
Cytogenetic Map14C1NCBI
Pnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,290,244 - 1,298,068 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,290,816 - 1,299,553 (+)NCBIChiLan1.0ChiLan1.0
PNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11419,396,114 - 19,403,907 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,396,114 - 19,403,907 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0141,343,921 - 1,351,670 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,808,454 - 17,815,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,808,461 - 17,815,676 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,291,391 - 18,298,968 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,065,565 - 18,073,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,065,663 - 18,074,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,748,318 - 17,755,891 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,802,993 - 17,810,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,932,170 - 17,939,749 (+)NCBIUU_Cfam_GSD_1.0
Pnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,705,514 - 77,711,679 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936877686,539 - 692,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,424,740 - 78,447,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,426,838 - 78,447,029 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,454,669 - 83,474,828 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q21-qterNCBI
PNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,992,892 - 21,001,400 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,993,280 - 21,001,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,428,857 - 25,437,006 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,690,831 - 4,700,717 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,688,662 - 4,699,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pnp
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:49
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000013582
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH127813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21223,894,451 - 23,894,659 (+)MAPPERmRatBN7.2
mRatBN7.21524,177,789 - 24,177,999 (+)MAPPERmRatBN7.2
Rnor_6.01527,883,084 - 27,883,293NCBIRnor6.0
Rnor_6.01226,945,077 - 26,945,284NCBIRnor6.0
Rnor_5.01228,924,234 - 28,924,441UniSTSRnor5.0
Rnor_5.01531,715,804 - 31,716,013UniSTSRnor5.0
RGSC_v3.41526,936,954 - 26,937,163UniSTSRGSC3.4
Celera1524,497,908 - 24,498,117UniSTS
Celera1225,640,469 - 25,640,676UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map15p14UniSTS
RH140701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,178,334 - 24,178,671 (+)MAPPERmRatBN7.2
Rnor_6.01527,883,629 - 27,883,965NCBIRnor6.0
Rnor_5.01531,716,349 - 31,716,685UniSTSRnor5.0
RGSC_v3.41526,937,499 - 26,937,835UniSTSRGSC3.4
Celera1524,498,453 - 24,498,789UniSTS
Cytogenetic Map15p14UniSTS
RH125524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21223,895,370 - 23,895,452 (+)MAPPERmRatBN7.2
Rnor_6.01226,946,000 - 26,946,081NCBIRnor6.0
Rnor_5.01228,925,157 - 28,925,238UniSTSRnor5.0
RGSC_v3.41224,988,258 - 24,988,339UniSTSRGSC3.4
Celera1225,641,388 - 25,641,469UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013582   ⟹   ENSRNOP00000013582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,170,602 - 24,178,269 (+)Ensembl
Rnor_6.0 Ensembl1527,875,911 - 27,883,350 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114039   ⟹   ENSRNOP00000077124
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,170,602 - 24,203,986 (+)Ensembl
RefSeq Acc Id: NM_001106031   ⟹   NP_001099501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,170,618 - 24,178,270 (+)NCBI
Rnor_6.01527,875,914 - 27,883,564 (+)NCBI
Rnor_5.01531,708,604 - 31,716,285 (+)NCBI
RGSC_v3.41526,929,784 - 26,937,434 (+)RGD
Celera1524,490,737 - 24,498,388 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251857   ⟹   XP_006251919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,170,456 - 24,178,274 (+)NCBI
Rnor_6.01527,875,883 - 27,883,566 (+)NCBI
Rnor_5.01531,708,604 - 31,716,285 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001099501   ⟸   NM_001106031
- Sequence:
RefSeq Acc Id: XP_006251919   ⟸   XM_006251857
- Peptide Label: isoform X1
- UniProtKB: P85973 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013582   ⟸   ENSRNOT00000013582
RefSeq Acc Id: ENSRNOP00000077124   ⟸   ENSRNOT00000114039
Protein Domains
PNP_UDP_1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P85973-F1-model_v2 AlphaFold P85973 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699627
Promoter ID:EPDNEW_R10149
Type:multiple initiation site
Name:Pnp_1
Description:purine nucleoside phosphorylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01527,875,903 - 27,875,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597189 AgrOrtholog
BioCyc Gene G2FUF-14047 BioCyc
BioCyc Pathway P121-PWY [adenine and adenosine salvage I] BioCyc
  PWY-4202 [arsenic detoxification (mammals)] BioCyc
  PWY-5695 [inosine 5'-phosphate degradation] BioCyc
  PWY-6608 [guanosine nucleotides degradation III] BioCyc
  PWY-6609 [adenine and adenosine salvage III] BioCyc
  PWY-6620 [guanine and guanosine salvage I] BioCyc
  PWY-7179 [purine deoxyribonucleosides degradation I] BioCyc
  PWY-7179-1 [purine deoxyribonucleosides degradation II] BioCyc
  PWY0-1296 [purine ribonucleosides degradation] BioCyc
  SALVADEHYPOX-PWY [adenosine nucleotides degradation II] BioCyc
  SALVPURINE2-PWY [xanthine and xanthosine salvage] BioCyc
Ensembl Genes ENSRNOG00000009982 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013582 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077124.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013582 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000114039.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1580 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleoside_phosphorylase_d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleoside_phosphorylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pur_Nuc_Pase_Ino/Guo-sp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Purine_phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Purine_phosphorylase-2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 290029 ENTREZGENE
PANTHER PTHR11904 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PNP_UDP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnp PhenoGen
PIRSF PurNPase UniProtKB/Swiss-Prot
PROSITE PNP_MTAP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53167 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs PNPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPH-PUNA-XAPA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y9C1_RAT UniProtKB/TrEMBL
  A6KEC5 ENTREZGENE
  P85973 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6KEC5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Pnp  purine nucleoside phosphorylase  Np  nucleoside phosphorylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-03-06 Np  nucleoside phosphorylase (mapped)  Np_mapped  nucleoside phosphorylase (mapped)  Data Merged 737654 PROVISIONAL
2006-11-20 Np  nucleoside phosphorylase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Np_mapped  nucleoside phosphorylase (mapped)  Np  nucleoside phosphorylase  Symbol and Name updated 1556543 APPROVED
2002-11-06 Np  nucleoside phosphorylase    Nucleoside phosphorylase  Name updated 625702 APPROVED
2002-06-10 Np  Nucleoside phosphorylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse purine-nucleoside phosphorylase (Pnp) exhibits purine-nucleoside phosphorylase and glycosyl transferase activities 704405