Gene: Atp5f1d (ATP synthase F1 subunit delta) Rattus norvegicus
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Symbol:
Atp5f1d
Name:
ATP synthase F1 subunit delta
Description:
Contributes to ATPase activity. Involved in ATP metabolic process and response to resveratrol. Localizes to mitochondrial proton-transporting ATP synthase complex, catalytic core F(1). Used to study obesity. Biomarker of colitis and myocardial infarction. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; aldehydo-D-glucose.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
ATP synthase subunit delta, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; Atp5d; F-ATPase delta subunit; hypothetical protein LOC690935; LOC690935
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ATP5F1D (ATP synthase F1 subunit delta) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Atp5d (ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Atp5f1d (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ATP5F1D (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ATP5F1D (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Atp5f1d (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ATP5F1D (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ATP5F1D (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Atp5f1d (ATP synthase F1 subunit delta) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Atp5d (ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoInspector|PANTHER|OrthoFinder|Hieranoid)
Homo sapiens (human):
ATP5F1D (ATP synthase F1 subunit delta)
Alliance
DIOPT (Ensembl Compara|InParanoid|Hieranoid|PhylomeDB|OMA|TreeFam|OrthoInspector|HGNC|OrthoFinder|PANTHER)
Danio rerio (zebrafish):
atp5f1d
Alliance
DIOPT (InParanoid|PhylomeDB|PANTHER|TreeFam|OrthoFinder|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
ATP16
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoFinder|OrthoInspector|PANTHER|Hieranoid)
Drosophila melanogaster (fruit fly):
ATPsyndelta
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoInspector|OrthoFinder|PANTHER|Hieranoid)
Caenorhabditis elegans (roundworm):
F58F12.1
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoInspector|OrthoFinder|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 12,426,807 - 12,432,120 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 12,426,809 - 12,432,130 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 12,596,910 - 12,602,225 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 11,072,820 - 11,075,906 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 11,072,819 - 11,075,906 (-) NCBI Celera 7 7,736,636 - 7,739,719 (-) NCBI Celera Cytogenetic Map 7 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
cerebral creatine deficiency syndrome ISO RGD:1353040 8554872 ClinVar Annotator: match by term: Cerebral creatine deficiency syndrome ClinVar PMID:28492532 mitochondrial complex V (ATP synthase) deficiency nuclear type 3 ISO RGD:1353040 8554872 ClinVar Annotator: match by term: Decreased activity of mitochondrial ATP synthase complex ClinVar PMID:29478781 Mitochondrial Complex V (ATP Synthase) Deficiency, Nuclear Type 5 ISO RGD:1353040 8554872 ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX V (ATP SYNTHASE) DEFICIENCY, NUCLEAR TYPE 5 ClinVar PMID:29478781 mitochondrial metabolism disease ISO RGD:1353040 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:29478781
Imported Annotations - CTD
urinary bladder cancer ISO RGD:1353040 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26039340 Imported Annotations - OMIM
Mitochondrial Complex V (ATP Synthase) Deficiency, Nuclear Type 5 ISO RGD:1353040 7240710 OMIM
14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:1353040 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of ATP5F1D mRNA CTD PMID:22101062 17alpha-ethynylestradiol increases expression ISO RGD:731351 6480464 Ethinyl Estradiol results in increased expression of ATP5D mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:731351 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5D mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731351 6480464 Tetrachlorodibenzodioxin results in increased expression of ATP5D mRNA CTD PMID:20399798 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ATP5F1D mRNA CTD PMID:27913140 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731351 6480464 Tetrachlorodibenzodioxin affects the expression of ATP5D mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731351 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5D mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of ATP5F1D mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine increases expression ISO RGD:731351 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ATP5D mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1353040 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ATP5D mRNA CTD PMID:28628672 5-fluorouracil multiple interactions ISO RGD:1353040 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of ATP5F1D mRNA] CTD PMID:15016801 aldehydo-D-glucose multiple interactions EXP 6480464 15-Hydroxy-11 alpha more ... CTD PMID:25305180 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ATP5F1D mRNA CTD PMID:16483693 amphetamine multiple interactions ISO RGD:731351 6480464 Amphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ATP5D