Gbp6 (guanylate binding protein family member 6) - Rat Genome Database

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Gene: Gbp6 (guanylate binding protein family member 6) Rattus norvegicus
Analyze
Symbol: Gbp6
Name: guanylate binding protein family member 6
RGD ID: 1561523
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in defense response to Gram-positive bacterium and defense response to protozoan. Predicted to act upstream of or within adhesion of symbiont to host and cellular response to type II interferon. Predicted to be located in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanylate binding protein 6; guanylate-binding protein 6-like; LOC305139; macrophage activation 2 like; Mpa2l; RGD1561523; similar to Hypothetical protein E430029F06
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,730,286 - 4,756,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,730,453 - 4,839,062 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0145,927,568 - 5,954,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,928,737 - 5,945,321 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,910,546 - 5,934,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,846,667 - 5,863,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera144,867,493 - 4,895,867 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
alpha-phellandrene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
cholesterol  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trovafloxacin  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18025219   PMID:19199708  


Genomics

Comparative Map Data
Gbp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,730,286 - 4,756,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,730,453 - 4,839,062 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0145,927,568 - 5,954,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,928,737 - 5,945,321 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,910,546 - 5,934,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,846,667 - 5,863,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera144,867,493 - 4,895,867 (+)NCBICelera
Cytogenetic Map14p22NCBI
GBP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,364,059 - 89,388,160 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl189,364,059 - 89,388,160 (+)EnsemblGRCh38hg38GRCh38
GRCh37189,829,618 - 89,853,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,602,024 - 89,626,307 (+)NCBINCBI36Build 36hg18NCBI36
Build 34189,541,637 - 89,564,040NCBI
Celera188,075,199 - 88,099,482 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef187,946,674 - 87,971,041 (+)NCBIHuRef
CHM1_1189,944,475 - 89,968,757 (+)NCBICHM1_1
T2T-CHM13v2.0189,207,324 - 89,231,426 (+)NCBIT2T-CHM13v2.0
Gbp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,224,332 - 105,258,255 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,225,496 - 105,287,405 (-)EnsemblGRCm39 Ensembl
GRCm385105,076,464 - 105,110,357 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,077,630 - 105,139,539 (-)EnsemblGRCm38mm10GRCm38
MGSCv375105,507,413 - 105,539,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365105,319,600 - 105,350,580 (-)NCBIMGSCv36mm8
Celera5102,242,069 - 102,269,501 (-)NCBICelera
Cytogenetic Map5E5NCBI
GBP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1190,792,021 - 90,814,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl190,791,487 - 90,817,250 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,040,822 - 92,063,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GBP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1659,150,665 - 59,170,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl659,158,855 - 59,169,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,860,238 - 61,879,530 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0659,662,040 - 59,682,280 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1659,229,465 - 59,248,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0659,182,578 - 59,202,814 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0659,669,159 - 59,688,480 (+)NCBIUU_Cfam_GSD_1.0
LOC100523310
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14127,177,337 - 127,201,984 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24139,275,334 - 139,300,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Gbp6
256 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:136
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000040985, ENSRNOT00000071877, ENSRNOT00000074889
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 18 3 19 3 21 7
Low 3 41 37 36 36 8 9 28 16 18 4 8
