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Gene: Pnp (purine nucleoside phosphorylase) Rattus norvegicus
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Symbol: Pnp
Name: purine nucleoside phosphorylase
Description: Exhibits purine-nucleoside phosphorylase activity. Involved in purine nucleoside metabolic process. Localizes to the cytoplasm; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inosine phosphorylase; inosine-guanosine phosphorylase; Np; Np_mapped; nucleoside phosphorylase; nucleoside phosphorylase (mapped)
Orthologs:
Homo sapiens (human) : PNP (purine nucleoside phosphorylase)  HGNC  Alliance
Mus musculus (house mouse) : Pnp2 (purine-nucleoside phosphorylase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pnp (purine nucleoside phosphorylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PNP (purine nucleoside phosphorylase)
Canis lupus familiaris (dog) : PNP (purine nucleoside phosphorylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pnp (purine nucleoside phosphorylase)
Sus scrofa (pig) : PNP (purine nucleoside phosphorylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01527,875,883 - 27,883,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01531,708,604 - 31,716,285 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,929,784 - 26,937,434 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1524,490,737 - 24,498,388 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pnp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1597189
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.