protein], PTN gene mutant form inhibits the reaction [Amphetamine results in decreased expression of ATP5D protein] CTD PMID:23459167 amphetamine decreases expression ISO RGD:731351 6480464 Amphetamine results in decreased expression of ATP5D protein CTD PMID:23459167 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of ATP5F1D mRNA CTD PMID:16648578 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ATP5F1D mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:1353040 6480464 bisphenol A affects the expression of ATP5D mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:1353040 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ATP5D mRNA CTD PMID:28628672 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ATP5F1D protein CTD PMID:20219716 cadmium atom increases expression ISO RGD:731351 6480464 Cadmium results in increased expression of ATP5D mRNA CTD PMID:26187450 carmustine decreases expression ISO RGD:1353040 6480464 Carmustine results in decreased expression of ATP5F1D mRNA CTD PMID:15980968 choline multiple interactions ISO RGD:731351 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP5D gene CTD PMID:20938992 cisplatin decreases expression ISO RGD:1353040 6480464 Cisplatin results in decreased expression of ATP5D mRNA CTD PMID:27594783 clofibrate multiple interactions ISO RGD:731351 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of ATP5D mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATP5D mRNA] CTD PMID:17585979 cyclosporin A decreases expression ISO RGD:1353040 6480464 Cyclosporine results in decreased expression of ATP5F1D mRNA CTD PMID:20106945 , PMID:25562108 D-glucose multiple interactions EXP 6480464 15-Hydroxy-11 alpha more ... CTD PMID:25305180 dexamethasone multiple interactions ISO RGD:1353040 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ATP5D mRNA CTD PMID:28628672 dibutyl phthalate decreases expression ISO RGD:731351 6480464 Dibutyl Phthalate results in decreased expression of ATP5D mRNA CTD PMID:21266533 dioxygen decreases expression ISO RGD:731351 6480464 Oxygen deficiency results in decreased expression of ATP5D protein CTD PMID:25937538 dioxygen multiple interactions EXP 6480464 15-Hydroxy-11 alpha more ... CTD PMID:25305180 doxorubicin decreases expression ISO RGD:731351 6480464 Doxorubicin results in decreased expression of ATP5D protein CTD PMID:21251210 doxorubicin decreases expression ISO RGD:1353040 6480464 Doxorubicin results in decreased expression of ATP5F1D mRNA CTD PMID:29803840 doxorubicin affects expression ISO RGD:1353040 6480464 Doxorubicin affects the expression of ATP5D protein CTD PMID:29385562 ethyl methanesulfonate decreases expression ISO RGD:1353040 6480464 Ethyl Methanesulfonate results in decreased expression of ATP5F1D mRNA CTD PMID:23649840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of ATP5F1D mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:731351 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP5D gene CTD PMID:20938992 gamma-hexachlorocyclohexane decreases expression EXP 6480464 Hexachlorocyclohexane results in decreased expression of ATP5F1D mRNA CTD PMID:17785943 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ATP5F1D mRNA CTD PMID:15350274 glucose multiple interactions EXP 6480464 15-Hydroxy-11 alpha more ... CTD PMID:25305180 glyphosate decreases expression EXP 6480464 glyphosate results in decreased expression of ATP5F1D mRNA CTD PMID:26302742 indometacin multiple interactions ISO RGD:1353040 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ATP5D mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:731351 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ATP5D gene CTD PMID:20938992 lipopolysaccharide multiple interactions ISO RGD:1353040 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of ATP5D mRNA CTD PMID:31059760 lithium atom increases expression EXP 6480464 Lithium results in increased expression of ATP5F1D protein CTD PMID:18296634 lithium hydride increases expression EXP 6480464 Lithium results in increased expression of ATP5F1D protein CTD PMID:18296634 methotrexate affects response to substance ISO RGD:1353040 6480464 ATP5F1D protein affects the susceptibility to Methotrexate CTD PMID:16217747 methyl methanesulfonate decreases expression ISO RGD:1353040 6480464 Methyl Methanesulfonate results in decreased expression of ATP5F1D mRNA CTD PMID:23649840 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of ATP5F1D mRNA CTD PMID:24136188 Niclosamide increases expression ISO RGD:1353040 6480464 Niclosamide results in increased expression of ATP5F1D mRNA CTD PMID:22576131 notoginsenoside R1 multiple interactions EXP 6480464 15-Hydroxy-11 alpha more ... CTD PMID:25305180 ochratoxin A increases expression ISO RGD:1353040 6480464 ochratoxin A results in increased expression of ATP5F1D mRNA CTD PMID:17316727 okadaic acid multiple interactions ISO RGD:1353040 6480464 [Okadaic Acid co-treated with gambierol] results in increased expression of ATP5F1D protein CTD PMID:19397276 okadaic acid decreases expression ISO RGD:1353040 6480464 Okadaic Acid results in decreased expression of ATP5F1D protein CTD PMID:19397276 paracetamol multiple interactions ISO RGD:731351 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of ATP5D mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATP5D