Below cutoff 2 2 2 2 28 19 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040985   ⟹   ENSRNOP00000043638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,730,453 - 4,756,364 (+)Ensembl
Rnor_6.0 Ensembl145,928,737 - 5,945,321 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000052308   ⟹   ENSRNOP00000048378
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,663,614 - 4,678,985 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000071877   ⟹   ENSRNOP00000067657
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,663,614 - 4,678,985 (-)Ensembl
Rnor_6.0 Ensembl145,928,737 - 5,945,321 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074889   ⟹   ENSRNOP00000064912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,730,453 - 4,756,364 (+)Ensembl
Rnor_6.0 Ensembl145,928,737 - 5,945,321 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109379   ⟹   ENSRNOP00000086939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,730,453 - 4,839,062 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111740   ⟹   ENSRNOP00000085883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,730,453 - 4,839,062 (+)Ensembl
RefSeq Acc Id: XM_006250609   ⟹   XP_006250671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2144,730,286 - 4,756,508 (+)NCBI
Rnor_6.0145,927,568 - 5,947,831 (+)NCBI
Rnor_5.0145,910,546 - 5,934,361 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006250671 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006250671   ⟸   XM_006250609
- Sequence:
RefSeq Acc Id: ENSRNOP00000067657   ⟸   ENSRNOT00000071877
RefSeq Acc Id: ENSRNOP00000043638   ⟸   ENSRNOT00000040985
RefSeq Acc Id: ENSRNOP00000064912   ⟸   ENSRNOT00000074889
RefSeq Acc Id: ENSRNOP00000048378   ⟸   ENSRNOT00000052308
RefSeq Acc Id: ENSRNOP00000086939   ⟸   ENSRNOT00000109379
RefSeq Acc Id: ENSRNOP00000085883   ⟸   ENSRNOT00000111740
Protein Domains
GB1/RHD3-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDF8-F1-model_v2 AlphaFold M0RDF8 1-565 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561523 AgrOrtholog
BioCyc Gene G2FUF-16535 BioCyc
Ensembl Genes ENSRNOG00000002134 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000068418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043638 ENTREZGENE
  ENSRNOP00000043638.3 UniProtKB/TrEMBL
  ENSRNOP00000048378.6 UniProtKB/TrEMBL
  ENSRNOP00000064912.1 UniProtKB/TrEMBL
  ENSRNOP00000067657.2 UniProtKB/TrEMBL
  ENSRNOP00000085883.1 UniProtKB/TrEMBL
  ENSRNOP00000086939.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040985 ENTREZGENE
  ENSRNOT00000040985.6 UniProtKB/TrEMBL
  ENSRNOT00000052308.6 UniProtKB/TrEMBL
  ENSRNOT00000071877.4 UniProtKB/TrEMBL
  ENSRNOT00000074889.2 UniProtKB/TrEMBL
  ENSRNOT00000109379.1 UniProtKB/TrEMBL
  ENSRNOT00000111740.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 305139 ENTREZGENE
PANTHER GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
  GUANYLATE BINDING PROTEIN 11-RELATED UniProtKB/TrEMBL
Pfam GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Gbp6 PhenoGen
PROSITE G_GB1_RHD3 UniProtKB/TrEMBL
Superfamily-SCOP GBP UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A3C3_RAT UniProtKB/TrEMBL
  A0A8I6A6V0_RAT UniProtKB/TrEMBL
  F1LVN3_RAT UniProtKB/TrEMBL
  F1LW83_RAT UniProtKB/TrEMBL
  M0R672_RAT UniProtKB/TrEMBL
  M0RDF8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-21 Gbp6  guanylate binding protein family member 6  Gbp6  guanylate binding protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-04 Gbp6  guanylate binding protein 6  Gbp6  guanylate binding protein family member 6  Name changed 629549 APPROVED
2017-07-18 Gbp6  guanylate binding protein family member 6  Mpa2l  macrophage activation 2 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Mpa2l  macrophage activation 2 like  RGD1561523  similar to Hypothetical protein E430029F06  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561523  similar to Hypothetical protein E430029F06   RGD1561523_predicted  similar to Hypothetical protein E430029F06 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 RGD1561523_predicted  similar to Hypothetical protein E430029F06 (predicted)  LOC683128  similar to guanylate binding protein family, member 6  Data Merged 1643240 APPROVED
2006-11-20 LOC683128  similar to guanylate binding protein family, member 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561523_predicted  similar to Hypothetical protein E430029F06 (predicted)  LOC305139  similar to Hypothetical protein E430029F06  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305139  similar to Hypothetical protein E430029F06      Symbol and Name status set to provisional 70820 PROVISIONAL