mRNA] CTD PMID:17585979 paracetamol multiple interactions ISO RGD:1353040 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of ATP5D mRNA CTD PMID:31059760 paracetamol decreases expression ISO RGD:1353040 6480464 Acetaminophen results in decreased expression of ATP5D mRNA, Acetaminophen results in decreased expression of ATP5F1D mRNA CTD PMID:22230336 more ... paracetamol affects response to substance ISO RGD:1353040 6480464 ATP5F1D gene polymorphism affects the susceptibility to Acetaminophen CTD PMID:26104854 paracetamol increases expression ISO RGD:731351 6480464 Acetaminophen results in increased expression of ATP5D protein CTD PMID:21329376 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731351 6480464 perfluorooctane sulfonic acid results in decreased expression of ATP5D mRNA CTD PMID:20936131 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:731351 6480464 PPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of ATP5D mRNA] CTD PMID:20936131 picrotoxin decreases expression EXP 6480464 Picrotoxin results in decreased expression of ATP5F1D mRNA CTD PMID:15170462 rotenone decreases expression ISO RGD:731351 6480464 Rotenone results in decreased expression of ATP5D mRNA CTD PMID:23186747 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of ATP5F1D mRNA CTD PMID:19072884 sunitinib decreases expression ISO RGD:1353040 6480464 Sunitinib results in decreased expression of ATP5F1D mRNA CTD PMID:31533062 tetrachloroethene decreases expression ISO RGD:731351 6480464 Tetrachloroethylene results in decreased expression of ATP5D mRNA CTD PMID:28973375 thimerosal decreases expression ISO RGD:1353040 6480464 Thimerosal results in decreased expression of ATP5F1D mRNA CTD PMID:27188386 titanium dioxide increases expression ISO RGD:731351 6480464 titanium dioxide results in increased expression of ATP5D mRNA CTD PMID:23131501 valproic acid increases methylation ISO RGD:1353040 6480464 Valproic Acid results in increased methylation of ATP5D gene CTD PMID:29154799 Y-27632 multiple interactions EXP 6480464 Y 27632 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein] CTD PMID:25305180 zidovudine decreases expression ISO RGD:1353040 6480464 Zidovudine results in decreased expression of ATP5F1D mRNA CTD PMID:16894629
Biological Process aerobic respiration ISO RGD:1353040 1624291 (PMID:29478781) RGD PMID:29478781 aerobic respiration IEA UniProtKB:P30049 , ensembl:ENSP000002153751600115 GO_REF:0000107 Ensembl GO_REF:0000107 aerobic respiration ISS UniProtKB:P30049 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ATP biosynthetic process TAS 724594 RGD ATP metabolic process IDA 2292427 RGD ATP synthesis coupled proton transport TAS 724594 RGD ATP synthesis coupled proton transport IBA PANTHER:PTN000352454 more ... 13792537 PMID:21873635 GO_Central ATP synthesis coupled proton transport IEA InterPro:IPR001469 , InterPro:IPR020546 1600115 GO_REF:0000002 InterPro GO_REF:0000002 mitochondrial ATP synthesis coupled proton transport ISO RGD:1353040 1624291 (PMID:12110673) RGD PMID:12110673 mitochondrial ATP synthesis coupled proton transport IEA UniProtKB:P30049 , ensembl:ENSP000002153751600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrial proton-transporting ATP synthase complex assembly ISS UniProtKB:P30049 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrial proton-transporting ATP synthase complex assembly ISO RGD:1353040 1624291 (PMID:29478781) RGD PMID:29478781 mitochondrial proton-transporting ATP synthase complex assembly IEA UniProtKB:P30049 , ensembl:ENSP000002153751600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to resveratrol IEP 13792665 RGD Cellular Component mitochondrial inner membrane IDA 2292224 RGD mitochondrial proton-transporting ATP synthase complex ISO RGD:1353040 1624291 (PMID:12110673) RGD PMID:12110673 mitochondrial proton-transporting ATP synthase complex IEA UniProtKB:P30049 , ensembl:ENSP000002153751600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrial proton-transporting ATP synthase complex IDA 8553598 PMID:17575325 UniProt mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IDA 2292427 RGD mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA PANTHER:PTN000352457 more ... 13792537 PMID:21873635 GO_Central proton-transporting ATP synthase complex TAS 724594 RGD proton-transporting ATP synthase complex, catalytic core F(1) IDA 724594 ; 2292224 RGD proton-transporting ATP synthase complex, catalytic core F(1) IEA InterPro:IPR001469 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Molecular Function ATPase activity contributes_to IDA 2292224 RGD protein binding ISO RGD:1353040 1624291 UniProtKB:P56381 (PMID:28514442) RGD PMID:28514442 protein-containing complex binding IDA 724594 RGD proton-transporting ATP synthase activity, rotational mechanism TAS 724594 RGD proton-transporting ATP synthase activity, rotational mechanism IEA UniProtKB:P30049 , ensembl:ENSP000002153751600115 GO_REF:0000107 Ensembl GO_REF:0000107 proton-transporting ATP synthase activity, rotational mechanism IEA InterPro:IPR001469 1600115 GO_REF:0000002 InterPro GO_REF:0000002 proton-transporting ATP synthase activity, rotational mechanism contributes_to ISO RGD:1353040 1624291 (PMID:12110673) RGD PMID:12110673
Gene-Chemical Interaction Annotations
